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Volumn 41, Issue 5, 2011, Pages 1334-1343

Activation of dendritic cells via TLR7 reduces Foxp3 expression and suppressive function in induced Tregs

Author keywords

DCs; Systemic lupus erythematosus; TLR7; Treg cells

Indexed keywords

INTERLEUKIN 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 9; TRANSCRIPTION FACTOR FOXP3;

EID: 79955142513     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201041014     Document Type: Article
Times cited : (49)

References (36)
  • 1
    • 26844467349 scopus 로고    scopus 로고
    • Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus
    • Barrat, F. J., Meeker, T., Gregorio, J., Chan, J. H., Uematsu, S., Akira, S., Chang, B. et al., Nucleic acids of mammalian origin can act as endogenous ligands for Toll-like receptors and may promote systemic lupus erythematosus. J. Exp. Med. 2005. 202: 1131-1139.
    • (2005) J. Exp. Med. , vol.202 , pp. 1131-1139
    • Barrat, F.J.1    Meeker, T.2    Gregorio, J.3    Chan, J.H.4    Uematsu, S.5    Akira, S.6    Chang, B.7
  • 2
    • 1542317550 scopus 로고    scopus 로고
    • Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA
    • Diebold, S. S., Kaisho, T., Hemmi, H., Akira, S. and Reis e Sousa, C., Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004. 303: 1529-1531.
    • (2004) Science , vol.303 , pp. 1529-1531
    • Diebold, S.S.1    Kaisho, T.2    Hemmi, H.3    Akira, S.4    Reis e Sousa, C.5
  • 3
    • 1542317578 scopus 로고    scopus 로고
    • Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8
    • Heil, F., Hemmi, H., Hochrein, H., Ampenberger, F., Kirschning, C., Akira, S., Lipford, G. et al., Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 2004. 303: 1526-1529.
    • (2004) Science , vol.303 , pp. 1526-1529
    • Heil, F.1    Hemmi, H.2    Hochrein, H.3    Ampenberger, F.4    Kirschning, C.5    Akira, S.6    Lipford, G.7
  • 4
    • 27744444832 scopus 로고    scopus 로고
    • RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement
    • Lau, C. M., Broughton, C., Tabor, A. S., Akira, S., Flavell, R. A., Mamula, M. J., Christensen, S. R. et al., RNA-associated autoantigens activate B cells by combined B cell antigen receptor/Toll-like receptor 7 engagement. J. Exp. Med. 2005. 202: 1171-1177.
    • (2005) J. Exp. Med. , vol.202 , pp. 1171-1177
    • Lau, C.M.1    Broughton, C.2    Tabor, A.S.3    Akira, S.4    Flavell, R.A.5    Mamula, M.J.6    Christensen, S.R.7
  • 5
    • 33645741218 scopus 로고    scopus 로고
    • U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7
    • Savarese, E., Chae, O. W., Trowitzsch, S., Weber, G., Kastner, B., Akira, S., Wagner, H. et al., U1 small nuclear ribonucleoprotein immune complexes induce type I interferon in plasmacytoid dendritic cells through TLR7. Blood 2006. 107: 3229-3234.
    • (2006) Blood , vol.107 , pp. 3229-3234
    • Savarese, E.1    Chae, O.W.2    Trowitzsch, S.3    Weber, G.4    Kastner, B.5    Akira, S.6    Wagner, H.7
  • 6
    • 28544449709 scopus 로고    scopus 로고
    • Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8
    • Vollmer, J., Tluk, S., Schmitz, C., Hamm, S., Jurk, M., Forsbach, A., Akira, S. et al., Immune stimulation mediated by autoantigen binding sites within small nuclear RNAs involves Toll-like receptors 7 and 8. J. Exp. Med. 2005. 202: 1575-1585.
    • (2005) J. Exp. Med. , vol.202 , pp. 1575-1585
    • Vollmer, J.1    Tluk, S.2    Schmitz, C.3    Hamm, S.4    Jurk, M.5    Forsbach, A.6    Akira, S.7
  • 7
    • 38949117752 scopus 로고    scopus 로고
    • Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination
    • Koyama, S., Ishii, K. J., Kumar, H., Tanimoto, T., Coban, C., Uematsu, S., Kawai, T. and Akira, S., Differential role of TLR- and RLR-signaling in the immune responses to influenza A virus infection and vaccination. J. Immunol. 2007. 179: 4711-4720.
    • (2007) J. Immunol. , vol.179 , pp. 4711-4720
