Lifestyle changes and lipid metabolism gene expression and protein content in skeletal muscle of subjects with impaired glucose tolerance

Diabetologia

Volumn 46, Issue 8, 2003, Pages 1082-1089

  Mensink, M ^a   Blaak, E E ^a   Vidal, H ^b   De Bruin, T W A ^c   Glatz, J F C ^d   Saris, W H M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

^b INSERM   (France)

^c MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

^d MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Acetyl CoA carboxylase; Fat oxidation; Fatty acids; Impaired glucose tolerance; Insulin resistance; Lifestyle intervention; Lipid metabolism; Muscle biopsy; Uncoupling protein

Indexed keywords

3 HYDROXYACYL COENZYME A DEHYDROGENASE; ACETYL COENZYME A CARBOXYLASE; CARNITINE PALMITOYLTRANSFERASE; CARRIER PROTEIN; CD36 ANTIGEN; CITRATE SYNTHASE; FATTY ACID; FATTY ACID BINDING PROTEIN; LIPOPROTEIN LIPASE; MESSENGER RNA; MUSCLE PROTEIN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

ADULT; ARTICLE; BODY FAT; CLINICAL ARTICLE; CONTROLLED STUDY; DIET THERAPY; FATTY ACID OXIDATION; FATTY ACID TRANSPORT; FEMALE; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; HUMAN; HUMAN TISSUE; IMPAIRED GLUCOSE TOLERANCE; LIFESTYLE; LIPID METABOLISM; MALE; MUSCLE BIOPSY; NON INSULIN DEPENDENT DIABETES MELLITUS; PHYSICAL ACTIVITY; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SKELETAL MUSCLE; VASTUS LATERALIS MUSCLE; WEIGHT REDUCTION;

3-HYDROXYACYL COA DEHYDROGENASES; ACETYL-COA CARBOXYLASE; BASE SEQUENCE; BODY CONSTITUTION; DNA PRIMERS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GLUCOSE INTOLERANCE; HUMANS; ION CHANNELS; LIFE STYLE; LIPID METABOLISM; LIPIDS; MALE; MEMBRANE TRANSPORT PROTEINS; MITOCHONDRIAL PROTEINS; MUSCLE PROTEINS; MUSCLE, SKELETAL; OXYGEN CONSUMPTION;

EID: 0041376878     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-003-1152-2     Document Type: Article

References (34)

