Nanoparticle uptake in tumors is mediated by the interplay of vascular and collagen density with interstitial pressure

Nanomedicine: Nanotechnology, Biology, and Medicine

Volumn 9, Issue 2, 2013, Pages 151-158

  Torosean, Sason ^a   Flynn, Brendan ^b   Axelsson, Johan ^b   Gunn, Jason ^b   Samkoe, Kimberley S ^c   Hasan, Tayyaba ^d   Doyley, Marvin M ^e   Pogue, Brian W ^a,b,c,d  

^a Dartmouth College   (United States)

^b DARTMOUTH COLLEGE   (United States)

^c DARTMOUTH MEDICAL SCHOOL   (United States)

^d MASSACHUSETTS GENERAL HOSPITAL   (United States)

^e University of Rochester   (United States)

Author keywords

Cancer; Collagen; Fluorescence; Microenvironment; Pressure

Indexed keywords

CANCER; COLLAGEN CONTENT; DELIVERY MODELS; DRUG PENETRATION; IN-VIVO; INTERSTITIAL FLUID PRESSURES; MICROENVIRONMENTS; NANOPARTICLE UPTAKES; NONINVASIVE METHODS; NORMAL TISSUE; SOLID TUMORS; TRANSMITTED LIGHT; VASCULAR PERMEABILITY;

COLLAGEN; FLUORESCENCE; NANOPARTICLES; NONINVASIVE MEDICAL PROCEDURES; PRESSURE;

TUMORS;

COLLAGEN; NANOPARTICLE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ARTIFACT; BLOOD VESSEL FUNCTION; BLUE LIGHT; DENSITY; DRUG UPTAKE; FEMALE; FLUORESCENCE IMAGING; HUMAN; HUMAN CELL; IN VIVO STUDY; MOUSE; NONHUMAN; QUANTITATIVE ANALYSIS; RAT; RIGIDITY; TISSUE PRESSURE; TUMOR CELL; VASCULAR CAPACITY; VASCULARIZATION;

ANIMALS; COLLAGEN; DRUG CARRIERS; EXTRACELLULAR FLUID; FEMALE; FLUORESCENCE; HUMANS; MICE; MICE, NUDE; NANOPARTICLES; NEOPLASMS; NEOVASCULARIZATION, PATHOLOGIC; PRESSURE; TUMOR MICROENVIRONMENT;

ANIMALIA;

EID: 84873705595     PISSN: 15499634     EISSN: 15499642     Source Type: Journal    
DOI: 10.1016/j.nano.2012.07.002     Document Type: Article

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