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Volumn 8, Issue 8, 2013, Pages

Contribution of Common Genetic Variants to Obesity and Obesity-Related Traits in Mexican Children and Adults

(16)  León Mimila, Paola a,b   Villamil Ramírez, Hugo a,b   Villalobos Comparán, Marisela c   Villarreal Molina, Teresa c   Romero Hidalgo, Sandra c   López Contreras, Blanca a   Gutiérrez Vidal, Roxana a,b   Vega Badillo, Joel a,b   Jacobo Albavera, Leonor c   Posadas Romeros, Carlos d   Canizalez Román, Adrián e   De Río Navarro, Blancal f   Campos Pérez, Francisco g   Acuña Alonzo, Victor h   Aguilar Salinas, Carlos b   Canizales Quinteros, Samuel a,b  


Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; BRAIN DERIVED NEUROTROPHIC FACTOR; LEPTIN RECEPTOR; MELANOCORTIN 4 RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROLACTIN; TRANSCRIPTION FACTOR MAF; UNCOUPLING PROTEIN 2; UNCOUPLING PROTEIN 3;

EID: 84881328438     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070640     Document Type: Article
Times cited : (91)

References (50)
  • 1
    • 51849146897 scopus 로고    scopus 로고
    • Global burden of obesity in 2005 and projections to 2030
    • Kelly T, Yang W, Chen C-S, Reynolds K, He J, (2008) Global burden of obesity in 2005 and projections to 2030. Int J Obes 32: 1431-1437.
    • (2008) Int J Obes , vol.32 , pp. 1431-1437
    • Kelly, T.1    Yang, W.2    Chen, C.-S.3    Reynolds, K.4    He, J.5
  • 2
    • 84875469916 scopus 로고    scopus 로고
    • Secretaría de Salud - Instituto Nacional de Salud Pública
    • Secretaría de Salud - Instituto Nacional de Salud Pública. (2012) Encuesta Nacional de Salud y Nutrición.
    • (2012) Encuesta Nacional de Salud y Nutrición
  • 3
    • 81055156636 scopus 로고    scopus 로고
    • The influence of indigenous status and community indigenous composition on obesity and diabetes among Mexican adults
    • Stoddard P, Handley MA, Vargas-Bustamante A, Schillinger D, (2011) The influence of indigenous status and community indigenous composition on obesity and diabetes among Mexican adults. Soc Sci Med 73: 1635-1643.
    • (2011) Soc Sci Med , vol.73 , pp. 1635-1643
    • Stoddard, P.1    Handley, M.A.2    Vargas-Bustamante, A.3    Schillinger, D.4
  • 4
    • 0030843960 scopus 로고    scopus 로고
    • Genetic and environmental factors in relative body weight and human adiposity
    • Maes HH, Neale MC, Eaves LJ, (2007) Genetic and environmental factors in relative body weight and human adiposity. Behav Genet 27: 325-351.
    • (2007) Behav Genet , vol.27 , pp. 325-351
    • Maes, H.H.1    Neale, M.C.2    Eaves, L.J.3
  • 6
    • 80155182174 scopus 로고    scopus 로고
    • Developments in obesity genetics in the era of genome-wide association studies
    • Day FR, Loos RJ, (2011) Developments in obesity genetics in the era of genome-wide association studies. J Nutrigenet Nutrigenomics 4: 222-238.
    • (2011) J Nutrigenet Nutrigenomics , vol.4 , pp. 222-238
    • Day, F.R.1    Loos, R.J.2
  • 10
    • 84873044014 scopus 로고    scopus 로고
    • Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children
    • Mejía-Benítez A, Klünder-Klünder M, Yengo L, Meyre D, Aradillas C, et al. (2013) Analysis of the contribution of FTO, NPC1, ENPP1, NEGR1, GNPDA2 and MC4R genes to obesity in Mexican children. BMC Med Genet 1: 14-21.
    • (2013) BMC Med Genet , vol.1 , pp. 14-21
    • Mejía-Benítez, A.1    Klünder-Klünder, M.2    Yengo, L.3    Meyre, D.4    Aradillas, C.5
  • 12
    • 33645825830 scopus 로고    scopus 로고
    • A common genetic variant is associated with adult and childhood obesity
    • Herbert A, Gerry NP, McQueen MB, Heid IM, Pfeufer A, et al. (2006) A common genetic variant is associated with adult and childhood obesity. Science 312: 279-283.
