-
1
-
-
77950521214
-
Mutant p53 gain-of-function in cancer
-
Oren M, Rotter V. Mutant p53 gain-of-function in cancer. Cold Spring Harb Perspect Biol (2010) 2(2):a001107. doi:10.1101/cshperspect.a001107
-
(2010)
Cold Spring Harb Perspect Biol
, vol.2
, Issue.2
-
-
Oren, M.1
Rotter, V.2
-
2
-
-
66349134417
-
Promyelocytic leukemia protein is required for gain of function by mutant p53
-
Haupt S, di Agostino S, Mizrahi I, Alsheich-Bartok O, Voorhoeve M, Damalas A, et al. Promyelocytic leukemia protein is required for gain of function by mutant p53. Cancer Res (2009) 69(11):4818-26. doi:10.1158/0008-5472.CAN-08-4010
-
(2009)
Cancer Res
, vol.69
, Issue.11
, pp. 4818-4826
-
-
Haupt, S.1
di Agostino, S.2
Mizrahi, I.3
Alsheich-Bartok, O.4
Voorhoeve, M.5
Damalas, A.6
-
3
-
-
45949110751
-
PML enhances the regulation of p53 by CK1 in response to DNA damage
-
Alsheich-Bartok O, Haupt S, Alkalay-Snir I, Saito S, Appella E, Haupt Y. PML enhances the regulation of p53 by CK1 in response to DNA damage. Oncogene (2008) 27(26):3653-61. doi:10.1038/sj.onc.1211036
-
(2008)
Oncogene
, vol.27
, Issue.26
, pp. 3653-3661
-
-
Alsheich-Bartok, O.1
Haupt, S.2
Alkalay-Snir, I.3
Saito, S.4
Appella, E.5
Haupt, Y.6
-
4
-
-
0041856232
-
The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation
-
Louria-Hayon I, Grossman T, Sionov RV, Alsheich O, PandolfiPP, Haupt Y. The promyelocytic leukemia protein protects p53 from Mdm2-mediated inhibition and degradation. J Biol Chem (2003) 278(35):33134-41. doi:10.1074/jbc. M301264200
-
(2003)
J Biol Chem
, vol.278
, Issue.35
, pp. 33134-33141
-
-
Louria-Hayon, I.1
Grossman, T.2
Sionov, R.V.3
Alsheich, O.4
Pandolfi, P.P.5
Haupt, Y.6
-
5
-
-
2442678753
-
PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains
-
Moller A, Sirma H, Hofmann TG, Rueffer S, Klimczak E, Droge W, et al. PML is required for homeodomain-interacting protein kinase 2 (HIPK2)-mediated p53 phosphorylation and cell cycle arrest but is dispensable for the formation of HIPK domains. Cancer Res (2003) 63(15):4310-4.
-
(2003)
Cancer Res
, vol.63
, Issue.15
, pp. 4310-4314
-
-
Moller, A.1
Sirma, H.2
Hofmann, T.G.3
Rueffer, S.4
Klimczak, E.5
Droge, W.6
-
6
-
-
0034644274
-
PML regulates p53 acetylation and premature senescence induced by oncogenic Ras
-
Pearson M, Carbone R, Sebastiani C, Cioce M, Fagioli M, Saito S, et al. PML regulates p53 acetylation and premature senescence induced by oncogenic Ras. Nature (2000) 406(6792):207-10. doi:10.1038/35018127
-
(2000)
Nature
, vol.406
, Issue.6792
, pp. 207-210
-
-
Pearson, M.1
Carbone, R.2
Sebastiani, C.3
Cioce, M.4
Fagioli, M.5
Saito, S.6
-
7
-
-
84874594177
-
MOZ increases p53 acetylation and premature senescence through its complex formation with PML
-
Rokudai S, Laptenko O, Arnal SM, Taya Y, Kitabayashi I, Prives C. MOZ increases p53 acetylation and premature senescence through its complex formation with PML. Proc Natl Acad Sci U S A (2013) 110(10):3895-900. doi:10.1073/pnas.1300490110
