A default pathway of memory CD8 T cell differentiation after dendritic cell immunization is deflected by encounter with inflammatory cytokines during antigen-driven proliferation

Journal of Immunology

Volumn 183, Issue 4, 2009, Pages 2337-2348

  Pham, Nhat Long L ^a   Badovinac, Vladimir P ^a,b   Harty, John T ^a  

^a UNIVERSITY OF IOWA   (United States)

^b UNIVERSITY OF IOWA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIGEN; TOLL LIKE RECEPTOR; AUTACOID; CPG ODN 1826; CYTOKINE; DNA; OVALBUMIN; OVALBUMIN (257 64), MOUSE; OVALBUMIN (257-64), MOUSE; PEPTIDE FRAGMENT; TLR9 PROTEIN, MOUSE; TOLL LIKE RECEPTOR 9;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CELL EXPANSION; CELL FUNCTION; CELL PROLIFERATION; CYTOKINE PRODUCTION; DENDRITIC CELL; IMMUNE RESPONSE; IMMUNIZATION; INFLAMMATION; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; ADOPTIVE TRANSFER; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; DRUG POTENTIATION; GENETICS; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; METABOLISM; MOUSE MUTANT; PATHOLOGY; PHYSIOLOGY; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE; TRANSPLANTATION;

ADOPTIVE TRANSFER; ANIMALS; CD8-POSITIVE T-LYMPHOCYTES; CELL DIFFERENTIATION; CELL PROLIFERATION; CYTOKINES; DENDRITIC CELLS; DNA; IMMUNOLOGIC MEMORY; INFLAMMATION MEDIATORS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; OVALBUMIN; PEPTIDE FRAGMENTS; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTOR 9;

EID: 70149106207     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.0901203     Document Type: Article

References (55)

