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Volumn 90, Issue 3, 2016, Pages 1333-1344

Dysregulation of toll-like receptor 7 compromises innate and adaptive T cell responses and host resistance to an attenuated West Nile virus infection in old mice

Author keywords

[No Author keywords available]

Indexed keywords

CELL ANTIGEN; CYTOKINE; INTERLEUKIN 10; RESIQUIMOD; TOLL LIKE RECEPTOR 7;

EID: 84958093696     PISSN: 0022538X     EISSN: 10985514     Source Type: Journal    
DOI: 10.1128/JVI.02488-15     Document Type: Article
Times cited : (27)

References (73)
  • 2
    • 0037454351 scopus 로고    scopus 로고
    • West Nile encephalitis
    • Solomon T, Ooi MH, Beasley DW, Mallewa M. 2003. West Nile encephalitis. BMJ 326:865-869. http://dx.doi.org/10.1136/bmj.326.7394.865.
    • (2003) BMJ , vol.326 , pp. 865-869
    • Solomon, T.1    Ooi, M.H.2    Beasley, D.W.3    Mallewa, M.4
  • 3
    • 3042854213 scopus 로고    scopus 로고
    • Immunity to West Nile virus
    • Wang T, Fikrig E. 2004. Immunity to West Nile virus. Curr Opin Immunol 16:519-523. http://dx.doi.org/10.1016/j.coi.2004.05.008.
    • (2004) Curr Opin Immunol , vol.16 , pp. 519-523
    • Wang, T.1    Fikrig, E.2
  • 7
    • 13744254078 scopus 로고    scopus 로고
    • Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins
    • Liu WJ, Wang XJ, Mokhonov VV, Shi PY, Randall R, Khromykh AA. 2005. Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins. J Virol 79:1934-1942. http://dx.doi.org/10.1128/JVI.79.3.1934-1942.2005.
    • (2005) J Virol , vol.79 , pp. 1934-1942
    • Liu, W.J.1    Wang, X.J.2    Mokhonov, V.V.3    Shi, P.Y.4    Randall, R.5    Khromykh, A.A.6
  • 8
    • 35448972183 scopus 로고    scopus 로고
    • Differential effects of mutations in NS4B on West Nile virus replication and inhibition of interferon signaling
    • Evans JD, Seeger C. 2007. Differential effects of mutations in NS4B on West Nile virus replication and inhibition of interferon signaling. J Virol 81:11809-11816. http://dx.doi.org/10.1128/JVI.00791-07.
    • (2007) J Virol , vol.81 , pp. 11809-11816
    • Evans, J.D.1    Seeger, C.2
  • 11
    • 79960623042 scopus 로고    scopus 로고
    • Immune responses to an attenuated West Nile virus NS4B-P38G mutant strain
    • Welte T, Xie G, Wicker JA, Whiteman MC, Li L, Rachamallu A, Barrett A, Wang T. 2011. Immune responses to an attenuated West Nile virus NS4B-P38G mutant strain. Vaccine 29:4853-4861. http://dx.doi.org/10.1016/j.vaccine.2011.04.057.
    • (2011) Vaccine , vol.29 , pp. 4853-4861
    • Welte, T.1    Xie, G.2    Wicker, J.A.3    Whiteman, M.C.4    Li, L.5    Rachamallu, A.6    Barrett, A.7    Wang, T.8
  • 12
    • 84921722508 scopus 로고    scopus 로고
    • A West Nile virus NS4B-P38G mutant strain induces cell intrinsic innate cytokine responses in human monocytic and macrophage cells
    • Xie G, Luo H, Tian B, Mann B, Bao X, McBride J, Tesh R, Barrett AD, Wang T. 2015. A West Nile virus NS4B-P38G mutant strain induces cell intrinsic innate cytokine responses in human monocytic and macrophage cells. Vaccine 33:869-878. http://dx.doi.org/10.1016/j.vaccine.2014.12.056.
    • (2015) Vaccine , vol.33 , pp. 869-878
    • Xie, G.1    Luo, H.2    Tian, B.3    Mann, B.4    Bao, X.5    McBride, J.6    Tesh, R.7    Barrett, A.D.8    Wang, T.9
  • 13
    • 73349101903 scopus 로고    scopus 로고
    • Key role of T cell defects in age-related vulnerability to West Nile virus
    • Brien JD, Uhrlaub JL, Hirsch A, Wiley CA, Nikolich-Zugich J. 2009. Key role of T cell defects in age-related vulnerability to West Nile virus. J Exp Med 206:2735-2745. http://dx.doi.org/10.1084/jem.20090222.
