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Volumn 37, Issue , 2015, Pages 425-435

Tumor microenvironment sensitive doxorubicin delivery and release to glioma using angiopep-2 decorated gold nanoparticles

Author keywords

Doxorubicin; Glioma; Gold nanoparticles; Sensitive release; Tumor microenvironment

Indexed keywords

FIBER OPTIC SENSORS; GOLD NANOPARTICLES; MAMMALS; METAL NANOPARTICLES; PARTICLE SIZE;

EID: 84922324826     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2014.10.007     Document Type: Article
Times cited : (305)

References (51)
  • 2
    • 80053435892 scopus 로고    scopus 로고
    • Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain
    • Agarwal S., Sane R., Oberoi R., Ohlfest J.R., Elmquist W.F. Delivery of molecularly targeted therapy to malignant glioma, a disease of the whole brain. Expert Rev Mol Med 2011, 13:e17.
    • (2011) Expert Rev Mol Med , vol.13 , pp. e17
    • Agarwal, S.1    Sane, R.2    Oberoi, R.3    Ohlfest, J.R.4    Elmquist, W.F.5
  • 3
    • 0021166954 scopus 로고
    • Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia and hyperglycemia
    • Jain R.K., Shah S.A., Finney P.L. Continuous noninvasive monitoring of pH and temperature in rat Walker 256 carcinoma during normoglycemia and hyperglycemia. JNatl Cancer Inst 1984, 73(2):429-436.
    • (1984) JNatl Cancer Inst , vol.73 , Issue.2 , pp. 429-436
    • Jain, R.K.1    Shah, S.A.2    Finney, P.L.3
  • 4
    • 0024232289 scopus 로고
    • Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure
    • Jain R.K., Baxter L.T. Mechanisms of heterogeneous distribution of monoclonal antibodies and other macromolecules in tumors: significance of elevated interstitial pressure. Cancer Res 1988, 48(24 Pt 1):7022-7032.
    • (1988) Cancer Res , vol.48 , Issue.24 , pp. 7022-7032
    • Jain, R.K.1    Baxter, L.T.2
  • 5
    • 1642536758 scopus 로고
    • Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice
    • Torres F.I., Leunig M., Yuan F., Intaglietta M., Jain R.K. Noninvasive measurement of microvascular and interstitial oxygen profiles in a human tumor in SCID mice. Proc Natl Acad Sci U S A 1994, 91(6):2081-2085.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , Issue.6 , pp. 2081-2085
    • Torres, F.I.1    Leunig, M.2    Yuan, F.3    Intaglietta, M.4    Jain, R.K.5
  • 6
    • 84883858762 scopus 로고    scopus 로고
    • Targeted delivery of nano-therapeutics for major disorders of the central nervous system
    • Gao H., Pang Z., Jiang X. Targeted delivery of nano-therapeutics for major disorders of the central nervous system. Pharm Res 2013, 30(10):2485-2498.
    • (2013) Pharm Res , vol.30 , Issue.10 , pp. 2485-2498
    • Gao, H.1    Pang, Z.2    Jiang, X.3
  • 7
    • 84856164075 scopus 로고    scopus 로고
    • Two-order targeted brain tumor imaging by using an optical/paramagnetic nanoprobe across the blood brain barrier
    • Yan H., Wang L., Wang J., Weng X., Lei H., Wang X., et al. Two-order targeted brain tumor imaging by using an optical/paramagnetic nanoprobe across the blood brain barrier. ACS Nano 2012, 6(1):410-420.
    • (2012) ACS Nano , vol.6 , Issue.1 , pp. 410-420
    • Yan, H.1    Wang, L.2    Wang, J.3    Weng, X.4    Lei, H.5    Wang, X.6
  • 8
    • 72149109532 scopus 로고    scopus 로고
    • Dual-targeting daunorubicin liposomes improve the therapeutic efficacy of brain glioma in animals
