Enhanced NADPH oxidases and reactive oxygen species in the mechanism of methanol-initiated protein oxidation and embryopathies in vivo and in embryo culture

Archives of Toxicology

Volumn 90, Issue 3, 2016, Pages 717-730

  Miller Pinsler, Lutfiya ^a   Sharma, Amy ^a   Wells, Peter G ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Embryopathies; Free radical spin trap; Methanol; NADPH oxidases; Oxidative stress; Phenytoin

Indexed keywords

5,8,11,14 ICOSATETRAYNOIC ACID; CHLORIDE; DIPHENYLENEIODONIUM CHLORIDE; DIPHENYLIODONIUM SALT; FREE RADICAL; ICOSATETRAYNOIC ACID; MESSENGER RNA; METHANOL; NITRONE DERIVATIVE; PHENYLBUTYLNITRONE; PHENYTOIN; PROSTAGLANDIN SYNTHASE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; UNCLASSIFIED DRUG; CATION; CYTOCHROME B; P22(PHOX) PROTEIN, MOUSE; PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EMBRYO; EMBRYO CULTURE; EMBRYOPATHY; FEMALE; IN VIVO CULTURE; MALE; MOUSE; NONHUMAN; OXIDATION; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN EXPRESSION; ANIMAL; DOSE RESPONSE; DRUG EFFECTS; GENE EXPRESSION REGULATION; GENETICS; INBRED MOUSE STRAIN; METABOLISM; PREGNANCY;

5,8,11,14-EICOSATETRAYNOIC ACID; ANIMALS; CYTOCHROME B GROUP; DOSE-RESPONSE RELATIONSHIP, DRUG; EMBRYO CULTURE TECHNIQUES; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; MALE; METHANOL; MICE, INBRED STRAINS; NADPH OXIDASE; ONIUM COMPOUNDS; OXIDATIVE STRESS; PREGNANCY; PROTEINS; REACTIVE OXYGEN SPECIES;

EID: 84958155509     PISSN: 03405761     EISSN: 14320738     Source Type: Journal    
DOI: 10.1007/s00204-015-1482-0     Document Type: Article

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