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, Issue.10
, pp. 3895-3900
-
-
Rokudai, S.1
Laptenko, O.2
Arnal, S.M.3
Taya, Y.4
Kitabayashi, I.5
Prives, C.6
-
8
-
-
1542285168
-
PML is a direct p53 target that modulates p53 effector functions
-
de Stanchina E, Querido E, Narita M, Davuluri RV, PandolfiPP, Ferbeyre G, et al. PML is a direct p53 target that modulates p53 effector functions. Mol Cell (2004) 13(4):523-35. doi:10.1016/S1097-2765(04)00062-0
-
(2004)
Mol Cell
, vol.13
, Issue.4
, pp. 523-535
-
-
de Stanchina, E.1
Querido, E.2
Narita, M.3
Davuluri, R.V.4
Pandolfi, P.P.5
Ferbeyre, G.6
-
9
-
-
2442704958
-
Cell cycle-dependent association of PML bodies with sites of active transcription in nuclei of mammalian cells
-
Kiesslich A, von Mikecz A, Hemmerich P. Cell cycle-dependent association of PML bodies with sites of active transcription in nuclei of mammalian cells. J Struct Biol (2002) 140(1-3):167-79. doi:10.1016/S1047-8477(02)00571-3
-
(2002)
J Struct Biol
, vol.140
, Issue.1-3
, pp. 167-179
-
-
Kiesslich, A.1
von Mikecz, A.2
Hemmerich, P.3
-
10
-
-
1642512435
-
Role of PML and the PML-nuclear body in the control of programmed cell death
-
Bernardi R, PandolfiPP. Role of PML and the PML-nuclear body in the control of programmed cell death. Oncogene (2003) 22(56):9048-57. doi:10.1038/sj.onc.1207106
-
(2003)
Oncogene
, vol.22
, Issue.56
, pp. 9048-9057
-
-
Bernardi, R.1
Pandolfi, P.P.2
-
11
-
-
0026513504
-
Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia
-
PandolfiPP, Alcalay M, Fagioli M, Zangrilli D, Mencarelli A, Diverio D, et al. Genomic variability and alternative splicing generate multiple PML/RAR alpha transcripts that encode aberrant PML proteins and PML/RAR alpha isoforms in acute promyelocytic leukaemia. EMBO J (1992) 11(4):1397-407.
-
(1992)
EMBO J
, vol.11
, Issue.4
, pp. 1397-1407
-
-
Pandolfi, P.P.1
Alcalay, M.2
Fagioli, M.3
Zangrilli, D.4
Mencarelli, A.5
Diverio, D.6
-
12
-
-
33748211158
-
Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation
-
Di Agostino S, Strano S, Emiliozzi V, Zerbini V, Mottolese M, Sacchi A, et al. Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation. Cancer Cell (2006) 10(3):191-202. doi:10.1016/j.ccr.2006.08.013
-
(2006)
Cancer Cell
, vol.10
, Issue.3
, pp. 191-202
-
-
Di Agostino, S.1
Strano, S.2
Emiliozzi, V.3
Zerbini, V.4
Mottolese, M.5
Sacchi, A.6
-
13
-
-
84879369074
-
Gender, mutant p53 and PML: a growing "affaire" in tumor suppression and oncogenesis
-
Di Agostino S, Strano S, Blandino G. Gender, mutant p53 and PML: a growing "affaire" in tumor suppression and oncogenesis. Cell Cycle (2013) 12(12):1824-5. doi:10.4161/cc.25174
-
(2013)
Cell Cycle
, vol.12
, Issue.12
, pp. 1824-1825
-
-
Di Agostino, S.1
Strano, S.2
Blandino, G.3
-
14
-
-
84928984232
-
Circadian variations of clock gene Per2 and cell cycle genes in different stages of carcinogenesis in golden hamster buccal mucosa
-
