Prognostic value of plasma tight-junction proteins for sepsis in emergency department: An observational study

Shock

Volumn 45, Issue 3, 2016, Pages 326-332

  Zhao, Guang Ju ^a   Li, Dong ^a   Zhao, Qian ^a   Lian, Jie ^a   Hu, Tian Tian ^a   Hong, Guang Liang ^a   Yao, Yong Ming ^b   Lu, Zhong Qiu ^a  

^a WENZHOU MEDICAL UNIVERSITY   (China)

^b CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

Lactate; multiple organ dysfunction syndromes; procalcitonin; sepsis; tight junction proteins; zonula occludens

Indexed keywords

CLAUDIN 5; LACTIC ACID; OCCLUDIN; PROCALCITONIN; PROTEIN ZO1; BIOLOGICAL MARKER; CLDN5 PROTEIN, HUMAN; OCLN PROTEIN, HUMAN; TJP1 PROTEIN, HUMAN;

ADULT; AGED; APACHE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; DISEASE SEVERITY; EMERGENCY WARD; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MORTALITY; MULTIPLE ORGAN FAILURE; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PREDICTIVE VALUE; PROGNOSIS; PROTEIN BLOOD LEVEL; SENSITIVITY AND SPECIFICITY; SEPSIS; SEPTIC SHOCK; SEQUENTIAL ORGAN FAILURE ASSESSMENT SCORE; BLOOD; DISEASE FREE SURVIVAL; HOSPITAL EMERGENCY SERVICE; HOSPITAL MORTALITY; METABOLISM; SURVIVAL RATE; TIGHT JUNCTION;

ADULT; AGED; BIOMARKERS; CLAUDIN-5; DISEASE-FREE SURVIVAL; EMERGENCY SERVICE, HOSPITAL; FEMALE; HOSPITAL MORTALITY; HUMANS; MALE; MIDDLE AGED; OCCLUDIN; PROGNOSIS; SEPSIS; SURVIVAL RATE; TIGHT JUNCTIONS; ZONULA OCCLUDENS-1 PROTEIN;

EID: 84959081241     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000524     Document Type: Article

References (39)

