A Radioactivity-Based Assay for Screening Human m6A-RNA Methyltransferase, METTL3-METTL14 Complex, and Demethylase ALKBH5

Journal of Biomolecular Screening

Volumn 21, Issue 3, 2016, Pages 290-297

  Li, Fengling ^a   Kennedy, Steven ^a   Hajian, Taraneh ^a   Gibson, Elisa ^a   Seitova, Alma ^a   Xu, Chao ^a   Arrowsmith, Cheryl H ^a,b   Vedadi, Masoud ^a  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

epigenetics; METTL14; METTL3; RNA demethylase; RNA methyltransferase

Indexed keywords

6 N METHYLADENOSINE; M6 A RNA DEMETHYLASE ALKBH5; METHYLTRANSFERASE LIKE 14; METHYLTRANSFERASE LIKE 3; MULTIENZYME COMPLEX; RNA METHYLTRANSFERASE; UNCLASSIFIED DRUG; ALKBH5 PROTEIN, HUMAN; ALKYLATED DNA REPAIR PROTEIN ALKB HOMOLOG 5; LIGAND; METHYLTRANSFERASE; METTL14 PROTEIN, HUMAN; METTL3 PROTEIN, HUMAN; PROTEIN BINDING;

ARTICLE; CATALYTIC EFFICIENCY; ENZYME ACTIVITY; ENZYME KINETICS; ENZYME MODIFICATION; ENZYME SUBSTRATE; HUMAN; ION EXCHANGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RADIOENZYMATIC ASSAY; RNA METHYLATION; BIOASSAY; DRUG DEVELOPMENT; KINETICS; METABOLISM; PROCEDURES; RADIOASSAY;

ALKB HOMOLOG 5, RNA DEMETHYLASE; BIOLOGICAL ASSAY; DRUG DISCOVERY; HUMANS; KINETICS; LIGANDS; METHYLTRANSFERASES; PROTEIN BINDING; RADIOLIGAND ASSAY;

EID: 84959242641     PISSN: 10870571     EISSN: 1552454X     Source Type: Journal    
DOI: 10.1177/1087057115623264     Document Type: Article

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