Loss of Muscle MTCH2 Increases Whole-Body Energy Utilization and Protects from Diet-Induced Obesity

Cell Reports

Volumn 14, Issue 7, 2016, Pages 1602-1610

  Buzaglo Azriel, Liat ^a   Kuperman, Yael ^a   Tsoory, Michael ^a   Zaltsman, Yehudit ^a   Shachnai, Liat ^a   Zaidman, Smadar Levin ^a   Bassat, Elad ^a   Michailovici, Inbal ^a   Sarver, Alona ^a   Tzahor, Eldad ^a   Haran, Michal ^b   Vernochet, Cecile ^c   Gross, Atan ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^b KAPLAN MEDICAL CENTER   (Israel)

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOHYDRATE; CELL PROTEIN; MITOCHONDRIAL CARRIER HOMOLOG 2 PROTEIN; UNCLASSIFIED DRUG; CARRIER PROTEIN; MTCH2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARBOHYDRATE METABOLISM; CONTROLLED STUDY; DIET INDUCED OBESITY; ENDURANCE TRAINING; ENERGY BALANCE; ENERGY EXPENDITURE; ENERGY METABOLISM; EXERCISE TOLERANCE; GENE DELETION; GLYCOLYSIS; HEART FUNCTION; HYPERINSULINEMIA; LIPID DIET; MALE; MITOCHONDRIAL RESPIRATION; MITOCHONDRIAL VOLUME; MOUSE; MUSCLE METABOLISM; MUSCLE MITOCHONDRION; NONHUMAN; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTECTION; PROTEIN ANALYSIS; PROTEIN DEFICIENCY; THERMOGENESIS; ANIMAL; BODY COMPOSITION; DEFICIENCY; DISEASE MODEL; GENE EXPRESSION; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; METABOLOME; MITOCHONDRION; OBESITY; PATHOLOGY; SKELETAL MUSCLE;

ANIMALS; BODY COMPOSITION; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; ENERGY METABOLISM; GENE EXPRESSION; GLYCOLYSIS; HUMANS; MALE; METABOLOME; MICE; MICE, KNOCKOUT; MITOCHONDRIA; MITOCHONDRIAL MEMBRANE TRANSPORT PROTEINS; MUSCLE, SKELETAL; OBESITY; OXIDATIVE PHOSPHORYLATION; PHYSICAL CONDITIONING, ANIMAL;

EID: 84959103267     PISSN: None     EISSN: 22111247     Source Type: Journal    
DOI: 10.1016/j.celrep.2016.01.046     Document Type: Article

References (30)

