Early life stress increases stress vulnerability through BDNF gene epigenetic changes in the rat hippocampus

Neuropharmacology

Volumn 105, Issue , 2016, Pages 388-397

  Seo, Mi Kyoung ^a   Ly, Nguyen Ngoc ^b   Lee, Chan Hong ^a   Cho, Hye Yeon ^a   Choi, Cheol Min ^b   Nhu, Le Hoa ^b   Lee, Jung Goo ^a,b,c   Lee, Bong Ju ^c   Kim, Gyung Mee ^c   Yoon, Bong June ^d   Park, Sung Woo ^a,b   Kim, Young Hoon ^a,b,c  

^a Paik Institute for Clinical Research   (South Korea)

^b Inje University   (South Korea)

^c Inje University College of Medicine   (South Korea)

^d Korea University   (South Korea)

Author keywords

BDNF; Epigenetic mechanism; Escitalopram; Maternal separation; Restraint stress

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; ESCITALOPRAM; HISTONE DEACETYLASE 5; HISTONE H3; HISTONE H4; ANTIDEPRESSANT AGENT; CITALOPRAM; HDAC5 PROTEIN, RAT; HISTONE; HISTONE DEACETYLASE;

ADULT; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BDNF GENE; BEHAVIOR CHANGE; CONTROLLED STUDY; EARLY LIFE STRESS; EPIGENETICS; EXON; FEMALE; FORCED SWIM TEST; GENE EXPRESSION; GENE SEQUENCE; HIPPOCAMPUS; IMMOBILITY; IMMOBILIZATION STRESS; IN VIVO STUDY; MALE; MATERNAL DEPRIVATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN ACETYLATION; PROTEIN EXPRESSION; RAT; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; EXERCISE; GENETIC EPIGENESIS; GENETICS; HUMAN; MENTAL STRESS; METABOLISM; PREGNANCY; PSYCHOLOGY; SEPARATION ANXIETY; SPRAGUE DAWLEY RAT; SWIMMING;

ADULT; ANIMALS; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; ANXIETY, SEPARATION; BRAIN-DERIVED NEUROTROPHIC FACTOR; CITALOPRAM; EPIGENESIS, GENETIC; FEMALE; HIPPOCAMPUS; HISTONE DEACETYLASES; HISTONES; HUMANS; MALE; PREGNANCY; RATS, SPRAGUE-DAWLEY; RESTRAINT, PHYSICAL; STRESS, PSYCHOLOGICAL; SWIMMING;

EID: 84958280180     PISSN: 00283908     EISSN: 18737064     Source Type: Journal    
DOI: 10.1016/j.neuropharm.2016.02.009     Document Type: Article

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