    • (2006) Science , vol.312 , pp. 279-283
    • Herbert, A.1    Gerry, N.P.2    McQueen, M.B.3    Heid, I.M.4    Pfeufer, A.5
  • 13
    • 34248594090 scopus 로고    scopus 로고
    • A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity
    • Frayling TM, Timpson NJ, Weedon MN, Zeggini E, Freathy RM, et al. (2007) A common variant in the FTO gene is associated with body mass index and predisposes to childhood and adult obesity. Science 316: 889-894.
    • (2007) Science , vol.316 , pp. 889-894
    • Frayling, T.M.1    Timpson, N.J.2    Weedon, M.N.3    Zeggini, E.4    Freathy, R.M.5
  • 14
    • 34249777814 scopus 로고    scopus 로고
    • Variation in FTO contributes to childhood obesity and severe adult obesity
    • Dina C, Meyre D, Gallina S, Durand E, Körner A, et al. (2007) Variation in FTO contributes to childhood obesity and severe adult obesity. Nat Genet 39: 724 -726.
    • (2007) Nat Genet , vol.39 , pp. 724-726
    • Dina, C.1    Meyre, D.2    Gallina, S.3    Durand, E.4    Körner, A.5
  • 15
    • 44349142294 scopus 로고    scopus 로고
    • Common variants near MC4R are associated with fat mass, weight and risk of obesity
    • Loos RJF, Lindgren CM, Li S, Wheeler E, Zhao JH, et al. (2008) Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet 40: 768-75.
    • (2008) Nat Genet , vol.40 , pp. 768-775
    • Loos, R.J.F.1    Lindgren, C.M.2    Li, S.3    Wheeler, E.4    Zhao, J.H.5
  • 16
    • 58149163142 scopus 로고    scopus 로고
    • Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    • Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, et al. (2009) Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 41: 25-34.
    • (2009) Nat Genet , vol.41 , pp. 25-34
    • Willer, C.J.1    Speliotes, E.K.2    Loos, R.J.3    Li, S.4    Lindgren, C.M.5
  • 17
    • 58149163141 scopus 로고    scopus 로고
    • Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity
    • Thorleifsson G, Walters GB, Gudbjartsson DF, Steinthorsdottir V, Sulem P, et al. (2009) Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity. Nat Genet 41: 18-24.
    • (2009) Nat Genet , vol.41 , pp. 18-24
    • Thorleifsson, G.1    Walters, G.B.2    Gudbjartsson, D.F.3    Steinthorsdottir, V.4    Sulem, P.5
  • 18
    • 59149097625 scopus 로고    scopus 로고
    • Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations
    • Meyre D, Delplanque J, Chèvre JC, Lecoeur C, Lobbens S, et al. (2009) Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 41: 157-159.
    • (2009) Nat Genet , vol.41 , pp. 157-159
    • Meyre, D.1    Delplanque, J.2    Chèvre, J.C.3    Lecoeur, C.4    Lobbens, S.5
  • 19
    • 77954144155 scopus 로고    scopus 로고
    • Association of R230C ABCA1 gene variant with low HDL-C levels and abnormal HDL subclass distribution in Mexican school-aged children
    • Flores-Dorantes T, Arellano-Campos O, Posadas-Sánchez R, Villarreal-Molina T, Medina-Urrutia A, et al. (2010) Association of R230C ABCA1 gene variant with low HDL-C levels and abnormal HDL subclass distribution in Mexican school-aged children. Clin Chim Acta 411: 1214-1217.
    • (2010) Clin Chim Acta , vol.411 , pp. 1214-1217
    • Flores-Dorantes, T.1    Arellano-Campos, O.2    Posadas-Sánchez, R.3    Villarreal-Molina, T.4    Medina-Urrutia, A.5
  • 21
    • 0034471041 scopus 로고    scopus 로고
    • Obesity: Preventing and managing the global epidemic. Report of a WHO consultation
    • World Health Organization (WHO)
    • World Health Organization (WHO) (2000) Obesity: Preventing and managing the global epidemic. Report of a WHO consultation. Tech Rep Ser 894: 1-253.
    • (2000) Tech Rep Ser , vol.894 , pp. 1-253
  • 23
    • 34347382714 scopus 로고    scopus 로고
    • The ATP-binding cassette transporter A1 R230C variant affects HDL cholesterol levels and BMI in the Mexican population: association with obesity and obesity-related comorbidities
    • Villarreal-Molina MT, Aguilar-Salinas CA, Rodríguez-Cruz M, Riaño D, Villalobos-Comparan M, et al. (2007) The ATP-binding cassette transporter A1 R230C variant affects HDL cholesterol levels and BMI in the Mexican population: association with obesity and obesity-related comorbidities. Diabetes 56: 1881-1887.