Tan XM, Ye H, Yang K, Chen D, Wang QQ, Tang H, et al. Circadian variations of clock gene Per2 and cell cycle genes in different stages of carcinogenesis in golden hamster buccal mucosa. Sci Rep (2015) 5:9997. doi:10.1038/srep09997
-
(2015)
Sci Rep
, vol.5
, pp. 9997
-
-
Tan, X.M.1
Ye, H.2
Yang, K.3
Chen, D.4
Wang, Q.Q.5
Tang, H.6
-
15
-
-
84884697860
-
p53 regulates period2 expression and the circadian clock
-
Miki T, Matsumoto T, Zhao Z, Lee CC. p53 regulates period2 expression and the circadian clock. Nat Commun (2013) 4:2444. doi:10.1038/ncomms3444
-
(2013)
Nat Commun
, vol.4
, pp. 2444
-
-
Miki, T.1
Matsumoto, T.2
Zhao, Z.3
Lee, C.C.4
-
16
-
-
84862822068
-
PML regulates PER2 nuclear localization and circadian function
-
Miki T, Xu Z, Chen-Goodspeed M, Liu M, Van Oort-Jansen A, Rea MA, et al. PML regulates PER2 nuclear localization and circadian function. EMBO J (2012) 31(6):1427-39. doi:10.1038/emboj.2012.1
-
(2012)
EMBO J
, vol.31
, Issue.6
, pp. 1427-1439
-
-
Miki, T.1
Xu, Z.2
Chen-Goodspeed, M.3
Liu, M.4
Van Oort-Jansen, A.5
Rea, M.A.6
-
17
-
-
41949123764
-
The circadian clock component BMAL1 is a critical regulator of p21WAF1/CIP1 expression and hepatocyte proliferation
-
Grechez-Cassiau A, Rayet B, Guillaumond F, Teboul M, Delaunay F. The circadian clock component BMAL1 is a critical regulator of p21WAF1/CIP1 expression and hepatocyte proliferation. J Biol Chem (2008) 283(8):4535-42. doi:10.1074/jbc. M705576200
-
(2008)
J Biol Chem
, vol.283
, Issue.8
, pp. 4535-4542
-
-
Grechez-Cassiau, A.1
Rayet, B.2
Guillaumond, F.3
Teboul, M.4
Delaunay, F.5
-
18
-
-
70450239457
-
Metabolism and cancer: the circadian clock connection
-
Sahar S, Sassone-Corsi P. Metabolism and cancer: the circadian clock connection. Nat Rev Cancer (2009) 9(12):886-96. doi:10.1038/nrc2747
-
(2009)
Nat Rev Cancer
, vol.9
, Issue.12
, pp. 886-896
-
-
Sahar, S.1
Sassone-Corsi, P.2
-
19
-
-
84857057191
-
The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis
-
Gu X, Xing L, Shi G, Liu Z, Wang X, Qu Z, et al. The circadian mutation PER2(S662G) is linked to cell cycle progression and tumorigenesis. Cell Death Differ (2012) 19(3):397-405. doi:10.1038/cdd.2011.103
-
(2012)
Cell Death Differ
, vol.19
, Issue.3
, pp. 397-405
-
-
Gu, X.1
Xing, L.2
Shi, G.3
Liu, Z.4
Wang, X.5
Qu, Z.6
-
20
-
-
84878568273
-
Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner
-
Haupt S, Mitchell C, Corneille V, Shortt J, Fox S, PandolfiPP, et al. Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner. Cell Cycle (2013) 12(11):1722-31. doi:10.4161/cc.24805
-
(2013)
Cell Cycle
, vol.12
, Issue.11
, pp. 1722-1731
-
-
Haupt, S.1
Mitchell, C.2
Corneille, V.3
Shortt, J.4
Fox, S.5
Pandolfi, P.P.6
-
21
-
-
77954322791
-
Melatonin resynchronizes dysregulated circadian rhythm circuitry in human prostate cancer cells
-
Jung-Hynes B, Huang W, Reiter RJ, Ahmad N. Melatonin resynchronizes dysregulated circadian rhythm circuitry in human prostate cancer cells. J Pineal Res (2010) 49(1):60-8. doi:10.1111/j.1600-079X.2010.00767.x
