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Volumn 96, Issue 4, 2014, Pages 418-422

Human Endotoxin Administration as an Experimental Model in Drug Development

Author keywords

[No Author keywords available]

Indexed keywords

ANTICOAGULANT AGENT; ENDOTOXIN; ERITORAN; FIBRINOLYTIC AGENT; INTERLEUKIN 1; LIPID A; STRESS HORMONE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR; ANTIINFLAMMATORY AGENT;

EID: 84921629240     PISSN: 00099236     EISSN: 15326535     Source Type: Journal    
DOI: 10.1038/clpt.2014.146     Document Type: Review
Times cited : (42)

References (10)
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    • Bahador, M. & Cross, A.S. From therapy to experimental model: A hundred years of endotoxin administration to human subjects. J. Endotoxin Res. 13, 251-279 (2007
    • (2007) J. Endotoxin Res. , vol.13 , pp. 251-279
    • Bahador, M.1    Cross, A.S.2
  • 2
    • 0017257463 scopus 로고
    • Preparation and properties of a national reference endotoxin
    • Rudbach, J.A. et al. Preparation and properties of a national reference endotoxin. J. Clin. Microbiol. 3, 21-25 (1976
    • (1976) J. Clin. Microbiol. , vol.3 , pp. 21-25
    • Rudbach, J.A.1
  • 4
    • 84878232476 scopus 로고    scopus 로고
    • The history of Toll-like receptors-redefining innate immunity
    • O'Neill, L.A., Golenbock, D. & Bowie, A.G. The history of Toll-like receptors-redefining innate immunity. Nat. Rev. Immunol. 13, 453-460 (2013
    • (2013) Nat. Rev. Immunol. , vol.13 , pp. 453-460
    • O'Neill, L.A.1    Golenbock, D.2    Bowie, A.G.3
  • 5
    • 84874457770 scopus 로고    scopus 로고
    • Genomic responses in mouse models poorly mimic human inflammatory diseases
    • Seok, J. et al. Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc. Natl. Acad. Sci. USA 110, 3507-3512 (2013
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 3507-3512
    • Seok, J.1
  • 6
    • 0037442501 scopus 로고    scopus 로고
    • Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia
    • Lynn, M. et al. Blocking of responses to endotoxin by E5564 in healthy volunteers with experimental endotoxemia. J. Infect. Dis. 187, 631-639 (2003
    • (2003) J. Infect. Dis. , vol.187 , pp. 631-639
    • Lynn, M.1
  • 7
    • 84875124740 scopus 로고    scopus 로고
    • Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: The ACCESS randomized trial
    • Opal, S.M. et al. Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: The ACCESS randomized trial. JAMA 309, 1154-1162 (2013
    • (2013) JAMA , vol.309 , pp. 1154-1162
    • Opal, S.M.1
  • 8
    • 0028063543 scopus 로고
    • Human responses to bacterial endotoxin
    • Burrell, R. Human responses to bacterial endotoxin. Circ. Shock 43, 137-153 (1994
    • (1994) Circ. Shock , vol.43 , pp. 137-153
    • Burrell, R.1
  • 9
    • 0024342856 scopus 로고
    • The cardiovascular response of normal humans to the administration of endotoxin
    • Suffredini, A.F. et al. The cardiovascular response of normal humans to the administration of endotoxin. N. Engl. J. Med. 321, 280-287 (1989
    • (1989) N. Engl. J. Med. , vol.321 , pp. 280-287
    • Suffredini, A.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.