Antioxidant, Antimicrobial and Urease Inhibitory Activities of Phenolics-Rich Pomegranate Peel Hydro-Alcoholic Extracts

Journal of Food Biochemistry

Volumn 40, Issue 4, 2016, Pages 550-558

  Ismail, Tariq ^a   Akhtar, Saeed ^a   Sestili, Piero ^b   Riaz, Muhammad ^a   Ismail, Amir ^a   Labbe, Ronald G ^c  

^a BAHAUDDIN ZAKARIYA UNIVERSITY   (Pakistan)

^b UNIVERSITY OF URBINO   (Italy)

^c UNIVERSITY OF MASSACHUSETTS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASPERGILLUS; BACTERIOLOGY; BIOMOLECULES; DEPRECIATION; ESCHERICHIA COLI; FREE RADICALS; FRUIT JUICES; RECOVERY; SALMONELLA;

1 ,1-DIPHENYL-2-PICRYLHYDRAZYL; BIOLOGICAL PROPERTIES; FERRIC REDUCING ANTIOXIDANT POWER; FREE RADICALS SCAVENGING; MINIMUM INHIBITORY CONCENTRATION; PSEUDOMONAS AERUGINOSA; SALMONELLA TYPHIMURIUM; STAPHYLOCOCCUS AUREUS;

ANTIOXIDANTS;

EID: 84958212149     PISSN: 01458884     EISSN: 17454514     Source Type: Journal    
DOI: 10.1111/jfbc.12250     Document Type: Article

References (54)