1. + T cell response. Immunity 25: 19-29.
2. + T cell homeostasis by perforin and interferon-γ. Science 290: 1354-1358.
3. + T cells. J. Immunol. 162: 3256-3262.
4. Curtsinger, J. M., J. O. Valenzuela, P. Agarwal, D. Lins, and M. F. Mescher. 2005. Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation. J. Immunol. 174: 4465-4469. (Pubitemid 40504523)
5. Kolumam, G. A., S. Thomas, L. J. Thompson, J. Sprent, and K. Murali-Krishna. 2005. Type I interferons act directly on CD8 T cells to allow clonal expansion and memory formation in response to viral infection. J. Exp. Med. 202: 637-650.
6. + T cells. Immunol. Rev. 211: 81-92.
7. Xiao, Z., K. A. Casey, S. C. Jameson, J. M. Curtsinger, and M. F. Mescher. 2009. Programming for CD8 T cell memory development requires IL-12 or type I IFN. J. Immunol. 182: 2786-2794.
8. + T cell contraction is controlled by early inflammation. Nat. Immunol. 5: 809-817.
9. Tewari, K., Y. Nakayama, and M. Suresh. 2007. Role of direct effects of IFN-γ on T cells in the regulation of CD8 T cell homeostasis. J. Immunol. 179: 2115-2125.
10. + T cell fates via the graded expression of T-bet transcription factor. Immunity 27: 281-295.
11. Joshi, N. S., and S. M. Kaech. 2008. Effector CD8 T cell development: a balancing act between memory cell potential and terminal differentiation. J. Immunol. 180: 1309-1315.
12. + T-cell memory and prime-boost response after dendritic-cell vaccination. Nat. Med. 11: 748-756.
13. Kaech, S. M., S. Hemby, E. Kersh, and R. Ahmed. 2002. Molecular and functional profiling of memory CD8 T cell differentiation. Cell 111: 837-851.
14. Blattman, J. N., R. Antia, D. J. Sourdive, X. Wang, S. M. Kaech, K. Murali-Krishna, J. D. Altman, and R. Ahmed. 2002. Estimating the precursor frequency of naive antigen-specific CD8 T cells. J. Exp. Med. 195: 657-664.
15. Kedzierska, K., E. B. Day, J. Pi, S. B. Heard, P. C. Doherty, S. J. Turner, and S. Perlman. 2006. Quantification of repertoire diversity of influenza-specific epitopes with predominant public or private TCR usage. J. Immunol. 177: 6705-6712. (Pubitemid 44715034)
16. + T cell precursor frequency regulates primary and memory responses to infection. Immunity 28: 859-869.
17. Pewe, L. L., J. M. Netland, S. B. Heard, and S. Perlman. 2004. Very diverse CD8 T cell clonotypic responses after virus infections. J. Immunol. 172: 3151-3156. (Pubitemid 38263705)
18. + T cells after infection. Nat. Immunol. 3: 619-626.
19. + T cell response to Listeria monocytogenes infection. J. Immunol. 173: 5679-5687.
20. + T cell response. J. Exp. Med. 203: 2135-2143.
21. Hogquist, K. A., S. C. Jameson, W. R. Heath, J. L. Howard, M. J. Bevan, and F. R. Carbone. 1994. T cell receptor antagonist peptides induce positive selection. Cell 76: 17-27.
22. Pope, C., S. K. Kim, A. Marzo, D. Masopust, K. Williams, J. Jiang, H. Shen, and L. Lefrancois. 2001. Organ-specific regulation of the CD8 T cell response to Listeria monocytogenes infection. J. Immunol. 166: 3402-3409.
23. + T cell response to infection. Immunity 26: 827-841.
24. Altman, J. D., P. A. Moss, P. J. Goulder, D. H. Barouch, M. G. McHeyzer-Williams, J. I. Bell, A. J. McMichael, and M. M. Davis. 1996. Phenotypic analysis of antigen-specific T lymphocytes. Science 274: 94-96.
25. Busch, D. H., I. M. Pilip, S. Vijh, and E. G. Pamer. 1998. Coordinate regulation of complex T cell populations responding to bacterial infection. Immunity 8: 353-362. (Pubitemid 28188895)
26. Kaech, S. M., E. J. Wherry, and R. Ahmed. 2002. Effector and memory T-cell differentiation: implications for vaccine development. Nat. Rev. 2: 251-262.
27. Sprent, J., and C. D. Surh. 2002. T cell memory. Ann. Rev. Immunol. 20: 551-579.
28. Cui, W., N. S. Joshi, A. Jiang, and S. M. Kaech. 2009. Effects of signal 3 during CD8 T cell priming: bystander production of IL-12 enhances effector T cell expansion but promotes terminal differentiation. Vaccine 27: 2177-2187.
29. + T-cell memory. Nat. Rev. 8: 107-119.
30. Akira, S., S. Uematsu, and O. Takeuchi. 2006. Pathogen recognition and innate immunity. Cell 124: 783-801.
31. Mempel, T. R., S. E. Henrickson, and U. H. Von Andrian. 2004. T-cell priming by dendritic cells in lymph nodes occurs in three distinct phases. Nature 427: 154-159.
32. Pearce, E. L., and H. Shen. 2007. Generation of CD8 T cell memory is regulated by IL-12. J. Immunol. 179: 2074-2081.
33. + T cells. Immunol. Rev. 186: 221-233.
34. + T cells that had developed an effector phenotype. Science 323: 505-509.
35. Harrington, L. E., K. M. Janowski, J. R. Oliver, A. J. Zajac, and C. T. Weaver. 2008. Memory CD4 T cells emerge from effector T-cell progenitors. Nature 452: 356-360.
36. Jacob, J., and D. Baltimore. 1999. Modelling T-cell memory by genetic marking of memory T cells in vivo. Nature 399: 593-597. (Pubitemid 129623067)
37. + T cell generation after acute infection. J. Immunol. 179: 53-63.
38. + T-cell differentiation in the context of infection. Immunol. Rev. 211: 197-202.
39. + T-cell memory. Immunol. Rev. 211: 67-80.
40. Hikono, H., J. E. Kohlmeier, K. H. Ely, I. Scott, A. D. Roberts, M. A. Blackman, and D. L. Woodland. 2006. T-cell memory and recall responses to respiratory virus infections. Immunol. Rev. 211: 119-132.
41. Lefrancois, L. 2006. Development, trafficking, and function of memory T-cell subsets. Immunol. Rev. 211: 93-103.
42. de Weerd, N. A., S. A. Samarajiwa, and P. J. Hertzog. 2007. Type I interferon receptors: biochemistry and biological functions. J. Biol. Chem. 282: 20053-20057.
43. Farrar, M. A., and R. D. Schreiber. 1993. The molecular cell biology of interferon-γ and its receptor. Annu. Rev. Immunol. 11: 571-611. (Pubitemid 23115018)
44. Hardy, M. P., P. J. Hertzog, and C. M. Owczarek. 2002. Multiple regions within the promoter of the murine Ifnar-2 gene confer basal and inducible expression. Biochem. J. 365: 355-367.
45. + T cells responding to infection. J. Immunol. 174: 6791-6802.
46. Szabo, S. J., A. S. Dighe, U. Gubler, and K. M. Murphy. 1997. Regulation of the interleukin (IL)-12Rβ2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185: 817-824.
47. - T cell subsets to express IL-18 receptor and produce IFN-γ in response to IL-18. J. Immunol. 160: 3759-3765.
48. Trinchieri, G. 2003. Interleukin-12 and the regulation of innate resistance and adaptive immunity. Nat. Rev. 3: 133-146.
49. Yoshimoto, T., K. Takeda, T. Tanaka, K. Ohkusu, S. Kashiwamura, H. Okamura, S. Akira, and K. Nakanishi. 1998. IL-12 up-regulates IL-18 receptor expression on T cells, Th1 cells, and B cells: synergism with IL-18 for IFN-γ production. J. Immunol. 161: 3400-3407.
50. Presky, D. H., H. Yang, L. J. Minetti, A. O. Chua, N. Nabavi, C. Y. Wu, M. K. Gately, and U. Gubler. 1996. A functional interleukin 12 receptor complex is composed of two β-type cytokine receptor subunits. Proc. Natl. Acad. Sci. USA 93: 14002-14007.
51. Avni, O., D. Lee, F. Macian, S. J. Szabo, L. H. Glimcher, and A. Rao. 2002. TH cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat. Immunol. 3: 643-651.
52. Wilson, C. B., K. W. Makar, M. Shnyreva, and D. R. Fitzpatrick. 2005. DNA methylation and the expanding epigenetics of T cell lineage commitment. Semin. Immunol. 17: 105-119.
53. Kaech, S. M., and R. Ahmed. 2001. Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naive cells. Nat. Immunol. 2: 415-422.
54. Masopust, D., S. M. Kaech, E. J. Wherry, and R. Ahmed. 2004. The role of programming in memory T-cell development. Curr. Opin. Immunol. 16: 217-225.
55. Murali-Krishna, K., J. D. Altman, M. Suresh, D. J. Sourdive, A. J. Zajac, J. D. Miller, J. Slansky, and R. Ahmed. 1998. Counting antigen-specific CD8 T cells: a reevaluation of bystander activation during viral infection. Immunity 8: 177-187.