Inhibition of mitochondrial protein translation sensitizes melanoma cells to arsenic trioxide cytotoxicity via a reactive oxygen species dependent mechanism

Cancer Chemotherapy and Pharmacology

Volumn 63, Issue 1, 2008, Pages 37-43

  Bowling, Benjamin D ^a,b   Doudican, Nicole ^a   Manga, Prashiela ^a   Orlow, Seth J ^a  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Arsenic trioxide; Chemoresistance; Melanoma; Reactive oxygen species; Thiostrepton

Indexed keywords

ACETYLCYSTEINE; ARSENIC TRIOXIDE; CYTOCHROME C OXIDASE; MITOCHONDRIAL PROTEIN; POLY(ADENOSINE DIPHOSPHATE RIBOSE); REACTIVE OXYGEN METABOLITE; THIOSTREPTON;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG POTENTIATION; HUMAN; HUMAN CELL; MELANOMA; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; APOPTOSIS; ARSENICALS; CELL LINE, TUMOR; DRUG EVALUATION, PRECLINICAL; DRUG RESISTANCE, NEOPLASM; DRUG SYNERGISM; ELECTRON TRANSPORT COMPLEX IV; HUMANS; INHIBITORY CONCENTRATION 50; MELANOMA; MITOCHONDRIAL PROTEINS; OXIDES; POLY ADENOSINE DIPHOSPHATE RIBOSE; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; REACTIVE OXYGEN SPECIES; TETRACYCLINES; THIOSTREPTON;

EID: 54849204400     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00280-008-0705-y     Document Type: Article

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