General Base-General Acid Catalysis in Human Histone Deacetylase 8

Biochemistry

Volumn 55, Issue 5, 2016, Pages 820-832

  Gantt, Sister M Lucy ^a,d   Decroos, Christophe ^b,e   Lee, Matthew S ^b   Gullett, Laura E ^b,f   Bowman, Christine M ^b,g   Christianson, David W ^b,c   Fierke, Carol A ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

^c HARVARD UNIVERSITY   (United States)

^d FRANCISCAN UNIVERSITY OF STEUBENVILLE   (United States)

^e AIX MARSEILLE UNIVERSITÉ   (France)

^f HARVARD UNIVERSITY   (United States)

^g UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; CATALYSTS; CELL DEATH; HYDROGEN BONDS; IONIZATION OF LIQUIDS; MOLECULES; QUANTUM CHEMISTRY; STABILIZATION; ZINC; ZINC COMPOUNDS;

ANTI-CANCER THERAPEUTICS; CATALYTIC FUNCTIONS; CATALYTIC MECHANISMS; GENERAL ACID CATALYSIS; HISTONE DEACETYLASES; SITE DIRECTED MUTAGENESIS; TRANSITION STATE STABILIZATION; X RAY CRYSTAL STRUCTURES;

CATALYSIS;

ACID; ALANINE; ASPARTIC ACID; BASE; CARBONYL DERIVATIVE; GLUTAMINE; HISTIDINE; HISTONE DEACETYLASE 8; HYDROGEN; METAL; PHENYLALANINE; TYROSINE; WATER; ZINC; ALKALI; HDAC8 PROTEIN, HUMAN; HISTONE DEACETYLASE; REPRESSOR PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; CATALYSIS; CATALYST; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVITY; ENZYME STRUCTURE; ENZYMOLOGY; HYDROGEN BOND; IONIZATION; MOLECULE; MUTANT; PH; PHASE TRANSITION; PRIORITY JOURNAL; PROTEIN STABILITY; SITE DIRECTED MUTAGENESIS; WILD TYPE; X RAY CRYSTALLOGRAPHY; CHEMISTRY; GENETICS; HUMAN;

ACIDS; ALKALIES; CATALYSIS; CRYSTALLOGRAPHY, X-RAY; HISTONE DEACETYLASES; HUMANS; HYDROGEN BONDING; HYDROGEN-ION CONCENTRATION; MUTAGENESIS, SITE-DIRECTED; REPRESSOR PROTEINS;

EID: 84957877175     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/acs.biochem.5b01327     Document Type: Article

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