p53 hot-spot mutants are resistant to ubiquitin-independent degradation by increased binding to NAD(P)H:quinone oxidoreductase 1

Proceedings of the National Academy of Sciences of the United States of America

Volumn 100, Issue 25, 2003, Pages 15065-15070

  Asher, Gad ^a   Lotem, Joseph ^a   Tsvetkov, Peter ^a   Reiss, Veronica ^a   Sachs, Leo ^a   Shaul, Yosef ^a  

^a WEIZMANN INSTITUTE OF SCIENCE   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; COUMARIN; DICOUMAROL; FLAVONE DERIVATIVE; OXIDOREDUCTASE; PROTEASOME; PROTEIN MDM2; PROTEIN P53; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE:QUINONE OXIDOREDUCTASE 1; UBIQUITIN; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; BINDING AFFINITY; CANCER; CONFORMATIONAL TRANSITION; HUMAN; HUMAN CELL; MOUSE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN STABILITY;

ANIMALS; APOPTOSIS; ARGININE; CELL LINE; CELL LINE, TUMOR; CELL SURVIVAL; CYSTEINE ENDOPEPTIDASES; DICUMAROL; DNA MUTATIONAL ANALYSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; GENES, P53; HUMANS; IMMUNOBLOTTING; MICE; MULTIENZYME COMPLEXES; MUTATION; NAD(P)H DEHYDROGENASE (QUINONE); NUCLEAR PROTEINS; PLASMIDS; PRECIPITIN TESTS; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BINDING; PROTEIN CONFORMATION; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-MDM2; TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; UBIQUITIN;

ANIMALIA;

EID: 0345598871     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.2436329100     Document Type: Article

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