-
1
-
-
79959340087
-
In vivo fluorescence imaging of exogenous enzyme activity in the gastrointestinal tract
-
1:CAS:528:DC%2BC3MXnsV2gsbY%3D 3107327 21576491 10.1073/pnas.1100285108
-
Fuhrmann G, Leroux J-C. In vivo fluorescence imaging of exogenous enzyme activity in the gastrointestinal tract. Proc Natl Acad Sci U S A. 2011;108:9032-7.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 9032-9037
-
-
Fuhrmann, G.1
Leroux, J.-C.2
-
2
-
-
0037362655
-
Effect of pegylation on pharmaceuticals
-
1:CAS:528:DC%2BD3sXhsFKrtLs%3D 12612647 10.1038/nrd1033
-
Harris JM, Chess RB. Effect of pegylation on pharmaceuticals. Nat Rev Drug Discov. 2003;2:214-21.
-
(2003)
Nat Rev Drug Discov
, vol.2
, pp. 214-221
-
-
Harris, J.M.1
Chess, R.B.2
-
3
-
-
0036906253
-
Protein engineering 20 years on
-
1:CAS:528:DC%2BD38XptFKnt7k%3D 12461562 10.1038/nrm975
-
Brannigan JA, Wilkinson AJ. Protein engineering 20 years on. Nat Rev Mol Cell Biol. 2002;3:964-70.
-
(2002)
Nat Rev Mol Cell Biol
, vol.3
, pp. 964-970
-
-
Brannigan, J.A.1
Wilkinson, A.J.2
-
4
-
-
0017695992
-
Comparative effects of antacids, cimetidine and enteric coating on the therapeutic response to oral enzymes in severe pancreatic insufficiency
-
1:STN:280:DyaE1c%2FhtVamsA%3D%3D 20572 10.1056/NEJM197710202971603
-
Regan PT, Malagelada J-R, DiMagno EP, Glanzman SL, Go VLW. Comparative effects of antacids, cimetidine and enteric coating on the therapeutic response to oral enzymes in severe pancreatic insufficiency. New Engl J Med. 1977;297:854-8.
-
(1977)
New Engl J Med
, vol.297
, pp. 854-858
-
-
Regan, P.T.1
Malagelada, J.-R.2
Dimagno, E.P.3
Glanzman, S.L.4
Go, V.L.W.5
-
5
-
-
18244365849
-
Protein drug stability: A formulation challenge
-
1:CAS:528:DC%2BD2MXivVartL0%3D 15803194 10.1038/nrd1695
-
Frokjaer S, Otzen DE. Protein drug stability: a formulation challenge. Nat Rev Drug Discov. 2005;4:298-306.
-
(2005)
Nat Rev Drug Discov
, vol.4
, pp. 298-306
-
-
Frokjaer, S.1
Otzen, D.E.2
-
6
-
-
0034008242
-
Systemic enzyme therapy in oncology - Effect and mode of action
-
1:CAS:528:DC%2BD3cXjsVOmurc%3D 10804034 10.2165/00003495-200059040-00004
-
Leipner J, Saller R. Systemic enzyme therapy in oncology - effect and mode of action. Drugs. 2000;59:769-80.
-
(2000)
Drugs
, vol.59
, pp. 769-780
-
-
Leipner, J.1
Saller, R.2
-
7
-
-
84864655629
-
Microencapsulation of probiotics for gastrointestinal delivery
-
1:CAS:528:DC%2BC38XhtFCltL%2FN 22698940 10.1016/j.jconrel.2012.06.003
-
Cook MT, Tzortzis G, Charalampopoulos D, Khutoryanskiy VV. Microencapsulation of probiotics for gastrointestinal delivery. J Control Release. 2012;162:56-67.
-
(2012)
J Control Release
, vol.162
, pp. 56-67
-
-
Cook, M.T.1
Tzortzis, G.2
Charalampopoulos, D.3
Khutoryanskiy, V.V.4
-
8
-
-
41549169241
-
Specificity of immobilized porcine pepsin in H/D exchange compatible conditions
-
1:CAS:528:DC%2BD1cXksFWku7Y%3D 18327892 10.1002/rcm.3467
-
Hamuro Y, Coales SJ, Molnar KS, Tuske SJ, Morrow JA. Specificity of immobilized porcine pepsin in H/D exchange compatible conditions. Rapid Commun Mass Spectrom. 2008;22:1041-6.
-
(2008)
Rapid Commun Mass Spectrom
, vol.22
, pp. 1041-1046
-
-
Hamuro, Y.1
Coales, S.J.2
Molnar, K.S.3
Tuske, S.J.4
Morrow, J.A.5
-
9
-
-
56549128445
-
Protein engineering of improved prolyl endopeptidases for celiac sprue therapy
-
1:CAS:528:DC%2BD1cXhtl2gs77M 2583057 18836204 10.1093/protein/gzn050
-
Ehren J, Govindarajan S, Moron B, Minshull J, Khosla C. Protein engineering of improved prolyl endopeptidases for celiac sprue therapy. Protein Eng Des Sel. 2008;21:699-707.
