Astrocyte stellation, a process dependent on Rac1 is sustained by the regulated exocytosis of enlargeosomes

GLIA

Volumn 60, Issue 3, 2012, Pages 465-475

  Racchetti, Gabriella ^a   D'Alessandro, Rosalba ^b   Meldolesi, Jacopo ^a  

^a SAN RAFFAELE HOSPITAL   (Italy)

^b S de Bellis Scientific Institute   (Italy)

Author keywords

Cytoskeleton; Membrane traffic; Process outgrowth; Small GTPases; Surface expansion

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATASE; RAC1 PROTEIN;

ANIMAL CELL; ARTICLE; ASTROCYTE; ASTROCYTE STELLATION; BRAIN TISSUE; CELL FUNCTION; CELL ORGANELLE; CONTROLLED STUDY; CYTOSKELETON; DOWN REGULATION; EXOCYTOSIS; NONHUMAN; PRIORITY JOURNAL; RAT;

8-BROMO CYCLIC ADENOSINE MONOPHOSPHATE; ACTIN CYTOSKELETON; AMIDES; ANIMALS; ANIMALS, NEWBORN; ASTROCYTES; CELL ENLARGEMENT; CELL MEMBRANE; CELLS, CULTURED; CEREBRAL CORTEX; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; EXOCYTOSIS; GLIAL FIBRILLARY ACIDIC PROTEIN; MEMBRANE PROTEINS; MICROTUBULES; NEOPLASM PROTEINS; PYRIDINES; RAC1 GTP-BINDING PROTEIN; RATS; RATS, SPRAGUE-DAWLEY; RNA, SMALL INTERFERING; TIME FACTORS;

EID: 84856235484     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22280     Document Type: Article

References (48)