    • (2007) Diabetes , vol.56 , pp. 1881-1887
    • Villarreal-Molina, M.T.1    Aguilar-Salinas, C.A.2    Rodríguez-Cruz, M.3    Riaño, D.4    Villalobos-Comparan, M.5
  • 24
    • 0031737373 scopus 로고    scopus 로고
    • Correct homeostasis model assessment (HOMA) evaluation uses the computer program
    • Levy JC, Matthews DR, Hermans MP, (1998) Correct homeostasis model assessment (HOMA) evaluation uses the computer program. Diabetes Care 21: 2191-2192.
    • (1998) Diabetes Care , vol.21 , pp. 2191-2192
    • Levy, J.C.1    Matthews, D.R.2    Hermans, M.P.3
  • 27
    • 33846596193 scopus 로고    scopus 로고
    • Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution
    • Helgason A, Pálsson S, Thorleifsson G, Grant SF, Emilsson V, et al. (2007) Refining the impact of TCF7L2 gene variants on type 2 diabetes and adaptive evolution. Nat Genet 39: 218-225.
    • (2007) Nat Genet , vol.39 , pp. 218-225
    • Helgason, A.1    Pálsson, S.2    Thorleifsson, G.3    Grant, S.F.4    Emilsson, V.5
  • 28
    • 65249183403 scopus 로고    scopus 로고
    • Meta-analysis in genome-wide association studies
    • Zeggini E, Ioannidis JP, (2009) Meta-analysis in genome-wide association studies. Pharmacogenomics 10: 191-201.
    • (2009) Pharmacogenomics , vol.10 , pp. 191-201
    • Zeggini, E.1    Ioannidis, J.P.2
  • 29
    • 80052397686 scopus 로고    scopus 로고
    • Studies of Metabolic Phenotypic Correlates of 15 Obesity Associated Gene Variants
    • Sandholt CH, Vestmar MA, Bille DS, Borglykke A, Almind K, et al. (2011) Studies of Metabolic Phenotypic Correlates of 15 Obesity Associated Gene Variants. Plos One 6: e23531.
    • (2011) Plos One , vol.6
    • Sandholt, C.H.1    Vestmar, M.A.2    Bille, D.S.3    Borglykke, A.4    Almind, K.5
  • 30
    • 73649136827 scopus 로고    scopus 로고
    • Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in Japanese population
    • Hotta K, Nakamura M, Nakamura T, Matsuo T, Nakata Y, et al. (2009) Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in Japanese population. J Hum Genet 54: 727-731.
    • (2009) J Hum Genet , vol.54 , pp. 727-731
    • Hotta, K.1    Nakamura, M.2    Nakamura, T.3    Matsuo, T.4    Nakata, Y.5
  • 31
    • 77952746932 scopus 로고    scopus 로고
    • Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese
    • Ng MC, Tam CH, So WY, Ho JS, Chan AW, et al. (2010) Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. J Clin Endocrinol Metab 95: 2418-25.
    • (2010) J Clin Endocrinol Metab , vol.95 , pp. 2418-2425
    • Ng, M.C.1    Tam, C.H.2    So, W.Y.3    Ho, J.S.4    Chan, A.W.5
  • 32
    • 64549158008 scopus 로고    scopus 로고
    • Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden
    • Renstrom F, Payne F, Nordstrom A, Brito E, Rolandsson O, et al. (2009) Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Hum Mol Genet 18: 1489-1496.
    • (2009) Hum Mol Genet , vol.18 , pp. 1489-1496
    • Renstrom, F.1    Payne, F.2    Nordstrom, A.3    Brito, E.4    Rolandsson, O.5
  • 33
    • 74049138315 scopus 로고    scopus 로고
    • Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies
    • Li S, Zhao JH, Luan J, Luben RN, Rodwell SA, et al. (2010) Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. Am J Clin Nutr 91: 184-190.
    • (2010) Am J Clin Nutr , vol.91 , pp. 184-190
    • Li, S.1    Zhao, J.H.2    Luan, J.3    Luben, R.N.4    Rodwell, S.A.5
  • 34
    • 84856278653 scopus 로고    scopus 로고
    • Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PSCK1 show evidence of association with adult in the Greek population
    • Rouskas K, Kouvatsi A, Paletas K, Papazoglou D, Tsapas A, et al. (2012) Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and PSCK1 show evidence of association with adult in the Greek population. Obesity (Silver Spring) 20: 389-395.