-
(2008)
Protein Eng des Sel
, vol.21
, pp. 699-707
-
-
Ehren, J.1
Govindarajan, S.2
Moron, B.3
Minshull, J.4
Khosla, C.5
-
10
-
-
78549291768
-
Enzyme supplementation in cystic fibrosis, chronic pancreatitis, pancreatic and periampullary cancer
-
1:CAS:528:DC%2BC3cXhsFOntbfO 21054452 10.1111/j.1365-2036.2010.04437.x
-
Imrie CW, Connett G, Hall RI, Charnley RM. Enzyme supplementation in cystic fibrosis, chronic pancreatitis, pancreatic and periampullary cancer. Aliment Pharmacol Ther. 2010;32:1-5.
-
(2010)
Aliment Pharmacol Ther
, vol.32
, pp. 1-5
-
-
Imrie, C.W.1
Connett, G.2
Hall, R.I.3
Charnley, R.M.4
-
11
-
-
79959351780
-
Chronic pancreatitis and persistent steatorrhea: What is the correct dose of enzymes
-
21377551 10.1016/j.cgh.2011.02.027
-
Domínguez-Muñoz JE. Chronic pancreatitis and persistent steatorrhea: what is the correct dose of enzymes. Clin Gastroenterol Hepatol. 2011;9:541-6.
-
(2011)
Clin Gastroenterol Hepatol
, vol.9
, pp. 541-546
-
-
Domínguez-Muñoz, J.E.1
-
12
-
-
0042999388
-
Pegaspargase: A review of clinical studies
-
1:CAS:528:DC%2BD3sXnt1yqsbk%3D 14499708 10.1016/S0169-409X(03)00110-8
-
Graham ML. Pegaspargase: a review of clinical studies. Adv Drug Deliv Rev. 2003;55:1293-302.
-
(2003)
Adv Drug Deliv Rev
, vol.55
, pp. 1293-1302
-
-
Graham, M.L.1
-
14
-
-
0023179963
-
Enzyme-substitution therapy with the yeast saccharomyces cerevisiae in congenital sucrase-isomaltase deficiency
-
1:STN:280:DyaL2s3gtFOksg%3D%3D 3553946 10.1056/NEJM198705213162104
-
Harms H-K, Bertele-Harms R-M, Bruer-Kleis D. Enzyme-substitution therapy with the yeast saccharomyces cerevisiae in congenital sucrase-isomaltase deficiency. New Engl J Med. 1987;316:1306-9.
-
(1987)
New Engl J Med
, vol.316
, pp. 1306-1309
-
-
Harms, H.-K.1
Bertele-Harms, R.-M.2
Bruer-Kleis, D.3
-
15
-
-
0033008474
-
Sacrosidase therapy for congenital sucrase-isomaltase deficiency
-
1:CAS:528:DyaK1MXmtVSltbg%3D 9932843 10.1097/00005176-199902000-00008
-
Treem WR, McAdams L, Stanford L, Kastoff G, Justinich C, Hyams J. Sacrosidase therapy for congenital sucrase-isomaltase deficiency. J Pediatr Gastroenterol Nutr. 1999;28:137-42.
-
(1999)
J Pediatr Gastroenterol Nutr
, vol.28
, pp. 137-142
-
-
Treem, W.R.1
McAdams, L.2
Stanford, L.3
Kastoff, G.4
Justinich, C.5
Hyams, J.6
-
16
-
-
0027317632
-
Evaluation of liquid yeast-derived sucrase enzyme replacement in patients with sucrase-isomaltase deficiency
-
1:STN:280:DyaK2c%2FhtVWitQ%3D%3D 8405850
-
Treem WR, Ahsan N, Sullivan B, Rossi T, Holmes R, Fitzgerald J, et al. Evaluation of liquid yeast-derived sucrase enzyme replacement in patients with sucrase-isomaltase deficiency. Gastroenterology. 1993;105:1061-8.
-
(1993)
Gastroenterology
, vol.105
, pp. 1061-1068
-
-
Treem, W.R.1
Ahsan, N.2
Sullivan, B.3
Rossi, T.4
Holmes, R.5
Fitzgerald, J.6
-
17
-
-
0036479030
-
Identification of a variant associated with adult-type hypolactasia
-
1:CAS:528:DC%2BD38XhtFWltbw%3D 11788828 10.1038/ng826
-
Enattah NS, Sahi T, Savilahti E, Terwilliger JD, Peltonen L, Jarvela I. Identification of a variant associated with adult-type hypolactasia. Nat Genet. 2002;30:233-7.
-
(2002)
Nat Genet
, vol.30
, pp. 233-237
-
-
Enattah, N.S.1
Sahi, T.2
Savilahti, E.3
Terwilliger, J.D.4
Peltonen, L.5
Jarvela, I.6
-
18
-
-
33845900450
-
Convergent adaptation of human lactase persistence in Africa and Europe
-
1:CAS:528:DC%2BD28XhtlGktLjK 2672153 17159977 10.1038/ng1946
-
Tishkoff SA, Reed FA, Ranciaro A, Voight BF, Babbitt CC, Silverman JS, et al. Convergent adaptation of human lactase persistence in Africa and Europe. Nat Genet. 2007;39:31-40.
