Hypoxia promotes drug resistance in osteosarcoma cells via activating AMP-activated protein kinase (AMPK) signaling

Journal of Bone Oncology

Volumn 5, Issue 1, 2016, Pages 22-29

  Zhao, Changfu ^a   Zhang, Qiao ^a   Yu, Tao ^b   Sun, Shudong ^b   Wang, Wenjun ^a   Liu, Guangyao ^a  

^a JILIN UNIVERSITY   (China)

^b THE SECOND HOSPITAL OF JILIN UNIVERSITY   (China)

Author keywords

AMPK signaling; Doxorubicin; Hypoxia; Osteosarcoma cells; Resistance

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; ACETYL COENZYME A CARBOXYLASE; CASPASE 3; DOXORUBICIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE ACTIVATOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; HYPOXIA INDUCIBLE FACTOR 1BETA; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; REACTIVE OXYGEN METABOLITE;

APOPTOSIS; ARTICLE; CANCER RESISTANCE; CELL VIABILITY; CHEMOSENSITIVITY; DISEASE ASSOCIATION; DOWN REGULATION; ENZYME ACTIVATION; HUMAN; HUMAN CELL; HYPOXIA; IN VITRO STUDY; MG 63 CELL LINE; OSTEOSARCOMA CELL LINE; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SENSITIVITY ANALYSIS; SIGNAL TRANSDUCTION; U2OS CELL LINE; UPREGULATION;

EID: 84957891082     PISSN: 22121374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jbo.2016.01.002     Document Type: Article

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