    • (2009) J Exp Med , vol.206 , pp. 2735-2745
    • Brien, J.D.1    Uhrlaub, J.L.2    Hirsch, A.3    Wiley, C.A.4    Nikolich-Zugich, J.5
  • 14
    • 45149110222 scopus 로고    scopus 로고
    • Role of two distinct gammadelta T cell subsets during West Nile virus infection
    • Welte T, Lamb J, Anderson JF, Born WK, O'Brien RL, Wang T. 2008. Role of two distinct gammadelta T cell subsets during West Nile virus infection. FEMS Immunol Med Microbiol 53:275-283. http://dx.doi.org/10.1111/j.1574-695X.2008.00430.x.
    • (2008) FEMS Immunol Med Microbiol , vol.53 , pp. 275-283
    • Welte, T.1    Lamb, J.2    Anderson, J.F.3    Born, W.K.4    O'Brien, R.L.5    Wang, T.6
  • 15
    • 60149109538 scopus 로고    scopus 로고
    • Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing
    • Town T, Bai F, Wang T, Kaplan AT, Qian F, Montgomery RR, Anderson JF, Flavell RA, Fikrig E. 2009. Toll-like receptor 7 mitigates lethal West Nile encephalitis via interleukin 23-dependent immune cell infiltration and homing. Immunity 30:242-253. http://dx.doi.org/10.1016/j.immuni.2008.11.012.
    • (2009) Immunity , vol.30 , pp. 242-253
    • Town, T.1    Bai, F.2    Wang, T.3    Kaplan, A.T.4    Qian, F.5    Montgomery, R.R.6    Anderson, J.F.7    Flavell, R.A.8    Fikrig, E.9
  • 17
    • 84881546504 scopus 로고    scopus 로고
    • A West Nile virus NS4B-P38G mutant strain induces adaptive immunity via TLR7-MyD88-dependent and independent signaling pathways
    • Xie G, Welte T, Wang J, Whiteman MC, Wicker JA, Saxena V, Cong Y, Barrett AD, Wang T. 2013. A West Nile virus NS4B-P38G mutant strain induces adaptive immunity via TLR7-MyD88-dependent and independent signaling pathways. Vaccine 31:4143-4151. http://dx.doi.org/10.1016/j.vaccine.2013.06.093.
    • (2013) Vaccine , vol.31 , pp. 4143-4151
    • Xie, G.1    Welte, T.2    Wang, J.3    Whiteman, M.C.4    Wicker, J.A.5    Saxena, V.6    Cong, Y.7    Barrett, A.D.8    Wang, T.9
  • 19
    • 50149119230 scopus 로고    scopus 로고
    • Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection
    • Daffis S, Samuel MA, Suthar MS, Keller BC, Gale M, Jr, Diamond MS. 2008. Interferon regulatory factor IRF-7 induces the antiviral alpha interferon response and protects against lethal West Nile virus infection. J Virol 82:8465-8475. http://dx.doi.org/10.1128/JVI.00918-08.
    • (2008) J Virol , vol.82 , pp. 8465-8475
    • Daffis, S.1    Samuel, M.A.2    Suthar, M.S.3    Keller, B.C.4    Gale, M.5    Diamond, M.S.6
  • 21
    • 11144273976 scopus 로고    scopus 로고
    • Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis
    • Wang T, Town T, Alexopoulou L, Anderson JF, Fikrig E, Flavell RA. 2004. Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis. Nat Med 10:1366-1373. http://dx.doi.org/10.1038/nm1140.
    • (2004) Nat Med , vol.10 , pp. 1366-1373
    • Wang, T.1    Town, T.2    Alexopoulou, L.3    Anderson, J.F.4    Fikrig, E.5    Flavell, R.A.6
  • 22
    • 0037738569 scopus 로고    scopus 로고
    • Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha + DC correlates with unresponsiveness to imidazoquinolines
    • Edwards AD, Diebold SS, Slack EM, Tomizawa H, Hemmi H, Kaisho T, Akira S, Reis e Sousa C. 2003. Toll-like receptor expression in murine DC subsets: lack of TLR7 expression by CD8 alpha + DC correlates with unresponsiveness to imidazoquinolines. Eur J Immunol 33:827-833. http://dx.doi.org/10.1002/eji.200323797.