-
(2007)
Nat Genet
, vol.39
, pp. 31-40
-
-
Tishkoff, S.A.1
Reed, F.A.2
Ranciaro, A.3
Voight, B.F.4
Babbitt, C.C.5
Silverman, J.S.6
-
19
-
-
0036083017
-
Lactose malabsorption and intolerance and peak bone mass
-
12055586 10.1053/gast.2002.33600
-
Di Stefano M, Veneto G, Malservisi S, Cecchetti L, Minguzzi L, Strocchi A, et al. Lactose malabsorption and intolerance and peak bone mass. Gastroenterology. 2002;122:1793-9.
-
(2002)
Gastroenterology
, vol.122
, pp. 1793-1799
-
-
Di Stefano, M.1
Veneto, G.2
Malservisi, S.3
Cecchetti, L.4
Minguzzi, L.5
Strocchi, A.6
-
20
-
-
0029054211
-
A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance
-
1:STN:280:DyaK2M3psFOmtg%3D%3D 7776987 10.1056/NEJM199507063330101
-
Suarez FL, Savaiano DA, Levitt MD. A comparison of symptoms after the consumption of milk or lactose-hydrolyzed milk by people with self-reported severe lactose intolerance. New Engl J Med. 1995;333:1-4.
-
(1995)
New Engl J Med
, vol.333
, pp. 1-4
-
-
Suarez, F.L.1
Savaiano, D.A.2
Levitt, M.D.3
-
21
-
-
0021152189
-
Enzyme replacement therapy for primary adult lactase deficiency. Effective reduction of lactose malabsorption and milk intolerance by direct addition of beta-galactosidase to milk at mealtime
-
1:CAS:528:DyaL2MXitleqsA%3D%3D 6434367
-
Rosado JL, Solomons NW, Lisker R, Bourges H. Enzyme replacement therapy for primary adult lactase deficiency. Effective reduction of lactose malabsorption and milk intolerance by direct addition of beta-galactosidase to milk at mealtime. Gastroenterology. 1984;87:1072-82.
-
(1984)
Gastroenterology
, vol.87
, pp. 1072-1082
-
-
Rosado, J.L.1
Solomons, N.W.2
Lisker, R.3
Bourges, H.4
-
22
-
-
0021322457
-
Yogurt - An autodigesting source of lactose
-
1:CAS:528:DyaL2cXhtVajs7Y%3D 6417539 10.1056/NEJM198401053100101
-
Kolars JC, Levitt MD, Aouji M, Savaiano DA. Yogurt - an autodigesting source of lactose. New Engl J Med. 1984;310:1-3.
-
(1984)
New Engl J Med
, vol.310
, pp. 1-3
-
-
Kolars, J.C.1
Levitt, M.D.2
Aouji, M.3
Savaiano, D.A.4
-
23
-
-
0029592785
-
The treatment of lactose intolerance
-
1:STN:280:DyaK28vit1Shug%3D%3D 8824645 10.1111/j.1365-2036.1995.tb00427.x
-
Suarez FL, Savaiano DA, Levitt MD. The treatment of lactose intolerance. Aliment Pharmacol Ther. 1995;9:589-97.
-
(1995)
Aliment Pharmacol Ther
, vol.9
, pp. 589-597
-
-
Suarez, F.L.1
Savaiano, D.A.2
Levitt, M.D.3
-
24
-
-
33748373397
-
Physicochemical characteristics of commercial lactases relevant to their application in the alleviation of lactose intolerance
-
16943638 10.1385/ABAB:134:2:179
-
O'Connell S, Walsh G. Physicochemical characteristics of commercial lactases relevant to their application in the alleviation of lactose intolerance. Appl Biochem Biotechnol. 2006;134:179-91.
-
(2006)
Appl Biochem Biotechnol
, vol.134
, pp. 179-191
-
-
O'Connell, S.1
Walsh, G.2
-
25
-
-
84876225476
-
Molecular sieving on the surface of a protein provides protection without loss of activity
-
10.1002/adfm.201202227
-
Liu M, Tirino P, Radivojevic M, Phillips D, Gibson M, Leroux J-C, et al. Molecular sieving on the surface of a protein provides protection without loss of activity. Adv Funct Mater. 2012;23:2007-15.
-
(2012)
Adv Funct Mater
, vol.23
, pp. 2007-2015
-
-
Liu, M.1
Tirino, P.2
Radivojevic, M.3
Phillips, D.4
Gibson, M.5
Leroux, J.-C.6
-
26
-
-
79951768697
-
Stabilization of a supplemental digestive enzyme by post-translational engineering using chemically-activated polyethylene glycol
-
1:CAS:528:DC%2BC3MXitFGntL0%3D 21103910 10.1007/s10529-010-0474-7
-
Turner KM, Pasut G, Veronese FM, Boyce A, Walsh G. Stabilization of a supplemental digestive enzyme by post-translational engineering using chemically-activated polyethylene glycol. Biotechnol Lett. 2011;33:617-21.
-
(2011)
Biotechnol Lett
, vol.33
, pp. 617-621
-
-
Turner, K.M.1
Pasut, G.2
Veronese, F.M.3
Boyce, A.4
Walsh, G.5
-
27
-
-
77249089742
-
A novel acid-stable, acid-active beta-galactosidase potentially suited to the alleviation of lactose intolerance
-
19806354 10.1007/s00253-009-2270-7
-
O'Connell S, Walsh G. A novel acid-stable, acid-active beta-galactosidase potentially suited to the alleviation of lactose intolerance. Appl Microbiol Biotechnol. 2010;86:517-24.
