New Zealand white rabbit progeny exposed in utero to methanol are resistant to skeletal anomalies reported for rodents, but exhibit a novel vertebral defect

Reproductive Toxicology

Volumn 58, Issue , 2015, Pages 104-110

  Sweeting, J Nicole ^a   Wells, Peter G ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Methanol (MeOH); New Zealand white (NZW) rabbit; Skeletal development; Teratology

Indexed keywords

METHANOL; TERATOGENIC AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE MALFORMATION; CONTROLLED STUDY; DISEASE RESISTANCE; FEMALE; FETUS; FETUS DISEASE; LIMB MALFORMATION; LUMBAR VERTEBRA; NEW ZEALAND WHITE (RABBIT); NONHUMAN; PRENATAL EXPOSURE; PROGENY; RISK ASSESSMENT; RODENT; SKELETON MALFORMATION; SPECIES DIFFERENCE; SPINE DISEASE; TERATOGENICITY; ABNORMALITIES; ABNORMALITIES, DRUG-INDUCED; ANIMAL; DRUG EFFECTS; GESTATIONAL AGE; MATERNAL EXPOSURE; MOUSE; PATHOLOGY; PATHOPHYSIOLOGY; PREGNANCY; RABBIT; RAT; SPINE;

ABNORMALITIES, DRUG-INDUCED; ANIMALS; FEMALE; GESTATIONAL AGE; MATERNAL EXPOSURE; METHANOL; MICE; MODELS, ANIMAL; OSTEOGENESIS; PREGNANCY; RABBITS; RATS; RISK ASSESSMENT; SPECIES SPECIFICITY; SPINE; TERATOGENS;

EID: 84944075106     PISSN: 08906238     EISSN: 18731708     Source Type: Journal    
DOI: 10.1016/j.reprotox.2015.09.004     Document Type: Article

References (49)

