-
2
-
-
33745631754
-
Antigen presentation in autoimmunity and CNS inflammation: How T lymphocytes recognize the brain
-
DOI 10.1007/s00109-006-0065-1
-
Becher, B., I. Bechmann, and M. Greter. 2006. Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain. J. Mol. Med. 84: 532-543. (Pubitemid 43992845)
-
(2006)
Journal of Molecular Medicine
, vol.84
, Issue.7
, pp. 532-543
-
-
Becher, B.1
Bechmann, I.2
Greter, M.3
-
3
-
-
0030970058
-
Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis
-
DOI 10.1007/s001090050101
-
Benveniste, E. N. 1997. Role of macrophages/microglia in multiple sclerosis and experimental allergic encephalomyelitis. J. Mol. Med. 75: 165-173. (Pubitemid 27132679)
-
(1997)
Journal of Molecular Medicine
, vol.75
, Issue.3
, pp. 165-173
-
-
Benveniste, E.N.1
-
4
-
-
0035892908
-
Administration of dehydroepiandrosterone suppresses experimental allergic encephalomyelitis in SJL/J mice
-
Du, C., M. W. Khalil, and S. Sriram. 2001. Administration of dehydroepiandrosterone suppresses experimental allergic encephalomyelitis in SJL/J mice. J. Immunol. 167: 7094-7101. (Pubitemid 33144206)
-
(2001)
Journal of Immunology
, vol.167
, Issue.12
, pp. 7094-7101
-
-
Du, C.1
Wahid Khalil, M.2
Sriram, S.3
-
6
-
-
0034674520
-
Activation of nuclear factor-kB in the spinal cord of experimental allergic encephalomyelitis
-
DOI 10.1016/S0304-3940(00)01167-8, PII S0304394000011678
-
Pahan, K., and M. Schmid. 2000. Activation of nuclear factor-κB in the spinal cord of experimental allergic encephalomyelitis. Neurosci. Lett. 287: 17-20. (Pubitemid 30332367)
-
(2000)
Neuroscience Letters
, vol.287
, Issue.1
, pp. 17-20
-
-
Pahan, K.1
Schmid, M.2
-
7
-
-
17644444933
-
Inflammation and degeneration in multiple sclerosis
-
Bruck, W., and C. Stadelmann. 2003. Inflammation and degeneration in multiple sclerosis. Neurol. Sci. 24(Suppl. 5): S265-S267.
-
(2003)
Neurol. Sci.
, vol.24
, Issue.SUPPL. 5
-
-
Bruck, W.1
Stadelmann, C.2
-
9
-
-
0031943618
-
The interleukin-12/interleukin-12-receptor system: Role in normal and pathologic immune responses
-
Gately, M. K., L. M. Renzetti, J. Magram, A. S. Stern, L. Adorini, U. Gubler, D. H. Presky. 1998. The interleukin-12/interleukin-12-receptor system: role in normal and pathologic immune responses. Annu. Rev. Immunol. 16: 495-521.
-
(1998)
Annu. Rev. Immunol.
, vol.16
, pp. 495-521
-
-
Gately, M.K.1
Renzetti, L.M.2
Magram, J.3
Stern, A.S.4
Adorini, L.5
Gubler, U.6
Presky, D.H.7
-
10
-
-
0037799912
-
Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice
-
DOI 10.1172/JCI200317085
-
Kobayashi, M., M. N. Kweon, H. Kuwata, R. D. Schreiber, H. Kiyono, K. Takeda, and S. Akira. 2003. Toll-like receptor-dependent production of IL-12p40 causes chronic enterocolitis in myeloid cell-specific Stat3-deficient mice. J. Clin. Invest. 111: 1297-1308. (Pubitemid 36554700)
-
(2003)
Journal of Clinical Investigation
, vol.111
, Issue.9
, pp. 1297-1308
-
-
Kobayashi, M.1
Kweon, M.-N.2
Kuwata, H.3
Schreiber, R.D.4
Kiyono, H.5
Takeda, K.6
Akira, S.7
-
11
-
-
0033638507
-
Novel p19 protein engages IL-12p40 to form a cytokine: IL-23, with biological activities similar as well as distinct from IL-12
-
Oppmann, B., R. Lesley, B. Blom, J. C. Timans, Y. Xu, B. Hunte, F. Vega, N. Yu, J. Wang, K. Singh, et al. 2000. Novel p19 protein engages IL-12p40 to form a cytokine: IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13: 715-725.