-
(2010)
Appl Microbiol Biotechnol
, vol.86
, pp. 517-524
-
-
O'Connell, S.1
Walsh, G.2
-
28
-
-
67649236365
-
An acidophilic beta-galactosidase from bispora sp MEY-1 with high lactose hydrolytic activity under simulated gastric conditions
-
1:CAS:528:DC%2BD1MXmtVGktLw%3D 19453169 10.1021/jf900369e
-
Wang H, Luo H, Bai Y, Wang Y, Yang P, Shi P, et al. An acidophilic beta-galactosidase from bispora sp MEY-1 with high lactose hydrolytic activity under simulated gastric conditions. J Agric Food Chem. 2009;57:5535-41.
-
(2009)
J Agric Food Chem
, vol.57
, pp. 5535-5541
-
-
Wang, H.1
Luo, H.2
Bai, Y.3
Wang, Y.4
Yang, P.5
Shi, P.6
-
29
-
-
0015929760
-
Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency
-
1:STN:280:DyaE3s7ks1ygtg%3D%3D 4693931 10.1056/NEJM197304192881603
-
DiMagno EP, Go VLW, Summerskill WHJ. Relations between pancreatic enzyme outputs and malabsorption in severe pancreatic insufficiency. New Engl J Med. 1973;288:813-5.
-
(1973)
New Engl J Med
, vol.288
, pp. 813-815
-
-
Dimagno, E.P.1
Go, V.L.W.2
Summerskill, W.H.J.3
-
30
-
-
18344395560
-
Cystic fibrosis
-
1:CAS:528:DC%2BD2MXjvFyrtLY%3D 15888700 10.1056/NEJMra043184
-
Rowe SM, Miller S, Sorscher EJ. Cystic fibrosis. New Engl J Med. 2005;352:1992-2001.
-
(2005)
New Engl J Med
, vol.352
, pp. 1992-2001
-
-
Rowe, S.M.1
Miller, S.2
Sorscher, E.J.3
-
31
-
-
79958139589
-
Enzyme replacement therapy for pancreatic insufficiency: Present and future
-
3132852 21753892
-
Fieker A, Philpott J, Armand M. Enzyme replacement therapy for pancreatic insufficiency: present and future. Clin Exp Gastroenterol. 2011;4:55-73.
-
(2011)
Clin Exp Gastroenterol
, vol.4
, pp. 55-73
-
-
Fieker, A.1
Philpott, J.2
Armand, M.3
-
32
-
-
80053529657
-
Exocrine pancreatic insufficiency in diabetes mellitus: A complication of diabetic neuropathy or a different type of diabetes?
-
10.1155/2011/761950 3148449 21822421
-
Hardt PD, Ewald N. Exocrine pancreatic insufficiency in diabetes mellitus: a complication of diabetic neuropathy or a different type of diabetes? Exp Diabetes Res. 2011. doi: 10.1155/2011/761950.
-
(2011)
Exp Diabetes Res
-
-
Hardt, P.D.1
Ewald, N.2
-
33
-
-
79960081296
-
The role of fecal elastase-1 in detecting exocrine pancreatic disease
-
1:CAS:528:DC%2BC3MXotl2ls7Y%3D 21629239 10.1038/nrgastro.2011.91
-
Leeds JS, Oppong K, Sanders DS. The role of fecal elastase-1 in detecting exocrine pancreatic disease. Nat Rev Gastroenterol Hepatol. 2011;8:405-15.
-
(2011)
Nat Rev Gastroenterol Hepatol
, vol.8
, pp. 405-415
-
-
Leeds, J.S.1
Oppong, K.2
Sanders, D.S.3
-
34
-
-
33846288269
-
Is exocrine pancreatic insufficiency in adult coeliac disease a cause of persisting symptoms?
-
1:CAS:528:DC%2BD2sXjtlelsbY%3D 17269988 10.1111/j.1365-2036.2006.03206.x
-
Leeds JS, Hopper AD, Hurlstone DP, Edwards SJ, McAlindon ME, Lobo AJ, et al. Is exocrine pancreatic insufficiency in adult coeliac disease a cause of persisting symptoms? Aliment Pharmacol Ther. 2007;25:265-71.
-
(2007)
Aliment Pharmacol Ther
, vol.25
, pp. 265-271
-
-
Leeds, J.S.1
Hopper, A.D.2
Hurlstone, D.P.3
Edwards, S.J.4
McAlindon, M.E.5
Lobo, A.J.6
-
35
-
-
77957925663
-
Pancreatic insufficiency in adult celiac disease: Do patients require long-term enzyme supplementation?
-
1:CAS:528:DC%2BC3cXhtF2lurjI 20458623 10.1007/s10620-010-1261-y
-
Evans KE, Leeds JS, Morley S, Sanders DS. Pancreatic insufficiency in adult celiac disease: do patients require long-term enzyme supplementation? Dig Dis Sci. 2010;55:2999-3004.
