Methylprednisolone inhibits the expression of glial fibrillary acidic protein and chondroitin sulfate proteoglycans in reactivated astrocytes

GLIA

Volumn 56, Issue 13, 2008, Pages 1390-1400

  Liu, Wei Lin ^a,b   Lee, Yi Hsuan ^a,b,c   Tsai, Shih Ying ^a   Hsu, Chung Yi ^b   Sun, Yu Yo ^a,c   Yang, Liang Yo ^a,b,c   Tsai, Shing Han ^a,d   Yang, Wei Chung Vivian ^a  

^a TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Central nervous system; Chondroitin sulfate proteoglycans; Gliosis; Glucocorticoid; Spinal cord injury

Indexed keywords

ALPHA AMINO 3 HYDROXY 5 METHYL 4 ISOXAZOLEPROPIONIC ACID; CYCLOTHIAZIDE; GLIAL FIBRILLARY ACIDIC PROTEIN; METHYLPREDNISOLONE; MIFEPRISTONE; NEUROCAN; PROTEOCHONDROITIN SULFATE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASTROCYTE; CELL ACTIVATION; CELL REGENERATION; CONTROLLED STUDY; CULTURE MEDIUM; DOWN REGULATION; DRUG MECHANISM; FEMALE; GROWTH INHIBITION; NERVE FIBER GROWTH; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN SYNTHESIS INHIBITION; RAT; SPINAL CORD INJURY; SPINAL GANGLION;

ANIMALS; ASTROCYTES; CELL SURVIVAL; CELLS, CULTURED; GENE EXPRESSION REGULATION; GLIAL FIBRILLARY ACIDIC PROTEIN; METHYLPREDNISOLONE; PROTEOCHONDROITIN SULFATES; RATS; RATS, SPRAGUE-DAWLEY;

EID: 51349157220     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.20706     Document Type: Article

References (57)