-
(2000)
Immunity
, vol.13
, pp. 715-725
-
-
Oppmann, B.1
Lesley, R.2
Blom, B.3
Timans, J.C.4
Xu, Y.5
Hunte, B.6
Vega, F.7
Yu, N.8
Wang, J.9
Singh, K.10
-
12
-
-
0037434789
-
Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
-
Cua, D. J., J. Sherlock, Y. Chen, C. A. Murphy, B. Joyce, B. Seymour, L. Lucian, W. To, S. Kwan, T. Churakova, et al. 2003. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421: 744-748.
-
(2003)
Nature
, vol.421
, pp. 744-748
-
-
Cua, D.J.1
Sherlock, J.2
Chen, Y.3
Murphy, C.A.4
Joyce, B.5
Seymour, B.6
Lucian, L.7
To, W.8
Kwan, S.9
Churakova, T.10
-
13
-
-
0037238897
-
A unique role for IL-23 in promoting cellular immunity
-
Lankford, C. S., and D. M. Frucht. 2003. A unique role for IL-23 in promoting cellular immunity. J. Leukocyte Biol. 73: 49-56.
-
(2003)
J. Leukocyte Biol.
, vol.73
, pp. 49-56
-
-
Lankford, C.S.1
Frucht, D.M.2
-
14
-
-
33646518184
-
Pathophysiology of interleukin-23 in experimental autoimmune encephalomyelitis
-
Touil, T., D. Fitzgerald, G. X. Zhang, A. Rostami, and B. Gran. 2006. Pathophysiology of interleukin-23 in experimental autoimmune encephalomyelitis. Drug News Perspect. 19: 77-83.
-
(2006)
Drug News Perspect.
, vol.19
, pp. 77-83
-
-
Touil, T.1
Fitzgerald, D.2
Zhang, G.X.3
Rostami, A.4
Gran, B.5
-
15
-
-
0030944709
-
Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat
-
Smith, T., A. K. Hewson, C. I. Kingsley, J. P. Leonard, and M. L. Cuzner. 1997. Interleukin-12 induces relapse in experimental allergic encephalomyelitis in the Lewis rat. Am. J. Pathol. 150: 1909-1917. (Pubitemid 27233064)
-
(1997)
American Journal of Pathology
, vol.150
, Issue.6
, pp. 1909-1917
-
-
Smith, T.1
Hewson, A.K.2
Kingsley, C.I.3
Leonard, J.P.4
Cuzner, M.L.5
-
16
-
-
0035177433
-
Modulation of susceptibility and resistance to an autoimmune model of multiple sclerosis in prototypically susceptible and resistant strains by neutralization of interleukin-12 and interleukin-4, respectively
-
Constantinescu, C. S., B. Hilliard, E. Ventura, M. Wysocka, L. Showe, E. Lavi, T. Fujioka, P. Scott, G. Trinchieri, and A. Rostami. 2001. Modulation of susceptibility and resistance to an autoimmune model of multiple sclerosis in prototypically susceptible and resistant strains by neutralization of interleukin-12 and interleukin-4, respectively. Clin. Immunol. 98: 23-50.
-
(2001)
Clin. Immunol.
, vol.98
, pp. 23-50
-
-
Constantinescu, C.S.1
Hilliard, B.2
Ventura, E.3
Wysocka, M.4
Showe, L.5
Lavi, E.6
Fujioka, T.7
Scott, P.8
Trinchieri, G.9
Rostami, A.10
-
17
-
-
0028806468
-
Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: Dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β
-
Issazadeh, S., A. Ljungdahl, B. Hojeberg, M. Mustafa, and T. Olson. 1995. Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β. J. Neuroimmunol. 61: 205-212.
-
(1995)
J. Neuroimmunol.
, vol.61
, pp. 205-212
-
-
Issazadeh, S.1
Ljungdahl, A.2
Hojeberg, B.3
Mustafa, M.4
Olson, T.5
-
18
-
-
0028966091
-
Prevention of experimental allergic encephalomyelitis by antibodies against interleukin-12
-
Leonard, J. P., K. E. Waldburger, and S. J. Goldman. 1995. Prevention of experimental allergic encephalomyelitis by antibodies against interleukin-12. J. Exp. Med. 181: 381-386.