-
(2010)
J Pineal Res
, vol.49
, Issue.1
, pp. 60-68
-
-
Jung-Hynes, B.1
Huang, W.2
Reiter, R.J.3
Ahmad, N.4
-
22
-
-
51849086880
-
PTEN: a new guardian of the genome
-
Yin Y, Shen WH. PTEN: a new guardian of the genome. Oncogene (2008) 27(41):5443-53. doi:10.1038/onc.2008.241
-
(2008)
Oncogene
, vol.27
, Issue.41
, pp. 5443-5453
-
-
Yin, Y.1
Shen, W.H.2
-
23
-
-
0041450058
-
PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and-independent mechanisms
-
Freeman DJ, Li AG, Wei G, Li HH, Kertesz N, Lesche R, et al. PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and-independent mechanisms. Cancer Cell (2003) 3(2):117-30. doi:10.1016/S1535-6108(03)00021-7
-
(2003)
Cancer Cell
, vol.3
, Issue.2
, pp. 117-130
-
-
Freeman, D.J.1
Li, A.G.2
Wei, G.3
Li, H.H.4
Kertesz, N.5
Lesche, R.6
-
24
-
-
40949097860
-
PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations
-
Li Y, Guessous F, Kwon S, Kumar M, Ibidapo O, Fuller L, et al. PTEN has tumor-promoting properties in the setting of gain-of-function p53 mutations. Cancer Res (2008) 68(6):1723-31. doi:10.1158/0008-5472.CAN-07-1963
-
(2008)
Cancer Res
, vol.68
, Issue.6
, pp. 1723-1731
-
-
Li, Y.1
Guessous, F.2
Kwon, S.3
Kumar, M.4
Ibidapo, O.5
Fuller, L.6
-
25
-
-
0034854091
-
Regulation of PTEN transcription by p53
-
Stambolic V, MacPherson D, Sas D, Lin Y, Snow B, Jang Y, et al. Regulation of PTEN transcription by p53. Mol Cell (2001) 8(2):317-25. doi:10.1016/S1097-2765(01)00323-9
-
(2001)
Mol Cell
, vol.8
, Issue.2
, pp. 317-325
-
-
Stambolic, V.1
MacPherson, D.2
Sas, D.3
Lin, Y.4
Snow, B.5
Jang, Y.6
-
26
-
-
84881067866
-
A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy
-
Huang X, Zhang Y, Tang Y, Butler N, Kim J, Guessous F, et al. A novel PTEN/mutant p53/c-Myc/Bcl-XL axis mediates context-dependent oncogenic effects of PTEN with implications for cancer prognosis and therapy. Neoplasia (2013) 15(8):952-65. doi:10.1593/neo.13376
-
(2013)
Neoplasia
, vol.15
, Issue.8
, pp. 952-965
-
-
Huang, X.1
Zhang, Y.2
Tang, Y.3
Butler, N.4
Kim, J.5
Guessous, F.6
-
27
-
-
0042132030
-
Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells
-
Burns TF, Fei P, Scata KA, Dicker DT, El-Deiry WS. Silencing of the novel p53 target gene Snk/Plk2 leads to mitotic catastrophe in paclitaxel (taxol)-exposed cells. Mol Cell Biol (2003) 23(16):5556-71. doi:10.1128/MCB.23.16.5556-5571.2003
-
(2003)
Mol Cell Biol
, vol.23
, Issue.16
, pp. 5556-5571
-
-
Burns, T.F.1
Fei, P.2
Scata, K.A.3
Dicker, D.T.4
El-Deiry, W.S.5
-
28
-
-
84055190665
-
Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop
-
Valenti F, Fausti F, Biagioni F, Shay T, Fontemaggi G, Domany E, et al. Mutant p53 oncogenic functions are sustained by Plk2 kinase through an autoregulatory feedback loop. Cell Cycle (2011) 10(24):4330-40. doi:10.4161/cc.10.24.18682
-
(2011)
Cell Cycle
, vol.10
, Issue.24
, pp. 4330-4340
-
-
Valenti, F.1