-
(2010)
Dig Dis Sci
, vol.55
, pp. 2999-3004
-
-
Evans, K.E.1
Leeds, J.S.2
Morley, S.3
Sanders, D.S.4
-
36
-
-
0034795278
-
Efficacy of oral pancreatic enzyme therapy for the treatment of fat malabsorption in HIV-infected patients
-
1:CAS:528:DC%2BD3MXnvVCgs7Y%3D 11564002 10.1046/j.1365-2036.2001.01070.x
-
Carroccio A, Guarino A, Zuin G, Verghi F, Berni Canani R, Fontana M, et al. Efficacy of oral pancreatic enzyme therapy for the treatment of fat malabsorption in HIV-infected patients. Aliment Pharmacol Ther. 2001;15:1619-25.
-
(2001)
Aliment Pharmacol Ther
, vol.15
, pp. 1619-1625
-
-
Carroccio, A.1
Guarino, A.2
Zuin, G.3
Verghi, F.4
Berni Canani, R.5
Fontana, M.6
-
37
-
-
37549047170
-
In vitro comparative study of three pancreatic enzyme preparations: Dissolution profiles, active enzyme release and acid stability
-
1:CAS:528:DC%2BD1cXitFKmt7s%3D 17973644 10.1111/j.1365-2036.2007.03563.x
-
Aloulou A, Puccinelli D, Sarles J, Laugier R, Leblondt Y, Carriere F. In vitro comparative study of three pancreatic enzyme preparations: dissolution profiles, active enzyme release and acid stability. Aliment Pharmacol Ther. 2008;27:283-92.
-
(2008)
Aliment Pharmacol Ther
, vol.27
, pp. 283-292
-
-
Aloulou, A.1
Puccinelli, D.2
Sarles, J.3
Laugier, R.4
Leblondt, Y.5
Carriere, F.6
-
38
-
-
34147190334
-
13C-mixed triglyceride breath test to assess oral enzyme substitution therapy in patients with chronic pancreatitis
-
17445754 10.1016/j.cgh.2007.01.004
-
Domínguez-Muñoz JE, Iglesias-García J, Vilariño-Insua M, Iglesias-Rey M. 13C-mixed triglyceride breath test to assess oral enzyme substitution therapy in patients with chronic pancreatitis. Clin Gastroenterol Hepatol. 2007;5:484-8.
-
(2007)
Clin Gastroenterol Hepatol
, vol.5
, pp. 484-488
-
-
Domínguez-Muñoz, J.E.1
Iglesias-García, J.2
Vilariño-Insua, M.3
Iglesias-Rey, M.4
-
39
-
-
84873445883
-
Variant of the Thermomyces lanuginosus lipase with improved kinetic stability: A candidate for enzyme replacement therapy
-
1:CAS:528:DC%2BC3sXisVOku74%3D 23357413 10.1016/j.bpc.2012.12.003
-
Wang H, Hagedorn J, Svendsen A, Borch K, Otzen DE. Variant of the Thermomyces lanuginosus lipase with improved kinetic stability: a candidate for enzyme replacement therapy. Biophys Chem. 2013;172:43-52.
-
(2013)
Biophys Chem
, vol.172
, pp. 43-52
-
-
Wang, H.1
Hagedorn, J.2
Svendsen, A.3
Borch, K.4
Otzen, D.E.5
-
40
-
-
43149109689
-
Polymer masked-unmasked protein therapy. 1. Bioresponsive dextrin-trypsin and -melanocyte stimulating hormone conjugates designed for alpha-amylase activation
-
1:CAS:528:DC%2BD1cXjsVGnsbk%3D 18348531 10.1021/bm701073n
-
Duncan R, Gilbert HRP, Carbajo RJ, Vicent MJ. Polymer masked-unmasked protein therapy. 1. bioresponsive dextrin-trypsin and -melanocyte stimulating hormone conjugates designed for alpha-amylase activation. Biomacromolecules. 2008;9:1146-54.
-
(2008)
Biomacromolecules
, vol.9
, pp. 1146-1154
-
-
Duncan, R.1
Gilbert, H.R.P.2
Carbajo, R.J.3
Vicent, M.J.4
-
41
-
-
78649893491
-
Prevention measures and exploratory pharmacological treatments of celiac disease
-
1:CAS:528:DC%2BC3cXhsFajs77L 20877349 10.1038/ajg.2010.372
-
Pinier M, Fuhrmann G, Verdu E, Leroux J-C. Prevention measures and exploratory pharmacological treatments of celiac disease. Am J Gastroenterol. 2010;105:2551-61.
-
(2010)
Am J Gastroenterol
, vol.105
, pp. 2551-2561
-
-
Pinier, M.1
Fuhrmann, G.2
Verdu, E.3
Leroux, J.-C.4
-
42
-
-
84858285419
-
Coeliac disease, new approaches to therapy
-
1:CAS:528:DC%2BC38Xmt1Cgu74%3D 3912561 22324389 10.1111/j.1365-2036.2012. 05013.x
-
Rashtak S, Murray JA. Coeliac disease, new approaches to therapy. Aliment Pharmacol Ther. 2012;35:768-81.
-
(2012)
Aliment Pharmacol Ther
, vol.35
, pp. 768-781
-
-
Rashtak, S.1
Murray, J.A.2
-
43
-
-
77950860750
-
The spectrum of celiac disease: Epidemiology, clinical aspects and treatment
-
1:CAS:528:DC%2BC3cXktlyjtbo%3D 20212505 10.1038/nrgastro.2010.23
-
Tack GJ, Verbeek WHM, Schreurs MWJ, Mulder CJJ. The spectrum of celiac disease: epidemiology, clinical aspects and treatment. Nat Rev Gastroenterol Hepatol. 2010;7:204-13.
