Disabling mitochondrial peroxide metabolism via combinatorial targeting of peroxiredoxin 3 as an effective therapeutic approach for malignant mesothelioma

PLoS ONE

Volumn 10, Issue 5, 2015, Pages

  Cunniff, Brian ^a   Newick, Kheng ^b   Nelson, Kimberly J ^c   Wozniak, Alexandra N ^a   Beuschel, Stacie ^a   Leavitt, Bruce ^a   Bhave, Anant ^a   Butnor, Kelly ^a   Koenig, Andreas ^d   Chouchani, Edward T ^e,f   James, Andrew M ^e   Haynes, Alexina C ^c   Lowther, W Todd ^c   Murphy, Michael P ^e   Shukla, Arti ^a   Heintz, Nicholas H ^a  

^a UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c WAKE FOREST SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF VERMONT   (United States)

^e MEDICAL RESEARCH COUNCIL   (United Kingdom)

^f UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CATALASE; CRYSTAL VIOLET; CYSTEINE; DIMER; HOMODIMER; PEROXIDE; PEROXIREDOXIN 3; THIOREDOXIN 2; THIOSTREPTON; THIOREDOXIN;

AMINO ACID SEQUENCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; COVALENT BOND; CROSS LINKING; DISULFIDE BOND; DRUG POTENTIATION; DRUG SENSITIVITY; DRUG TOLERABILITY; GENE SILENCING; HUMAN; HUMAN CELL; MALE; MALIGNANT MESOTHELIOMA; MAMMAL; MESOTHELIUM CELL; MITOCHONDRIAL RESPIRATION; MOLECULARLY TARGETED THERAPY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; SCID MOUSE; ANIMAL; DRUG EFFECTS; EPITHELIUM; LUNG NEOPLASMS; MESOTHELIOMA; METABOLISM; MITOCHONDRION; OXIDATION REDUCTION REACTION; PHYSIOLOGY; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CATALASE; CELL PROLIFERATION; EPITHELIUM; HUMANS; LUNG NEOPLASMS; MALE; MESOTHELIOMA; MICE; MICE, SCID; MITOCHONDRIA; OXIDATION-REDUCTION; PEROXIDES; PEROXIREDOXIN III; RATS; SIGNAL TRANSDUCTION; THIOREDOXINS; THIOSTREPTON;

EID: 84958578230     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0127310     Document Type: Article

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