1. Hantson P., Lambermont J.Y., Mahieu P. Methanol poisoning during late pregnancy. J. Toxicol. Clin. Toxicol. 1997, 35(2):187-191.
2. Belson M., Morgan B.W. Methanol toxicity in a newborn. J. Toxicol. Clin. Toxicol. 2004, 42(5):673-677.
3. Wells P.G., McCallum G.P., Miller L., Siu M.T., Sweeting J.N. Oxidative stress and species differences in the metabolism, developmental toxicity and carcinogenic potential of methanol and ethanol. The Toxicology of Methanol 2013, 169-253. Wiley, Hoboken, USA. J. Clary (Ed.).
4. Siu M.T., Wiley M.J., Wells P.G. Methanol teratogenicity in mutant mice with deficient catalase activity and transgenic mice expressing human catalase. Reprod. Toxicol. 2013, 36:33-39.
5. Sweeting J.N., Siu M., Wiley M.J., Wells P.G. Species- and strain-dependent teratogenicity of methanol in rabbits and mice. Reprod. Toxicol. 2011, 31(1):50-58.
6. Rogers J.M., Brannen K.C., Barbee B.D., Zucker R.M., Degitz S.J. Methanol exposure during gastrulation causes holoprosencephaly, facial dysgenesis, and cervical vertebral malformations in C57BL/6J mice. Birth Defects Res. B Dev. Reprod. Toxicol. 2004, 71(2):80-88.
7. Siu M.T., Shapiro A.M., Wiley M.J., Wells P.G. A role for glutathione, independent of oxidative stress, in the developmental toxicity of methanol. Toxicol. Appl. Pharmacol. 2013, 273(3):508-515.
8. Rogers J.M., Mole M.L. Critical periods of sensitivity to the developmental toxicity of inhaled methanol in the CD-1 mouse. Teratology 1997, 55(6):364-372.
9. Bolon B., Welsch F., Morgan K.T. Methanol-induced neural tube defects in mice: pathogenesis during neurulation. Teratology 1994, 49(6):497-517.
10. Cederbaum A.I., Qureshi A. Role of catalase and hydroxyl radicals in the oxidation of methanol by rat liver microsomes. Biochem. Pharmacol. 1982, 31(3):329-335.
11. Blomstrand R., Ingemansson S.O. Studies on the effect of 4-methylpyrazole on methanol poisoning using the monkey as an animal model: with particular reference to the ocular toxicity. Drug Alcohol Depend. 1984, 13(4):343-355.
12. Harris C., Dixon M., Hansen J.M. Glutathione depletion modulates methanol, formaldehyde and formate toxicity in cultured rat conceptuses. Cell Biol. Toxicol. 2004, 20(3):133-145.
13. Johlin F.C., Fortman C.S., Nghiem D.D., Tephly T.R. Studies on the role of folic acid and folate-dependent enzymes in human methanol poisoning. Mol. Pharmacol. 1987, 31(5):557-561.
14. McMartin K.E., Martin-Amat G., Makar A.B., Tephly T.R. Methanol poisoning: V. Role of formate metabolism in the monkey. J. Pharmacol. Exp. Ther. 1977, 201(3):564-572.
15. Chance B. On the reaction of catalase peroxides with acceptors. J. Biol. Chem. 1950, 182:649-658.
16. Halliwell B., Gutteridge J.M. Free Radicals in Biology and Medicine 2007, Oxford University Press, Oxford.
17. Wells P.G., McCallum G.P., Chen C.S., Henderson J.T., Lee C.J., Perstin J., Preston T.J., Wiley M.J., Wong A.W. Oxidative stress in developmental origins of disease: teratogenesis, neurodevelopmental deficits, and cancer. Toxicol. Sci. 2009, 108(1):4-18.
18. Miller L., Wells P.G. Altered methanol embryopathies in embryo culture with mutant catalase-deficient mice and transgenic mice expressing human catalase. Toxicol. Appl. Pharmacol. 2011, 252(1):55-61.
19. Miller-Pinsler L., Sharma A.M., Wells P.G. Enhanced NADPH oxidases and reactive oxygen species in the mechanism of methanol-initiated embryonic protein oxidation and embryopathies in CD-1 mice. Arch. Toxicol. 2015, (In press, Epub ahead of print). 10.1007/s00204-014-1397-1.
20. Fratta I.D., Sigg E.B., Maiorana K. Teratogenic effects of thalidomide in rabbits, rats, hamsters, and mice. Toxicol. Appl. Pharmacol. 1965, 7:268-286.
21. Carney E.W., Tornesi B., Markham D.A., Rasoulpour R.J., Moore N. Species-specificity of ethylene glycol-induced developmental toxicity: toxicokinetic and whole embryo culture studies in the rabbit. Birth Defects Res. B Dev. Reprod. Toxicol. 2008, 83(6):573-581.
22. Otani M. Alcohol dehydrogenase activity in animal tissues. Nichidai Igaku Zasshi 1978, 37:341-350.
23. Sweeting J.N., Wells P.G. Methanol and species differences in adult and embryonic antioxidative and peroxidative catalase activities and alcohol dehydrogenase activities. Toxicol. Sci. (Supplement: The Toxicologist) 2010, 114(1):177. (Abstract No. 834).