-
(2010)
Nat Rev Gastroenterol Hepatol
, vol.7
, pp. 204-213
-
-
Tack, G.J.1
Verbeek, W.H.M.2
Schreurs, M.W.J.3
Mulder, C.J.J.4
-
46
-
-
84856207904
-
The copolymer P(HEMA-co-SS) binds gluten and reduces immune response in gluten-sensitized mice and human tissues
-
1:CAS:528:DC%2BC38XhsVOmu7k%3D 22079593 10.1053/j.gastro.2011.10.038
-
Pinier M, Fuhrmann G, Galipeau HJ, Rivard N, Murray JA, David CS, et al. The copolymer P(HEMA-co-SS) binds gluten and reduces immune response in gluten-sensitized mice and human tissues. Gastroenterology. 2012;142:316-325. e312.
-
(2012)
Gastroenterology
, vol.142
-
-
Pinier, M.1
Fuhrmann, G.2
Galipeau, H.J.3
Rivard, N.4
Murray, J.A.5
David, C.S.6
-
47
-
-
84864109994
-
Celiac disease: Advances in treatment via gluten modification
-
3788609 22728383 10.1016/j.cgh.2012.06.005
-
Stoven S, Murray JA, Marietta E. Celiac disease: advances in treatment via gluten modification. Clin Gastroenterol Hepatol. 2012;10:859-62.
-
(2012)
Clin Gastroenterol Hepatol
, vol.10
, pp. 859-862
-
-
Stoven, S.1
Murray, J.A.2
Marietta, E.3
-
48
-
-
76049115164
-
The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo
-
1:CAS:528:DC%2BC3cXitVOhurY%3D 19942485 10.1016/j.clim.2009.11.001
-
Tye-Din JA, Anderson RP, Ffrench RA, Brown GJ, Hodsman P, Siegel M, et al. The effects of ALV003 pre-digestion of gluten on immune response and symptoms in celiac disease in vivo. Clin Immunol. 2010;134:289-95.
-
(2010)
Clin Immunol
, vol.134
, pp. 289-295
-
-
Tye-Din, J.A.1
Anderson, R.P.2
Ffrench, R.A.3
Brown, G.J.4
Hodsman, P.5
Siegel, M.6
-
49
-
-
77951861703
-
Can prolyl endoprotease enzyme treatment mitigate the toxic effect of gluten in coeliac patients?
-
10.1053/j.gastro.2010.03.012
-
Tack GJ, van de Water JM, Kooy-Winkelaar EM, van Bergen J, Meijer GA, von Blomberg BM, et al. Can prolyl endoprotease enzyme treatment mitigate the toxic effect of gluten in coeliac patients? Gastroenterology. 2010;138:S-54.
-
(2010)
Gastroenterology
, vol.138
, pp. 54
-
-
Tack, G.J.1
Van De Water, J.M.2
Kooy-Winkelaar, E.M.3
Van Bergen, J.4
Meijer, G.A.5
Von Blomberg, B.M.6
-
50
-
-
84856744117
-
Safety, tolerability, and activity of alv003: Results from two phase 1 single. Escalating-dose clinical trials
-
1:CAS:528:DC%2BC38XhsVWit7Y%3D 21948339 10.1007/s10620-011-1906-5
-
Siegel M, Garber M, Spencer A, Botwick W, Kumar P, Williams R, et al. Safety, tolerability, and activity of alv003: results from two phase 1 single. Escalating-dose clinical trials. Dig Dis Sci. 2012;57:440-50.
-
(2012)
Dig Dis Sci
, vol.57
, pp. 440-450
-
-
Siegel, M.1
Garber, M.2
Spencer, A.3
Botwick, W.4
Kumar, P.5
Williams, R.6
-
51
-
-
34447102461
-
Enhancement of dietary protein digestion by conjugated bile acids
-
1:CAS:528:DC%2BD2sXptFKit70%3D 17631126 10.1053/j.gastro.2007.04.008
-
Gass J, Vora H, Hofmann AF, Gray GM, Khosla C. Enhancement of dietary protein digestion by conjugated bile acids. Gastroenterology. 2007;133:16-23.
-
(2007)
Gastroenterology
, vol.133
, pp. 16-23
-
-
Gass, J.1
Vora, H.2
Hofmann, A.F.3
Gray, G.M.4
Khosla, C.5
-
52
-
-
28844445640
-
Fermentation, purification, formulation, and pharmacological evaluation of a prolyl endopeptidase from Myxococcus xanthus: Implications for Celiac Sprue therapy
-
1:CAS:528:DC%2BD2MXhtlSqt7rL 16136593 10.1002/bit.20643
-
Gass J, Ehren J, Strohmeier G, Isaacs I, Khosla C. Fermentation, purification, formulation, and pharmacological evaluation of a prolyl endopeptidase from Myxococcus xanthus: implications for Celiac Sprue therapy. Biotechnol Bioeng. 2005;92:674-84.