    • (2003) Eur J Immunol , vol.33 , pp. 827-833
    • Edwards, A.D.1    Diebold, S.S.2    Slack, E.M.3    Tomizawa, H.4    Hemmi, H.5    Kaisho, T.6    Akira, S.7    Reis e Sousa, C.8
  • 25
    • 58849165766 scopus 로고    scopus 로고
    • West Nile virus-specific CD4 T cells exhibit direct antiviral cytokine secretion and cytotoxicity and are sufficient for antiviral protection
    • Brien JD, Uhrlaub JL, Nikolich-Zugich J. 2008. West Nile virus-specific CD4 T cells exhibit direct antiviral cytokine secretion and cytotoxicity and are sufficient for antiviral protection. J Immunol 181:8568-8575. http://dx.doi.org/10.4049/jimmunol.181.12.8568.
    • (2008) J Immunol , vol.181 , pp. 8568-8575
    • Brien, J.D.1    Uhrlaub, J.L.2    Nikolich-Zugich, J.3
  • 26
    • 34447557656 scopus 로고    scopus 로고
    • Protective capacity and epitope specificity of CD8(+) T cells responding to lethal West Nile virus infection
    • Brien JD, Uhrlaub JL, Nikolich-Zugich J. 2007. Protective capacity and epitope specificity of CD8(+) T cells responding to lethal West Nile virus infection. Eur J Immunol 37:1855-1863. http://dx.doi.org/10.1002/eji.200737196.
    • (2007) Eur J Immunol , vol.37 , pp. 1855-1863
    • Brien, J.D.1    Uhrlaub, J.L.2    Nikolich-Zugich, J.3
  • 28
    • 27144486896 scopus 로고    scopus 로고
    • Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival
    • Samuel MA, Diamond MS. 2005. Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survival. J Virol 79:13350-13361. http://dx.doi.org/10.1128/JVI.79.21.13350-13361.2005.
    • (2005) J Virol , vol.79 , pp. 13350-13361
    • Samuel, M.A.1    Diamond, M.S.2
  • 30
    • 41749120606 scopus 로고    scopus 로고
    • Prior exposure to uninfected mosquitoes enhances mortality in naturally-transmitted West Nile virus infection
    • Schneider BS, McGee CE, Jordan JM, Stevenson HL, Soong L, Higgs S. 2007. Prior exposure to uninfected mosquitoes enhances mortality in naturally-transmitted West Nile virus infection. PLoS One 2:e1171. http://dx.doi.org/10.1371/journal.pone.0001171.
    • (2007) PLoS One , vol.2
    • Schneider, B.S.1    McGee, C.E.2    Jordan, J.M.3    Stevenson, H.L.4    Soong, L.5    Higgs, S.6
  • 33
    • 0037319970 scopus 로고    scopus 로고
    • B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus
    • Diamond MS, Shrestha B, Marri A, Mahan D, Engle M. 2003. B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus. J Virol 77:2578-2586. http://dx.doi.org/10.1128/JVI.77.4.2578-2586.2003.
    • (2003) J Virol , vol.77 , pp. 2578-2586
    • Diamond, M.S.1    Shrestha, B.2    Marri, A.3    Mahan, D.4    Engle, M.5
  • 34
    • 33645992767 scopus 로고    scopus 로고
    • CD8+ T cells require perforin to clear West Nile virus from infected neurons
    • Shrestha B, Samuel MA, Diamond MS. 2006. CD8+ T cells require perforin to clear West Nile virus from infected neurons. J Virol 80:119-129. http://dx.doi.org/10.1128/JVI.80.1.119-129.2006.
    • (2006) J Virol , vol.80 , pp. 119-129
    • Shrestha, B.1    Samuel, M.A.2    Diamond, M.S.3
  • 35
    • 0344736813 scopus 로고    scopus 로고
    • CD8+ T cells mediate recovery and immunopathology in West Nile virus encephalitis
    • Wang Y, Lobigs M, Lee E, Mullbacher A. 2003. CD8+ T cells mediate recovery and immunopathology in West Nile virus encephalitis. J Virol 77:13323-13334. http://dx.doi.org/10.1128/JVI.77.24.13323-13334.2003.
