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Volumn 4, Issue , 2014, Pages

Small molecule inhibitors of HCV replication from Pomegranate

Author keywords

[No Author keywords available]

Indexed keywords

ANTIVIRUS AGENT; ELLAGIC ACID; MOLECULAR LIBRARY; NS3 PROTEIN, HEPATITIS C VIRUS; PROTEIN BINDING; PUNICALAGIN; PUNICALIN; TANNIN; VIRUS PROTEIN;

EID: 84903202749     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep05411     Document Type: Article
Times cited : (62)

References (60)
  • 1
    • 0034092720 scopus 로고    scopus 로고
    • Pathogenesis, diagnosis and management of hepatitis C
    • Boyer, N. & Marcellin, P. Pathogenesis, diagnosis and management of hepatitis C. J. Hepatol. 32, 98-112 (2000). (Pubitemid 30123628)
    • (2000) Journal of Hepatology, Supplement , vol.32 , Issue.1 , pp. 98-112
    • Boyer, N.1    Marcellin, P.2
  • 2
    • 84880285547 scopus 로고    scopus 로고
    • Regulation of hepatic innate immunity by hepatitis C virus
    • Horner, S. M. & Gale, M. Jr. Regulation of hepatic innate immunity by hepatitis C virus. Nat. Med. 19, 879-888 (2013).
    • (2013) Nat. Med. , vol.19 , pp. 879-888
    • Horner, S.M.1    Gale, Jr.M.2
  • 3
    • 84859716196 scopus 로고    scopus 로고
    • Understanding silibinin's modes of action against HCV using viral kinetic modeling
    • Guedj, J., Dahari, H., Pohl, R. T., Ferenci, P. & Perelson, A. S. Understanding silibinin's modes of action against HCV using viral kinetic modeling. J. Hepatol. 56, 1019-1024 (2012).
    • (2012) J. Hepatol. , vol.56 , pp. 1019-1024
    • Guedj, J.1    Dahari, H.2    Pohl, R.T.3    Ferenci, P.4    Perelson, A.S.5
  • 4
    • 84860732768 scopus 로고    scopus 로고
    • Dietary compounds as potent inhibitors of signal transducers and activators of transcription (STAT) 3 regulatory network
    • Trecul, A., Morceau, F., Dicato, M. & Diederich, M. Dietary compounds as potent inhibitors of signal transducers and activators of transcription (STAT) 3 regulatory network. Genes Nutr. 7, 111-125 (2012).
    • (2012) Genes Nutr. , vol.7 , pp. 111-125
    • Trecul, A.1    Morceau, F.2    Dicato, M.3    Diederich, M.4
  • 5
    • 43949087893 scopus 로고    scopus 로고
    • Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin
    • DOI 10.1002/hep.22197
    • Nahmias, Y. et al. Apolipoprotein B-dependent hepatitis C virus secretion is inhibited by the grapefruit flavonoid naringenin. Hepatology 47, 1437-1445 (2008). (Pubitemid 351702727)
    • (2008) Hepatology , vol.47 , Issue.5 , pp. 1437-1445
    • Nahmias, Y.1    Goldwasser, J.2    Casali, M.3    Van Poll, D.4    Wakita, T.5    Chung, R.T.6    Yarmush, M.L.7
  • 6
    • 69249104937 scopus 로고    scopus 로고
    • Proanthocyanidin from blueberry leaves suppresses expressionofsubgenomic hepatitisC virusRNA
    • Takeshita, M. et al. Proanthocyanidin from blueberry leaves suppresses expressionofsubgenomic hepatitisC virusRNA.J.Biol. Chem. 284, 21165-21176 (2009).
    • (2009) J.Biol. Chem. , vol.284 , pp. 21165-21176
    • Takeshita, M.1
  • 7
    • 77649270720 scopus 로고    scopus 로고
    • Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway
    • Kim, K. et al. Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway. FEBS Lett. 584, 707-712 (2010).
    • (2010) FEBS Lett. , vol.584 , pp. 707-712
    • Kim, K.1
  • 8
    • 84902281747 scopus 로고    scopus 로고
    • Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells
    • Anggakusuma. et al. Turmeric curcumin inhibits entry of all hepatitis C virus genotypes into human liver cells. Gut. (2013).
    • (2013) Gut.