-
(2005)
Biotechnol Bioeng
, vol.92
, pp. 674-684
-
-
Gass, J.1
Ehren, J.2
Strohmeier, G.3
Isaacs, I.4
Khosla, C.5
-
53
-
-
84871377260
-
Computational design of an α-Gliadin Peptidase
-
1:CAS:528:DC%2BC38Xhs1OltLvL 3526107 23153249 10.1021/ja3094795
-
Gordon SR, Stanley EJ, Wolf S, Toland A, Wu SJ, Hadidi D, et al. Computational design of an α-Gliadin Peptidase. J Am Chem Soc. 2012;134:20513-20.
-
(2012)
J Am Chem Soc
, vol.134
, pp. 20513-20520
-
-
Gordon, S.R.1
Stanley, E.J.2
Wolf, S.3
Toland, A.4
Wu, S.J.5
Hadidi, D.6
-
54
-
-
84878872675
-
-
P. Alvine (ed.), Vol. PCT/US2006/039714, Alvine Pharmaceuticals, USA
-
S. Robic. Pegylated glutenase polypeptides. In P. Alvine (ed.), Vol. PCT/US2006/039714, Alvine Pharmaceuticals, USA, 2007.
-
(2007)
Pegylated Glutenase Polypeptides
-
-
Robic, S.1
-
55
-
-
84879401007
-
Sustained gastrointestinal activity of dendronized polymer-enzyme conjugates
-
1:CAS:528:DC%2BC3sXptVamsb4%3D 23787748 10.1038/nchem.1675
-
Fuhrmann G, Grotzky A, Lukic R, Matoori S, Luciani P, Yu H, et al. Sustained gastrointestinal activity of dendronized polymer-enzyme conjugates. Nat Chem. 2013;5:582-9.
-
(2013)
Nat Chem
, vol.5
, pp. 582-589
-
-
Fuhrmann, G.1
Grotzky, A.2
Lukic, R.3
Matoori, S.4
Luciani, P.5
Yu, H.6
-
56
-
-
0019856019
-
Neonatal mass screening for metabolic disorders
-
Bickel H, Bachmann C, Beckers R, Brandt NJ, Clayton BE, Corrado G, et al. Neonatal mass screening for metabolic disorders. Eur J Pediatr. 1981;137:133-9.
-
(1981)
Eur J Pediatr
, vol.137
, pp. 133-139
-
-
Bickel, H.1
Bachmann, C.2
Beckers, R.3
Brandt, N.J.4
Clayton, B.E.5
Corrado, G.6
-
57
-
-
82755189346
-
Up to date knowledge on different treatment strategies for phenylketonuria
-
21967857 10.1016/j.ymgme.2011.08.009
-
Bélanger-Quintana A, Burlina A, Harding CO, Muntau AC. Up to date knowledge on different treatment strategies for phenylketonuria. Mol Genet Metab. 2011;104:S19-25.
-
(2011)
Mol Genet Metab
, vol.104
-
-
Bélanger-Quintana, A.1
Burlina, A.2
Harding, C.O.3
Muntau, A.C.4
-
58
-
-
4344715044
-
Trends in enzyme therapy for phenylketonuria
-
15294168 10.1016/j.ymthe.2004.05.001
-
Kim W, Erlandsen H, Surendran S, Stevens RC, Gamez A, Michols-Matalon K, et al. Trends in enzyme therapy for phenylketonuria. Mol Ther. 2004;10:220-4.
-
(2004)
Mol Ther
, vol.10
, pp. 220-224
-
-
Kim, W.1
Erlandsen, H.2
Surendran, S.3
Stevens, R.C.4
Gamez, A.5
Michols-Matalon, K.6
-
59
-
-
0033514997
-
A different approach to treatment of phenylketonuria: Phenylalanine degradation with recombinant phenylalanine ammonia lyase
-
1:CAS:528:DyaK1MXhvVSqtLw%3D 26785 10051643 10.1073/pnas.96.5.2339
-
Sarkissian CN, Shao Z, Blain F, Peevers R, Su H, Heft R, et al. A different approach to treatment of phenylketonuria: Phenylalanine degradation with recombinant phenylalanine ammonia lyase. Proc Natl Acad Sci U S A. 1999;96:2339-44.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 2339-2344
-
-
Sarkissian, C.N.1
Shao, Z.2
Blain, F.3
Peevers, R.4
Su, H.5
Heft, R.6
-
60
-
-
34447268200
-
Structure-based epitope and PEGylation sites mapping of phenylalanine ammonia-lyase for enzyme substitution treatment of phenylketonuria
-
17560821 10.1016/j.ymgme.2007.04.015
-
Gámez A, Wang L, Sarkissian CN, Wendt D, Fitzpatrick P, Lemontt JF, et al. Structure-based epitope and PEGylation sites mapping of phenylalanine ammonia-lyase for enzyme substitution treatment of phenylketonuria. Mol Genet Metab. 2007;91:325-34.
-
(2007)
Mol Genet Metab
, vol.91
, pp. 325-334
-
-
Gámez, A.1
Wang, L.2
Sarkissian, C.N.3
Wendt, D.4
Fitzpatrick, P.5
Lemontt, J.F.6
-
61
-
-
58549094507
-
Preclinical evaluation of multiple species of PEGylated recombinant phenylalanine ammonia lyase for the treatment of phenylketonuria
-
1:CAS:528:DC%2BD1MXksFSruw%3D%3D 2634911 19095795 10.1073/pnas.0808421105
-
Sarkissian CN, Gámez A, Wang L, Charbonneau M, Fitzpatrick P, Lemontt JF, et al. Preclinical evaluation of multiple species of PEGylated recombinant phenylalanine ammonia lyase for the treatment of phenylketonuria. Proc Natl Acad Sci U S A. 2008;105:20894-9.
