Single-cell systems-level analysis of human Toll-like receptor activation defines a chemokine signature in patients with systemic lupus erythematosus

Journal of Allergy and Clinical Immunology

Volumn 136, Issue 5, 2015, Pages 1326-1336

  O'Gorman, William E ^a   Hsieh, Elena W Y ^a   Savig, Erica S ^a   Gherardini, Pier Federico ^a   Hernandez, Joseph D ^a,b   Hansmann, Leo ^a   Balboni, Imelda M ^a   Utz, Paul J ^b   Bendall, Sean C ^b   Fantl, Wendy J ^a   Lewis, David B ^a   Nolan, Garry P ^a,b   Davis, Mark M ^a,b  

^a STANFORD UNIVERSITY   (United States)

^b STANFORD UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

inflammation; Mass cytometry; monocyte chemotactic protein 1; monocytes; systemic lupus erythematosus; Toll like receptors

Indexed keywords

CD14 ANTIGEN; CD16 ANTIGEN; CELL SURFACE MARKER; CHEMOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 12; INTERLEUKIN 1BETA; INTERLEUKIN 8; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; MONOCYTE CHEMOTACTIC PROTEIN 1; SIGNAL PEPTIDE; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 2; TRANSCRIPTOME;

ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNE RESPONSE; IMMUNOCOMPETENT CELL; MASS CYTOMETRY; MONOCYTE; NATURAL KILLER CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RECEPTOR UPREGULATION; SIGNAL TRANSDUCTION; SINGLE CELL ANALYSIS; SYSTEMIC LUPUS ERYTHEMATOSUS; T LYMPHOCYTE SUBPOPULATION; ANTIBODY SPECIFICITY; CELL CULTURE; GENETICS; IMMUNOLOGY; LYMPHOCYTE ACTIVATION; METABOLISM; PROCEDURES; T LYMPHOCYTE;

ANTIGENS, CD14; CELLS, CULTURED; CHEMOKINES; HUMANS; KILLER CELLS, NATURAL; LUPUS ERYTHEMATOSUS, SYSTEMIC; LYMPHOCYTE ACTIVATION; MONOCYTES; NF-KAPPA B; ORGAN SPECIFICITY; SIGNAL TRANSDUCTION; SINGLE-CELL ANALYSIS; T-LYMPHOCYTES; TOLL-LIKE RECEPTORS; TRANSCRIPTOME;

EID: 84957447776     PISSN: 00916749     EISSN: 10976825     Source Type: Journal    
DOI: 10.1016/j.jaci.2015.04.008     Document Type: Article

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