Human adipose stromal/stem cells from obese donors show reduced efficacy in halting disease progression in the experimental autoimmune encephalomyelitis model of multiple sclerosis

Stem Cells

Volumn 34, Issue 3, 2016, Pages 614-626

  Strong, Amy L ^a   Bowles, Annie C ^a   Wise, Rachel M ^a   Morand, Joseph P ^a   Dutreil, Maria F ^a   Gimble, Jeffrey M ^a   Bunnell, Bruce A ^a  

^a TULANE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Adipose stromal stem cells; Adipose derived stromal stem cells; Experimental autoimmune encephalomyelitis; Immunomodulatory properties; Multiple sclerosis; Obesity; Therapeutic efficacy

Indexed keywords

COMPLEMENTARY DNA; GRANULOCYTE COLONY STIMULATING FACTOR; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 6; INTERLEUKIN 8; MESSENGER RNA; PLATELET DERIVED GROWTH FACTOR A; TUMOR NECROSIS FACTOR ALPHA;

ABDOMINAL SUBCUTANEOUS FAT; ADIPOSE DERIVED STEM CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY MASS; CD3+ T LYMPHOCYTE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CONTROLLED STUDY; DISEASE COURSE; DISEASE SEVERITY; ENDOCRINE DISEASE; FEMALE; FLOW CYTOMETRY; HUMAN; LYMPHOCYTE DIFFERENTIATION; MOTOR FUNCTION TEST; MOUSE; MULTIPLE SCLEROSIS; NONHUMAN; OBESITY; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ISOLATION; T LYMPHOCYTE; ADIPOCYTE; ADIPOSE TISSUE; ANIMAL; CELL DIFFERENTIATION; CYTOLOGY; DONOR; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; GENETICS; INFLAMMATION; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMA CELL; METABOLISM; PATHOLOGY; TRANSPLANTATION;

ADIPOCYTES; ADIPOSE TISSUE; ANIMALS; CELL DIFFERENTIATION; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; HUMANS; INFLAMMATION; MESENCHYMAL STEM CELL TRANSPLANTATION; MESENCHYMAL STROMAL CELLS; MICE; MULTIPLE SCLEROSIS; OBESITY; TISSUE DONORS;

EID: 84959282448     PISSN: 10665099     EISSN: 15494918     Source Type: Journal    
DOI: 10.1002/stem.2272     Document Type: Article

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