1. Abe K, Misawa M.2003.Astrocyte stellation induced by Rho kinase inhibitors in culture. Dev Brain Res 143:99-104.
2. Alberts P, Rudge R, Trinitopoulou T, Danglot L, Gauther-Rouvière C, Galli T.2006.Cdc42 and actin control polarized expression of TiVAMP vesicles to neuronal growth cones and their fusion with the plasma membrane. Mol. Biol Cell 17:1194-1203.
3. Boran MS, Garcia A.2007.The cyclic GMP-protein kinase G pathway regulates cytoskeleton dynamics and motility of astrocytes.J Neurochem 102:216-230.
4. Borgonovo B, Cocucci E, Racchetti G, Podini P, Bachi A, Meldolesi J.2002.Regulated exocytosis: A novel, widely expressed system. Nat Cell Biol 4:955-962.
5. Chao TI, Rickmann M, Wolff JR.2002.The synapse-astrocyte boundary: An anatomical basis for an integrative role of glia in synaptic transmission. In:Volterra A, et al., editors. The tripartite synapse: Glia in synaptic transmission.Oxford:Oxford University Press. pp 3-23.
6. Chieregatti E, Meldolesi J.2005.Regulated exocytosis: New organelles for non-secretory purposes. Nat Rev Mol Cell Biol 6:181-187.
7. Cocucci E, Racchetti G, Podini P, Meldolesi J.2007.Enlargeosome traffic: Exocytosis triggered by various signals is followed by endocytosis, membrane shedding or both. Traffic 8:742-757.
8. D'Alessandro R, Klajn A, Stucchi L, Podini P, Malosio ML, Meldolesi J. 2008.Expression of the neurosecretory process in PC12 cells is governed by REST.J Neurochem 105:1369-1383.
9. Derouiche A, Frotscher M.2001.Peripheral astrocyte processing: Monitoring by selective immunostaining for the actin-binding ERM proteins. Glia 36:330-341.
10. Favero CB, Mandell JW.2007.A pharmacological activator of AMP-activated protein kinase (AMPK) induces astrocyte stellation. Brain Res 1168:1-10.
11. Fukata M, Nakagawa M, Kaibuchi K.2003.Roles of Rho-family GTPases in cell polarisation and directional migration. Curr Opin Cell Biol 15:590-597.
12. Hall A.2005.Rho GTPases and the control of cell behavior. Biochem Soc Trans 33:891-895.
13. Hirose M, Ishizaki T, Watanabe N, Uehata M, Kranenburg O, Moolenaar WH, Matsumura F, Maekawa M, Bito H, Narumiya S.1998.Molecular dissection of the Rho-associated protein kinase (p160ROCK)-regulated neurite remodeling in neuroblastoma N1E-115 cells.J Cell Biol 141:625-636.
14. Holtje M, Hoffmann A, Hoffmann F, Mucke C, Grosse G, Van Rooijen N, Kettenmann H, Just I, Ahnert-Hilger G.2005.Role of Rho GTPase in astrocyte morphology and migratory response during in vitro wound healing.J Neurochem 9:1237-1248.
15. John GR, Chen L, Riviccio MA, Melendez-Vasquez CV, Hartley A, Brosnan CF.2004.Interleukin-1β induces reactive astroglial phenotype via deactivation of the Rho GTPase-Rock axis.J Neurosci 24:2837-2845.
16. Kasai H, Kishimoto T, Liu TT, Miyashita Y, Podini P, Grohovaz F, Meldolesi J.1999.Multiplicity and diversity of regulated exocytosis in wild-type and defective PC12 cells. Proc Natl Acad Sci USA 96:945-949.
17. Lau C, O'shea R, Broberg B, Bischof Beart P.2011.The Rho kinas inhibitor Fasudil upregulates astrocytic glutamate transport subsequent to actin re-modeling in murine cultured astrocytes. Br J Pharmacol 163:533-545.
18. Lavialle M, Aumann G, Anlauf E, Prols F, Arpin M and Deouiche A.2011.Structural plasticity of perisynaptic astrocyte processes involves ezrin and metabotropic glutamate receptors. Proc Natl Acad Sci USA 108:12915-12919.
19. Lichtenstein MP, Carriba P, Baltrons MA, Wojciak-Stothard B, Peterson JR, García A, Galea E.2010.Secretase-independent and RhoGTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivatives.J Alzheimers Dis 22:1135-1155.
20. Lin R, Mitsunobu K 1974. Brain cells in culture: Morphological transformation by a protein. Science 185:63-66.
21. Lin R, Mitsunobu K, Li WK.1973.Maturation-stimulated effect of brain extract and dibutyryl cyclic AMP on dissociated embryonic brain cells in culture. Exp Cell Res 79:243-246.
22. Mamboisse F, Houy S, Ory S, Calco V, Bader MF, Gasman S.2011.How important are Rho GTPases in neurosecretion?J Neurochem 117:623-631
23. Maxfield FR, McGraw TE.2004.Endocytic recycling. Nat Rev Mol Cell Biol 5:121-132.
24. Meldolesi J.2011.Neurite outgrowth: This process, first discovered by Santiago Ramon y Cajal, is sustained by the exocytosis of two distinct types of vesicles. Brain Res Rev 66:246-255.