Fausti, F.2
Biagioni, F.3
Shay, T.4
Fontemaggi, G.5
Domany, E.6
-
29
-
-
84856081709
-
Mutant p53 subverts PLK2 function in a novel, reinforced loop of corruption
-
Haupt S, Haupt Y. Mutant p53 subverts PLK2 function in a novel, reinforced loop of corruption. Cell Cycle (2012) 11(2):217-8. doi:10.4161/cc.11.2.18977
-
(2012)
Cell Cycle
, vol.11
, Issue.2
, pp. 217-218
-
-
Haupt, S.1
Haupt, Y.2
-
30
-
-
84935901131
-
Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities
-
Kollareddy M, Dimitrova E, Vallabhaneni KC, Chan A, Le T, Chauhan KM, et al. Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities. Nat Commun (2015) 6:7389. doi:10.1038/ncomms8389
-
(2015)
Nat Commun
, vol.6
, pp. 7389
-
-
Kollareddy, M.1
Dimitrova, E.2
Vallabhaneni, K.C.3
Chan, A.4
Le, T.5
Chauhan, K.M.6
-
32
-
-
1942506067
-
The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression
-
Schwartzenberg-Bar-Yoseph F, Armoni M, Karnieli E. The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression. Cancer Res (2004) 64(7):2627-33. doi:10.1158/0008-5472.CAN-03-0846
-
(2004)
Cancer Res
, vol.64
, Issue.7
, pp. 2627-2633
-
-
Schwartzenberg-Bar-Yoseph, F.1
Armoni, M.2
Karnieli, E.3
-
33
-
-
33745918951
-
TIGAR, a p53-inducible regulator of glycolysis and apoptosis
-
Bensaad K, Tsuruta A, Selak MA, Vidal MN, Nakano K, Bartrons R, et al. TIGAR, a p53-inducible regulator of glycolysis and apoptosis. Cell (2006) 126(1):107-20. doi:10.1016/j.cell.2006.05.036
-
(2006)
Cell
, vol.126
, Issue.1
, pp. 107-120
-
-
Bensaad, K.1
Tsuruta, A.2
Selak, M.A.3
Vidal, M.N.4
Nakano, K.5
Bartrons, R.6
-
34
-
-
0031669403
-
Analysis of K-ras gene mutations in lung carcinomas: correlation with gender, histological subtypes, and clinical outcome
-
Wang YC, Lee HS, Chen SK, Yang SC, Chen CY. Analysis of K-ras gene mutations in lung carcinomas: correlation with gender, histological subtypes, and clinical outcome. J Cancer Res Clin Oncol (1998) 124(9):517-22. doi:10.1007/s004320050208
-
(1998)
J Cancer Res Clin Oncol
, vol.124
, Issue.9
, pp. 517-522
-
-
Wang, Y.C.1
Lee, H.S.2
Chen, S.K.3
Yang, S.C.4
Chen, C.Y.5
-
35
-
-
79952280229
-
p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
-
Jiang P, Du W, Wang X, Mancuso A, Gao X, Wu M, et al. p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase. Nat Cell Biol (2011) 13(3):310-6. doi:10.1038/ncb2172
-
(2011)
Nat Cell Biol
, vol.13
, Issue.3
, pp. 310-316
-
-
Jiang, P.1
Du, W.2
Wang, X.3
Mancuso, A.4
Gao, X.5
Wu, M.6
-
36
-
-
84890695935
-
Tumour-associated mutant p53 drives the Warburg effect
-
Zhang C, Liu J, Liang Y, Wu R, Zhao Y, Hong X, et al. Tumour-associated mutant p53 drives the Warburg effect. Nat Commun (2013) 4:2935. doi:10.1038/ncomms3935
-
(2013)
Nat Commun
, vol.4
, pp. 2935
-
-
Zhang, C.1
Liu, J.2
Liang, Y.3
Wu, R.4
Zhao, Y.5
Hong, X.6
-
37
-
-
84870948750
-
Dietary downregulation of mutant p53 levels via glucose restriction: mechanisms and implications for tumor therapy
-
