Arylboronic acids as dual-action FAAH and TRPV1 ligands

Bioorganic and Medicinal Chemistry Letters

Volumn 26, Issue 5, 2016, Pages 1401-1405

  Morera, Enrico ^a   Di Marzo, Vincenzo ^b   Monti, Ludovica ^a   Allarà, Marco ^b   Schiano Moriello, Aniello ^b   Nalli, Marianna ^a   Ortar, Giorgio ^a   De Petrocellis, Luciano ^b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b CNR   (Italy)

Author keywords

Boronic acids; Dual ligands; FAAH; Fatty acid amide hydrolase; Transient receptor potential vanilloid type 1 channel; TRPV1

Indexed keywords

4 CHLORO N (3 METHOXYPHENYL)CINNAMAMIDE; BORONIC ACID DERIVATIVE; CAPSAICIN; CAPSAZEPINE; FATTY ACID AMIDASE; FATTY ACID AMIDASE INHIBITOR; LIGAND; N (3 PYRIDAZINYL) 4 [3 (5 TRIFLUOROMETHYL 2 PYRIDINYLOXY)BENZYLIDENE] 1 PIPERIDINECARBOXAMIDE; N (4 TERT BUTYLPHENYL) 4 (3 CHLORO 2 PYRIDINYL) 1 PIPERAZINECARBOXAMIDE; VANILLOID RECEPTOR 1; VANILLOID RECEPTOR 1 ANTAGONIST; AMIDASE; ENZYME INHIBITOR; FATTY-ACID AMIDE HYDROLASE; TRPV1 PROTEIN, HUMAN; VANILLOID RECEPTOR;

ANALGESIA; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CHEMICAL STRUCTURE; DRUG EFFICACY; DRUG POTENCY; DRUG TARGETING; ENZYME INHIBITION; MODEL; NEUTRON CAPTURE THERAPY; PHARMACOPHORE; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DOSE RESPONSE; HUMAN; IC50; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

AMIDOHYDROLASES; BORONIC ACIDS; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; LIGANDS; MOLECULAR STRUCTURE; STRUCTURE-ACTIVITY RELATIONSHIP; TRPV CATION CHANNELS;

EID: 84957841142     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2016.01.071     Document Type: Article

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