    • Anggakusuma1
  • 9
    • 84857376631 scopus 로고    scopus 로고
    • (-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry
    • Calland, N. et al. (-)-Epigallocatechin-3-gallate is a new inhibitor of hepatitis C virus entry. Hepatology 55, 720-729 (2012).
    • (2012) Hepatology , vol.55 , pp. 720-729
    • Calland, N.1
  • 10
    • 84872831778 scopus 로고    scopus 로고
    • Green tea phenolic epicatechins inhibit hepatitis C virus replication via cycloxygenase-2 and attenuate virus-induced inflammation
    • Lin, Y. T. et al. Green tea phenolic epicatechins inhibit hepatitis C virus replication via cycloxygenase-2 and attenuate virus-induced inflammation. PLoS One 8, e54466 (2013).
    • (2013) PLoS One , vol.8
    • Lin, Y.T.1
  • 11
    • 73149090363 scopus 로고    scopus 로고
    • The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production
    • Gonzalez, O. et al. The heat shock protein inhibitor Quercetin attenuates hepatitis C virus production. Hepatology 50, 1756-1764 (2009).
    • (2009) Hepatology , vol.50 , pp. 1756-1764
    • Gonzalez, O.1
  • 12
    • 84855834570 scopus 로고    scopus 로고
    • Suppression of hepatitis C virus by the flavonoid quercetin is mediated by inhibition of NS3 protease activity
    • Bachmetov, L. et al. Suppression of hepatitis C virus by the flavonoid quercetin is mediated by inhibition of NS3 protease activity. J. Viral Hepat. 19, e81-e88 (2012).
    • (2012) J. Viral Hepat. , vol.19
    • Bachmetov, L.1
  • 13
    • 47549111139 scopus 로고    scopus 로고
    • Therapeutic applications of pomegranate (Punica granatum L.): A review
    • Jurenka, J. S. Therapeutic applications of pomegranate (Punica granatum L.): a review. Altern. Med. Rev. 13, 128-144 (2008).
    • (2008) Altern. Med. Rev. , vol.13 , pp. 128-144
    • Jurenka, J.S.1
  • 14
    • 77649212752 scopus 로고    scopus 로고
    • Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro
    • Adams, L. S., Zhang, Y., Seeram, N. P., Heber, D. & Chen, S. Pomegranate ellagitannin-derived compounds exhibit antiproliferative and antiaromatase activity in breast cancer cells in vitro. Cancer Prev. Res. (Phila) 3, 108-113 (2010).
    • (2010) Cancer Prev. Res. (Phila) , vol.3 , pp. 108-113
    • Adams, L.S.1    Zhang, Y.2    Seeram, N.P.3    Heber, D.4    Chen, S.5
  • 15
    • 10144220702 scopus 로고    scopus 로고
    • Punica granatum (Pomegrante) juice provides an HIV-1 entry inhibitor and candidate topical microbicide
    • Neurath, A. R., Strick, N., Li, Y. Y. & Debnath, A. K. Punica granatum (Pomegrante) juice provides an HIV-1 entry inhibitor and candidate topical microbicide. BMC Infect. Dis. 4, 41 (2004).
    • (2004) BMC Infect. Dis. , vol.4 , pp. 41
    • Neurath, A.R.1    Strick, N.2    Li, Y.Y.3    Debnath, A.K.4
  • 17
    • 77956896558 scopus 로고    scopus 로고
    • Influenza virus variation in susceptibility to inactivation by pomegranate polyphenols is determined by envelope glycoproteins
    • Sundararajan, A. et al. Influenza virus variation in susceptibility to inactivation by pomegranate polyphenols is determined by envelope glycoproteins. Antiviral Res. 88, 1-9 (2010).
    • (2010) Antiviral Res. , vol.88 , pp. 1-9
    • Sundararajan, A.1
  • 18
    • 84870412876 scopus 로고    scopus 로고
    • Antiviral activity of punicalagin toward human enterovirus 71 in vitro and in vivo
    • Yang, Y., Xiu, J., Zhang, L., Qin, C. & Liu, J. Antiviral activity of punicalagin toward human enterovirus 71 in vitro and in vivo. Phytomedicine 20, 67-70 (2012).
    • (2012) Phytomedicine , vol.20 , pp. 67-70
    • Yang, Y.1    Xiu, J.2    Zhang, L.3    Qin, C.4    Liu, J.5
  • 19
    • 0033788223 scopus 로고    scopus 로고
    • Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing
    • Gil, M. I., Tomas-Barberan, F. A., Hess-Pierce, B., Holcroft, D. M. & Kader, A. A. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J. Agric. Food Chem. 48, 4581-4589 (2000).