Rodriguez OC, Choudhury S, Kolukula V, Vietsch EE, Catania J, Preet A, et al. Dietary downregulation of mutant p53 levels via glucose restriction: mechanisms and implications for tumor therapy. Cell Cycle (2012) 11(23):4436-46. doi:10.4161/cc.22778
-
(2012)
Cell Cycle
, vol.11
, Issue.23
, pp. 4436-4446
-
-
Rodriguez, O.C.1
Choudhury, S.2
Kolukula, V.3
Vietsch, E.E.4
Catania, J.5
Preet, A.6
-
38
-
-
84881481258
-
Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets
-
Paoli A, Rubini A, Volek JS, Grimaldi KA. Beyond weight loss: a review of the therapeutic uses of very-low-carbohydrate (ketogenic) diets. Eur J Clin Nutr (2013) 67(8):789-96. doi:10.1038/ejcn.2013.116
-
(2013)
Eur J Clin Nutr
, vol.67
, Issue.8
, pp. 789-796
-
-
Paoli, A.1
Rubini, A.2
Volek, J.S.3
Grimaldi, K.A.4
-
39
-
-
84921405225
-
Metformin in cancer treatment and prevention
-
Morales DR, Morris AD. Metformin in cancer treatment and prevention. Annu Rev Med (2015) 66:17-29. doi:10.1146/annurev-med-062613-093128
-
(2015)
Annu Rev Med
, vol.66
, pp. 17-29
-
-
Morales, D.R.1
Morris, A.D.2
-
40
-
-
0036251153
-
SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver
-
Horton JD, Goldstein JL, Brown MS. SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest (2002) 109(9):1125-31. doi:10.1172/JCI15593
-
(2002)
J Clin Invest
, vol.109
, Issue.9
, pp. 1125-1131
-
-
Horton, J.D.1
Goldstein, J.L.2
Brown, M.S.3
-
41
-
-
0038491561
-
p53 activation in adipocytes of obese mice
-
Yahagi N, Shimano H, Matsuzaka T, Najima Y, Sekiya M, Nakagawa Y, et al. p53 activation in adipocytes of obese mice. J Biol Chem (2003) 278(28):25395-400. doi:10.1074/jbc. M302364200
-
(2003)
J Biol Chem
, vol.278
, Issue.28
, pp. 25395-25400
-
-
Yahagi, N.1
Shimano, H.2
Matsuzaka, T.3
Najima, Y.4
Sekiya, M.5
Nakagawa, Y.6
-
42
-
-
84862908644
-
Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway
-
Freed-Pastor WA, Mizuno H, Zhao X, Langerod A, Moon SH, Rodriguez-Barrueco R, et al. Mutant p53 disrupts mammary tissue architecture via the mevalonate pathway. Cell (2012) 148(1-2):244-58. doi:10.1016/j.cell.2011.12.017
-
(2012)
Cell
, vol.148
, Issue.1-2
, pp. 244-258
-
-
Freed-Pastor, W.A.1
Mizuno, H.2
Zhao, X.3
Langerod, A.4
Moon, S.H.5
Rodriguez-Barrueco, R.6
-
43
-
-
84897504519
-
The role of reactive oxygen species and metabolism on cancer cells and their microenvironment
-
Costa A, Scholer-Dahirel A, Mechta-Grigoriou F. The role of reactive oxygen species and metabolism on cancer cells and their microenvironment. Semin Cancer Biol (2014) 25:23-32. doi:10.1016/j.semcancer.2013.12.007
-
(2014)
Semin Cancer Biol
, vol.25
, pp. 23-32
-
-
Costa, A.1
Scholer-Dahirel, A.2
Mechta-Grigoriou, F.3
-
44
-
-
84857493148
-
Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein
-
Camp ND, James RG, Dawson DW, Yan F, Davison JM, Houck SA, et al. Wilms tumor gene on X chromosome (WTX) inhibits degradation of NRF2 protein through competitive binding to KEAP1 protein. J Biol Chem (2012) 287(9):6539-50. doi:10.1074/jbc. M111.316471