-
(1995)
J. Exp. Med.
, vol.181
, pp. 381-386
-
-
Leonard, J.P.1
Waldburger, K.E.2
Goldman, S.J.3
-
19
-
-
0032211092
-
Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis
-
Constantinescu, C. S., M. Wysocka, B. Hilliard, E. S. Ventura, E. Lavi, G. Trinchieri, and Rostami, A. 1998. Antibodies against IL-12 prevent superantigen-induced and spontaneous relapses of experimental autoimmune encephalomyelitis. J. Immunol. 161: 5097-5104. (Pubitemid 28492093)
-
(1998)
Journal of Immunology
, vol.161
, Issue.9
, pp. 5097-5104
-
-
Constantinescu, C.S.1
Wysocka, M.2
Hilliard, B.3
Ventura, E.S.4
Lavi, E.5
Trinchieri, G.6
Rostami, A.7
-
20
-
-
0037479043
-
Induction of tumor necrosis factor-α (TNF-α) by interleukin-12 p40 monomer and homodimer in microglia and macrophages
-
DOI 10.1046/j.1471-4159.2003.01864.x
-
Jana, M., S. Dasgupta, R. N. Saha, X. Liu, and K. Pahan. 2003. Induction of tumor necrosis factor α (TNF-α) by interleukin-12 p40 monomer and homodimer in microglia and macrophages. J. Neurochem. 86: 519-528. (Pubitemid 36842451)
-
(2003)
Journal of Neurochemistry
, vol.86
, Issue.2
, pp. 519-528
-
-
Jana, M.1
Dasgupta, S.2
Saha, R.N.3
Liu, X.4
Pahan, K.5
-
21
-
-
0035896521
-
Induction of Nitric-oxide Synthase and Activation of NF-κ B by Interleukin-12 p40 in Microglial Cells
-
DOI 10.1074/jbc.M008262200
-
Pahan, K., F. G. Sheikh, X. Liu, S. Hilger, M. McKinney, and T. M. Petro. 2001. Induction of nitric-oxide synthase and activation of NF-κB by interleukin-12 p40 in microglial cells. J. Biol. Chem. 276: 7899-7905. (Pubitemid 37385585)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.11
, pp. 7899-7905
-
-
Pahan, K.1
Sheikh, F.G.2
Liu, X.3
Hilger, S.4
McKinney, M.5
Petro, T.M.6
-
22
-
-
59249089569
-
IL-12 p40 homodimer, but not IL-12 p70, induces the expression of IL-16 in microglia and macrophages
-
Jana, M., and K. Pahan. 2009. IL-12 p40 homodimer, but not IL-12 p70, induces the expression of IL-16 in microglia and macrophages. Mol. Immunol. 46: 773-783.
-
(2009)
Mol. Immunol.
, vol.46
, pp. 773-783
-
-
Jana, M.1
Pahan, K.2
-
23
-
-
66549113544
-
Induction of lymphotoxin-α by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70
-
In press
-
Jana, M., and K. Pahan. 2009. Induction of lymphotoxin-α by interleukin-12 p40 homodimer, the so-called biologically inactive molecule, but not IL-12 p70. Immunology. In press.
-
(2009)
Immunology
-
-
Jana, M.1
Pahan, K.2
-
24
-
-
50349097488
-
Generation of functional blocking monoclonal antibodies against mouse p40 homodimer and monomer
-
Dasgupta, S., M. Bandopadhyay, and K. Pahan. 2008. Generation of functional blocking monoclonal antibodies against mouse p40 homodimer and monomer. Hybridoma 27: 141-151.