    • (2012) Obesity (Silver Spring) , vol.20 , pp. 389-395
    • Rouskas, K.1    Kouvatsi, A.2    Paletas, K.3    Papazoglou, D.4    Tsapas, A.5
  • 35
    • 33846903056 scopus 로고    scopus 로고
    • Comment on "A common genetic variant is associated with adult and childhood obesity"
    • Dina C, Meyre D, Samson C, Tichet J, Marre M, et al. (2007) Comment on "A common genetic variant is associated with adult and childhood obesity". Science 315: 187.
    • (2007) Science , vol.315 , pp. 187
    • Dina, C.1    Meyre, D.2    Samson, C.3    Tichet, J.4    Marre, M.5
  • 36
    • 34247576412 scopus 로고    scopus 로고
    • The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but no all cohorts
    • Lyon HN, Emilsson V, Hinney A, Heid IM, Lasky-Su J, et al. (2007) The association of a SNP upstream of INSIG2 with body mass index is reproduced in several but no all cohorts. Plos Genet 27: e61.
    • (2007) Plos Genet , vol.27
    • Lyon, H.N.1    Emilsson, V.2    Hinney, A.3    Heid, I.M.4    Lasky-Su, J.5
  • 37
    • 50249187618 scopus 로고    scopus 로고
    • INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese
    • Hotta K, Nakamura M, Nakata Y, Matsuo T, Kamohara S, et al. (2008) INSIG2 gene rs7566605 polymorphism is associated with severe obesity in Japanese. J Hum Genet 53: 857-862.
    • (2008) J Hum Genet , vol.53 , pp. 857-862
    • Hotta, K.1    Nakamura, M.2    Nakata, Y.3    Matsuo, T.4    Kamohara, S.5
  • 38
    • 67649961406 scopus 로고    scopus 로고
    • The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts
    • Bressler J, Fornaje M, Hanis CL, Kao WH, Lewis CE, et al. (2009) The INSIG2 rs7566605 genetic variant does not play a major role in obesity in a sample of 24,722 individuals from four cohorts. BMC Med Genet 12: 56.
    • (2009) BMC Med Genet , vol.12 , pp. 56
    • Bressler, J.1    Fornaje, M.2    Hanis, C.L.3    Kao, W.H.4    Lewis, C.E.5
  • 39
    • 44349129013 scopus 로고    scopus 로고
    • Variations in the FTO gene are associated with severe obesity in the Japanese
    • Hotta K, Nakata Y, Matsuo T, Kamohara S, Kotani K, et al. (2008) Variations in the FTO gene are associated with severe obesity in the Japanese. J Hum Genet 53: 546-553.
    • (2008) J Hum Genet , vol.53 , pp. 546-553
    • Hotta, K.1    Nakata, Y.2    Matsuo, T.3    Kamohara, S.4    Kotani, K.5
  • 41
    • 0343953074 scopus 로고    scopus 로고
    • Dominant and recessive inheritance of morbid obesity associated with the melanocortin 4 receptor deficiency
    • Farooqui IS, Yeo GS, Keogh JM, Aminian S, Jebb SA, et al. (2000) Dominant and recessive inheritance of morbid obesity associated with the melanocortin 4 receptor deficiency. J Clin Invest 106: 271-279.
    • (2000) J Clin Invest , vol.106 , pp. 271-279
    • Farooqui, I.S.1    Yeo, G.S.2    Keogh, J.M.3    Aminian, S.4    Jebb, S.A.5
  • 42
    • 33845530762 scopus 로고    scopus 로고
    • Hyperphagia, severe obesity, impaired cognitive function, and, hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene
    • Gray J, Yeo GS, Cox JJ, Morton J, Adlam AL, et al. (2006) Hyperphagia, severe obesity, impaired cognitive function, and, hyperactivity associated with functional loss of one copy of the brain-derived neurotrophic factor (BDNF) gene. Diabetes 55: 3366-3371.
    • (2006) Diabetes , vol.55 , pp. 3366-3371
    • Gray, J.1    Yeo, G.S.2    Cox, J.J.3    Morton, J.4    Adlam, A.L.5
  • 43
    • 17944365228 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity
    • Yamauchi T, Kamon J, Waki H, Terauchi Y, Kubota N, et al. (2001) The fat-derived hormone adiponectin reverses insulin resistance associated with both lipoatrophy and obesity. Nat Med 7: 941-946.