    • Koyama, S.1    Ishii, K.J.2    Kumar, H.3    Tanimoto, T.4    Coban, C.5    Uematsu, S.6    Kawai, T.7    Akira, S.8
  • 8
    • 50549089824 scopus 로고    scopus 로고
    • Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupus
    • Anders, H. J., Krug, A. and Pawar, R. D., Molecular mimicry in innate immunity? The viral RNA recognition receptor TLR7 accelerates murine lupus. Eur. J. Immunol. 2008. 38: 1795-1799.
    • (2008) Eur. J. Immunol. , vol.38 , pp. 1795-1799
    • Anders, H.J.1    Krug, A.2    Pawar, R.D.3
  • 9
    • 33748470505 scopus 로고    scopus 로고
    • Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice
    • Berland, R., Fernandez, L., Kari, E., Han, J. H., Lomakin, I., Akira, S., Wortis, H. H. et al., Toll-like receptor 7-dependent loss of B cell tolerance in pathogenic autoantibody knockin mice. Immunity 2006. 25: 429-440.
    • (2006) Immunity , vol.25 , pp. 429-440
    • Berland, R.1    Fernandez, L.2    Kari, E.3    Han, J.H.4    Lomakin, I.5    Akira, S.6    Wortis, H.H.7
  • 10
    • 33748472865 scopus 로고    scopus 로고
    • Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus
    • Christensen, S. R., Shupe, J., Nickerson, K., Kashgarian, M., Flavell, R. A. and Shlomchik, M. J., Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. Immunity 2006. 25: 417-428.
    • (2006) Immunity , vol.25 , pp. 417-428
    • Christensen, S.R.1    Shupe, J.2    Nickerson, K.3    Kashgarian, M.4    Flavell, R.A.5    Shlomchik, M.J.6
  • 11
    • 36048962438 scopus 로고    scopus 로고
    • Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation
    • Deane, J. A., Pisitkun, P., Barrett, R. S., Feigenbaum, L., Town, T., Ward, J. M., Flavell, R. A. and Bolland, S., Control of toll-like receptor 7 expression is essential to restrict autoimmunity and dendritic cell proliferation. Immunity 2007. 27: 801-810.
    • (2007) Immunity , vol.27 , pp. 801-810
    • Deane, J.A.1    Pisitkun, P.2    Barrett, R.S.3    Feigenbaum, L.4    Town, T.5    Ward, J.M.6    Flavell, R.A.7    Bolland, S.8
  • 13
    • 42449117483 scopus 로고    scopus 로고
    • Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis
    • Savarese, E., Steinberg, C., Pawar, R. D., Reindl, W., Akira, S., Anders, H. J. and Krug, A., Requirement of Toll-like receptor 7 for pristane-induced production of autoantibodies and development of murine lupus nephritis. Arthritis Rheum. 2008. 58: 1107-1115.
    • (2008) Arthritis Rheum. , vol.58 , pp. 1107-1115
    • Savarese, E.1    Steinberg, C.2    Pawar, R.D.3    Reindl, W.4    Akira, S.5    Anders, H.J.6    Krug, A.7
  • 14
    • 8444245925 scopus 로고    scopus 로고
    • Toll-dependent control mechanisms of CD4 T cell activation
    • Pasare, C. and Medzhitov, R., Toll-dependent control mechanisms of CD4 T cell activation. Immunity 2004. 21: 733-741.
    • (2004) Immunity , vol.21 , pp. 733-741
    • Pasare, C.1    Medzhitov, R.2
  • 15
    • 44849130760 scopus 로고    scopus 로고
    • T-regulatory cells in systemic lupus erythematosus
    • La Cava, A., T-regulatory cells in systemic lupus erythematosus. Lupus 2008. 17: 421-425.
    • (2008) Lupus , vol.17 , pp. 421-425
    • La Cava, A.1
  • 16
    • 29144516273 scopus 로고    scopus 로고
    • Global natural regulatory T cell depletion in active systemic lupus erythematosus
    • Miyara, M., Amoura, Z., Parizot, C., Badoual, C., Dorgham, K., Trad, S., Nochy, D. et al., Global natural regulatory T cell depletion in active systemic lupus erythematosus. J. Immunol. 2005. 175: 8392-8400.
    • (2005) J. Immunol. , vol.175 , pp. 8392-8400
    • Miyara, M.1    Amoura, Z.2    Parizot, C.3    Badoual, C.4    Dorgham, K.5    Trad, S.6    Nochy, D.7
  • 17
    • 33846900430 scopus 로고    scopus 로고
    • Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus
    • Valencia, X., Yarboro, C., Illei, G. and Lipsky, P. E., Deficient CD4+CD25high T regulatory cell function in patients with active systemic lupus erythematosus. J. Immunol. 2007. 178: 2579-2588.
