Divergent evolution of a bifunctional de novo protein

Protein Science

Volumn 24, Issue 2, 2015, Pages 246-252

  Smith, Betsy A ^a,b   Mularz, Ann E ^a   Hecht, Michael H ^a  

^a PRINCETON UNIVERSITY   (United States)

^b ELMIRA COLLEGE   (United States)

Author keywords

bifunctional protein; binary code; directed evolution; four helix bundle; functional promiscuity; polar nonpolar patterning; protein design

Indexed keywords

BIFUNCTIONAL DE NOVO PROTEIN; IRON; ISOLEUCINE; PROTEIN; PROTEIN KINASE FES; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; BIOSYNTHESIS; CONTROLLED STUDY; DIVERGENT EVOLUTION; ESCHERICHIA COLI; GROWTH RATE; LIQUID CULTURE; MOLECULAR EVOLUTION; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; AMINO ACID SEQUENCE; CHEMISTRY; CYTOLOGY; DIRECTED MOLECULAR EVOLUTION; GENE DELETION; GENETICS; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOLECULAR GENETICS; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; DIRECTED MOLECULAR EVOLUTION; ESCHERICHIA COLI; EVOLUTION, MOLECULAR; GENE DELETION; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, SECONDARY; PROTEINS; SEQUENCE ALIGNMENT;

EID: 84928897102     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1002/pro.2611     Document Type: Article

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