Bacterial RNA:DNA hybrids are activators of the NLRP3 inflammasome

Proceedings of the National Academy of Sciences of the United States of America

Volumn 111, Issue 21, 2014, Pages 7765-7770

  Vanaja, Sivapriya Kailasan ^a,b   Rathinam, Vijay A K ^b   Atianand, Maninjay K ^b   Kalantari, Parisa ^b   Skehan, Brian ^b   Fitzgerald, Katherine A ^b,c   Leong, John M ^a  

^a TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL DNA; BACTERIAL RNA; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; RIBONUCLEASE H;

ARTICLE; BACTERIUM MUTANT; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOSOL; DNA RNA HYBRIDIZATION; ENTEROHEMORRHAGIC ESCHERICHIA COLI; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; BASE SEQUENCE; CARRIER PROTEINS; CASPASE 1; DNA, SINGLE-STRANDED; ENTEROHEMORRHAGIC ESCHERICHIA COLI; ENZYME-LINKED IMMUNOSORBENT ASSAY; ESCHERICHIA COLI PROTEINS; HEMOLYTIC-UREMIC SYNDROME; IMMUNOBLOTTING; INFLAMMASOMES; INTERLEUKIN-1BETA; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; MOLECULAR SEQUENCE DATA; RIBOSOMAL PROTEINS; RNA;

EID: 84901650255     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1400075111     Document Type: Article

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