    • (2007) J. Immunol. , vol.178 , pp. 2579-2588
    • Valencia, X.1    Yarboro, C.2    Illei, G.3    Lipsky, P.E.4
  • 18
    • 33845948381 scopus 로고    scopus 로고
    • IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+CD25+ T cell regulatory functions
    • Wan, S., Xia, C. and Morel, L., IL-6 produced by dendritic cells from lupus-prone mice inhibits CD4+CD25+ T cell regulatory functions. J. Immunol. 2007. 178: 271-279.
    • (2007) J. Immunol. , vol.178 , pp. 271-279
    • Wan, S.1    Xia, C.2    Morel, L.3
  • 20
    • 74949117648 scopus 로고    scopus 로고
    • Signaling through TLR7 enhances the immunosuppressive activity of murine CD4+CD25+ T regulatory cells
    • Forward, N. A., Furlong, S. J., Yang, Y., Lin, T. J. and Hoskin, D. W., Signaling through TLR7 enhances the immunosuppressive activity of murine CD4+CD25+ T regulatory cells. J. Leukoc. Biol. 2010. 87: 117-125.
    • (2010) J. Leukoc. Biol. , vol.87 , pp. 117-125
    • Forward, N.A.1    Furlong, S.J.2    Yang, Y.3    Lin, T.J.4    Hoskin, D.W.5
  • 21
    • 0037450804 scopus 로고    scopus 로고
    • Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide
    • Caramalho, I., Lopes-Carvalho, T., Ostler, D., Zelenay, S., Haury, M. and Demengeot, J., Regulatory T cells selectively express toll-like receptors and are activated by lipopolysaccharide. J. Exp. Med. 2003. 197: 403-411.
    • (2003) J. Exp. Med. , vol.197 , pp. 403-411
    • Caramalho, I.1    Lopes-Carvalho, T.2    Ostler, D.3    Zelenay, S.4    Haury, M.5    Demengeot, J.6
  • 22
    • 36749007248 scopus 로고    scopus 로고
    • Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells
    • Wei, J., Duramad, O., Perng, O. A., Reiner, S. L., Liu, Y. J. and Qin, F. X., Antagonistic nature of T helper 1/2 developmental programs in opposing peripheral induction of Foxp3+ regulatory T cells. Proc. Natl. Acad. Sci. USA 2007. 104: 18169-18174.
    • (2007) Proc. Natl. Acad. Sci. USA , vol.104 , pp. 18169-18174
    • Wei, J.1    Duramad, O.2    Perng, O.A.3    Reiner, S.L.4    Liu, Y.J.5    Qin, F.X.6
  • 23
    • 33847125247 scopus 로고    scopus 로고
    • Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression
    • Wan, Y. Y. and Flavell, R. A., Regulatory T-cell functions are subverted and converted owing to attenuated Foxp3 expression. Nature 2007. 445: 766-770.
    • (2007) Nature , vol.445 , pp. 766-770
    • Wan, Y.Y.1    Flavell, R.A.2
  • 24
    • 10744221289 scopus 로고    scopus 로고
    • Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells
    • Huehn, J., Siegmund, K., Lehmann, J. C., Siewert, C., Haubold, U., Feuerer, M., Debes, G. F. et al., Developmental stage, phenotype, and migration distinguish naive- and effector/memory-like CD4+ regulatory T cells. J. Exp. Med. 2004. 199: 303-313.
    • (2004) J. Exp. Med. , vol.199 , pp. 303-313
    • Huehn, J.1    Siegmund, K.2    Lehmann, J.C.3    Siewert, C.4    Haubold, U.5    Feuerer, M.6    Debes, G.F.7
  • 25
    • 52649147984 scopus 로고    scopus 로고
    • In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease
    • Zhao, D., Zhang, C., Yi, T., Lin, C. L., Todorov, I., Kandeel, F., Forman, S. and Zeng, D., In vivo-activated CD103+CD4+ regulatory T cells ameliorate ongoing chronic graft-versus-host disease. Blood 2008. 112: 2129-2138.
    • (2008) Blood , vol.112 , pp. 2129-2138
    • Zhao, D.1    Zhang, C.2    Yi, T.3    Lin, C.L.4    Todorov, I.5    Kandeel, F.6    Forman, S.7    Zeng, D.8
  • 27
    • 53349164200 scopus 로고    scopus 로고
    • Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses
    • Hall, J. A., Bouladoux, N., Sun, C. M., Wohlfert, E. A., Blank, R. B., Zhu, Q., Grigg, M. E. et al., Commensal DNA limits regulatory T cell conversion and is a natural adjuvant of intestinal immune responses. Immunity 2008. 29: 637-649.
    • (2008) Immunity , vol.29 , pp. 637-649