-
(2008)
Hybridoma
, vol.27
, pp. 141-151
-
-
Dasgupta, S.1
Bandopadhyay, M.2
Pahan, K.3
-
25
-
-
0347296187
-
Sodium phenylacetate inhibits adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice at multiple steps
-
Dasgupta, S., Y. Zhou, M. Jana, N. L. Banik, and K. Pahan. 2003. Sodium phenylacetate inhibits adoptive transfer of experimental allergic encephalomyelitis in SJL/J mice at multiple steps. J. Immunol. 170: 3874-3882. (Pubitemid 36359259)
-
(2003)
Journal of Immunology
, vol.170
, Issue.7
, pp. 3874-3882
-
-
Dasgupta, S.1
Zhou, Y.2
Jana, M.3
Banik, N.L.4
Pahan, K.5
-
26
-
-
3142774208
-
Antineuroinflammatory effect of NF-κB essential modifier-binding domain peptides in the adoptive transfer model of experimental allergic encephalomyelitis
-
Dasgupta, S., M. Jana, Y. Zhou, Y. K. Fung, S. Ghosh, and K. Pahan. 2004. Antineuroinflammatory effect of NF-κB essential modifier-binding domain peptides in the adoptive transfer model of experimental allergic encephalomyelitis. J. Immunol. 173: 1344-1354. (Pubitemid 38924314)
-
(2004)
Journal of Immunology
, vol.173
, Issue.2
, pp. 1344-1354
-
-
Dasgupta, S.1
Jana, M.2
Zhou, Y.3
Fung, Y.K.4
Ghosh, S.5
Pahan, K.6
-
27
-
-
34250809522
-
Sodium benzoate, a food additive and a metabolite of cinnamon, modifies T cells at multiple steps and inhibits adoptive transfer of experimental allergic encephalomyelitis
-
Brahmachari, S., and K. Pahan. 2007. Sodium benzoate, a commonly-used food additive, modifies T cells at multiple steps and suppresses experimental allergic encephalomyelitis. J. Immunol. 179: 275-283. (Pubitemid 46986543)
-
(2007)
Journal of Immunology
, vol.179
, Issue.1
, pp. 275-283
-
-
Brahmachari, S.1
Pahan, K.2
-
28
-
-
34748917549
-
Gemfibrozil ameliorates relapsing-remitting experimental autoimmune encephalomyelitis independent of PPAR-α
-
Dasgupta, S., A. Roy, M. Jana, D. M. Hartley, K. Pahan. 2007. Gemfibrozil ameliorates relapsing-remitting experimental autoimmune encephalomyelitis independent of PPAR-α. Mol. Pharmacol. 72: 934-946.
-
(2007)
Mol. Pharmacol.
, vol.72
, pp. 934-946
-
-
Dasgupta, S.1
Roy, A.2
Jana, M.3
Hartley, D.M.4
Pahan, K.5
-
29
-
-
33646947850
-
Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide
-
DOI 10.1523/JNEUROSCI.5480-05.2006
-
Brahmachari, S., Y. K. Fung, and K. Pahan, K. 2006. Induction of glial fibrillary acidic protein expression in astrocytes by nitric oxide. J. Neurosci. 26: 4930-4939. (Pubitemid 44315335)
-
(2006)
Journal of Neuroscience
, vol.26
, Issue.18
, pp. 4930-4939
-
-
Brahmachari, S.1
Fung, Y.K.2
Pahan, K.3
-
30
-
-
46749156738
-
Role of cytokine p40 family in multiple sclerosis
-
Brahmachari, S., and K. Pahan. 2008. Role of cytokine p40 family in multiple sclerosis. Minerva Med. 99: 105-118. (Pubitemid 351946149)
-
(2008)
Minerva Medica
, vol.99
, Issue.2
, pp. 105-118
-
-
Brahmachari, S.1
Pahan, K.2
-
31
-
-
0034733828
-
Murine macrophages stimulated with central and peripheral nervous system myelin or purified myelin proteins release inflammatory products
-
Constantinescu, C. S., D. B. Goodman, B. Hilliard, M. Wysocka, and J. A. Cohen. 2000. Murine macrophages stimulated with central and peripheral nervous system myelin or purified myelin proteins release inflammatory products. Neurosci. Lett. 287: 171-174.
-
(2000)
Neurosci. Lett.