24. Sweeting J.N., Siu M., McCallum G.P., Miller L., Wells P.G. Species differences in methanol and formic acid pharmacokinetics in mice, rabbits and primates. Toxicol. Appl. Pharmacol. 2010, 247(1):28-35.
25. Carlson B.M. Human Embryology and Developmental Biology 2009, Mosby Elsevier, Philadelphia.
26. Weisbroth S.H., Flatt R.E., Kraus A.L. The Biology of the Laboratory Rabbit 1974, Academic Press, Inc., New York, London.
27. Tyl R.W., Chernoff N., Rogers J.M. Altered axial skeletal development. Birth Defects Res. B Dev. Reprod. Toxicol. 2007, 80(6):451-472.
28. Brewer N.R. Biology of the rabbit. J. Am. Assoc. Lab. Anim. Sci. 2006, 45(1):8-24.
29. Perkins R.A., Ward K.W., Pollack G.M. A pharmacokinetic model of inhaled methanol in humans and comparison to methanol disposition in mice and rats. Environ. Health Perspect. 1995, 103(7-8):726-733.
30. Makar A.B., Mannering G.J. Role of the intracellular distribution of hepatic catalase in the peroxidative oxidation of methanol. Mol. Pharmacol. 1968, 4(5):484-491.
31. Mannering G.J., Parks R.E. Inhibition of methanol metabolism with 3-amino-1,2,4-triazole. Science 1957, 126(3285):1241-1242.
32. Bradford B.U., Seed C.B., Handler J.A., Forman D.T., Thurman R.G. Evidence that catalase is a major pathway of ethanol oxidation in vivo: dose-response studies in deer mice using methanol as a selective substrate. Arch. Biochem. Biophys. 1993, 303(1):172-176.
33. Makar A.B., Tephly T.R., Mannering G.J. Methanol metabolism in the monkey. Mol. Pharmacol. 1968, 4(5):471-483.
34. Andrews J.E., Ebron-McCoy M., Logsdon T.R., Mole L.M., Kavlock R.J., Rogers J.M. Developmental toxicity of methanol in whole embryo culture: a comparative study with mouse and rat embryos. Toxicology 1993, 81(3):205-215.
35. Nelson B.K., Brightwell W.S., MacKenzie D.R., Khan A., Burg J.R., Weigel W.W., Goad P.T. Teratological assessment of methanol and ethanol at high inhalation levels in rats. Fundam. Appl. Toxicol. 1985, 5(4):727-736.
36. Degitz S.J., Zucker R.M., Kawanishi C.Y., Massenburg G.S., Rogers J.M. Pathogenesis of methanol-induced craniofacial defects in C57BL/6J mice. Birth Defects Res. A Clin. Mol. Teratol. 2004, 70(4):172-178.
37. Crary D.D., Fox R.R., Sawin P.B. Spina bifida in the rabbit. J. Hered. 1966, 57(6):236-243.
38. Lendon R.G. The embryogenesis of trypan-blue induced spina bifida aperta and short tail in the rat. Dev. Med. Child Neurol. Suppl. 1975, 35:3-10.
39. Cozens D.D. Abnormalities of the external form and of the skeleton in the New Zealand white rabbit. Food Cosmet. Toxicol. 1965, 3(5):695-700.
40. Sawin P.B. Morphogenetic studies of the rabbit; regional specificity of hereditary factors affecting homoeotic variations in the axial skeleton. J. Exp. Zool. 1945, 100:301-329.
41. Nolen G.A., Buehler E.V. The effects of disodium etidronate on the reproductive functions and embryogeny of albino rats and New Zealand rabbits. Toxicol. Appl. Pharmacol. 1971, 18(3):548-561.
42. Copp A.J., Greene N.D., Murdoch J.N. The genetic basis of mammalian neurulation. Nat. Rev. Genet. 2003, 4(10):784-793.
43. Maroto M., Bone R.A., Dale J.K. Somitogenesis. Development 2012, 139(14):2453-2456.
44. Kotch L.E., Sulik K.K. Patterns of ethanol-induced cell death in the developing nervous system of mice; neural fold states through the time of anterior neural tube closure. Int. J. Dev. Neurosci. 1992, 10(4):273-279.
45. Wang G., Bieberich E. Prenatal alcohol exposure triggers ceramide-induced apoptosis in neural crest-derived tissues concurrent with defective cranial development. Cell Death Dis. 2010, 1:e46.
46. Kotch L.E., Chen S.Y., Sulik K.K. Ethanol-induced teratogenesis: free radical damage as a possible mechanism. Teratology 1995, 52(3):128-136.
47. Chen S.Y., Sulik K.K. Free radicals and ethanol-induced cytotoxicity in neural crest cells. Alcohol Clin. Exp. Res. 1996, 20(6):1071-1076.
48. Kirkham G.R., Lovrics A., Byrne H.M., Jensen O.E., King J.R., Shakesheff K.M., Buttery L.D. Early gene regulation of osteogenesis in embryonic stem cells. Integr. Biol. 2012, 4(12):1470-1477.
49. Fritz H. Prenatal ossification in rabbits as indicative of fetal maturity. Teratology 1975, 11(3):313-319.