    • (2003) J Virol , vol.77 , pp. 13323-13334
    • Wang, Y.1    Lobigs, M.2    Lee, E.3    Mullbacher, A.4
  • 36
    • 79955001064 scopus 로고    scopus 로고
    • Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus
    • Qian F, Wang X, Zhang L, Lin A, Zhao H, Fikrig E, Montgomery RR. 2011. Impaired interferon signaling in dendritic cells from older donors infected in vitro with West Nile virus. J Infect Dis 203:1415-1424. http://dx.doi.org/10.1093/infdis/jir048.
    • (2011) J Infect Dis , vol.203 , pp. 1415-1424
    • Qian, F.1    Wang, X.2    Zhang, L.3    Lin, A.4    Zhao, H.5    Fikrig, E.6    Montgomery, R.R.7
  • 37
    • 33644752821 scopus 로고    scopus 로고
    • West Nile virus evades activation of interferon regulatory factor 3 through RIG-I-dependent and-independent pathways without antagonizing host defense signaling
    • Fredericksen BL, Gale M, Jr. 2006. West Nile virus evades activation of interferon regulatory factor 3 through RIG-I-dependent and-independent pathways without antagonizing host defense signaling. J Virol 80: 2913-2923. http://dx.doi.org/10.1128/JVI.80.6.2913-2923.2006.
    • (2006) J Virol , vol.80 , pp. 2913-2923
    • Fredericksen, B.L.1    Gale, M.2
  • 38
    • 55249084240 scopus 로고    scopus 로고
    • Toll-like receptor 3 has a protective role against West Nile virus infection
    • Daffis S, Samuel MA, Suthar MS, Gale M, Jr, Diamond MS. 2008. Toll-like receptor 3 has a protective role against West Nile virus infection. J Virol 82:10349-10358. http://dx.doi.org/10.1128/JVI.00935-08.
    • (2008) J Virol , vol.82 , pp. 10349-10358
    • Daffis, S.1    Samuel, M.A.2    Suthar, M.S.3    Gale, M.4    Diamond, M.S.5
  • 42
    • 84869044834 scopus 로고    scopus 로고
    • TLR7 recognition is dispensable for influenza virus A infection, but important for the induction of hemagglutinin-specific antibodies in response to the 2009 pandemic split vaccine in mice
    • Jeisy-Scott V, Kim JH, Davis WG, Cao W, Katz JM, Sambhara S. 2012. TLR7 recognition is dispensable for influenza virus A infection, but important for the induction of hemagglutinin-specific antibodies in response to the 2009 pandemic split vaccine in mice. J Virol 86:10988-10998. http://dx.doi.org/10.1128/JVI.01064-12.
    • (2012) J Virol , vol.86 , pp. 10988-10998
    • Jeisy-Scott, V.1    Kim, J.H.2    Davis, W.G.3    Cao, W.4    Katz, J.M.5    Sambhara, S.6
  • 43
    • 79957592934 scopus 로고    scopus 로고
    • Safety and immunogenicity of a chimeric vaccine for West Nile virus in aged subjects
    • Beasley DW. 2011. Safety and immunogenicity of a chimeric vaccine for West Nile virus in aged subjects. Expert Rev Vaccines 10:601-604. http://dx.doi.org/10.1586/erv.11.47.
    • (2011) Expert Rev Vaccines , vol.10 , pp. 601-604
    • Beasley, D.W.1
  • 44
    • 79955007859 scopus 로고    scopus 로고
    • Repeated in vivo stimulation of T and B cell responses in old mice generates protective immunity against lethal West Nile virus encephalitis
    • Uhrlaub JL, Brien JD, Widman DG, Mason PW, Nikolich-Zugich J. 2011. Repeated in vivo stimulation of T and B cell responses in old mice generates protective immunity against lethal West Nile virus encephalitis. J Immunol 186:3882-3891. http://dx.doi.org/10.4049/jimmunol.1002799.
    • (2011) J Immunol , vol.186 , pp. 3882-3891
    • Uhrlaub, J.L.1    Brien, J.D.2    Widman, D.G.3    Mason, P.W.4    Nikolich-Zugich, J.5
  • 47
    • 84879529796 scopus 로고    scopus 로고
    • Immunity versus immunopathology in West Nile virus induced encephalitis
    • Ruzek D (ed)
    • Wang T, Welte T, Saxena V, Xie G. 2011. Immunity versus immunopathology in West Nile virus induced encephalitis. In Ruzek D (ed), Flavivirus encephalitis InTech. http://dx.doi.org/10.5772/20355.
