A West Nile virus NS4B-P38G mutant strain induces cell intrinsic innate cytokine responses in human monocytic and macrophage cells

Vaccine

Volumn 33, Issue 7, 2015, Pages 869-878

  Xie, Guorui ^a   Luo, Huanle ^a   Tian, Bing ^a   Mann, Brian ^a   Bao, Xiaoyong ^a   McBride, Jere ^a   Tesh, Robert ^a   Barrett, Alan D ^a   Wang, Tian ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

Author keywords

Cytokine; Immune response; NS4B protein; West Nile virus

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CASPASE 9; CYTOKINE; GAMMA INTERFERON INDUCIBLE PROTEIN 10; I KAPPA B ALPHA; I KAPPA B KINASE BETA; INTERLEUKIN 12; INTERLEUKIN 12P40; INTERLEUKIN 19; INTERLEUKIN 1BETA; INTERLEUKIN 6; NONSTRUCTURAL PROTEIN 4B; RANTES; RETINOIC ACID INDUCIBLE PROTEIN I; STAT1 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 1; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 7; TUMOR NECROSIS FACTOR ALPHA; WEST NILE VACCINE; VIRUS RNA;

ANIMAL CELL; ARTICLE; CYTOKINE RESPONSE; GENE EXPRESSION; HUMAN; HUMAN CELL; IMMUNOGENICITY; INNATE IMMUNITY; MACROPHAGE; MONOCYTE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; VERO CELL LINE; VIRUS LOAD; WEST NILE FEVER; WEST NILE FLAVIVIRUS; ANIMAL; CELL LINE; GENETICS; IMMUNOLOGY; METABOLISM; MOUSE; PATHOGENICITY; POLYMERASE CHAIN REACTION; VIROLOGY; WEST NILE VIRUS;

ANIMALS; CELL LINE; CYTOKINES; HUMANS; INTERLEUKIN-12; INTERLEUKIN-1BETA; INTERLEUKIN-6; MACROPHAGES; MICE; MONOCYTES; POLYMERASE CHAIN REACTION; RNA, VIRAL; TUMOR NECROSIS FACTOR-ALPHA; WEST NILE VIRUS;

EID: 84921722508     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2014.12.056     Document Type: Article

References (44)