1. Anderson DK, Saunders RD, Demediuk P, Dugan LL, Braughler JM, Hall ED, Means ED, Horrocks LA. 1985. Lipid hydrolysis and peroxidation in injured spinal cord: partial protection with methylprednisolone or vitamin E, selenium. Cent Nerv Syst Trauma 2:257-267.
2. Asher RA, Morgenstern DA, Fidler PS, Adcock KH, Oohira A, Braistead JE, Levine JM, Margolis RU, Rogers JH, Fawcett JW. 2000. Neurocan is upregulated in injured brain and in cytokine-treated astrocytes. J Neurosci 20:2427-2438.
3. Balasingam V, Tejada-Berges T, Wright E, Bouckova R, Yong VW. 1994. Reactive astrogliosis in the neonatal mouse brain and its modulation by cytokines. J Neurosci 14:846-856.
4. Barritt AW, Davies M, Marchand F, Hartley R, Grist J, Yip P, McMahon SB, Bradbury EJ. 2006. Chondroitinase ABC promotes sprouting of intact and injured spinal systems after spinal cord injury. J Neurosci 26:10856-10867.
5. Bartholdi D, Schwab ME. 1995. Methylprednisolone inhibits early inflammatory processes but not ischemic cell death after experimental spinal cord lesion in the rat. Brain Res 672:177-186.
6. Bignami A, Dahl D. 1974. Astrocyte-specific protein and neuroglial differentiation. An immunofluorescence study with antibodies to the glial fibrillary acidic protein. J Comp Neurol 153:27-38.
7. Bignami A, Eng LF, Dahl D, Uyeda CT. 1972. Localization of the glial fibrillary acidic protein in astrocytes by immunofluorescence. Brain Res 43:429-435.
8. Bracken MB. 1990. Methylprednisolone in the management of acute spinal cord injuries. Med J Aust 153:368
9. Bracken MB. 1991. Treatment of acute spinal cord injury with methylprednisolone: results of a multicenter, randomized clinical trial. J Neurotrauma 8(Suppl 1):S47-S50; discussion S51-S42.
10. Bracken MB, Shepard MJ, Collins WF, Jr, Holford TR, Baskin DS, Eisenberg HM, Flamm E, Leo-Summers L, Maroon JC, Marshall LF, Perot PL, Jr, Piepmeier J, Sonntag VKH, Wagner FC, Jr, Wilberger JL, Winn HR, Young W. 1992. Methylprednisolone or naloxone treatment after acute spinal cord injury: 1-year follow-up data. Results of the second National Acute Spinal Cord Injury Study. J Neurosurg 76:23-31.
11. Bradbury EJ, Moon LD, Popat RJ, King VR, Bennett GS, Patel PN, Fawcett JW, McMahon SB. 2002. Chondroitinase ABC promotes functional recovery after spinal cord injury. Nature 416:636-640.
12. Canning DR, McKeon RJ, DeWitt DA, Perry G, Wujek JR, Frederickson RC, Silver J. 1993. Beta-Amyloid of Alzheimer's disease induces reactive gliosis that inhibits axonal outgrowth. Exp Neurol 124:289-298.
13. Cato AC, Wade E. 1996. Molecular mechanisms of anti-inflammatory action of glucocorticoids. Bioessays 18:371-378.
14. Constantini S, Young W. 1994. The effects of methylprednisolone and the ganglioside GM1 on acute spinal cord injury in rats. J Neurosurg 80:97-111.
15. Dahl D, Bignami A. 1974. Heterogeneity of the glial fibrillary acidic protein in gliosed human brains. J Neurol Sci 23:551-563.
16. Dahl D, Bignami A. 1976. Immunogenic properties of the glial fibrillary acidic protein. Brain Res 116:150-157.
17. David JC, Yamada KA, Bagwe MR, Goldberg MP. 1996. AMPA receptor activation is rapidly toxic to cortical astrocytes when desensitization is blocked. J Neurosci 16:200-209.
18. Deupree DL, Tang XW, Yarom M, Dickman E, Kirch RD, Schloss JV, Wu JY. 1996. Studies of NMDA- and non-NMDA-mediated neurotoxicity in cultured neurons. Neurochem Int 29:255-261.
19. Eddleston M, Mucke L. 1993. Molecular profile of reactive astrocytes-implications for their role in neurologic disease. Neuroscience 54:15-36.
20. Fitch MT, Silver J. 1997a. Activated macrophages and the blood-brain barrier: Inflammation after CNS injury leads to increases in putative inhibitory molecules. Exp Neurol 148:587-603.
21. Fitch MT, Silver J. 1997b. Glial cell extracellular matrix: Boundaries for axon growth in development and regeneration. Cell Tissue Res 290:379-384.
22. Haas CA, Rauch U, Thon N, Merten T, Deller T. 1999. Entorhinal cortex lesion in adult rats induces the expression of the neuronal chondroitin sulfate proteoglycan neurocan in reactive astrocytes. J Neurosci 19:9953-9963.
23. Hall ED, Braughler JM. 1981. Acute effects of intravenous glucocorticoid pretreatment on the in vitro peroxidation of cat spinal cord tissue. Exp Neurol 73:321-324.
24. Hausmann ON. 2003. Post-traumatic inflammation following spinal cord injury. Spinal Cord 41:369-378.
25. Honer C, Nam K, Fink C, Marshall P, Ksander G, Chatelain RE, Cornell W, Steele R, Schweitzer R, Schumacher C. 2003. Glucocorticoid receptor antagonism by cyproterone acetate and RU486. Mol Pharmacol 63:1012-1020.
26. Hosli E, Hosli L. 1993. Receptors for neurotransmitters on astrocytes in the mammalian central nervous system. Prog Neurobiol 40:477-506.
27. Hsu CY, Dimitrijevic MR. 1990. Methylprednisolone in spinal cord injury: The possible mechanism of action. J Neurotrauma 7:115-119.
28. Jonat C, Rahmsdorf HJ, Park KK, Cato AC, Gebel S, Ponta H, Herrlich P. 1990. Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62: 1189-1204.