    • Ying X., Wen H., Lu W.L., Du J., Guo J., Tian W., et al. Dual-targeting daunorubicin liposomes improve the therapeutic efficacy of brain glioma in animals. JControl Release 2010, 141(2):183-192.
    • (2010) JControl Release , vol.141 , Issue.2 , pp. 183-192
    • Ying, X.1    Wen, H.2    Lu, W.L.3    Du, J.4    Guo, J.5    Tian, W.6
  • 9
    • 84860387204 scopus 로고    scopus 로고
    • Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles
    • Gao H., Qian J., Cao S., Yang Z., Pang Z., Pan S., et al. Precise glioma targeting of and penetration by aptamer and peptide dual-functioned nanoparticles. Biomaterials 2012, 33(20):5115-5123.
    • (2012) Biomaterials , vol.33 , Issue.20 , pp. 5115-5123
    • Gao, H.1    Qian, J.2    Cao, S.3    Yang, Z.4    Pang, Z.5    Pan, S.6
  • 10
    • 33750017850 scopus 로고    scopus 로고
    • Functional characterization of the brain-to-blood efflux clearance of human amyloid-beta peptide (1-40) across the rat blood-brain barrier
    • Ito S., Ohtsuki S., Terasaki T. Functional characterization of the brain-to-blood efflux clearance of human amyloid-beta peptide (1-40) across the rat blood-brain barrier. Neurosci Res 2006, 56(3):246-252.
    • (2006) Neurosci Res , vol.56 , Issue.3 , pp. 246-252
    • Ito, S.1    Ohtsuki, S.2    Terasaki, T.3
  • 11
    • 0342368730 scopus 로고    scopus 로고
    • Human glioblastoma cell lines: levels of low-density lipoprotein receptor and low-density lipoprotein receptor-related protein
    • Maletinska L., Blakely E.A., Bjornstad K.A., Deen D.F., Knoff L.J., Forte T.M. Human glioblastoma cell lines: levels of low-density lipoprotein receptor and low-density lipoprotein receptor-related protein. Cancer Res 2000, 60(8):2300-2303.
    • (2000) Cancer Res , vol.60 , Issue.8 , pp. 2300-2303
    • Maletinska, L.1    Blakely, E.A.2    Bjornstad, K.A.3    Deen, D.F.4    Knoff, L.J.5    Forte, T.M.6
  • 12
    • 84887019309 scopus 로고    scopus 로고
    • Nanoparticles of 2-deoxy-D-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment
    • Jiang X., Xin H., Ren Q., Gu J., Zhu L., Du F., et al. Nanoparticles of 2-deoxy-D-glucose functionalized poly(ethylene glycol)-co-poly(trimethylene carbonate) for dual-targeted drug delivery in glioma treatment. Biomaterials 2014, 35(1):518-529.
    • (2014) Biomaterials , vol.35 , Issue.1 , pp. 518-529
    • Jiang, X.1    Xin, H.2    Ren, Q.3    Gu, J.4    Zhu, L.5    Du, F.6
  • 13
    • 79960561767 scopus 로고    scopus 로고
    • Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticles for glioma
    • Huang S., Li J., Han L., Liu S., Ma H., Huang R., et al. Dual targeting effect of Angiopep-2-modified, DNA-loaded nanoparticles for glioma. Biomaterials 2011, 32(28):6832-6838.
    • (2011) Biomaterials , vol.32 , Issue.28 , pp. 6832-6838
    • Huang, S.1    Li, J.2    Han, L.3    Liu, S.4    Ma, H.5    Huang, R.6
  • 14
    • 79955104821 scopus 로고    scopus 로고
    • Angiopep-conjugated poly(ethylene glycol)-co-poly(epsilon-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma
    • Xin H., Jiang X., Gu J., Sha X., Chen L., Law K., et al. Angiopep-conjugated poly(ethylene glycol)-co-poly(epsilon-caprolactone) nanoparticles as dual-targeting drug delivery system for brain glioma. Biomaterials 2011, 32(18):4293-4305.
    • (2011) Biomaterials , vol.32 , Issue.18 , pp. 4293-4305
    • Xin, H.1    Jiang, X.2    Gu, J.3    Sha, X.4    Chen, L.5    Law, K.6
  • 15
    • 39649120532 scopus 로고    scopus 로고
