Astrocytic GAP43 induced by the TLR4/NF-κB/STAT3 axis attenuates astrogliosis-mediated microglial activation and neurotoxicity

Journal of Neuroscience

Volumn 36, Issue 6, 2016, Pages 2027-2043

  Hung, Chia Chi ^a,b   Lin, Chun Hua ^c   Chang, Hsuan ^b   Wang, Chen Yu ^b   Lin, Shang Hsuan ^b   Hsu, Pei Chien ^b   Sun, Yu Yo ^d   Lin, Teng Nan ^e   Shie, Feng Shiun ^f   Kao, Lung Sen ^b   Chou, Chih Ming ^a   Lee, Yi Hsuan ^a,b  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL YANG MING UNIVERSITY   (Taiwan)

^c Kang Ning Junior College of M C and M   (Taiwan)

^d EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^e INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^f NATIONAL HEALTH RESEARCH INSTITUTES   (Taiwan)

Author keywords

Astrogliosis; EAAT2; GAP43; Microglial activation; MKL1; Neurotoxicity

Indexed keywords

EXCITATORY AMINO ACID TRANSPORTER 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 6; NEUROMODULIN; STAT3 PROTEIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA; CYTOKINE; MKL1 PROTEIN, RAT; SLC1A2 PROTEIN, RAT; STAT3 PROTEIN, RAT; TLR4 PROTEIN, RAT; TRANSACTIVATOR PROTEIN;

ACTIN POLYMERIZATION; ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; ASTROCYTOSIS; CHROMATIN IMMUNOPRECIPITATION; CONFOCAL MICROSCOPY; CONTROLLED STUDY; EMBRYO; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; GENE EXPRESSION; IMMUNOHISTOCHEMISTRY; IMMUNOMODULATION; IMMUNOREACTIVITY; LUCIFERASE ASSAY; MALE; MICROGLIA; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; WESTERN BLOTTING; ANIMAL; ASTROCYTE; BIOSYNTHESIS; DRUG EFFECTS; GENETICS; GLIOSIS; MACROPHAGE ACTIVATION; NERVE CELL; PATHOLOGY; PHOSPHORYLATION; SPRAGUE DAWLEY RAT; TOXICITY AND INTOXICATION;

ANIMALS; ASTROCYTES; CYTOKINES; EXCITATORY AMINO ACID TRANSPORTER 2; GAP-43 PROTEIN; GLIOSIS; MACROPHAGE ACTIVATION; MICROGLIA; NEURONS; NEUROTOXICITY SYNDROMES; NF-KAPPA B; PHOSPHORYLATION; RATS; RATS, SPRAGUE-DAWLEY; STAT3 TRANSCRIPTION FACTOR; TOLL-LIKE RECEPTOR 4; TRANS-ACTIVATORS;

EID: 84958756879     PISSN: 02706474     EISSN: 15292401     Source Type: Journal    
DOI: 10.1523/JNEUROSCI.3457-15.2016     Document Type: Article

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