-
(2012)
J Biol Chem
, vol.287
, Issue.9
, pp. 6539-6550
-
-
Camp, N.D.1
James, R.G.2
Dawson, D.W.3
Yan, F.4
Davison, J.M.5
Houck, S.A.6
-
45
-
-
67449128222
-
Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response
-
Chen W, Sun Z, Wang XJ, Jiang T, Huang Z, Fang D, et al. Direct interaction between Nrf2 and p21(Cip1/WAF1) upregulates the Nrf2-mediated antioxidant response. Mol Cell (2009) 34(6):663-73. doi:10.1016/j.molcel.2009.04.029
-
(2009)
Mol Cell
, vol.34
, Issue.6
, pp. 663-673
-
-
Chen, W.1
Sun, Z.2
Wang, X.J.3
Jiang, T.4
Huang, Z.5
Fang, D.6
-
46
-
-
77449127476
-
Ubiquitin-independent p53 proteasomal degradation
-
Tsvetkov P, Reuven N, Shaul Y. Ubiquitin-independent p53 proteasomal degradation. Cell Death Differ (2010) 17(1):103-8. doi:10.1038/cdd.2009.67
-
(2010)
Cell Death Differ
, vol.17
, Issue.1
, pp. 103-108
-
-
Tsvetkov, P.1
Reuven, N.2
Shaul, Y.3
-
47
-
-
0345598871
-
P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1
-
Asher G, Lotem J, Tsvetkov P, Reiss V, Sachs L, Shaul Y. P53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1. Proc Natl Acad Sci U S A (2003) 100(25):15065-70. doi:10.1073/pnas.2436329100
-
(2003)
Proc Natl Acad Sci U S A
, vol.100
, Issue.25
, pp. 15065-15070
-
-
Asher, G.1
Lotem, J.2
Tsvetkov, P.3
Reiss, V.4
Sachs, L.5
Shaul, Y.6
-
48
-
-
84873532942
-
Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species
-
Kalo E, Kogan-Sakin I, Solomon H, Bar-Nathan E, Shay M, Shetzer Y, et al. Mutant p53R273H attenuates the expression of phase 2 detoxifying enzymes and promotes the survival of cells with high levels of reactive oxygen species. J Cell Sci (2012) 125(22):5578-86. doi:10.1242/jcs.106815
-
(2012)
J Cell Sci
, vol.125
, Issue.22
, pp. 5578-5586
-
-
Kalo, E.1
Kogan-Sakin, I.2
Solomon, H.3
Bar-Nathan, E.4
Shay, M.5
Shetzer, Y.6
-
49
-
-
0034063604
-
A common polymorphism acts as an intragenic modifier of mutant p53 behaviour
-
Marin MC, Jost CA, Brooks LA, Irwin MS, O'Nions J, Tidy JA, et al. A common polymorphism acts as an intragenic modifier of mutant p53 behaviour. Nat Genet (2000) 25(1):47-54. doi:10.1038/75586
-
(2000)
Nat Genet
, vol.25
, Issue.1
, pp. 47-54
-
-
Marin, M.C.1
Jost, C.A.2
Brooks, L.A.3
Irwin, M.S.4
O'Nions, J.5
Tidy, J.A.6
-
50
-
-
10744230945
-
p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis
-
Bergamaschi D, Gasco M, Hiller L, Sullivan A, Syed N, Trigiante G, et al. p53 polymorphism influences response in cancer chemotherapy via modulation of p73-dependent apoptosis. Cancer Cell (2003) 3(4):387-402. doi:10.1016/S1535-6108(03)00079-5
-
(2003)
Cancer Cell
, vol.3
, Issue.4
, pp. 387-402
-
-
Bergamaschi, D.1
Gasco, M.2
Hiller, L.3
Sullivan, A.4
Syed, N.5
Trigiante, G.6
-
51
-
-
84871830221
-
p53 mutations in cancer
-
Muller PA, Vousden KH. p53 mutations in cancer. Nat Cell Biol (2013) 15(1):2-8. doi:10.1038/ncb2641
-
(2013)
Nat Cell Biol
, vol.15