1. Petersen L.R., Brault A.C., Nasci R.S. West Nile virus: review of the literature. JAMA 2013, 310(Jul (3)):308-315.
2. Gubler D.J. The continuing spread of West Nile virus in the western hemisphere. Clin Infect Dis 2007, 45(Oct (8)):1039-1046.
3. Kramer L.D., Styer L.M., Ebel G.D. A global perspective on the epidemiology of West Nile virus. Annu Rev Entomol 2008, 53:61-81.
4. Carson P.J., Konewko P., Wold K.S., Mariani P., Goli S., Bergloff P., et al. Long-term clinical and neuropsychological outcomes of West Nile virus infection. Clin Infect Dis 2006, 43(Sep (6)):723-730.
5. Ravindra K.V., Freifeld A.G., Kalil A.C., Mercer D.F., Grant W.J., Botha J.F., et al. West Nile virus-associated encephalitis in recipients of renal and pancreas transplants: case series and literature review. Clin Infect Dis 2004, 38(May (9)):1257-1260.
6. Ou A.C., Ratard R.C. One-year sequelae in patients with West Nile Virus encephalitis and meningitis in Louisiana. J La State Med Soc 2005, 157(Jan-Feb (1)):42-46.
7. Cook R.L., Xu X., Yablonsky E.J., Sakata N., Tripp J.H., Hess R., et al. Demographic and clinical factors associated with persistent symptoms after West Nile virus infection. Am J Trop Med Hyg 2010, 83(Nov (5)):1133-1136.
8. Sadek J.R., Pergam S.A., Harrington J.A., Echevarria L.A., Davis L.E., Goade D., et al. Persistent neuropsychological impairment associated with West Nile virus infection. J Clin Exp Neuropsychol 2010, 32(1):81-87.
9. Anderson J.F., Andreadis T.G., Vossbrinck C.R., Tirrell S., Wakem E.M., French R.A., et al. Isolation of West Nile virus from mosquitoes, crows, and a Cooper's hawk in Connecticut. Science 1999, 286(5448):2331-2333.
10. Lanciotti R.S., Roehrig J.T., Deubel V., Smith J., Parker M., Steele K., et al. Origin of the West Nile virus responsible for an outbreak of encephalitis in the northeastern United States. Science 1999, 286(5448):2333-2337.
11. Wilson J.R., de Sessions P.F., Leon M.A., Scholle F. West Nile virus nonstructural protein 1 inhibits TLR3 signal transduction. J Virol 2008, 82(Sep (17)):8262-8271.
12. Scholle F., Mason P.W. West Nile virus replication interferes with both poly(I:C)-induced interferon gene transcription and response to interferon treatment. Virology 2005, 342(Nov (1)):77-87.
13. Diamond M.S. Mechanisms of evasion of the type I interferon antiviral response by flaviviruses. J Interferon Cytokine Res 2009, 29(Sep (9)):521-530.
14. Munoz-Jordan J.L., Sanchez-Burgos G.G., Laurent-Rolle M., Garcia-Sastre A. Inhibition of interferon signaling by dengue virus. Proc Natl Acad Sci USA 2003, 100(Nov (24)):14333-14338.
15. Wicker J.A., Whiteman M.C., Beasley D.W., Davis C.T., McGee C.E., Lee J.C., et al. Mutational analysis of the West Nile virus NS4B protein. Virology 2012, 426(Apr (1)):22-33.
16. Van Slyke G.A., Jia Y., Whiteman M.C., Wicker J.A., Barrett A.D., Kramer L.D. Vertebrate attenuated West Nile virus mutants have differing effects on vector competence in Culex tarsalis mosquitoes. J Gen Virol 2013, 94(May (Pt 5)):1069-1072.
17. Welte T., Xie G., Wicker J.A., Whiteman M.C., Li L., Rachamallu A., et al. Immune responses to an attenuated West Nile virus NS4B-P38G mutant strain. Vaccine 2011, 29(Jun (29-30)):4853-4861.
18. Xie G., Welte T., Wang J., Whiteman M.C., Wicker J.A., Saxena V., et al. A West Nile virus NS4B-P38G mutant strain induces adaptive immunity via TLR7-MyD88-dependent and independent signaling pathways. Vaccine 2013, 31(Aug (38)):4143-4151.
19. Park E.K., Jung H.S., Yang H.I., Yoo M.C., Kim C., Kim K.S. Optimized THP-1 differentiation is required for the detection of responses to weak stimuli. Inflamm Res 2007, 56(1):45-50.
20. Lanciotti R.S., Kerst A.J., Nasci R.S., Godsey M.S., Mitchell C.J., Savage H.M., et al. Rapid detection of West Nile virus from human clinical specimens, field- collected mosquitoes, and avian samples by a TaqMan reverse transcriptase-PCR assay. J Clin Microbiol 2000, 38(11):4066-4071.
21. Colmont C.S., Raby A.C., Dioszeghy V., Lebouder E., Foster T.L., Jones S.A., et al. Human peritoneal mesothelial cells respond to bacterial ligands through a specific subset of Toll-like receptors. Nephrol Dial Transplant 2011, 26(12):4079-4090.
22. Shen N., Fu Q., Deng Y., Qian X., Zhao J., Kaufman K.M., et al. Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus. Proc Natl Acad Sci USA 2010, 107(Sep (36)):15838-15843.
23. Zhang N.N., Shen S.H., Jiang L.J., Zhang W., Zhang H.X., Sun Y.P., et al. RIG-I plays a critical role in negatively regulating granulocytic proliferation. Proc Natl Acad Sci USA 2008, 105(Jul (30)):10553-10558.