    • Hall, J.A.1    Bouladoux, N.2    Sun, C.M.3    Wohlfert, E.A.4    Blank, R.B.5    Zhu, Q.6    Grigg, M.E.7
  • 28
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli, E., Carrier, Y., Gao, W., Korn, T., Strom, T. B., Oukka, M., Weiner, H. L. and Kuchroo, V. K., Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 2006. 441: 235-238.
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6    Weiner, H.L.7    Kuchroo, V.K.8
  • 29
    • 57449112782 scopus 로고    scopus 로고
    • IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells
    • Korn, T., Mitsdoerffer, M., Croxford, A. L., Awasthi, A., Dardalhon, V. A., Galileos, G., Vollmar, P. et al., IL-6 controls Th17 immunity in vivo by inhibiting the conversion of conventional T cells into Foxp3+ regulatory T cells. Proc. Natl. Acad. Sci. USA 2008. 105: 18460-18465.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 18460-18465
    • Korn, T.1    Mitsdoerffer, M.2    Croxford, A.L.3    Awasthi, A.4    Dardalhon, V.A.5    Galileos, G.6    Vollmar, P.7
  • 30
    • 45149109643 scopus 로고    scopus 로고
    • In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells
    • Lochner, M., Peduto, L., Cherrier, M., Sawa, S., Langa, F., Varona, R., Riethmacher, D. et al., In vivo equilibrium of proinflammatory IL-17+ and regulatory IL-10+ Foxp3+ RORgamma t+ T cells. J. Exp. Med. 2008. 205: 1381-1393.
    • (2008) J. Exp. Med. , vol.205 , pp. 1381-1393
    • Lochner, M.1    Peduto, L.2    Cherrier, M.3    Sawa, S.4    Langa, F.5    Varona, R.6    Riethmacher, D.7
  • 31
    • 46749138596 scopus 로고    scopus 로고
    • Molecular antagonism and plasticity of regulatory and inflammatory T cell programs
    • Yang, X. O., Nurieva, R., Martinez, G. J., Kang, H. S., Chung, Y., Pappu, B. P., Shah, B. et al., Molecular antagonism and plasticity of regulatory and inflammatory T cell programs. Immunity 2008. 29: 44-56.
    • (2008) Immunity , vol.29 , pp. 44-56
    • Yang, X.O.1    Nurieva, R.2    Martinez, G.J.3    Kang, H.S.4    Chung, Y.5    Pappu, B.P.6    Shah, B.7
  • 32
    • 59849085588 scopus 로고    scopus 로고
    • Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation
    • Lal, G., Zhang, N., van der Touw, W., Ding, Y., Ju, W., Bottinger, E. P., Reid, S. P. et al., Epigenetic regulation of Foxp3 expression in regulatory T cells by DNA methylation. J. Immunol. 2009. 182: 259-273.
    • (2009) J. Immunol. , vol.182 , pp. 259-273
    • Lal, G.1    Zhang, N.2    van der Touw, W.3    Ding, Y.4    Ju, W.5    Bottinger, E.P.6    Reid, S.P.7
  • 33
    • 52949138267 scopus 로고    scopus 로고
    • TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3
    • Samanta, A., Li, B., Song, X., Bembas, K., Zhang, G., Katsumata, M., Saouaf, S. J. et al., TGF-beta and IL-6 signals modulate chromatin binding and promoter occupancy by acetylated FOXP3. Proc. Natl. Acad. Sci. USA 2008. 105: 14023-14027.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 14023-14027
    • Samanta, A.1    Li, B.2    Song, X.3    Bembas, K.4    Zhang, G.5    Katsumata, M.6    Saouaf, S.J.7
  • 34
    • 0037436119 scopus 로고    scopus 로고
    • Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells
    • Pasare, C. and Medzhitov, R., Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells. Science 2003. 299: 1033-1036.
    • (2003) Science , vol.299 , pp. 1033-1036
    • Pasare, C.1    Medzhitov, R.2
  • 35
    • 0036008014 scopus 로고    scopus 로고
    • Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway
    • Hemmi, H., Kaisho, T., Takeuchi, O., Sato, S., Sanjo, H., Hoshino, K., Horiuchi, T. et al., Small anti-viral compounds activate immune cells via the TLR7 MyD88-dependent signaling pathway. Nat. Immunol. 2002. 3: 196-200.
    • (2002) Nat. Immunol. , vol.3 , pp. 196-200
    • Hemmi, H.1    Kaisho, T.2    Takeuchi, O.3    Sato, S.4    Sanjo, H.5    Hoshino, K.6    Horiuchi, T.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.