1. Kelley DE, Mandarino LJ (2000) Fuel selection in human skeletal muscle in insulin resistance: a reexamination. Diabetes 49:677-683
2. Kelley DE, Simoneau JA (1994) Impaired free fatty acid utilization by skeletal muscle in non-insulin-dependent diabetes mellitus. J Clin Invest 94:2349-2356
3. Blaak EE, Wagenmakers AJ, Glatz JF et al. (2000) Plasma FFA utilization and fatty acid-binding protein content are diminished in type 2 diabetic muscle. Am J Physiol Endocrinol Metab 279:E146-E154
4. Mensink M, Blaak EE, Baak MA van, Wagenmakers AJ, Saris WH (2001) Plasma free fatty acid uptake and oxidation are already diminished in subjects at high risk for developing type 2 diabetes. Diabetes 50:2548-2554
5. Falholt K, Jensen I, Lindkaer Jensen S et al. (1988) Carbohydrate and lipid metabolism of skeletal muscle in type 2 diabetic patients. Diabet Med 5:27-31
6. Goodpaster BH, He J, Watkins S, Kelley DE (2001) Skeletal muscle lipid content and insulin resistance: evidence for a paradox in endurance-trained athletes. J Clin Endocrinol Metab 86:5755-5761
7. Pan DA, Lillioja S, Kriketos AD et al. (1997) Skeletal muscle triglyceride levels are inversely related to insulin action. Diabetes 46:983-988
8. 13C nuclear magnetic resonance spectroscopy assessment in offspring of type 2 diabetic parents. Diabetes 48:1600-1606
9. McGarry JD (2002) Banting lecture 2001: dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51:7-18
10. Simoneau JA, Veerkamp JH, Turcotte LP and Kelley DE (1999) Markers of capacity to utilize fatty acids in human skeletal muscle: relation to insulin resistance and obesity and effects of weight loss. FASEB J 13:2051-2060
11. Ruderman NB, Saha AK, Vavvas D, Witters LA (1999) Malonyl-CoA, fuel sensing, and insulin resistance. Am J Physiol 276:E1-E18
12. Simoneau JA, Kelley DE, Neverova M and Warden CH (1998) Overexpression of muscle uncoupling protein 2 content in human obesity associates with reduced skeletal muscle lipid utilization. FASEB J 12:1739-1745
13. Schrauwen P, Schaart G, Saris WH et al. (2000) The effect of weight reduction on skeletal muscle UCP2 and UCP3 mRNA expression and UCP3 protein content in Type II diabetic subjects. Diabetologia 43:1408-1416
14. Blaak EE, Wolffenbuttel BH, Saris WH, Pelsers MM, Wagenmakers AJ (2001) Weight reduction and the impaired plasma-derived free fatty acid oxidation in type 2 diabetic subjects. J Clin Endocrinol Metab 86:1638-1644
15. Kiens B (1997) Effect of endurance training on fatty acid metabolism: local adaptations. Med Sci Sports Exerc 29:640-645
16. Tunstall RJ, Mehan KA, Wadley GD et al. (2002) Exercise training increases lipid metabolism gene expression in human skeletal muscle. Am J Physiol Endocrinol Metab 283:E66-E72
17. Spina RJ, Chi MM, Hopkins MG, Nemeth PM, Lowry OH, Holloszy JO (1996) Mitochondrial enzymes increase in muscle in response to 7-10 days of cycle exercise. J Appl Physiol 80:2250-2254
18. Schrauwen P, Van Aggel-Leijssen DP, Hul G et al. (2002) The effect of a 3-month low-intensity endurance training program on fat oxidation and acetyl-coA carboxylase-2 expression. Diabetes 51:2220-2226
19. Clarke SD, Gasperikova D, Nelson C, Lapillonne A, Heird WC (2002) Fatty acid regulation of gene expression: a genomic explanation for the benefits of the mediterranean diet. Ann NY Acad Sci 967:283-298
20. Tuomilehto J, Lindstrom J, Eriksson JG et al. (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343-1350
21. Knowler WC, Barrett-Connor E, Fowler SE, et al. (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393-403
22. Mensink M, Feskens EJ, Saris WH, De Bruin TW, Blaak EE (2003) Study on Lifestyle Intervention and Impaired Glucose Tolerance Maastricht (SLIM): preliminary results after one year. Int J Obes Relat Metab Disord 27:377-384
23. Siri W (1956) The gross composition of the body. Adv Bio Med Physiol 4:239-280
24. Bergstrom J, Hermansen L, Hultman E, Saltin B (1967) Diet, muscle glycogen and physical performance. Acta Physiol Scand 71:140-150
25. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenolchloroform extraction. Anal Biochem 162:156-159
26. Auboeuf D, Vidal H (1997) The use of the reverse transcription-competitive polymerase chain reaction to investigate the in vivo regulation of gene expression in small tissue samples. Anal Biochem 245:141-148
27. Pelsers MM, Lutgerink JT, Nieuwenhoven FA et al. (1999) A sensitive immunoassay for rat fatty acid translocase (CD36) using phage antibodies selected on cell transfectants: abundant presence of fatty acid translocase/ CD36 in cardiac and red skeletal muscle and up-regulation in diabetes. Biochem J 337:407-414
28. Wodzig KW, Pelsers MM, van der Vusse GJ, Roos W, Glatz JF (1997) One-step enzyme-linked immunosorbent assay (ELISA) for plasma fatty acid-binding protein. Ann Clin Biochem 34:263-268
29. Shepherd D, Garland PB (1969) The kinetic properties of citrate synthase from rat liver mitochondria. Biochem J 114:597-610
30. Bergmeyer H (1974)3-Hydroxyacyl CoA dehydrogenase. Lactate dehydrogenase. In: Bergmeyer H (ed.) Methods of enzymatic analysis, vol 1. Academic Press, New York
31. Mensink M, Blaak E, Wagenmakers A, Saris W (2002) Fatty acid metabolism and impaired glucose tolerance: effect of a one-year lifestyle-intervention program (SLIM). Diabetes 51:A336 (Abstract)
32. Vidal H, Langin D, Andreelli F, Millet L, Larrouy D, Laville M (1999) Lack of skeletal muscle uncoupling protein 2 and 3 mRNA induction during fasting in type-2 diabetic subjects. Am J Physiol 277:E830-E837
33. Saleh MC, Wheeler MB, Chan CB (2002) Uncoupling protein-2: evidence for its function as a metabolic regulator. Diabetologia 45:174-187
34. Khalfallah Y, Fages S, Laville M, Langin D, Vidal H (2000) Regulation of uncoupling protein-2 and uncoupling protein-3 mRNA expression during lipid infusion in human skeletal muscle and subcutaneous adipose tissue. Diabetes 49:25-31