A dual strategy to improve the penetration and treatment of breast cancer by combining shrinking nanoparticles with collagen depletion by losartan

Acta Biomaterialia

Volumn 31, Issue , 2016, Pages 186-196

  Cun, Xingli ^a   Ruan, Shaobo ^a   Chen, Jiantao ^a   Zhang, Li ^a   Li, Jianping ^a   He, Qin ^a   Gao, Huile ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Deep tumor penetration; Losartan; Size shrinkable nanoparticles; Tumor extracellular matrix

Indexed keywords

COLLAGEN; CONTROLLED DRUG DELIVERY; EFFICIENCY; ENZYME ACTIVITY; ENZYME INHIBITION; NANOPARTICLES; SHRINKAGE; TARGETED DRUG DELIVERY;

BREAST CANCER; BREAST TUMOUR; DEEP TUMOR PENETRATION; EXTRACELLULAR MATRICES; LOSARTAN; SIZE-SHRINKABLE NANOPARTICLE; THERAPEUTIC OUTCOMES; TUMOR EXTRACELLULAR MATRIX; TUMOR PENETRATION; TUMOR TREATMENT;

TUMORS;

COLLAGEN; DOXORUBICIN; DOXORUBICIN LOADED GOLD NANOPARTICLE ONTO MATRIX METALLOPROTEINASE 2 DEGRADABLE GELATIN NANOPARTICLE; GELATIN; GOLD NANOPARTICLE; LOSARTAN; MATRIX METALLOPROTEINASE; NANOCARRIER; UNCLASSIFIED DRUG; GELATINASE A; GOLD; METAL NANOPARTICLE; MMP2 PROTEIN, MOUSE; NANOPARTICLE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREAST CANCER; CANCER INHIBITION; CONTROLLED STUDY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG PENETRATION; DRUG POTENTIATION; DRUG RELEASE; EXTRACELLULAR MATRIX; GENE OVEREXPRESSION; IN VITRO STUDY; IN VIVO STUDY; MOUSE; NANOFABRICATION; NANOMEDICINE; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; ANIMAL; BAGG ALBINO MOUSE; CANCER TRANSPLANTATION; CELL SURVIVAL; CHEMISTRY; FEMALE; GENE EXPRESSION REGULATION; MAMMARY NEOPLASMS, ANIMAL; METABOLISM; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PATHOLOGY; TUMOR CELL LINE;

ANIMALS; CELL LINE, TUMOR; CELL SURVIVAL; COLLAGEN; EXTRACELLULAR MATRIX; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GOLD; LOSARTAN; MAGNETIC RESONANCE SPECTROSCOPY; MAMMARY NEOPLASMS, ANIMAL; MATRIX METALLOPROTEINASE 2; METAL NANOPARTICLES; MICE; MICE, INBRED BALB C; NANOPARTICLES; NEOPLASM TRANSPLANTATION; PARTICLE SIZE;

EID: 84957435180     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2015.12.002     Document Type: Article

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