    • Areview of stimuli-responsive nanocarriers for drug and gene delivery
    • Ganta S., Devalapally H., Shahiwala A., Amiji M. Areview of stimuli-responsive nanocarriers for drug and gene delivery. JControl Release 2008, 126(3):187-204.
    • (2008) JControl Release , vol.126 , Issue.3 , pp. 187-204
    • Ganta, S.1    Devalapally, H.2    Shahiwala, A.3    Amiji, M.4
  • 16
    • 75749093027 scopus 로고    scopus 로고
    • Emerging applications of stimuli-responsive polymer materials
    • Stuart M.A., Huck W.T., Genzer J., Muller M., Ober C., Stamm M., et al. Emerging applications of stimuli-responsive polymer materials. Nat Mater 2010, 9(2):101-113.
    • (2010) Nat Mater , vol.9 , Issue.2 , pp. 101-113
    • Stuart, M.A.1    Huck, W.T.2    Genzer, J.3    Muller, M.4    Ober, C.5    Stamm, M.6
  • 17
  • 18
    • 78649934086 scopus 로고    scopus 로고
    • PH-Responsive nanoparticles for drug delivery
    • Gao W., Chan J.M., Farokhzad O.C. pH-Responsive nanoparticles for drug delivery. Mol Pharmacol 2010, 7(6):1913-1920.
    • (2010) Mol Pharmacol , vol.7 , Issue.6 , pp. 1913-1920
    • Gao, W.1    Chan, J.M.2    Farokhzad, O.C.3
  • 19
    • 31944435486 scopus 로고    scopus 로고
    • Tumor marker-responsive behavior of gels prepared by biomolecular imprinting
    • Miyata T., Jige M., Nakaminami T., Uragami T. Tumor marker-responsive behavior of gels prepared by biomolecular imprinting. Proc Natl Acad Sci U S A 2006, 103(5):1190-1193.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.5 , pp. 1190-1193
    • Miyata, T.1    Jige, M.2    Nakaminami, T.3    Uragami, T.4
  • 20
    • 70349784859 scopus 로고    scopus 로고
    • Biotin-avidin as a protease-responsive cap system for controlled guest release from colloidal mesoporous silica
    • Schlossbauer A., Kecht J., Bein T. Biotin-avidin as a protease-responsive cap system for controlled guest release from colloidal mesoporous silica. Angew Chem Int Ed Engl 2009, 48(17):3092-3095.
    • (2009) Angew Chem Int Ed Engl , vol.48 , Issue.17 , pp. 3092-3095
    • Schlossbauer, A.1    Kecht, J.2    Bein, T.3
  • 21
    • 33748999805 scopus 로고    scopus 로고
    • An intramolecular cyclization reaction is responsible for the invivo inefficacy and apparent pH insensitive hydrolysis kinetics of hydrazone carboxylate derivatives of doxorubicin
    • Lee C.C., Cramer A.T., Szoka F.J., Frechet J.M. An intramolecular cyclization reaction is responsible for the invivo inefficacy and apparent pH insensitive hydrolysis kinetics of hydrazone carboxylate derivatives of doxorubicin. Bioconjug Chem 2006, 17(5):1364-1368.
    • (2006) Bioconjug Chem , vol.17 , Issue.5 , pp. 1364-1368
    • Lee, C.C.1    Cramer, A.T.2    Szoka, F.J.3    Frechet, J.M.4
  • 22
    • 0029971428 scopus 로고    scopus 로고
    • Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer
    • Gerweck L.E., Seetharaman K. Cellular pH gradient in tumor versus normal tissue: potential exploitation for the treatment of cancer. Cancer Res 1996, 56(6):1194-1198.
    • (1996) Cancer Res , vol.56 , Issue.6 , pp. 1194-1198
    • Gerweck, L.E.1    Seetharaman, K.2
  • 23
    • 0035291243 scopus 로고    scopus 로고
    • Delivery of molecular and cellular medicine to solid tumors
    • Jain R.K. Delivery of molecular and cellular medicine to solid tumors. Adv Drug Deliv Rev 2001, 46(1-3):149-168.
    • (2001) Adv Drug Deliv Rev , vol.46 , Issue.1-3 , pp. 149-168