    • (2000) J. Agric. Food Chem. , vol.48 , pp. 4581-4589
    • Gil, M.I.1    Tomas-Barberan, F.A.2    Hess-Pierce, B.3    Holcroft, D.M.4    Kader, A.A.5
  • 23
    • 80052227542 scopus 로고    scopus 로고
    • HCV NS3-4A serine protease
    • Tan, S. L., editor. Norfolk (UK): Horizon Bioscience; 2006. Chapter 6
    • Lin, C. (2006). HCV NS3-4A serine protease. In: Tan, S. L., editor. Hepatitis C viruses: Genomes and Molecular Biology. Norfolk (UK): Horizon Bioscience; 2006. Chapter 6. http://www.ncbi.nlm.nih.gov/books/NBK1623/.
    • (2006) Hepatitis C Viruses: Genomes and Molecular Biology
    • Lin, C.1
  • 24
    • 84864602817 scopus 로고    scopus 로고
    • The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors
    • Romano, K. P. et al. The molecular basis of drug resistance against hepatitis C virus NS3/4A protease inhibitors. PLoS Pathog. 8, e1002832 (2012).
    • (2012) PLoS Pathog. , vol.8
    • Romano, K.P.1
  • 25
    • 1542297721 scopus 로고    scopus 로고
    • X-ray and NMR characterization of covalent complexes of trypsin, borate, and alcohols
    • DOI 10.1021/bi035782y
    • Transue, T. R., Krahn, J. M., Gabel, S. A., DeRose, E. F. & London, R. E. X-ray and NMR characterization of covalent complexes of trypsin, borate and alcohols. Biochemistry. 43, 2829-2839 (2004). (Pubitemid 38327814)
    • (2004) Biochemistry , vol.43 , Issue.10 , pp. 2829-2839
    • Transue, T.R.1    Krahn, J.M.2    Gabel, S.A.3    DeRose, E.F.4    London, R.E.5
  • 26
    • 0028961335 scopus 로고
    • SCOP: A structural classification of proteins database for the investigation of sequences and structures
    • Murzin, A. G., Brenner, S. E., Hubbard, T. & Chothia, C. SCOP: a structural classification of proteins database for the investigation of sequences and structures. J. Mol. Biol. 247, 536-540 (1995).
    • (1995) J. Mol. Biol. , vol.247 , pp. 536-540
    • Murzin, A.G.1    Brenner, S.E.2    Hubbard, T.3    Chothia, C.4
  • 27
    • 17644392830 scopus 로고    scopus 로고
    • TM-align: A protein structure alignment algorithm based on the TM-score
    • DOI 10.1093/nar/gki524
    • Zhang, Y. & Skolnick, J. TM-align: a protein structure alignment algorithm based on the TM-score. Nucleic Acids Res. 33, 2302-2309 (2005). (Pubitemid 41439897)
    • (2005) Nucleic Acids Research , vol.33 , Issue.7 , pp. 2302-2309
    • Zhang, Y.1    Skolnick, J.2
  • 29
    • 0027935048 scopus 로고
    • Demonstration of in vitro infection of chimpanzee hepatocytes with hepatitis C virus using strand-specific RT/PCR
    • DOI 10.1006/viro.1994.1381
    • Lanford, R. E., Sureau, C., Jacob, J. R., White, R. & Fuerst, T. R. Demonstration of in vitro infection of chimpanzee hepatocytes with hepatitis C virus using strand-specific RT/PCR. Virology 202, 606-614 (1994). (Pubitemid 24254873)
    • (1994) Virology , vol.202 , Issue.2 , pp. 606-614
    • Lanford, R.E.1    Sureau, C.2    Jacob, J.R.3    White, R.4    Fuerst, T.R.5
  • 30
    • 0035022639 scopus 로고    scopus 로고
    • Development of a strand-specific RT-PCR based assay to detect the replicative form of hepatitis C virus RNA
    • DOI 10.1016/S0166-0934(01)00281-6, PII S0166093401002816
    • Craggs, J. K., Ball, J. K., Thomson, B. J., Irving, W. L. & Grabowska, A. M. Development of a strand-specific RT-PCR based assay to detect the replicative form of hepatitis C virus RNA. J. Virol. Methods 94, 111-120 (2001). (Pubitemid 32411483)
    • (2001) Journal of Virological Methods , vol.94 , Issue.1-2 , pp. 111-120
    • Craggs, J.K.1    Ball, J.K.2    Thomson, B.J.3    Irving, W.L.4    Grabowska, A.M.5
  • 31
    • 79956329892 scopus 로고    scopus 로고
    • Viral infectious disease and natural products with antiviral activity
    • Kitazato, K., Wang, Y. & Kobayashi, N. Viral infectious disease and natural products with antiviral activity. Drug Discov. Ther. 1, 14-22 (2007).
