Potent irreversible P2Y12 inhibition does not reduce LPS-induced coagulation activation in a randomized, double-blind, placebo-controlled trial

Clinical Science

Volumn 130, Issue 6, 2016, Pages 433-440

  Schoergenhofer, Christian ^a   Schwameis, Michael ^a   Hobl, Eva Luise ^a   Ay, Cihan ^a   Key, Nigel S ^b   Derhaschnig, Ulla ^a   Jilma, Bernd ^a   Spiel, Alexander O ^a  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

Author keywords

Blood coagulation; Histones; Lipopolysaccharide; P2Y12 receptor; Prasugrel; Thromboelastometry

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CD40 LIGAND; DNA; ESCHERICHIA COLI ENDOTOXIN; HISTONE; PADGEM PROTEIN; PLACEBO; PRASUGREL; PROTHROMBIN; PURINERGIC P2Y12 RECEPTOR; THROMBIN ANTITHROMBIN COMPLEX; THROMBOPLASTIN; ANTITHROMBOCYTIC AGENT; BIOLOGICAL MARKER; LIPOPOLYSACCHARIDE; PURINERGIC P2Y RECEPTOR ANTAGONIST;

ADULT; ARTICLE; BLOOD CLOTTING; CLINICAL ARTICLE; CONTROLLED STUDY; CROSSOVER PROCEDURE; DOUBLE BLIND PROCEDURE; DRUG EFFECT; ENDOTOXEMIA; ENZYME IMMUNOASSAY; EXTRACELLULAR TRAP; HUMAN; INFLAMMATION; LEUKOCYTE AGGREGATION; LEUKOCYTE FUNCTION; LOADING DRUG DOSE; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEPSIS; THROMBOCYTE AGGREGATION; THROMBOCYTE FUNCTION; BLOOD; DRUG EFFECTS; THROMBOCYTE ACTIVATION; THROMBOELASTOGRAPHY; YOUNG ADULT;

ADULT; BIOMARKERS; BLOOD COAGULATION; DNA; DOUBLE-BLIND METHOD; HEALTHY VOLUNTEERS; HUMANS; LIPOPOLYSACCHARIDES; MALE; PLATELET ACTIVATION; PLATELET AGGREGATION INHIBITORS; PRASUGREL HYDROCHLORIDE; PURINERGIC P2Y RECEPTOR ANTAGONISTS; THROMBELASTOGRAPHY; YOUNG ADULT;

EID: 84958087904     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20150591     Document Type: Article

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