The free radical spin trapping agent phenylbutylnitrone reduces fetal brain DNA oxidation and postnatal cognitive deficits caused by in utero exposure to a non-structurally teratogenic dose of ethanol: A role for oxidative stress

Free Radical Biology and Medicine

Volumn 60, Issue , 2013, Pages 223-232

  Miller, Lutfiya ^a   Shapiro, Aaron M ^b   Cheng, Jun ^a   Wells, Peter G ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

C57BL 6 mice; CD 1 mice; DNA oxidation; Ethanol; Free radicals; Neurodevelopmental deficits; Passive avoidance test; PBN; Reactive oxygen species; Teratogenesis

Indexed keywords

ALCOHOL; DNA; N TERT BUTYL ALPHA PHENYLNITRONE;

ANIMAL EXPERIMENT; ARTICLE; BIRTH DEFECT; BRAIN; COGNITIVE DEFECT; COMPARATIVE STUDY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CROWN RUMP LENGTH; DNA DAMAGE; DOSE RESPONSE; FEMALE; FETUS; FETUS RESORPTION; FETUS WEIGHT; LATENT PERIOD; LEARNING DISORDER; LEARNING TEST; MALE; MOUSE; NONHUMAN; OXIDATIVE STRESS; PASSIVE AVOIDANCE; PERINATAL PERIOD; PRENATAL EXPOSURE; PRIORITY JOURNAL; PROGENY; SPIN TRAPPING; TERATOLOGY; WEIGHT GAIN;

ANIMALS; BRAIN; CYCLIC N-OXIDES; DNA; DNA DAMAGE; ETHANOL; FEMALE; FETUS; FREE RADICALS; LEARNING; MALE; MICE; OXIDATION-REDUCTION; PREGNANCY; REACTIVE OXYGEN SPECIES; SPIN TRAPPING;

MUS;

EID: 84875954851     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2013.02.015     Document Type: Article

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