    • (2011) Flavivirus encephalitis InTech
    • Wang, T.1    Welte, T.2    Saxena, V.3    Xie, G.4
  • 48
    • 31144458579 scopus 로고    scopus 로고
    • Direct costimulatory effect of TLR3 ligand poly(I:C) on human gamma delta T lymphocytes
    • Wesch D, Beetz S, Oberg HH, Marget M, Krengel K, Kabelitz D. 2006. Direct costimulatory effect of TLR3 ligand poly(I:C) on human gamma delta T lymphocytes. J Immunol 176:1348-1354. http://dx.doi.org/10.4049/jimmunol.176.3.1348.
    • (2006) J Immunol , vol.176 , pp. 1348-1354
    • Wesch, D.1    Beetz, S.2    Oberg, H.H.3    Marget, M.4    Krengel, K.5    Kabelitz, D.6
  • 49
    • 84969372202 scopus 로고    scopus 로고
    • In vitro analysis of MyD88-mediated cellular immune response to West Nile virus mutant strain infection
    • Xie G, Whiteman MC, Wicker JA, Barrett AD, Wang T. 2014. In vitro analysis of MyD88-mediated cellular immune response to West Nile virus mutant strain infection. J Vis Exp http://dx.doi.org/10.3791/52121:e52121.
    • (2014) J Vis Exp
    • Xie, G.1    Whiteman, M.C.2    Wicker, J.A.3    Barrett, A.D.4    Wang, T.5
  • 50
    • 77951956835 scopus 로고    scopus 로고
    • Gammadelta T cells promote the maturation of dendritic cells during West Nile virus infection
    • Fang H, Welte T, Zheng X, Chang GJ, Holbrook MR, Soong L, Wang T. 2010. Gammadelta T cells promote the maturation of dendritic cells during West Nile virus infection. FEMS Immunol Med Microbiol 59:71-80. http://dx.doi.org/10.1111/j.1574-695X.2010.00663.x.
    • (2010) FEMS Immunol Med Microbiol , vol.59 , pp. 71-80
    • Fang, H.1    Welte, T.2    Zheng, X.3    Chang, G.J.4    Holbrook, M.R.5    Soong, L.6    Wang, T.7
  • 51
    • 78650647731 scopus 로고    scopus 로고
    • TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism
    • Jones SC, Brahmakshatriya V, Huston G, Dibble J, Swain SL. 2010. TLR-activated dendritic cells enhance the response of aged naive CD4 T cells via an IL-6-dependent mechanism. J Immunol 185:6783-6794. http://dx.doi.org/10.4049/jimmunol.0901296.
    • (2010) J Immunol , vol.185 , pp. 6783-6794
    • Jones, S.C.1    Brahmakshatriya, V.2    Huston, G.3    Dibble, J.4    Swain, S.L.5
  • 53
    • 79955780015 scopus 로고    scopus 로고
    • Expansion of regulatory T cells in aged mice following influenza infection
    • Williams-Bey Y, Jiang J, Murasko DM. 2011. Expansion of regulatory T cells in aged mice following influenza infection. Mech Ageing Dev 132: 163-170. http://dx.doi.org/10.1016/j.mad.2011.03.001.
    • (2011) Mech Ageing Dev , vol.132 , pp. 163-170
    • Williams-Bey, Y.1    Jiang, J.2    Murasko, D.M.3
  • 55
    • 79955142513 scopus 로고    scopus 로고
    • Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs
    • Hackl D, Loschko J, Sparwasser T, Reindl W, Krug AB. 2011. Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs. Eur J Immunol 41:1334-1343. http://dx.doi.org/10.1002/eji.201041014.
    • (2011) Eur J Immunol , vol.41 , pp. 1334-1343
    • Hackl, D.1    Loschko, J.2    Sparwasser, T.3    Reindl, W.4    Krug, A.B.5
  • 56
    • 79959718812 scopus 로고    scopus 로고
    • Treatment with the TLR7 agonist R848 induces regulatory T-cell-mediated suppression of established asthma symptoms
    • Van LP, Bardel E, Gregoire S, Vanoirbeek J, Schneider E, Dy M, Thieblemont N. 2011. Treatment with the TLR7 agonist R848 induces regulatory T-cell-mediated suppression of established asthma symptoms. Eur J Immunol 41:1992-1999. http://dx.doi.org/10.1002/eji.201040914.