, vol.287
, pp. 171-174
-
-
Constantinescu, C.S.1
Goodman, D.B.2
Hilliard, B.3
Wysocka, M.4
Cohen, J.A.5
-
32
-
-
0031721520
-
Increased release of interleukin-12p40 in MS: Association with intracerebral inflammation
-
Fassbender, K., A. Ragoschke, S. Rossol, A. Schwartz, O. Mielke, A. Paulig, and M. Hennerici. 1998. Increased release of interleukin-12p40 in MS: association with intracerebral inflammation. Neurology 51: 753-758. (Pubitemid 28449255)
-
(1998)
Neurology
, vol.51
, Issue.3
, pp. 753-758
-
-
Fassbender, K.1
Ragoschke, A.2
Rossol, S.3
Schwartz, A.4
Mielke, O.5
Paulig, A.6
Hennerici, M.7
-
33
-
-
0032005162
-
Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalitis
-
Bright, J. J., B. F. Musuro, C. Du, and S. Sriram. 1998. Expression of IL-12 in CNS and lymphoid organs of mice with experimental allergic encephalitis. J. Neuroimmunol. 82: 22-30.
-
(1998)
J. Neuroimmunol.
, vol.82
, pp. 22-30
-
-
Bright, J.J.1
Musuro, B.F.2
Du, C.3
Sriram, S.4
-
34
-
-
0030035947
-
Lymphocyte targeting of the CNS: A review of afferent and efferent CNS-immune pathways
-
Weller, R. O., B. Engelhardt, and M. J. Phillips. 1996. Lymphocyte targeting of the CNS: a review of afferent and efferent CNS-immune pathways. Brain Pathol. 6: 275-288.
-
(1996)
Brain Pathol.
, vol.6
, pp. 275-288
-
-
Weller, R.O.1
Engelhardt, B.2
Phillips, M.J.3
-
35
-
-
0028283232
-
Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse
-
Steffen, B. J., E. C. Butcher, and B. Engelhardt. 1994. Evidence for involvement of ICAM-1 and VCAM-1 in lymphocyte interaction with endothelium in experimental autoimmune encephalomyelitis in the central nervous system in the SJL/J mouse. Am. J. Pathol. 145: 189-201.
-
(1994)
Am. J. Pathol.
, vol.145
, pp. 189-201
-
-
Steffen, B.J.1
Butcher, E.C.2
Engelhardt, B.3
-
36
-
-
20944452157
-
Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII
-
Piccio, L., B. Rossi, L. Colantonio, R. Grenningloh, A. Gho, L. Ottoboni, J. W. Homeister, E. Scarpini, M. Martinello, C. Laudanna, et al. 2005. Efficient recruitment of lymphocytes in inflamed brain venules requires expression of cutaneous lymphocyte antigen and fucosyltransferase-VII. J. Immunol. 174: 5805-5813. (Pubitemid 40593225)
-
(2005)
Journal of Immunology
, vol.174
, Issue.9
, pp. 5805-5813
-
-
Piccio, L.1
Rossi, B.2
Colantonio, L.3
Grenningloh, R.4
Gho, A.5
Ottoboni, L.6
Homeister, J.W.7
Scarpini, E.8
Martinello, M.9
Laudanna, C.10
D'Ambrosio, D.11
Lowe, J.B.12
Constantin, G.13
-
37
-
-
0035006560
-
Nitric oxide and blood-brain barrier integrity
-
Thiel, V. E., and K. L. Audus. 2001. Nitric oxide and blood-brain barrier integrity. Antioxid. Redox. Signal. 3: 273-278.
-
(2001)
Antioxid. Redox. Signal
, vol.3
, pp. 273-278
-
-
Thiel, V.E.1
Audus, K.L.2
-
38
-
-
0035896372
-
Nitric-oxide-induced inhibition of glyceraldehyde-3-phosphate dehydrogenase may mediate reduced endothelial cell monolayer integrity in an in vitro model blood-brain barrier
-
Hurst, R. D., S. Azam, A. Hurst, and J. B. Clark. 2001. Nitric-oxide-induced inhibition of glyceraldehyde-3-phosphate dehydrogenase may mediate reduced endothelial cell monolayer integrity in an in vitro model blood-brain barrier. Brain Res. 894: 181-188.
-
(2001)
Brain Res.
, vol.894
, pp. 181-188
-
-
Hurst, R.D.1
Azam, S.2
Hurst, A.3
Clark, J.B.4
-
39
-
-
0030944188
-
Current and investigational therapies used to alter the course of disease in multiple sclerosis
-
Miller, A. 1997. Current and investigational therapies used to alter the course of disease in multiple sclerosis. South. Med. J. 90: 367-375. (Pubitemid 27176396)
-
(1997)
Southern Medical Journal
, vol.90
, Issue.4
, pp. 367-375
-
-
Miller, A.1
|