    • (2007) Drug Discov. Ther. , vol.1 , pp. 14-22
    • Kitazato, K.1    Wang, Y.2    Kobayashi, N.3
  • 32
    • 77954931489 scopus 로고    scopus 로고
    • Hepatitis C virus non structural protein 3 (HCV NS3): A multifunctional antiviral target
    • Raney, K. D., Sharma, S. D., Moustafa, I. M. & Cameron, C. E. Hepatitis C virus non structural protein 3 (HCV NS3): a multifunctional antiviral target. J. Biol. Chem. 285, 22725-22731 (2010).
    • (2010) J. Biol. Chem. , vol.285 , pp. 22725-22731
    • Raney, K.D.1    Sharma, S.D.2    Moustafa, I.M.3    Cameron, C.E.4
  • 33
    • 80052073390 scopus 로고    scopus 로고
    • Molecular mechanisms of viral and host cell substrate recognition by hepatitis C virus NS3/4A protease
    • Romano, K. P. et al. Molecular mechanisms of viral and host cell substrate recognition by hepatitis C virus NS3/4A protease. J. Virol. 85, 6106-6116 (2011).
    • (2011) J. Virol. , vol.85 , pp. 6106-6116
    • Romano, K.P.1
  • 34
    • 0030515619 scopus 로고    scopus 로고
    • Natural polyphenols (vegetable tannins) as drugs: Possible modes of action
    • DOI 10.1021/np960040+
    • Haslam, E. Natural polyphenols (vegetable tannins) as drugs: possible modes of action. J. Nat. Prod. 59, 205-215 (1996). (Pubitemid 27079849)
    • (1996) Journal of Natural Products , vol.59 , Issue.2 , pp. 205-215
    • Haslam, E.1
  • 35
    • 33750963983 scopus 로고    scopus 로고
    • Prediction of binding for a kind of non-peptic HCV NS3 serine protease inhibitors from plants by molecular docking and MM-PBSA method
    • DOI 10.1016/j.bmc.2006.09.074, PII S0968089606008121
    • Li, X., Zhang, W., Qiao, X. & Xu, X. Prediction of binding for a kind of non-peptic HCV NS3 serine protease inhibitors from plants by molecular docking and MM-PBSA method. Bioorg. Med. Chem. 15, 220-226 (2007). (Pubitemid 44738583)
    • (2007) Bioorganic and Medicinal Chemistry , vol.15 , Issue.1 , pp. 220-226
    • Li, X.1    Zhang, W.2    Qiao, X.3    Xu, X.4
  • 36
    • 22544447811 scopus 로고    scopus 로고
    • 2 in RNA replication
    • DOI 10.1128/JVI.79.15.9725-9734.2005
    • Waris, G. & Siddiqui, A. Hepatitis C virus stimulates the expression of cyclooxygenase-2 via oxidative stress: role of prostaglandin E2 in RNA replication. J. Virol. 79, 9725-9734 (2005). (Pubitemid 41022315)
    • (2005) Journal of Virology , vol.79 , Issue.15 , pp. 9725-9734
    • Waris, G.1    Siddiqui, A.2
  • 37
    • 0041822007 scopus 로고    scopus 로고
    • Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through Akt activation: Evidence for Akt inhibition in celecoxib-induced apoptosis
    • DOI 10.1053/jhep.2003.50380
    • Leng, J., Han, C., Demetris, A. J., Michalopoulos, G. K. & Wu, T. Cyclooxygenase-2 promotes hepatocellular carcinoma cell growth through AKT activation: evidence for AKT inhibition in celecoxib-induced apoptosis. Hepatology 38, 756-768 (2003). (Pubitemid 37052162)
    • (2003) Hepatology , vol.38 , Issue.3 , pp. 756-768
    • Leng, J.1    Han, C.2    Demetris, A.J.3    Michalopoulos, G.K.4    Wu, T.5
  • 38
    • 2442686585 scopus 로고    scopus 로고
    • The pivotal role of phosphatidylinositol 3-kinase-Akt signal transduction in virus survival
    • DOI 10.1099/vir.0.19771-0
    • Cooray, S. The pivotal role of phosphotidylinositol 3-kinase-Akt signal transduction in virus survival. J. Gen. Virol. 85, 1065-1076 (2004). (Pubitemid 38659771)
    • (2004) Journal of General Virology , vol.85 , Issue.5 , pp. 1065-1076
    • Cooray, S.1
  • 39
    • 47349127080 scopus 로고    scopus 로고
    • Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro
    • Shukla, M., Gupta, K., Rasheed, Z., Khan, K. A. & Haqqi, T. M. Bioavailable constituents/metabolites of pomegranate (Punica granatum L) preferentially inhibit COX2 activity ex vivo and IL-1beta-induced PGE2 production in human chondrocytes in vitro. J. Inflamm. (Lond) 5, 9 (2008).