, Issue.1
, pp. 2-8
-
-
Muller, P.A.1
Vousden, K.H.2
-
52
-
-
33646807491
-
Transcriptional regulation by p53: one protein, many possibilities
-
Laptenko O, Prives C. Transcriptional regulation by p53: one protein, many possibilities. Cell Death Differ (2006) 13(6):951-61. doi:10.1038/sj.cdd.4401916
-
(2006)
Cell Death Differ
, vol.13
, Issue.6
, pp. 951-961
-
-
Laptenko, O.1
Prives, C.2
-
53
-
-
0037151072
-
SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription
-
Lee D, Kim JW, Seo T, Hwang SG, Choi EJ, Choe J. SWI/SNF complex interacts with tumor suppressor p53 and is necessary for the activation of p53-mediated transcription. J Biol Chem (2002) 277(25):22330-7. doi:10.1074/jbc. M111987200
-
(2002)
J Biol Chem
, vol.277
, Issue.25
, pp. 22330-22337
-
-
Lee, D.1
Kim, J.W.2
Seo, T.3
Hwang, S.G.4
Choi, E.J.5
Choe, J.6
-
54
-
-
38049173494
-
The activity of p53 is differentially regulated by Brm-and Brg1-containing SWI/SNF chromatin remodeling complexes
-
Xu Y, Zhang J, Chen X. The activity of p53 is differentially regulated by Brm-and Brg1-containing SWI/SNF chromatin remodeling complexes. J Biol Chem (2007) 282(52):37429-35. doi:10.1074/jbc. M706039200
-
(2007)
J Biol Chem
, vol.282
, Issue.52
, pp. 37429-37435
-
-
Xu, Y.1
Zhang, J.2
Chen, X.3
-
55
-
-
84933501783
-
Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells
-
Pfister NT, Fomin V, Regunath K, Zhou JY, Zhou W, Silwal-Pandit L, et al. Mutant p53 cooperates with the SWI/SNF chromatin remodeling complex to regulate VEGFR2 in breast cancer cells. Genes Dev (2015) 29(12):1298-315. doi:10.1101/gad.263202.115
-
(2015)
Genes Dev
, vol.29
, Issue.12
, pp. 1298-1315
-
-
Pfister, N.T.1
Fomin, V.2
Regunath, K.3
Zhou, J.Y.4
Zhou, W.5
Silwal-Pandit, L.6
-
56
-
-
79961141113
-
p53 interacts with RNA polymerase II through its core domain and impairs Pol II processivity in vivo
-
Kim S, Balakrishnan SK, Gross DS. p53 interacts with RNA polymerase II through its core domain and impairs Pol II processivity in vivo. PLoS One (2011) 6(8):e22183. doi:10.1371/journal.pone.0022183
-
(2011)
PLoS One
, vol.6
, Issue.8
-
-
Kim, S.1
Balakrishnan, S.K.2
Gross, D.S.3
-
57
-
-
84859869155
-
Mutant p53 cooperates with ETS2 to promote etoposide resistance
-
Do PM, Varanasi L, Fan S, Li C, Kubacka I, Newman V, et al. Mutant p53 cooperates with ETS2 to promote etoposide resistance. Genes Dev (2012) 26(8):830-45. doi:10.1101/gad.181685.111
-
(2012)
Genes Dev
, vol.26
, Issue.8
, pp. 830-845
-
-
Do, P.M.1
Varanasi, L.2
Fan, S.3
Li, C.4
Kubacka, I.5
Newman, V.6
-
58
-
-
84941220446
-
Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth
-
Zhu J, Sammons MA, Donahue G, Dou Z, Vedadi M, Getlik M, et al. Gain-of-function p53 mutants co-opt chromatin pathways to drive cancer growth. Nature (2015) 525(7568):206-11. doi:10.1038/nature15251
-
(2015)
Nature
, vol.525
, Issue.7568
, pp. 206-211
-
-
Zhu, J.1
Sammons, M.A.2
Donahue, G.3
Dou, Z.4
Vedadi, M.5
Getlik, M.6
|