-
(2008)
Proc Natl Acad Sci U S A
, vol.105
, pp. 20894-20899
-
-
Sarkissian, C.N.1
Gámez, A.2
Wang, L.3
Charbonneau, M.4
Fitzpatrick, P.5
Lemontt, J.F.6
-
62
-
-
82455199281
-
Evaluation of orally administered PEGylated phenylalanine ammonia lyase in mice for the treatment of phenylketonuria
-
1:CAS:528:DC%2BC3MXhtl2rt7jL 3205297 21803624 10.1016/j.ymgme.2011.06.016
-
Sarkissian CN, Kang TS, Gamez A, Scriver CR, Stevens RC. Evaluation of orally administered PEGylated phenylalanine ammonia lyase in mice for the treatment of phenylketonuria. Mol Genet Metab. 2011;104:249-54.
-
(2011)
Mol Genet Metab
, vol.104
, pp. 249-254
-
-
Sarkissian, C.N.1
Kang, T.S.2
Gamez, A.3
Scriver, C.R.4
Stevens, R.C.5
-
63
-
-
10744223043
-
Toward PKU enzyme replacement therapy: PEGylation with activity retention for three forms of recombinant phenylalanine hydroxylase
-
1:CAS:528:DC%2BD2cXntVOisA%3D%3D 14741785 10.1016/j.ymthe.2003.11.002
-
Gamez A, Wang L, Straub M, Patch MG, Stevens RC. Toward PKU enzyme replacement therapy: PEGylation with activity retention for three forms of recombinant phenylalanine hydroxylase. Mol Ther. 2004;9:124-9.
-
(2004)
Mol Ther
, vol.9
, pp. 124-129
-
-
Gamez, A.1
Wang, L.2
Straub, M.3
Patch, M.G.4
Stevens, R.C.5
-
64
-
-
34548186685
-
A novel approach for enzyme replacement therapy - The use of phenylalanine hydroxylase-based fusion proteins for the treatment of phenylketonuria
-
1:CAS:528:DC%2BD2sXosVyrsbk%3D 17565982 10.1074/jbc.M703367200
-
Eavri R, Lorberboum-Galski H. A novel approach for enzyme replacement therapy - The use of phenylalanine hydroxylase-based fusion proteins for the treatment of phenylketonuria. J Biol Chem. 2007;282:23402-9.
-
(2007)
J Biol Chem
, vol.282
, pp. 23402-23409
-
-
Eavri, R.1
Lorberboum-Galski, H.2
-
65
-
-
35948988152
-
Injectable nanocarriers for biodetoxification
-
1:CAS:528:DC%2BD2sXht1GksrvO 18654405 10.1038/nnano.2007.339
-
Leroux J-C. Injectable nanocarriers for biodetoxification. Nat Nanotechnol. 2007;2:679-84.
-
(2007)
Nat Nanotechnol
, vol.2
, pp. 679-684
-
-
Leroux, J.-C.1
-
66
-
-
70349232776
-
Molecular characterization, physicochemical properties, known and potential applications of phytases: An overview
-
1:CAS:528:DC%2BD1MXlvFGntr0%3D 19514894 10.1080/07388550902919571
-
Rao DECS, Rao KV, Reddy TP, Reddy VD. Molecular characterization, physicochemical properties, known and potential applications of phytases: an overview. Crit Rev Biotechnol. 2009;29:182-98.
-
(2009)
Crit Rev Biotechnol
, vol.29
, pp. 182-198
-
-
Rao, D.1
Rao, K.V.2
Reddy, T.P.3
Reddy, V.D.4
-
67
-
-
33846402455
-
The effect of oral α-galactosidase on intestinal gas production and gas-related symptoms
-
17151807 10.1007/s10620-006-9296-9
-
Di Stefano M, Miceli E, Gotti S, Missanelli A, Mazzocchi S, Corazza GR. The effect of oral α-galactosidase on intestinal gas production and gas-related symptoms. Dig Dis Sci. 2007;52:78-83.
-
(2007)
Dig Dis Sci
, vol.52
, pp. 78-83
-
-
Di Stefano, M.1
Miceli, E.2
Gotti, S.3
Missanelli, A.4
Mazzocchi, S.5
Corazza, G.R.6
-
68
-
-
78751573957
-
Directed evolution of hydrolases for prevention of G-type nerve agent intoxication
-
1:CAS:528:DC%2BC3MXjtVKrtg%3D%3D 21217689 10.1038/nchembio.510
-
Gupta RD, Goldsmith M, Ashani Y, Simo Y, Mullokandov G, Bar H, et al. Directed evolution of hydrolases for prevention of G-type nerve agent intoxication. Nat Chem Biol. 2011;7:120-5.
-
(2011)
Nat Chem Biol
, vol.7
, pp. 120-125
-
-
Gupta, R.D.1
Goldsmith, M.2
Ashani, Y.3
Simo, Y.4
Mullokandov, G.5
Bar, H.6
|