29. Jones LL, Margolis RU, Tuszynski MH. 2003. The chondroitin sulfate proteoglycans neurocan, brevican, phosphacan, and versican are differentially regulated following spinal cord injury. Exp Neurol 182:399-411.
30. Koh JY, Choi DW. 1987. Quantitative determination of glutamate mediated cortical neuronal injury in cell culture by lactate dehydrogenase efflux assay. J Neurosci Methods 20:83-90.
31. Lemons ML, Howland DR, Anderson DK. 1999. Chondroitin sulfate proteoglycan immunoreactivity increases following spinal cord injury and transplantation. Exp Neurol 160:51-65.
32. Levison SW, McCarthy KD. 1991. Astroglia in culture. In: Banker GA, Goslin K, editors. Culturing nerve cells. Cambridge: MIT Press. pp 309-336.
33. Mace K, Saxod R, Feuerstein C, Sadoul R, Hemming FJ. 2002. Chondroitin and keratan sulfates have opposing effects on attachment and outgrowth of ventral mesencephalic explants in culture. J Neurosci Res 70:46-56.
34. Magnus T, Chan A, Grauer O, Toyka KV, Gold R. 2001. Microglial phagocytosis of apoptotic inflammatory T cells leads to down-regulation of microglial immune activation. J Immunol 167:5004-5010.
35. Masood K, Besnard F, Su Y, Brenner M. 1993. Analysis of a segment of the human glial fibrillary acidic protein gene that directs astrocyte-specific transcription. J Neurochem 61:160-166.
36. McKeon RJ, Jurynec MJ, Buck CR. 1999. The chondroitin sulfate proteoglycans neurocan and phosphacan are expressed by reactive astrocytes in the chronic CNS glial scar. J Neurosci 19:10778-10788.
37. McKeon RJ, Schreiber RC, Rudge JS, Silver J. 1991. Reduction of neurite outgrowth in a model of glial scarring following CNS injury is correlated with the expression of inhibitory molecules on reactive astrocytes. J Neurosci 11:3398-3411.
38. Morgenstern DA, Asher RA, Fawcett JW. 2002. Chondroitin sulphate proteoglycans in the CNS injury response. Prog Brain Res 137:313-332.
39. Mosmann T. 1983. Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays. J Immunol Methods 65:55-63.
40. Norenberg MD. 1994. Astrocyte responses to CNS injury. J Neuropathol Exp Neurol 53:213-220.
41. Powell EM, Geller HM. 1999. Dissection of astrocyte-mediated cues in neuronal guidance and process extension. Glia 26:73-83.
42. Ransom B, Behar T, Nedergaard M. 2003. New roles for astrocytes (stars at last). Trends Neurosci 26:520-522.
43. Rozovsky I, Laping NJ, Krohn K, Teter B, O'Callaghan JP, Finch CE. 1995. Transcriptional regulation of glial fibrillary acidic protein by corticosterone in rat astrocytes in vitro is influenced by the duration of time in culture and by astrocyte-neuron interactions. Endocrinology 136:2066-2073.
44. Sarid J. 1991. Identification of a cis-acting positive regulatory element of the glial fibrillary acidic protein gene. J Neurosci Res 28:217-228.
45. Schnell L, Fearn S, Klassen H, Schwab ME, Perry VH. 1999a. Acute inflammatory responses to mechanical lesions in the CNS: Differences between brain and spinal cord. Eur J Neurosci 11:3648-3658.
46. Schnell L, Fearn S, Schwab ME, Perry VH, Anthony DC. 1999b. Cytokine-induced acute inflammation in the brain and spinal cord. J Neuropathol Exp Neurol 58:245-254.
47. Shank SS, Scheuer DA. 2003. Glucocorticoids reduce responses to AMPA receptor activation and blockade in nucleus tractus solitarius. Am J Physiol Heart Circ Physiol 284:H1751-H1761.
48. Shirakawa H, Katsuki H, Kume T, Kaneko S, Akaike A. 2005. Pregnenolone sulphate attenuates AMPA cytotoxicity on rat cortical neurons. Eur J Neurosci 21:2329-2335.
49. Smoak KA, Cidlowski JA. 2004. Mechanisms of glucocorticoid receptor signaling during inflammation. Mech Ageing Dev 125:697-706.
50. Snow DM, Lemmon V, Carrino DA, Caplan AI, Silver J. 1990. Sulfated proteoglycans in astroglial barriers inhibit neurite outgrowth in vitro. Exp Neurol 109:111-130.
51. Snow DM, Smith JD, Cunningham AT, McFarlin J, Goshorn EC. 2003. Neurite elongation on chondroitin sulfate proteoglycans is characterized by axonal fasciculation. Exp Neurol 182:310-321.
52. Sorrell JM, Carrino DA, Caplan AI. 1993. Structural domains in chondroitin sulfate identified by anti-chondroitin sulfate monoclonal antibodies. Immunosequencing of chondroitin sulfates. Matrix 13:351-361.
53. Xu J, Fan G, Chen S, Wu Y, Xu XM, Hsu CY. 1998. Methylprednisolone inhibition of TNF-α expression and NF-κB activation after spinal cord injury in rats. Brain Res Mol Brain Res 59:135-142.
54. Xu J, Kim GM, Ahmed SH, Xu J, Yan P, Xu XM, Hsu CY. 2001. Glucocorticoid receptor-mediated suppression of activator protein-1 activation and matrix metalloproteinase expression after spinal cord injury. J Neurosci 21:92-97.
55. Yang-Yen HF, Chambard JC, Sun YL, Smeal T, Schmidt TJ, Drouin J, Karin M. 1990. Transcriptional interference between c-Jun and the glucocorticoid receptor: Mutual inhibition of DNA binding due to direct protein-protein interaction. Cell 62:1205-1215.
56. Yick LW, Cheung PT, So KF, Wu W. 2003. Axonal regeneration of Clarke's neurons beyond the spinal cord injury scar after treatment with chondroitinase ABC. Exp Neurol 182:160-168.
57. Young W, Bracken MB. 1992. The second national acute spinal cord injury study. J Neurotrauma 9(Suppl 1):S397-S405.