    • (2011) Eur J Immunol , vol.41 , pp. 1992-1999
    • Van, L.P.1    Bardel, E.2    Gregoire, S.3    Vanoirbeek, J.4    Schneider, E.5    Dy, M.6    Thieblemont, N.7
  • 57
    • 74949117648 scopus 로고    scopus 로고
    • Signaling through TLR7 enhances the immunosuppressive activity of murine CD4+CD25+ T regulatory cells
    • Forward NA, Furlong SJ, Yang Y, Lin TJ, Hoskin DW. 2010. Signaling through TLR7 enhances the immunosuppressive activity of murine CD4+CD25+ T regulatory cells. J Leukoc Biol 87:117-125. http://dx.doi.org/10.1189/jlb.0908559.
    • (2010) J Leukoc Biol , vol.87 , pp. 117-125
    • Forward, N.A.1    Furlong, S.J.2    Yang, Y.3    Lin, T.J.4    Hoskin, D.W.5
  • 58
    • 0037450804 scopus 로고    scopus 로고
    • Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
    • Caramalho I, Lopes-Carvalho T, Ostler D, Zelenay S, Haury M, Demengeot J. 2003. Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J Exp Med 197:403-411. http://dx.doi.org/10.1084/jem.20021633.
    • (2003) J Exp Med , vol.197 , pp. 403-411
    • Caramalho, I.1    Lopes-Carvalho, T.2    Ostler, D.3    Zelenay, S.4    Haury, M.5    Demengeot, J.6
  • 59
    • 47749112908 scopus 로고    scopus 로고
    • Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly
    • Kong KF, Delroux K, Wang X, Qian F, Arjona A, Malawista SE, Fikrig E, Montgomery RR. 2008. Dysregulation of TLR3 impairs the innate immune response to West Nile virus in the elderly. J Virol 82:7613-7623. http://dx.doi.org/10.1128/JVI.00618-08.
    • (2008) J Virol , vol.82 , pp. 7613-7623
    • Kong, K.F.1    Delroux, K.2    Wang, X.3    Qian, F.4    Arjona, A.5    Malawista, S.E.6    Fikrig, E.7    Montgomery, R.R.8
  • 60
    • 80053092279 scopus 로고    scopus 로고
    • Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice
    • Jeisy-Scott V, Davis WG, Patel JR, Bowzard JB, Shieh WJ, Zaki SR, Katz JM, Sambhara S. 2011. Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice. PLoS One 6:e25242. http://dx.doi.org/10.1371/journal.pone.0025242.
    • (2011) PLoS One , vol.6
    • Jeisy-Scott, V.1    Davis, W.G.2    Patel, J.R.3    Bowzard, J.B.4    Shieh, W.J.5    Zaki, S.R.6    Katz, J.M.7    Sambhara, S.8
  • 61
    • 70149106207 scopus 로고    scopus 로고
    • A default pathway of memory CD8 T cell differentiation after dendritic cell immunization is deflected by encounter with inflammatory cytokines during antigendriven proliferation
    • Pham NL, Badovinac VP, Harty JT. 2009. A default pathway of memory CD8 T cell differentiation after dendritic cell immunization is deflected by encounter with inflammatory cytokines during antigendriven proliferation. J Immunol 183:2337-2348. http://dx.doi.org/10.4049/jimmunol.0901203.
    • (2009) J Immunol , vol.183 , pp. 2337-2348
    • Pham, N.L.1    Badovinac, V.P.2    Harty, J.T.3
  • 62
    • 76249100916 scopus 로고    scopus 로고
    • TLR2 engagement on dendritic cells promotes high frequency effector and memory CD4 T cell responses
    • Chandran SS, Verhoeven D, Teijaro JR, Fenton MJ, Farber DL. 2009. TLR2 engagement on dendritic cells promotes high frequency effector and memory CD4 T cell responses. J Immunol 183:7832-7841. http://dx.doi.org/10.4049/jimmunol.0901683.