1. Kaukonen KM, Bailey M, Suzuki S, Bellomo R. Mortality related to severe sepsis, and septic shock among critically ill patients in Australia, and New Zealand, 2000-2012. JAMA 311: 1308-1316, 2014
2. Mann EAI, Baun MM, Meininger JC, Wade CE. Comparison of mortality associated with sepsis in the burn, trauma, and general intensive care unit patient: a systematic review of the literature. Shock 37: 4-16, 2012
3. Nin N, El-Assar M, Sánchez C, Ferruelo A, Sánchez-Ferrer A, Martínez-Caro L, Rojas Y, Paula Md, Hurtado J, Esteban A, et al. Vascular dysfunction in sepsis: effects of the peroxynitrite decomposition catalyst MnTMPyP. Shock 36: 156-161, 2011
4. Boisramé-Helms J, Kremer H, Schini-Kerth V, Meziani F. Endothelial dysfunction in sepsis. Curr Vasc Pharmacol 11: 150-160, 2013
5. Goldenberg NM, Steinberg BE, Slutsky AS, Lee WL. Broken barriers: a new take on sepsis pathogenesis. Sci Transl Med 3: 88s25, 2011
6. Dejana E, Tournier-Lasserve E, Weinstein BM. The control of vascular integrity by endothelial cell junctions: molecular basis, and pathological implications. Dev Cell 16: 209-221, 2009
7. Wallez Y, Huber P. Endothelial adherens, and tight junctions in vascular homeostasis, inflammationandangiogenesis.BiochimBiophysActa1778: 794-809, 2008
8. Bazzoni G, Dejana E. Endothelial cell-to-cell junctions: molecular organization, and role in vascular homeostasis. Physiol Rev 84: 869-901, 2004
9. Morita K, Furuse M, Fujimoto K, Tsukita S. Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc Natl Acad Sci U S A 96: 511-516, 1999
10. Clark PR, Kim RK, Pober JS, Kluger MS. Tumor necrosis factor disrupts claudin-5 endothelial tight junction barriers in two distinct NF-kB-dependent phases. PLoS One 10: e0120075, 2015
11. Minhas N, Xue M, Fukudome K, Jackson CJ. Activated protein C utilizes the angiopoietin/Tie2 axis to promote endothelial barrier function. FASEB J 24: 873-881, 2010
12. Yu H, Huang X, Ma Y, Gao M, Wang O, Gao T, Shen Y, Liu X. Interleukin-8 regulates endothelial permeability by down-regulation of tight junction but not dependent on integrins induced focal adhesions. Int J Biol Sci 9: 966-979, 2013
13. Capaldo CT, Nusrat A. Cytokine regulation of tight junctions. Biochim Biophys Acta 1788: 864-871, 2009
14. Fasano A, Not T, Wang W, Uzzau S, Berti I, Tommasini A, Goldblum SE. Zonulin, a newly discovered modulator of intestinal permeability, and its expression in coeliac disease. Lancet 355: 1518-1519, 2000
15. Sapone A, de Magistris L, Pietzak M, Clemente MG, Tripathi A, Cucca F, Lampis R, Kryszak D, Cartenì M, Generoso M, et al. Zonulin upregulation is associated with increased gut permeability in subjects with type 1 diabetes, and their relatives. Diabetes 55: 1443-1449, 2006
16. Kazmierski R, Michalak S, Wencel-Warot A, Nowinski WL. Serum tightjunction proteins predict hemorrhagic transformation in ischemic stroke patients. Neurology 79: 1677-1685, 2012
17. Levy MMI, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G. SCCM/ESICM/ACCP/ATS/SIS: 2001 SCCC/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 31: 1250-1256, 2003
18. McGown CC, Brookes ZL. Beneficial effects of statins on the microcirculation during sepsis: the role of nitric oxide. Br J Anaesth 98: 163-175, 2007
19. Felinski EA, Antonetti DA. Glucocorticoid regulation of endothelial cell tight junction gene expression: novel treatments for diabetic retinopathy. Curr Eye Res 30: 949-957, 2005
20. Dellinger RP, Levy MM, Rhodes A, Annane D, Gerlach H, Opal SM, Sevransky JE, Sprung CL, Douglas IS, Jaeschke R, et al. , Surviving Sepsis Campaign Guidelines Committee including the Pediatric Subgroup. Surviving sepsis campaign: international guidelines for management of severe sepsis, and septic shock: 2012. Crit Care Med 41: 580-637, 2013
21. Aird WC. The role of the endothelium in severe sepsis, and multiple organ dysfunction syndrome. Blood 101: 3765-3777, 2003
22. Semeraro N, Ammollo CT, Semeraro F, Colucci M. Sepsis, thrombosis, and organ dysfunction. Thromb Res 129: 290-295, 2012
23. Desai TR, Leeper NJ, Hynes KL, Gewertz BL. Interleukin-6 causes endothelial barrier dysfunction via the protein kinase C pathway. J Surg Res 104: 118-123, 2002
24. Lee WL, Slutsky AS. Sepsis, and endothelial permeability. N Engl J Med 363: 689-691, 2010
25. Castanares-Zapatero D, Bouleti C, Mathivet T, Gerber B, Oury C, Bertrand L, Vanoverschelde JL, Laterre PF, Horman S, Beauloye C. AMP-activated protein kinase preserves endothelial tight junctions in the coronary microcirculation during sepsis. Crit Care 16: 30, 2012
26. London NR, Zhu W, Bozza FA, Smith MC, Greif DM, Sorensen LK, Chen L, Kaminoh Y, Chan AC, Passi SF, et al. Targeting Robo4-dependent Slit signaling to survive the cytokine storm in sepsis, and influenza. Sci Transl Med 2: 23ra19, 2010
27. Zhang RY, Liu YY, Li L, Cui W, Zhao KJ, Huang WC, Gu XW, Liu W, Wu J, Min D, et al. Increased levels of soluble vascular endothelial cadherin are associated with poor outcome in severe sepsis. J Int Med Res 38: 1497-1506, 2010
28. Escudero-Esparza A, Jiang WG, Martin TA. Claudin-5 participates in the regulation of endothelial cell motility. Mol Cell Biochem 362: 71-85, 2012
29. Morita K, Sasaki H, Furuse M, Tsukita S. Endothelial claudin: claudin-5/TMVCF constitutes tight junction strands in endothelial cells. J Cell Biol 147: 185-194, 1999
30. Nitta T, Hata M, Gotoh S, Seo Y, Sasaki H, Hashimoto N, Furuse M, Tsukita S. Size-selective loosening of the blood-brain barrier in claudin-5-deficient mice. J Cell Biol 161: 653-660, 2003
31. Bauer AT, Bürgers HF, Rabie T, Marti HH. Matrix metalloproteinase-9 mediates hypoxia-induced vascular leakage in the brain via tight junction rearrangement. J Cereb Blood Flow Metab 30: 837-848, 2010
32. Tang BM, Eslick GD, Craig JC, McLean AS. Accuracy of procalcitonin for sepsis diagnosis in critically ill patients: systematic review, and meta-analysis. Lancet Infect Dis 7: 210-217, 2007
33. Wacker C, Prkno A, Brunkhorst FM, Schlattmann P. Procalcitonin as a diagnostic marker for sepsis: a systematic review, and meta-analysis. Lancet Infect Dis 13: 426-435, 2013
34. Castelli GP, Pognani C, Meisner M, Stuani A, Bellomi D, Sgarbi L. Procalcitonin, and C-reactive protein during systemic inflammatory response syndrome, sepsis, and organ dysfunction. Crit Care 8: R234-R242, 2004
35. Shapiro NI, Howell MD, Talmor D, Nathanson LA, Lisbon A, Wolfe RE, Weiss JW. Serum lactate as a predictor of mortality in emergency department patients with infection. Ann Emerg Med 45: 524-528, 2005
36. Mikkelsen ME, Miltiades AN, Gaieski DF, Goyal M, Fuchs BD, Shah CV, Bellamy SL, Christie JD. Serum lactate is associated with mortality in severe sepsis independent of organ failure, and shock. Crit Care Med 37: 1670-1677, 2009
37. Puskarich MA, Trzeciak S, Shapiro NI, Albers AB, Heffner AC, Kline JA, Jones AE. Whole blood lactate kinetics in patients undergoing quantitative resuscitation for severe sepsis, and septic shock. Chest 143: 1548-1553, 2013
38. Guzman JA, Cumbo-Nacheli G, Xu M, Arelli V, Sasidhar M. Day to Day Change in Procalcitonin (PCT), and Lactate to Predict Sepsis, and Hospital Mortality. Chest 142(4 MeetingAbstracts): 285A, 2012
39. Mihajlovic DM, Lendak DF, Brkic SV, Draskovic BG, Mitic GP, Novakov Mikic AS, Cebovic TN. Endocan is useful biomarker of survival, and severity in sepsis. Microvasc Res 93: 92-97, 2014