    • (2008) J. Inflamm. (Lond) , vol.5 , pp. 9
    • Shukla, M.1    Gupta, K.2    Rasheed, Z.3    Khan, K.A.4    Haqqi, T.M.5
  • 41
    • 84892426198 scopus 로고    scopus 로고
    • Apoptotic markers in a prostate cancer cell line: Effect of ellagic acid
    • Vanella, L. et al. Apoptotic markers in a prostate cancer cell line: effect of ellagic acid. Oncol. Rep. 30, 2804-2810 (2013).
    • (2013) Oncol. Rep. , vol.30 , pp. 2804-2810
    • Vanella, L.1
  • 42
    • 54349088525 scopus 로고    scopus 로고
    • Ellagic acid induces apoptosis through inhibition of nuclear factor kappa B in pancreatic cancer cells
    • Edderkaoui, M. et al. Ellagic acid induces apoptosis through inhibition of nuclear factor kappa B in pancreatic cancer cells. World J. Gastroenterol. 14, 3672-3680 (2008).
    • (2008) World J. Gastroenterol. , vol.14 , pp. 3672-3680
    • Edderkaoui, M.1
  • 43
    • 80055001945 scopus 로고    scopus 로고
    • Anti-carcinogenic action of ellagic acid mediated via modulationof oxidative stress regulated genes inDalton lymphoma bearing mice
    • Mishra, S. & Vinayak, M. Anti-carcinogenic action of ellagic acid mediated via modulationof oxidative stress regulated genes inDalton lymphoma bearing mice. Leuk. Lymphoma 52, 2155-2161 (2011).
    • (2011) Leuk. Lymphoma , vol.52 , pp. 2155-2161
    • Mishra, S.1    Vinayak, M.2
  • 44
    • 0037219635 scopus 로고    scopus 로고
    • Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice
    • DOI 10.1007/s00394-003-0396-4
    • Cerda, B., LIorach, R., Ceron, J. J., Espin, J. C. & Tomas-Barberan, F. A. Evaluation of the bioavailability and metabolism in the rat of punicalagin, anantioxidant polyphenol from pomegranate juice. Eur. J. Nutr. 42, 18-28 (2003). (Pubitemid 36286302)
    • (2003) European Journal of Nutrition , vol.42 , Issue.1 , pp. 18-28
    • Cerda, B.1    Llorach, R.2    Ceron, J.J.3    Espin, J.C.4    Tomas-Barberan, F.A.5
  • 45
    • 0038284925 scopus 로고    scopus 로고
    • Repeated oral administration of high doses of the pomegranate ellagitannin punicalagin to rats for 37 days is not toxic
    • Cerda, B., Ceron, J. J., Tomas-Barberan, F. A. & Espin, J. C. Repeated oral administration of high doses of the pomegranate ellagitannin punicalagin to rats for 37 days is not toxic. J. Agric. Food Chem. 51, 3493-3501 (2003).
    • (2003) J. Agric. Food Chem. , vol.51 , pp. 3493-3501
    • Cerda, B.1    Ceron, J.J.2    Tomas-Barberan, F.A.3    Espin, J.C.4
  • 46
    • 34548828780 scopus 로고    scopus 로고
    • Cell culture and infection system for hepatitis C virus
    • Kato, T. et al. Cell culture and infection system for hepatitis C virus. Nat. Protoc. 1, 2334-2339 (2006).