24. Welte T., Aronson J., Gong B., Rachamallu A., Mendell N., Tesh R., et al. Vgamma4+ T cells regulate host immune response to West Nile virus infection. FEMS Immunol Med Microbiol 2011, 63(Nov (2)):183-192.
25. Mather T., Takeda T., Tassello J., Ohagen A., Serebryanik D., Kramer E., et al. West Nile virus in blood: stability, distribution, and susceptibility to PEN110 inactivation. Transfusion 2003, 43(8):1029-1037.
26. Tsai Y.T., Chang S.Y., Lee C.N., Kao C.L. Human TLR3 recognizes dengue virus and modulates viral replication in vitro. Cell Microbiol 2009, 11(4):604-615.
27. Indoh T., Yokota S., Okabayashi T., Yokosawa N., Fujii N. Suppression of NF-kappaB and AP-1 activation in monocytic cells persistently infected with measles virus. Virology 2007, 361(May (2)):294-303.
28. Uehara A., Iwashiro A., Sato T., Yokota S., Takada H. Antibodies to proteinase 3 prime human monocytic cells via protease-activated receptor-2 and NF-kappaB for Toll-like receptor- and NOD-dependent activation. Mol Immunol 2007, 44(Jul (14)):3552-3562.
29. Verma R., Jung J.H., Kim J.Y. 1,25-Dihydroxyvitamin D3 up-regulates TLR10 while down-regulating TLR2, 4, and 5 in human monocyte THP-1. J Steroid Biochem Mol Biol 2014, 141(May):1-6.
30. Navarro-Sanchez E., Altmeyer R., Amara A., Schwartz O., Fieschi F., Virelizier J.L., et al. Dendritic-cell-specific ICAM3-grabbing non-integrin is essential for the productive infection of human dendritic cells by mosquito-cell-derived dengue viruses. EMBO Rep 2003, 4(7):723-728.
31. Munoz-Jordan J.L., Laurent-Rolle M., Ashour J., Martinez-Sobrido L., Ashok M., Lipkin W.I., et al. Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses. J Virol 2005, 79(Jul (13)):8004-8013.
32. Liu W.J., Wang X.J., Mokhonov V.V., Shi P.Y., Randall R., Khromykh A.A. Inhibition of interferon signaling by the New York 99 strain and Kunjin subtype of West Nile virus involves blockage of STAT1 and STAT2 activation by nonstructural proteins. J Virol 2005, 79(Feb (3)):1934-1942.
33. Evans J.D., Seeger C. Differential effects of mutations in NS4B on West Nile virus replication and inhibition of interferon signaling. J Virol 2007, 81(Nov (21)):11809-11816.
34. Shi P.Y. Structural biology. Unraveling a flavivirus enigma. Science 2014, 343(Feb (6173)):849-850.
35. Davis C.T., Beasley D.W., Guzman H., Siirin M., Parsons R.E., Tesh R.B., et al. Emergence of attenuated West Nile virus variants in Texas, 2003. Virology 2004, 330(Dec (1)):342-350.
36. Hanley K.A., Manlucu L.R., Gilmore L.E., Blaney J.E., Hanson C.T., Murphy B.R., et al. A trade-off in replication in mosquito versus mammalian systems conferred by a point mutation in the NS4B protein of dengue virus type 4. Virology 2003, 312(Jul (1)):222-232.
37. Puig-Basagoiti F., Tilgner M., Bennett C.J., Zhou Y., Munoz-Jordan J.L., Garcia-Sastre A., et al. A mouse cell-adapted NS4B mutation attenuates West Nile virus RNA synthesis. Virology 2007, 361(Apr (1)):229-241.
38. Zou J., Xie X., Lee le T., Chandrasekaran R., Reynaud A., Yap L., et al. Dimerization of flavivirus NS4B protein. J Virol 2014, 88(Mar (6)):3379-3391.
39. Grant D., Tan G.K., Qing M., Ng J.K., Yip A., Zou G., et al. A single amino acid in nonstructural protein NS4B confers virulence to dengue virus in AG129 mice through enhancement of viral RNA synthesis. J Virol 2011, 85(Aug (15)):7775-7787.
40. Kaufusi P.H., Kelley J.F., Yanagihara R., Nerurkar V.R. Induction of endoplasmic reticulum-derived replication-competent membrane structures by West Nile virus non-structural protein 4B. PLoS One 2014, 9(1):e84040.
41. Youn S., Li T., McCune B.T., Edeling M.A., Fremont D.H., Cristea I.M., et al. Evidence for a genetic and physical interaction between nonstructural proteins NS1 and NS4B that modulates replication of West Nile virus. J Virol 2012, 86(Jul (13)):7360-7371.
42. Umareddy I., Chao A., Sampath A., Gu F., Vasudevan S.G. Dengue virus NS4B interacts with NS3 and dissociates it from single-stranded RNA. J Gen Virol 2006, 87(Sep (Pt 9)):2605-2614.
43. Isakov N. ITIMs and ITAMs, The Yin and Yang of antigen and Fc receptor-linked signaling machinery. Immunol Res 1997, 16(Feb (1)):85-100.
44. Rios M., Zhang M.J., Grinev A., Srinivasan K., Daniel S., Wood O., et al. Monocytes-macrophages are a potential target in human infection with West Nile virus through blood transfusion. Transfusion 2006, 46(4):659-667.