Silibinin, a natural flavonoid, induces autophagy via ROS-dependent mitochondrial dysfunction and loss of ATP involving BNIP3 in human MCF7 breast cancer cells

Oncology Reports

Volumn 33, Issue 6, 2015, Pages 2711-2718

  Jiang, Kai ^a   Wang, Wei ^a   Jin, Xin ^a   Wang, Zhaoyang ^b   Ji, Zhiwei ^c   Meng, Guanmin ^a  

^a TONGDE HOSPITAL OF ZHEJIANG PROVINCE   (China)

^b SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^c TONGJI UNIVERSITY   (China)

Author keywords

ATP; Autophagy; BNIP3; Mitochondrial membrane potential; Reactive oxygen species; Silibinin

Indexed keywords

3 METHYLADENINE; ADENOSINE TRIPHOSPHATE; AUTOPHAGY PROTEIN 5; BAFILOMYCIN A1; BECLIN 1; BH3 PROTEIN; IMMUNOGLOBULIN LIGHT CHAIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN BNIP3; PROTON TRANSPORTING ADENOSINE TRIPHOSPHATASE; REACTIVE OXYGEN METABOLITE; SILIBININ; SMALL INTERFERING RNA; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, HUMAN; BNIP3 PROTEIN, HUMAN; FLAVONOID; MEMBRANE PROTEIN; ONCOPROTEIN; SILYMARIN;

ANTIOXIDANT ACTIVITY; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BREAST CANCER; BREAST CANCER CELL LINE; CELL DEATH; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DISORDERS OF MITOCHONDRIAL FUNCTIONS; ENZYME LOCALIZATION; HUMAN; HUMAN CELL; IMMUNOREACTIVITY; MITOCHONDRIAL MEMBRANE POTENTIAL; OXIDATIVE PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; UPREGULATION; WESTERN BLOTTING; APOPTOSIS; BIOSYNTHESIS; BREAST NEOPLASMS; DRUG EFFECTS; FEMALE; GENE EXPRESSION REGULATION; GENETICS; MCF-7 CELL LINE; METABOLISM; MITOCHONDRION; PATHOLOGY; SIGNAL TRANSDUCTION;

ADENOSINE TRIPHOSPHATE; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BECLIN-1; BREAST NEOPLASMS; FEMALE; FLAVONOIDS; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MCF-7 CELLS; MEMBRANE POTENTIAL, MITOCHONDRIAL; MEMBRANE PROTEINS; MITOCHONDRIA; PROTO-ONCOGENE PROTEINS; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; SILYMARIN;

EID: 84928894986     PISSN: 1021335X     EISSN: 17912431     Source Type: Journal    
DOI: 10.3892/or.2015.3915     Document Type: Article

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