1. Brüning J.C., Michael M.D., Winnay J.N., Hayashi T., Hörsch D., Accili D., Goodyear L.J., Kahn C.R. A muscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol. Cell 1998, 2:559-569.
2. Chan M.C., Arany Z. The many roles of PGC-1α in muscle--recent developments. Metabolism 2014, 63:441-451.
3. Choi C.S., Befroy D.E., Codella R., Kim S., Reznick R.M., Hwang Y.-J., Liu Z.-X., Lee H.-Y., Distefano A., Samuel V.T., et al. Paradoxical effects of increased expression of PGC-1α on muscle mitochondrial function and insulin-stimulated muscle glucose metabolism. Proc. Natl. Acad. Sci. USA 2008, 105:19926-19931.
4. de Lange P., Moreno M., Silvestri E., Lombardi A., Goglia F., Lanni A. Fuel economy in food-deprived skeletal muscle: signaling pathways and regulatory mechanisms. FASEB J. 2007, 21:3431-3441.
5. Fall T., Arnlöv J., Berne C., Ingelsson E. The role of obesity-related genetic loci in insulin sensitivity. Diabet. Med. 2012, 29:e62-e66.
6. Fawcett D.W., McNutt N.S. The ultrastructure of the cat myocardium. I. Ventricular papillary muscle. J. Cell Biol. 1969, 42:1-45.
7. Giménez-Cassina A., Danial N.N. Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins. Trends Endocrinol. Metab. 2015, 26:165-175.
8. Giménez-Cassina A., Garcia-Haro L., Choi C.S., Osundiji M.A., Lane E.A., Huang H., Yildirim M.A., Szlyk B., Fisher J.K., Polak K., et al. Regulation of hepatic energy metabolism and gluconeogenesis by BAD. Cell Metab. 2014, 19:272-284.
9. Grinberg M., Schwarz M., Zaltsman Y., Eini T., Niv H., Pietrokovski S., Gross A. Mitochondrial carrier homolog 2 is a target of tBID in cells signaled to die by tumor necrosis factor alpha. Mol. Cell. Biol. 2005, 25:4579-4590.
10. Heid I.M., Jackson A.U., Randall J.C., Winkler T.W., Qi L., Steinthorsdottir V., Thorleifsson G., Zillikens M.C., Speliotes E.K., Mägi R., et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat. Genet. 2010, 42:949-960. MAGIC.
11. Hong K.W., Oh B. Recapitulation of genome-wide association studies on body mass index in the Korean population. Int. J. Obes. 2012, 36:1127-1130.
12. León-Mimila P., Villamil-Ramírez H., Villalobos-Comparán M., Villarreal-Molina T., Romero-Hidalgo S., López-Contreras B., Gutiérrez-Vidal R., Vega-Badillo J., Jacobo-Albavera L., Posadas-Romeros C., et al. Contribution of common genetic variants to obesity and obesity-related traits in mexican children and adults. PLoS ONE 2013, 8:e70640.
13. Lewis G.D., Farrell L., Wood M.J., Martinovic M., Arany Z., Rowe G.C., Souza A., Cheng S., McCabe E.L., Yang E., et al. Metabolic signatures of exercise in human plasma. Sci. Transl. Med. 2010, 2:33ra37.
14. Lin J., Wu H., Tarr P.T., Zhang C.-Y., Wu Z., Boss O., Michael L.F., Puigserver P., Isotani E., Olson E.N., et al. Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres. Nature 2002, 418:797-801.
15. Lowell B.B., Shulman G.I. Mitochondrial dysfunction and type 2 diabetes. Science 2005, 307:384-387.
16. Lowman X.H., McDonnell M.A., Kosloske A., Odumade O.A., Jenness C., Karim C.B., Jemmerson R., Kelekar A. The proapoptotic function of Noxa in human leukemia cells is regulated by the kinase Cdk5 and by glucose. Mol. Cell 2010, 40:823-833.
17. Maryanovich M., Zaltsman Y., Ruggiero A., Goldman A., Shachnai L., Zaidman S.L., Porat Z., Golan K., Lapidot T., Gross A. An MTCH2 pathway repressing mitochondria metabolism regulates haematopoietic stem cell fate. Nat. Commun. 2015, 6:7901.
18. Mei H., Chen W., Jiang F., He J., Srinivasan S., Smith E.N., Schork N., Murray S., Berenson G.S. Longitudinal replication studies of GWAS risk SNPs influencing body mass index over the course of childhood and adulthood. PLoS ONE 2012, 7:e31470.
19. Mensink M., Blaak E.E., Vidal H., De Bruin T.W.A., Glatz J.F.C., Saris W.H.M. Lifestyle changes and lipid metabolism gene expression and protein content in skeletal muscle of subjects with impaired glucose tolerance. Diabetologia 2003, 46:1082-1089.
20. Monné M., Palmieri F. Antiporters of the mitochondrial carrier family. Curr. Top. Membr. 2014, 73:289-320.
21. Mootha V.K., Lindgren C.M., Eriksson K.-F., Subramanian A., Sihag S., Lehar J., Puigserver P., Carlsson E., Ridderstråle M., Laurila E., et al. PGC-1alpha-responsive genes involved in oxidative phosphorylation are coordinately downregulated in human diabetes. Nat. Genet. 2003, 34:267-273.
22. Patti M.E., Butte A.J., Crunkhorn S., Cusi K., Berria R., Kashyap S., Miyazaki Y., Kohane I., Costello M., Saccone R., et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc. Natl. Acad. Sci. USA 2003, 100:8466-8471.
23. Pospisilik J.A., Knauf C., Joza N., Benit P., Orthofer M., Cani P.D., Ebersberger I., Nakashima T., Sarao R., Neely G., et al. Targeted deletion of AIF decreases mitochondrial oxidative phosphorylation and protects from obesity and diabetes. Cell 2007, 131:476-491.
24. Rolfe D.F., Brown G.C. Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol. Rev. 1997, 77:731-758.
25. Summermatter S., Shui G., Maag D., Santos G., Wenk M.R., Handschin C. PGC-1α improves glucose homeostasis in skeletal muscle in an activity-dependent manner. Diabetes 2013, 62:85-95.
26. Tschöp M.H., Speakman J.R., Arch J.R., Auwerx J., Brüning J.C., Chan L., Eckel R.H., Farese R.V., Galgani J.E., Hambly C., et al. A guide to analysis of mouse energy metabolism. Nat. Methods 2012, 9:57-63.
27. van Vliet-Ostaptchouk J.V., den Hoed M., Luan J., Zhao J.H., Ong K.K., van der Most P.J., Wong A., Hardy R., Kuh D., van der Klauw M.M., et al. Pleiotropic effects of obesity-susceptibility loci on metabolic traits: a meta-analysis of up to 37,874 individuals. Diabetologia 2013, 56:2134-2146.
28. Wang J., Mei H., Chen W., Jiang Y., Sun W., Li F., Fu Q., Jiang F. Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty. Int. J. Obes. 2012, 36:542-547.
29. Willer C.J., Speliotes E.K., Loos R.J., Li S., Lindgren C.M., Heid I.M., Berndt S.I., Elliott A.L., Jackson A.U., Lamina C., et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat. Genet. 2009, 41:25-34. Wellcome Trust Case Control Consortium, Genetic Investigation of ANthropometric Traits ConsortiumGenetic Investigation of ANthropometric Traits Consortium.
30. Zaltsman Y., Shachnai L., Yivgi-Ohana N., Schwarz M., Maryanovich M., Houtkooper R.H., Vaz F.M., De Leonardis F., Fiermonte G., Palmieri F., et al. MTCH2/MIMP is a major facilitator of tBID recruitment to mitochondria. Nat. Cell Biol. 2010, 12:553-562.