Facile oxidation of leucomethylene blue and dihydroflavins by artemisinins: Relationship with flavoenzyme function and antimalarial mechanism of action

ChemMedChem

Volumn 5, Issue 8, 2010, Pages 1282-1299

  Haynes, Richard K ^a   Chan, Wing Chi ^a   Wong, Ho Ning ^a   Li, Ka Yan ^a   Wu, Wai Keung ^a   Fan, Kit Man ^a   Sung, Herman H Y ^a   Williams, Ian D ^a   Prosperi, Davide ^c   Melato, Sergio ^b   Coghi, Paolo ^b   Monti, Diego ^b  

^a HONG KONG UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Hong Kong)

^b CNR   (Italy)

^c Department of Biotechnology and Bioscience ^*  (Italy)

Author keywords

Artemisinins; Flavins; Flavoenzymes; Malaria; Oxidative stress

Indexed keywords

9 EPIARTEMISININ; ANTIMALARIAL AGENT; ARTEMETHER; ARTEMISININ DERIVATIVE; ARTEMISONE; ARTESUNATE; ASCORBIC ACID; DIHYDROARTEMISININ; DIHYDROFLAVIN DERIVATIVE; DOXORUBICIN; FERROUS ION; FLAVINE ADENINE NUCLEOTIDE; FLAVOPROTEIN; GLUTATHIONE REDUCTASE; LEUCOMETHYLENE BLUE; METHYLENE BLUE; N BENZYLDIHYDRONICOTINAMIDE; NICOTINAMIDE; OXYGEN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; RIBOFLAVIN; SODIUM DITHIONITE; UNCLASSIFIED DRUG;

AEROBIC CAPACITY; ANTIMALARIAL ACTIVITY; ARTICLE; AUTOOXIDATION; CATALYSIS; CONTROLLED STUDY; DRUG POTENTIATION; ELECTRON TRANSPORT; OXIDATION; PH MEASUREMENT; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION; YEAST;

ANTIMALARIALS; ARTEMISININS; CRYSTALLOGRAPHY, X-RAY; FLAVINS; GLUTATHIONE REDUCTASE; METHYLENE BLUE; MOLECULAR CONFORMATION; OXIDATION-REDUCTION; PROTOZOAN PROTEINS; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77955105107     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000225     Document Type: Article

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