Predictive teratology: Teratogenic risk-hazard identification partnered in the discovery process

Current Drug Metabolism

Volumn 9, Issue 9, 2008, Pages 971-977

  Augustine Rauch, Karen A ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Proactive discovery safety assessment; Risk and hazard assessment; Teratogenic; Teratogenicity screen

Indexed keywords

ALCOHOL; ALKALOID; CYCLOPAMINE; CYCLOPHOSPHAMIDE; ENDOTHELIN RECEPTOR AGONIST; ENDOTHELIN RECEPTOR ANTAGONIST; ETHYLNITROSOUREA; JERVANE; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN 1 INHIBITOR; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN INHIBITOR; SB 236057; SEROTONIN; SEROTONIN 2B RECEPTOR; SEROTONIN UPTAKE INHIBITOR; SOLASODINE; TERATOGENIC AGENT; UNCLASSIFIED DRUG; VERATRAMINE; DRUG; ENDOTHELIN RECEPTOR;

DNA REPLICATION; DRUG EFFICACY; DRUG INHIBITION; DRUG SAFETY; DRUG SELECTIVITY; DRUG STRUCTURE; EMBRYO CULTURE; EMBRYO DEVELOPMENT; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GENE TARGETING; GENETIC LINKAGE; GENOTYPE; HUMAN; METABOLIC ACTIVATION; NONHUMAN; REVIEW; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; RNA INTERFERENCE; STRUCTURE ACTIVITY RELATION; TERATOGEN TESTING; TERATOGENICITY; TOXICOGENETICS; TOXICOKINETICS; ANIMAL; DRUG ANTAGONISM; DRUG DESIGN; METHODOLOGY; TERATOLOGY;

ANIMALS; DRUG DESIGN; HUMANS; PHARMACEUTICAL PREPARATIONS; RECEPTORS, ENDOTHELIN; RISK ASSESSMENT; STRUCTURE-ACTIVITY RELATIONSHIP; TERATOGENS; TERATOLOGY;

EID: 60749133186     PISSN: 13892002     EISSN: None     Source Type: Journal    
DOI: 10.2174/138920008786485137     Document Type: Review

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