Transition from an autoimmune-prone state to fatal autoimmune disease in CCR7 and RORγt double-deficient mice is dependent on gut microbiota

Journal of Autoimmunity

Volumn 47, Issue , 2013, Pages 58-72

  Wichner, Katharina ^a   Fischer, André ^b   Winter, Susann ^a,c   Tetzlaff, Solveig ^a   Heimesaat, Markus M ^b   Bereswill, Stefan ^b   Rehm, Armin ^a,b   Lipp, Martin ^a   Höpken, Uta E ^a  

^a MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c KAROLINSKA INSTITUTE   (Sweden)

Author keywords

Gut microbiota; Homeostatic chemokine receptor; Mucosal inflammation; Retinoic acid receptor related orphan receptor; Thymic T cell development

Indexed keywords

AMPICILLIN; CHEMOKINE RECEPTOR CCR7; COLISTIN; RETINOID RELATED ORPHAN RECEPTOR GAMMA; STREPTOMYCIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIBIOTIC THERAPY; ARTICLE; AUTOIMMUNE DISEASE; COMMENSAL ESCHERICHIA COLI; CONTROLLED STUDY; FETUS; INTESTINE FLORA; LEUKOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; THYMOCYTE; TISSUE SPECIFICITY; WASTING SYNDROME;

CCR7/RORΓT DOUBLE-DEFICIENT; DKO; GUT MICROBIOTA; HOMEOSTATIC CHEMOKINE RECEPTOR; ILFS; ISOLATED LYMPHOID FOLLICLES; LTIS; LYMPHOID TISSUE INDUCER CELLS; MUCOSAL INFLAMMATION; REGULATORY T CELLS; RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTOR; SECONDARY LYMPHOID ORGAN; SLO; THYMIC T CELL DEVELOPMENT; TREGS;

AMPICILLIN; ANIMALS; ANTI-BACTERIAL AGENTS; AUTOANTIBODIES; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CHIMERA; COLISTIN; INFLAMMATION; INTESTINAL MUCOSA; LEUKOCYTES; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROBIOTA; NUCLEAR RECEPTOR SUBFAMILY 1, GROUP F, MEMBER 3; RECEPTORS, CCR7; STREPTOMYCIN;

EID: 84888202649     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2013.08.007     Document Type: Article

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