1. Ahmed, M.A.E., El Morsy, E.M., and Ahmed, A.A.E. 2014. Pomegranate extract protects against cerebral ischemia/reperfusion injury and preserves brain DNA integrity in rats. Life Sci. 110, 61–69.
2. Akhtar, S., Sarker, M.R., and Hossain, A. 2014. Microbiological food safety: A dilemma of developing societies. Crit. Rev. Microbiol. 40, 348–359.
3. Akhtar, S., Ismail, T., Fraternale, D., and Sestili, P. 2015. Pomegranate peel and peel extracts: Chemistry and food features. Food Chem. 174, 417–425.
4. Al-Said, F., Opara, L., and Al-Yahyai, R. 2009. Physico-chemical and textural quality attributes of pomegranate cultivars (Punica granatum L.) grown in the Sultanate of Oman. J. Food Eng. 90, 129–134.
5. Altunkaya, A., Hedegaard, R.V., Harholt, J., Brimer, L., Gokmen, V., and Skibsted, L.H. 2013. Palatability and chemical safety of apple juice fortified with pomegranate peel extract. Food Funct 4, 1468–1473.
6. Al-Zoreky, N.S. 2009. Antimicrobial activity of pomegranate (Punica granatum L.) fruit peels. Int. J. Food Microbiol. 134, 244–248.
7. Amyrgialaki, E., Makris, D.P., Mauromoustakos, A., and Kefalas, P. 2014. Optimisation of the extraction of pomegranate (Punica granatum) husk phenolics using water/ethanol solvent systems and response surface methodology. Ind. Crop Prod. 59, 216–222.
8. Ardekani, Shams, M.R., Hajimahmoodi, M., Oveisi, M.R., Sadeghi, N., Jannat, B., Ranjbar, A.M., Gholam, N., Moridi, T. 2011. Comparative antioxidant activity and total flavonoid content of Persian pomegranate (Punica granatum L.) cultivars. Iran. J. Pharm. Res. 10, 519.
9. Arfan, M., Ali, M., Ahmad, H., Anis, I., Khan, A., Choudhary, M.I., and Shah, M.R. 2010. Urease inhibitors from Hypericum oblongifolium WALL. J. Enzyme Inhib. Med. Chem. 25, 296–299.
10. Atta-Ur-Rehman, Choudhary, M.I., and Thomsen, W. 2001. Bioassay Techniques for Drug Development. Harwood Academic Publisher, Netherlands.
11. Biglar, M., Soltani, K., Nabati, F., Bazl, R., Mojab, F., and Amanlou, M. 2012. Investigation of the jack-bean urease inhibition by randomly selected traditionally used herbal medicine. Iran. J. Pharm. Res. 11, 831.
12. Bopitiya, D., and Madhujith, T. 2014. Efficacy of pomegranate (Punica granatum L.) peel extracts in suppressing oxidation of white coconut oil used for deep frying. Trop. Agric. Res. 25, 298–306.
13. Burne, R.A., and Chen, Y.Y.M. 2000. Bacterial ureases in infectious diseases. Microbes Infect. 2, 533–542.
14. Carballo, L.J., Hernandez-Inda, L.Z., Perez, P., and Gravalos, M.D. 2002. A comparison between two brine shrimp assays to detect in vitro cytotoxicity in marine natural products. BMC Biotechnol. 2, 1–10.
15. Chen, Z., Bertin, R., and Froldi, G. 2013. EC50 estimation of antioxidant activity in DPPH assay using several statistical programs. Food Chem. 138, 414–420.
16. Choi, J.G., Kang, O.H., Lee, Y.S., Chae, H.S., Oh, Y.C., Brice, O.O., and Kwon, D.Y. 2011. In vitro and in vivo antibacterial activity of Punica granatum peel ethanol extract against Salmonella. Evidence-Based Compliment. Altern. Med. 1–8.
17. Duman, A.D., Ozgen, M., Dayisoylu, K.S., Erbil, N., and Durgac, C. 2009. Antimicrobial activity of six pomegranate (Punica granatum L.) varieties and their relation to some of their pomological and phytonutrient characteristics. Molecules 14, 1808–1817.
18. El Kar, C., Ferchichi, A., Attia, F., and Bouajila, J. 2011. Pomegranate (Punica granatum) juices: Chemical composition, micronutrient cations, and antioxidant capacity. J. Food Sci. 76, C795–C800.
19. Fawole, O.A., and Opara, U.L. 2013. Seasonal variation in chemical composition, aroma volatiles and antioxidant capacity of pomegranate during development. Afr. J. Biotechnol. 12, 4006–4019.
20. Fawole, O.A., Makunga, N.P., and Opara, U.L. 2012. Antibacterial, antioxidant and tyrosinase-inhibition activities of pomegranate fruit peel methanolic extract. BMC Complement Altern. Med. 12, 200.
21. Fernandez, M.G., Delgado, G., Puche, J.E., Gonzalez-Baron, S., and Castilla, I. 2008. Low doses of insulin-like growth factor I improve insulin resistance, lipid metabolism, and oxidative damage in aging rats. Endocrinol. 14, 524–542.
22. Forgacs, I., and Loganayagam, A. 2008. Overprescribing proton pump inhibitors. BMJ 336, 2–3.
23. Gilgun-Sherki, Y., Melamed, E., and Offen, D. 2001. Oxidative stress induced-neurodegenerative diseases: the need for antioxidants that penetrate the blood brain barrier. Neuropharmacol. 40, 959–975.
24. Ismail, T., Sestili, P., and Akhtar, S. 2012. Pomegranate peel and fruit extracts: a review of potential anti-inflammatory and anti-infective effects. J. Ethnopharmacol. 143, 397–405.
25. Klaunig, J.E., Kamendulis, L.M., and Hocevar, B.A. 2010. Oxidative stress and oxidative damage in carcinogenesis. Toxicol. Pathol. 38, 96–109.
26. Li, Y., Guo, C., Yang, J., Wei, J., Xu, J., and Cheng, S. 2006. Evaluation of antioxidant properties of pomegranate peel extract in comparison with pomegranate pulp extract. Food Chem. 96, 254–260.
27. Lim, C.S.H., and Lim, S.L. 2013. Ferric reducing capacity versus ferric reducing antioxidant power for measuring total antioxidant capacity. Lab. Med. 44, 51–55.