    • (2006) Nat. Protoc. , vol.1 , pp. 2334-2339
    • Kato, T.1
  • 47
    • 33846111662 scopus 로고    scopus 로고
    • Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious intergenotypic chirneric hepatitis C virus
    • DOI 10.1128/JVI.01890-06
    • Yi, M., Ma, Y., Yates, J. & Lemon, S. M. Compensatory mutations in E1, p7, NS2, and NS3 enhance yields of cell culture-infectious inter genotypic chimeric hepatitis C virus. J. Virol. 81, 629-638 (2007). (Pubitemid 46067890)
    • (2007) Journal of Virology , vol.81 , Issue.2 , pp. 629-638
    • Yi, M.1    Ma, Y.2    Yates, J.3    Lemon, S.M.4
  • 49
    • 0021738226 scopus 로고
    • Fluorescein isothiocyanate-labeled casein assay for proteolytic enzymes
    • DOI 10.1016/0003-2697(84)90553-0
    • Twining, S. S. Fluorescein isothiocyanate-labeled casein assay for proteaolytic enzymes. Anal. Biochem. 143, 30-34 (1984). (Pubitemid 15157534)
    • (1984) Analytical Biochemistry , vol.143 , Issue.1 , pp. 30-34
    • Twining, S.S.1
  • 50
    • 0017411710 scopus 로고
    • The protein data bank: A computer based archival file for macromolecular structures
    • Bernstein, F. C. et al. The Protein Data Bank: a computer-based archival file for macromolecular structures. J. Mol. Biol. 112, 535-542 (1977). (Pubitemid 8109216)
    • (1977) Journal of Molecular Biology , vol.112 , Issue.3 , pp. 535-542
    • Bernstein, F.C.1    Koetzle, T.F.2    Williams, G.J.B.3
  • 52
    • 13044272912 scopus 로고    scopus 로고
    • Automated analysis of interatomic contacts in proteins
    • DOI 10.1093/bioinformatics/15.4.327
    • Sobolev, V., Sorokine, A., Prilusky, J., Abola, E. E. & Edelman, M. Automated analysis of interatomic contacts in proteins. Bioinformatics 15, 327-332 (1999). (Pubitemid 29213759)
    • (1999) Bioinformatics , vol.15 , Issue.4 , pp. 327-332
    • Sobolev, V.1    Sorokine, A.2    Prilusky, J.3    Abola, E.E.4    Edelman, M.5
  • 53
    • 0345864027 scopus 로고    scopus 로고
    • The Catalytic Site Atlas: A resource of catalytic sites and residues identified in enzymes using structural data
    • Porter, C. T., Bartlett, G. J. & Thornton, J. M. The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data. Nucleic Acids Res. 32, D129-133 (2004). (Pubitemid 38081621)
    • (2004) Nucleic Acids Research , vol.32 , Issue.DATABASE ISS.
    • Porter, C.T.1    Bartlett, G.J.2    Thornton, J.M.3
  • 54
    • 79251561193 scopus 로고    scopus 로고
    • TCM Database@Taiwan: The world's largest traditional Chinese medicine database for drug screening in silico
    • Chen, C. Y. TCM Database@Taiwan: the world's largest traditional Chinese medicine database for drug screening in silico. PLoS One 6, e15939 (2011).
    • (2011) PLoS One , vol.6
    • Chen, C.Y.1
  • 55
    • 70349932423 scopus 로고    scopus 로고
    • AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility
    • Morris, G. M. et al. AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility. J. Comput. Chem. 30, 2785-2791 (2009).
    • (2009) J. Comput. Chem. , vol.30 , pp. 2785-2791
    • Morris, G.M.1
  • 56
    • 84903164224 scopus 로고    scopus 로고
    • The PyMOL Molecular Graphics System, Version 1.5.0.4 Schrodinger, LLC
    • The PyMOL Molecular Graphics System, Version 1.5.0.4 Schrodinger, LLC.
  • 60
    • 84862004384 scopus 로고    scopus 로고
    • A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes
    • Haid, S. et al. A plant-derived flavonoid inhibits entry of all HCV genotypes into human hepatocytes. Gastroenterology 143, 213-222 (2012).
    • (2012) Gastroenterology , vol.143 , pp. 213-222
    • Haid, S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.