The rat whole embryo culture assay using the dysmorphology score system

Methods in Molecular Biology

Volumn 947, Issue , 2013, Pages 423-450

  Zhang, Cindy ^a   Panzica Kelly, Julie ^a   Augustine Rauch, Karen ^a  

^a BRISTOL MYERS SQUIBB   (United States)

Author keywords

Dysmorphology score system; Rat embryo morphology; Rat whole embryo culture; Teratogenicity screening

Indexed keywords

RATTUS;

EID: 84871911563     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-131-8_30     Document Type: Article

References (7)

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2. Brown NA, Fabro S (1981) Quantitation of rat embryonic development in vitro: a morphological scoring system. Teratology 24:65-78
3. Fujinaga M et al (1988) Rat whole embryo culture: an in vitro model for testing nitrous oxide teratogenicity. Anesthesiology 69:401-404
4. Cockroft DL (1990) Postimplantation mammalian embryos. Oxford University Press, Oxford, A practical approach
5. Genschow E et al (2000) Development of prediction models for three in vitro embryo-toxicity tests in an ECVAM validation study. In Vitr Mol Toxicol 13:51-66
6. Augustine-Rauch KA et al (2004) A study of vehicles for dosing rodent whole embryo culture with non aqueous soluble compounds. Reprod Toxicol 18:391-398
7. Zhang C et al (2010) The dysmorphology-based score system: a morphological score system for assessing abnormalities in rodent embryos. Birth Defect Research (Part B) 83:1-8