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Volumn 28, Issue 7, 2016, Pages 1455-1460

Site-Specific Polymer Conjugation Stabilizes Therapeutic Enzymes in the Gastrointestinal Tract

(7) Schulz, Jessica D a Patt, Melanie a Basler, Sophie a Kries, Hajo a Hilvert, Donald a Gauthier, Marc A b Leroux, Jean Christophe a

a ETH ZURICH (Switzerland)

b INSTITUT NATIONAL DE LA RECHERCHE SCIENTIFIQUE (Canada)

Author keywords

gastrointestinal stability; poly(ethylene glycol); site specific polymer conjugation, therapeutic enzymes

Indexed keywords

AMINO ACIDS; CONJUGATED POLYMERS; ENZYMES; POLYETHYLENE GLYCOLS; POLYMERS;

CYSTEINE RESIDUES; GASTROINTESTINAL TRACT; NATIVE ENZYMES; POLYMER STRUCTURE; PROLYL ENDOPEPTIDASE; SITE-SPECIFIC; THERAPEUTIC ENZYME;

FUNCTIONAL POLYMERS;

MACROGOL DERIVATIVE; PROTEINASE;

ANIMAL; BINDING SITE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME STABILITY; ENZYMOLOGY; GASTROINTESTINAL TRACT; METABOLISM; MOLECULAR MODEL; MYXOCOCCUS XANTHUS; RAT;

ANIMALS; BINDING SITES; CATALYTIC DOMAIN; ENDOPEPTIDASES; ENZYME STABILITY; GASTROINTESTINAL TRACT; MODELS, MOLECULAR; MYXOCOCCUS XANTHUS; POLYETHYLENE GLYCOLS; RATS;

EID: 84958115804 PISSN: 09359648 EISSN: 15214095 Source Type: Journal
DOI: 10.1002/adma.201504797 Document Type: Article

Times cited : (33)

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