    • (2009) J Immunol , vol.183 , pp. 7832-7841
    • Chandran, S.S.1    Verhoeven, D.2    Teijaro, J.R.3    Fenton, M.J.4    Farber, D.L.5
  • 63
    • 10844235608 scopus 로고    scopus 로고
    • Reciprocal activating interaction between dendritic cells and pamidronate-stimulated gammadelta T cells: role of CD86 and inflammatory cytokines
    • Conti L, Casetti R, Cardone M, Varano B, Martino A, Belardelli F, Poccia F, Gessani S. 2005. Reciprocal activating interaction between dendritic cells and pamidronate-stimulated gammadelta T cells: role of CD86 and inflammatory cytokines. J Immunol 174:252-260. http://dx.doi.org/10.4049/jimmunol.174.1.252.
    • (2005) J Immunol , vol.174 , pp. 252-260
    • Conti, L.1    Casetti, R.2    Cardone, M.3    Varano, B.4    Martino, A.5    Belardelli, F.6    Poccia, F.7    Gessani, S.8
  • 65
    • 0034680811 scopus 로고    scopus 로고
    • Regulation of antigenspecific CD8+T cell homeostasis by perforin and interferon-gamma
    • Badovinac VP, Tvinnereim AR, Harty JT. 2000. Regulation of antigenspecific CD8+T cell homeostasis by perforin and interferon-gamma. Science 290:1354-1358. http://dx.doi.org/10.1126/science.290.5495.1354.
    • (2000) Science , vol.290 , pp. 1354-1358
    • Badovinac, V.P.1    Tvinnereim, A.R.2    Harty, J.T.3
  • 66
    • 18344362061 scopus 로고    scopus 로고
    • Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation
    • Curtsinger JM, Valenzuela JO, Agarwal P, Lins D, Mescher MF. 2005. Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation. J Immunol 174:4465-4469. http://dx.doi.org/10.4049/jimmunol.174.8.4465.
    • (2005) J Immunol , vol.174 , pp. 4465-4469
    • Curtsinger, J.M.1    Valenzuela, J.O.2    Agarwal, P.3    Lins, D.4    Mescher, M.F.5
  • 67
    • 64849085607 scopus 로고    scopus 로고
    • Programming for CD8 T cell memory development requires IL-12 or type I IFN
    • Xiao Z, Casey KA, Jameson SC, Curtsinger JM, Mescher MF. 2009. Programming for CD8 T cell memory development requires IL-12 or type I IFN. J Immunol 182:2786-2794. http://dx.doi.org/10.4049/jimmunol.0803484.
    • (2009) J Immunol , vol.182 , pp. 2786-2794
    • Xiao, Z.1    Casey, K.A.2    Jameson, S.C.3    Curtsinger, J.M.4    Mescher, M.F.5
  • 69
    • 36749022938 scopus 로고    scopus 로고
    • CpG oligonucleotides as adjuvant in therapeutic vaccines against parasitic infections
    • Zimmermann S, Dalpke A, Heeg K. 2008. CpG oligonucleotides as adjuvant in therapeutic vaccines against parasitic infections. Int J Med Microbiol 298:39-44. http://dx.doi.org/10.1016/j.ijmm.2007.07.011.
    • (2008) Int J Med Microbiol , vol.298 , pp. 39-44
    • Zimmermann, S.1    Dalpke, A.2    Heeg, K.3
  • 71
    • 56649108016 scopus 로고    scopus 로고
    • Engagement of TLR signaling as adjuvant: towards smarter vaccine and beyond
    • Lahiri A, Das P, Chakravortty D. 2008. Engagement of TLR signaling as adjuvant: towards smarter vaccine and beyond. Vaccine 26:6777-6783. http://dx.doi.org/10.1016/j.vaccine.2008.09.045.
    • (2008) Vaccine , vol.26 , pp. 6777-6783
    • Lahiri, A.1    Das, P.2    Chakravortty, D.3
  • 73
    • 84880856650 scopus 로고    scopus 로고
    • The use of Toll-like receptor 7/8 agonists as vaccine adjuvants
    • Vasilakos JP, Tomai MA. 2013. The use of Toll-like receptor 7/8 agonists as vaccine adjuvants. Expert Rev Vaccines 12:809-819. http://dx.doi.org/10.1586/14760584.2013.811208.
    • (2013) Expert Rev Vaccines , vol.12 , pp. 809-819
    • Vasilakos, J.P.1    Tomai, M.A.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.