His499 regulates dimerization and prevents oncogenic activation by asparagine mutations of the human thrombopoietin receptor

Journal of Biological Chemistry

Volumn 291, Issue 6, 2016, Pages 2974-2987

  Leroy, Emilie ^a,b   Defour, Jean Philippe ^a,b   Sato, Takeshi ^c   Dass, Sharmila ^d   Gryshkova, Vitalina ^a,b   Shwe, Myat M ^a,b   Staerk, Judith ^e   Constantinescu, Stefan N ^a,b   Smith, Steven O ^d  

^a LUDWIG INSTITUTE FOR CANCER RESEARCH   (Belgium)

^b DE DUVE INSTITUTE   (Belgium)

^c OSAKA UNIVERSITY   (Japan)

^d STONY BROOK UNIVERSITY   (United States)

^e EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DIMERIZATION; ENZYME ACTIVITY;

EXTRACELLULAR DOMAINS; HUMAN RECEPTORS; INTRACELLULAR DOMAIN; ONCOGENIC ACTIVATION; SMALL MOLECULES; SPECIFIC ORIENTATION; STRUCTURAL STUDIES; THROMBOPOIETIN RECEPTORS;

CHEMICAL ACTIVATION;

ASPARAGINE; ELTROMBOPAG; MUTANT PROTEIN; THROMBOPOIETIN RECEPTOR; HISTIDINE; MPL PROTEIN, HUMAN; MPL PROTEIN, MOUSE; ONCOPROTEIN;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; ASPARAGINE SCANNING MUTAGENESIS; DIMERIZATION; LIGAND BINDING; MUTATION; ONCOGENIC ACTIVATION; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN MODIFICATION; PROTEIN STRUCTURE; REGULATORY MECHANISM; ANIMAL; CELL LINE; GENETICS; HUMAN; METABOLISM; MISSENSE MUTATION; MOUSE; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE;

ANIMALS; ASPARAGINE; CELL LINE; HISTIDINE; HUMANS; MICE; MUTATION, MISSENSE; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; RECEPTORS, THROMBOPOIETIN;

EID: 84958019754     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M115.696534     Document Type: Article

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