Shiga toxins activate the NLRP3 inflammasome pathway to promote both production of the proinflammatory cytokine interleukin-1β and apoptotic cell death

Infection and Immunity

Volumn 84, Issue 1, 2015, Pages 172-186

  Lee, Moo Seung ^a   Kwon, Haenaem ^b   Lee, Eun Young ^b   Kim, Dong Jae ^b   Park, Jong Hwan ^c   Tesh, Vernon L ^d   Oh, Tae Kwang ^a   Kim, Myung Hee ^a  

^a Korea Research Institute of Bioscience and Biotechnology (KRIBB)   (South Korea)

^b New Drug Development Center   (South Korea)

^c Chonnam National University   (South Korea)

^d TEXAS A AND M HEALTH SCIENCE CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 3; CASPASE 8; CRYOPYRIN; CXCL1 CHEMOKINE; GLOBOTRIAOSYLCERAMIDE; GLYCOSPHINGOLIPID; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1; SHIGA TOXIN; TUMOR NECROSIS FACTOR ALPHA; AIM2 PROTEIN, HUMAN; CALCIUM BINDING PROTEIN; CARRIER PROTEIN; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; CERAMIDE TRIHEXOSIDE; CYTOSKELETON PROTEIN; DNA BINDING PROTEIN; IL1B PROTEIN, HUMAN; NLRC4 PROTEIN, HUMAN; NLRP3 PROTEIN, HUMAN; PYCARD PROTEIN, HUMAN; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENDOCYTOSIS; ENZYME ACTIVATION; ENZYME ACTIVITY; GENE SILENCING; INNATE IMMUNITY; INTRACELLULAR SIGNALING; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYROPTOSIS; SHIGELLA DYSENTERIAE; UPREGULATION; BIOSYNTHESIS; GENETICS; HUMAN; IMMUNOLOGY; INFLAMMATION; METABOLISM; RNA INTERFERENCE; SECRETION (PROCESS); SHIGA TOXIN PRODUCING ESCHERICHIA COLI; SIGNAL TRANSDUCTION; TUMOR CELL LINE;

CALCIUM-BINDING PROTEINS; CARD SIGNALING ADAPTOR PROTEINS; CARRIER PROTEINS; CASPASE 1; CASPASE 3; CASPASE 8; CELL LINE, TUMOR; CYTOSKELETAL PROTEINS; DNA-BINDING PROTEINS; ENZYME ACTIVATION; GLYCOSPHINGOLIPIDS; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PYROPTOSIS; RNA INTERFERENCE; RNA, SMALL INTERFERING; SHIGA TOXINS; SHIGA-TOXIGENIC ESCHERICHIA COLI; SIGNAL TRANSDUCTION; TRIHEXOSYLCERAMIDES; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84957664999     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01095-15     Document Type: Article

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