    • (2001) Nat Med , vol.7 , pp. 941-946
    • Yamauchi, T.1    Kamon, J.2    Waki, H.3    Terauchi, Y.4    Kubota, N.5
  • 44
    • 0031019249 scopus 로고    scopus 로고
    • Uncouplin protein-2: a novel gene linked to obesity and hyperinsulinemia
    • Fleury C, Neverova M, Collins S, Raimbault S, Champigny O, et al. (1997) Uncouplin protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet 15: 269-272.
    • (1997) Nat Genet , vol.15 , pp. 269-272
    • Fleury, C.1    Neverova, M.2    Collins, S.3    Raimbault, S.4    Champigny, O.5
  • 45
    • 84857094622 scopus 로고    scopus 로고
    • Longitudinal replication studies of GWAS risk SNPs influencing body mass index over the course of childhood and adulthood
    • Mei H, Chen W, Jiang F, He J, Srinivasan S, et al. (2012) Longitudinal replication studies of GWAS risk SNPs influencing body mass index over the course of childhood and adulthood. PLoS One 7: e31470.
    • (2012) PLoS One , vol.7
    • Mei, H.1    Chen, W.2    Jiang, F.3    He, J.4    Srinivasan, S.5
  • 46
    • 84855705730 scopus 로고    scopus 로고
    • Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian population
    • Dorajoo R, Blaquemore AI, Sim X, Ong RT, Ng DP, et al. (2012) Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian population. Int J Obes (Lond) 36: 159-163.
    • (2012) Int J Obes (Lond) , vol.36 , pp. 159-163
    • Dorajoo, R.1    Blaquemore, A.I.2    Sim, X.3    Ong, R.T.4    Ng, D.P.5
  • 47
    • 77949894041 scopus 로고    scopus 로고
    • Life course variations in the associations between FTO and MC4R gene variants and body size
    • Hardy R, Wills AK, Wong A, Elks CE, Wareham NJ, et al. (2010) Life course variations in the associations between FTO and MC4R gene variants and body size. Hum Mol Genet 19: 545-552.
    • (2010) Hum Mol Genet , vol.19 , pp. 545-552
    • Hardy, R.1    Wills, A.K.2    Wong, A.3    Elks, C.E.4    Wareham, N.J.5
  • 48
    • 35548953160 scopus 로고    scopus 로고
    • Heritability and genetic correlations of metabolic disease-related phenotypes in Mexico: preliminary report from the GEMM Family Study
    • Bastarrachea RA, Kent JW Jr, Rozada G, Cole SA, López-Alvarenga JC, et al. (2007) Heritability and genetic correlations of metabolic disease-related phenotypes in Mexico: preliminary report from the GEMM Family Study. Hum Biol 79: 121-129.
    • (2007) Hum Biol , vol.79 , pp. 121-129
    • Bastarrachea, R.A.1    Kent Jr., J.W.2    Rozada, G.3    Cole, S.A.4    López-Alvarenga, J.C.5
  • 49
    • 33846876760 scopus 로고    scopus 로고
    • Genetic effects on obesity assessed by bivariate genome scan: the Mexican-American coronary artery disease study
    • Li X, Quiñonez MJ, Wang D, Bulnes-Enriquez I, Jimenez X, et al. (2006) Genetic effects on obesity assessed by bivariate genome scan: the Mexican-American coronary artery disease study. Obesity (Silver Spring) 14: 1192-1200.
    • (2006) Obesity (Silver Spring) , vol.14 , pp. 1192-1200
    • Li, X.1    Quiñonez, M.J.2    Wang, D.3    Bulnes-Enriquez, I.4    Jimenez, X.5
  • 50
    • 63249107785 scopus 로고    scopus 로고
    • Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians
    • Rong R, Hanson RL, Ortiz D, Wiedrich C, Kobes S, et al. (2009) Association analysis of variation in/near FTO, CDKAL1, SLC30A8, HHEX, EXT2, IGF2BP2, LOC387761, and CDKN2B with type 2 diabetes and related quantitative traits in Pima Indians. Diabetes 58: 478-488.
    • (2009) Diabetes , vol.58 , pp. 478-488
    • Rong, R.1    Hanson, R.L.2    Ortiz, D.3    Wiedrich, C.4    Kobes, S.5


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