25. Moonen G, Cam Y, Sensenbrenner M, Mandel P.1975.Variability of the effects of serum-free medium, dibutyryl cyclic AMP or theophilline on the morphology of cultured new-born rat astrocytes. Cell Tissue Res 163:365-372.
26. Morris CE, Homann U.2001. Cell surface area regulation and membrane tension.J Membr Biol 179:79-102.
27. Nakayama M, Goto TM, Sugimoto M, Nishimura T, Shinagawa T, Ohno S, Amano M, Kaibuchi K.2008.Rho-kinase phosphorylates PAR-3 and disrupts PAR complex formation. Dev Cell 14:205-215.
28. Narumiya S, Ishizaki T, Uehata M.2000.Use and properties of ROCK-specific inhibitor Y27632.Methods Enzymol 325:273-284.
29. Neary JT, Baker L, Jorgensen SL, Norenberg MD.1994.Extracellular ATP induces stellation and increases glial fibrillary acidic protein content and DNA synthesis in primary astrocyte cultures. Acta Neuropathol 87:8-13.
30. Otha Y, Hartwig JH, Stossel TP.2006.FilGAP, Rho- and ROCK-regulated GAP for Rac, binds filamin A to control actin remodeling. Nat Cell Biol 8:803-814.
31. Parpura V, Zorec R.2010.Gliotransmission: Exocytotic release from astrocytes. Brain Res Rev 63:83-92.
32. Pelish HE, Peterson JR, Salvarezza SB, Rodriguez-Boulan E, Chen JL, Stamnes M, Macia E, Feng Y, Shair MD, Kirchhausen T.2006.Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. Nat Chem Biol 2:39-46.
33. Pfenninger KH.2009.Plasma membrane expansion: A neuron's herculean task. Nat Neurosci 10:251-261.
34. Prada I, Marchaland J, Podini P, Magrassi L, D'Alessandro R, Bezzi P, Meldolesi J.2011.REST/NRSF governs the expression of dense-core vesicle gliosecretion in astrocytes.J Cell Biol 193:537-549.
35. Racchetti G, Lorusso A, Schulte C, Gavello D, Carabelli V, D'Alessandro R, Meldolesi J.2010.Rapid neurite outgrowth in neurosecretory cells and neurons is sustained by the exocytosis of a cytoplasmic organelle, the enlargeosome.J Cell Sci 123:165-170.
36. Reichembach A, Derouiche A, Kirchoff F.2011.Morphology and dynamics of perisynaptic glia. Brain Res Rev 63:11-26.
37. Ridley AJ.2006.Rho GTPases and actin dynamics in membrane protrusions and vesicle trafficking. Trends Cell Biol 16:522-529.
38. Rosso L, Pierson PM, Golfier C, Petery-Brumback B, Deroanne C, Van Obberghen-Schilling E, Mienville JM.2007.Pituicyte stellation is prevented by RhoA- or Cdc42-dependent actin polymerization. Cell Mol Neurobiol 27:791-804.
39. Salhia B, Rutten F, Nakada M, Beaudry C, Barens M, Kwan A, Rulka JT.2005.Inhibition of Rho-kinase affects astrocytoma morphology, motility and invasion through activation of Rac1.Cancer Res 65:8792-8800.
40. Shutes A, Onesto C, Picard V, Leblond B, Schweighoffer F, Der CJ.2007.Specificity and mechanism of action of EHT 1864, a novel small molecule inhibitor of Rac family small GTPases.J Biol Chem 282:35666-35678.
41. Suidan HS, Nobes CD, Hall A, Monard D.1997.Astrocyte spreading in response to thrombin and lysophosphatidic acid is dependent on the Rho GTPase. Glia 21:244-252.
42. Takefuji M, Mori K, Morita Y, Arimura N, Nishimura T, Nakayama H, Hoshino M, Twamatsu A, Murohara T, Kaibuchi K, Amano M.2007.Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation. Biochem Biophys Res Comm 355:788-794.
43. Theodosis DT, Poulain DA, Oliet SH.2008.Activity-dependent structural and functional plasticity of astrocyte-neuron interactions. Physiol Rev 88:983-1008.
44. Tomasoni R, Negrini S., Fiordaliso S, Klajn A, Tkatch T, Mondino A, Meldolesi J, D'Alessandro R.2011.REST, TSC2 and β-catenin, interconnected in a signaling loop, govern proliferation and functions in PC12 neural cells.J Cell Sci 124:3174-3186.
45. Volterra A, Meldolesi J.2005.Astrocytes, from brain glue to communication elements: The revolution continues. Nat Rev Neurosci 6:626-640.
46. Wang Z, Thurmond DC.2010.Differential phosphorylation of RhoGDI mediates the distinct cycling of Cdc42 and Rac1 to regulate second phase insulin secretion.J Biol Chem 285:6186-6197.
47. Yamaguchi Y, Katoh H, Yasui H, Mori K, Negishi M.2001.RhoA inhibits the nerve growth factor-induced Rac1 activation through Rho-associated kinase-dependent pathway.J Biol Chem 276:18977-18983.
48. Zhang D, Hu X, Quian L, O'Callaghan JP, Hong JS.2010.Astrogliosis in CNS pathologies: Is there a role for microglia?Mol Neurobiol 41:232-241.