28. Malviya, S., Jha, A., and Hettiarachchy, N. 2014. Antioxidant and antibacterial potential of pomegranate peel extracts. J. Food Sci. Technol. 51, 4132–4137.
29. Manasathien, J., Indrapichate, K., and Intarapichet, K. 2012. Antioxidant activity and bioefficacy of pomegranate Punica granatum Linn peel and seed extracts. Global J. Pharmacol. 6,131–141.
30. Mates, J.M., and Sanchez-Limenez, F.M. 2000. Role of reactive oxygen species in apopotosis: Implications for cancer therapy. Int. J. Biochem. Cell Biol. 32, 157–170.
31. Mo, J., Panichayupakaranant, P., Kaewnopparat, N., Songkro, S., and Reanmongkol, W. 2013. Topical anti-inflammatory potential of standardized pomegranate rind extract and ellagic acid in contact dermatitis. Phytother. Res. 28, 629–632.
32. Mobley, H.L., and Hausinger, R.P. 1989. Microbial ureases: significance, regulation, and molecular characterization. Microbiol. Rev, 53, 85–108.
33. Mphahlele, R.R., Fawole, O.A., Stander, M.A., and Opara, U.L. 2014. Preharvest and postharvest factors influencing bioactive compounds in pomegranate (Punica granatum L.) – a review. Sci. Hort. 178, 114–123.
34. Nabati, F., Mojab, F., Habibi-Rezaei, M., Bagherzadeh, K., Amanlou, M., and Yousefi, B. 2012. Large scale screening of commonly used Iranian traditional medicinal plants against urease activity. DARU J. Pharm. Sci. 20, 72.
35. Negi, P.S., and Jayaprakasha, G.K. 2003. Antioxidant and antibacterial activities of Punica granatum peel extracts. J. Food Sci. 68, 1473–1477.
36. Negi, P.S., Jayaprakasha, G.K., and Jena, B.S. 2003. Antioxidant and antimutagenic activities of pomegranate peel extracts. Food Chem. 80, 393–397.
37. Panichayupakaranant, P., Tewtrakul, S., and Yuenyongsawad, S. 2010. Antibacterial, anti-inflammatory and anti-allergic activities of standardised pomegranate rind extract. Food Chem. 123, 400–403.
38. Qnais, E.Y., Elokda, A.S., Abu Ghalyun, Y.Y., and Abdulla, F.A. 2007. Antidiarrheal activity of the aqueous extract of Punica granatum (Pomegranate) peels. Pharm. Biol. 45, 715–720.
39. Qu, W., Pan, Z., and Ma, H. 2010. Extraction modeling and activities of antioxidants from pomegranate marc. J. Food Eng. 99, 16–23.
40. Rahman, T., Hosen, I., Towhidul Islam, M.M., and Shekhar, H.U. 2012. Oxidative stress and human health. Adv. Biosci. Biotechnol. 3, 997–1019.
41. Reddy, U., Mullick, R., Kumar, A., Sudha, G., Srinivasan, N., and Das, S. 2014. Small molecule inhibitors of HCV replication from Pomegranate. Sci. Rep. 4, 5411.
42. Rodriguez, J., Gilson, H., Jamart, C., Naslain, D., Pierre, N., Deldicque, L., and Francaux, M. 2014. Pomegranate and green tea extracts protect against ER stress induced by a high-fat diet in skeletal muscle of mice. Eur. J. Nutr. 54, 377–389.
43. Sadeghian, A., Ghorbani, A., Mohamadi-Nejad, A., and Rakhshandeh, H. 2011. Antimicrobial activity of aqueous and methanolic extracts of pomegranate fruit skin. Avicenna J. Phytomed. 1, 67–73.
44. Scalbert, A., Deprez, S., Mila, I., Albrecht, A.M., Huneau, J.F., and Rabot, S. 2000. Proanthocyanidins and human health: Systemic effects and local effects in the gut. Biofactors 13, 115–120.
45. Sharma, O.P., and Bhat, T.K. 2009. DPPH antioxidant assay revisited. Food Chem. 113, 1202–1205.
46. Steel, R.G.D., Torrie, J.H., and Dickey, D. 1997. Principals and Procedures of Statistics, 3rd Ed., McGraw Hills, New York.
47. Sumbul, S., Ahmad, M.A., Mohd, A., and Mohd, A. (2011). Role of phenolic compounds in peptic ulcer: An overview. J. Pharm. Bioall. Sci. 3, 361–367.
48. Sun, B., Ricardo-Da-Silva, J.M., and Spranger, I. 1998. Critical factors of vanillin assay for catechins and proanthocyanidins. J. Agric. Food Chem. 46, 4267–4274.
49. Waly, M., Al-Rawahi, A.S., Al-Riyami, M., Al-Kindi, M., Al-Issaei, H.K., Farooq, S.A., Al-Alawi, A., and Rahman, M.S. 2014. Amelioration of azoxymethane induced-carcinogenesis by reducing oxidative stress in rat colon by natural extracts. BMC Complement. Altern. Med. 14, 60.
50. Wang, J.Y., Zhu, C., Qian, T.W., Zhang, F., and Yin, X. 2015. Extracts of black bean peel and pomegranate peel ameliorate oxidative stress–induced hyperglycemia in mice. Exp. Ther. Med. 9, 43–48.
51. Zahin, M., Aqil, F., and Ahmad, I. 2010. Broad spectrum antimutagenic activity of antioxidant active fraction of Punica granatum L. peel extracts. Mutat. Res. 703, 99–107.
52. Zam, W., Bashour, G., Abdelwahed, W., and Khayata, W. 2012. Separation and purification of proanthocyanidins extracted from pomegranate's peels (Punica granatum). Int. J. Pharm. Sci. Nanotechnol. 3, 1808–1813.
53. Zargar, M., and Pourahmad, J. 2014. Protective effect of Punica granatum L. (pomegranate) fruit extracts and ellagic acid against cytotoxicity induced by methyl tertiary butyl ether in isolated rat hepatocytes. Toxicol. Environ. Chem. 96, 150–161.
54. Zhao, X., Yuan, Z., Fang, Y., Yin, Y., and Feng, L. 2013. Characterization and evaluation of major anthocyanins in pomegranate (Punica granatum L.) peel of different cultivars and their developmental phases. Eur. Food Res. Technol. 236, 109–117.