    • Jain, R.K.1
  • 24
    • 69249203493 scopus 로고    scopus 로고
    • Gold nanoparticles with a monolayer of doxorubicin-conjugated amphiphilic block copolymer for tumor-targeted drug delivery
    • Prabaharan M., Grailer J.J., Pilla S., Steeber D.A., Gong S. Gold nanoparticles with a monolayer of doxorubicin-conjugated amphiphilic block copolymer for tumor-targeted drug delivery. Biomaterials 2009, 30(30):6065-6075.
    • (2009) Biomaterials , vol.30 , Issue.30 , pp. 6065-6075
    • Prabaharan, M.1    Grailer, J.J.2    Pilla, S.3    Steeber, D.A.4    Gong, S.5
  • 25
    • 80051516660 scopus 로고    scopus 로고
    • Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells
    • Wang F., Wang Y.C., Dou S., Xiong M.H., Sun T.M., Wang J. Doxorubicin-tethered responsive gold nanoparticles facilitate intracellular drug delivery for overcoming multidrug resistance in cancer cells. ACS Nano 2011, 5(5):3679-3692.
    • (2011) ACS Nano , vol.5 , Issue.5 , pp. 3679-3692
    • Wang, F.1    Wang, Y.C.2    Dou, S.3    Xiong, M.H.4    Sun, T.M.5    Wang, J.6
  • 26
    • 84893660534 scopus 로고    scopus 로고
    • Novel nanostructured lipid carrier co-loaded with doxorubicin and docosahexaenoic acid demonstrates enhanced invitro activity and overcomes drug resistance in MCF-7/Adr cells
    • Mussi S.V., Sawant R., Perche F., Oliveira M.C., Azevedo R.B., Ferreira L.A., et al. Novel nanostructured lipid carrier co-loaded with doxorubicin and docosahexaenoic acid demonstrates enhanced invitro activity and overcomes drug resistance in MCF-7/Adr cells. Pharm Res 2014, 10.1007/s11095-013-1290-2.
    • (2014) Pharm Res
    • Mussi, S.V.1    Sawant, R.2    Perche, F.3    Oliveira, M.C.4    Azevedo, R.B.5    Ferreira, L.A.6
  • 27
    • 84899790254 scopus 로고    scopus 로고
    • Codelivery of doxorubicin and paclitaxel by cross-linked multilamellar liposome enables synergistic antitumor activity
    • Liu Y., Fang J., Kim Y.J., Wong M.K., Wang P. Codelivery of doxorubicin and paclitaxel by cross-linked multilamellar liposome enables synergistic antitumor activity. Mol Pharmacol 2014, 11(5):1651-1661.
    • (2014) Mol Pharmacol , vol.11 , Issue.5 , pp. 1651-1661
    • Liu, Y.1    Fang, J.2    Kim, Y.J.3    Wong, M.K.4    Wang, P.5
  • 30
    • 84891371917 scopus 로고    scopus 로고
    • Drug-loaded gold plasmonic nanoparticles for treatment of multidrug resistance in cancer
    • Lee S.M., Kim H.J., Kim S.Y., Kwon M.K., Kim S., Cho A., et al. Drug-loaded gold plasmonic nanoparticles for treatment of multidrug resistance in cancer. Biomaterials 2014, 35(7):2272-2282.
    • (2014) Biomaterials , vol.35 , Issue.7 , pp. 2272-2282
    • Lee, S.M.1    Kim, H.J.2    Kim, S.Y.3    Kwon, M.K.4    Kim, S.5    Cho, A.6
  • 32
    • 84867468134 scopus 로고    scopus 로고
    • PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics
    • Perry J.L., Reuter K.G., Kai M.P., Herlihy K.P., Jones S.W., Luft J.C., et al. PEGylated PRINT nanoparticles: the impact of PEG density on protein binding, macrophage association, biodistribution, and pharmacokinetics. Nano Lett 2012, 12(10):5304-5310.
    • (2012) Nano Lett , vol.12 , Issue.10 , pp. 5304-5310
    • Perry, J.L.1    Reuter, K.G.2    Kai, M.P.3    Herlihy, K.P.4    Jones, S.W.5    Luft, J.C.6
  • 33
    • 79952851365 scopus 로고    scopus 로고
    • Seeded growth synthesis of uniform gold nanoparticles with diameters of 15-300nm
    • Ziegler C., Eychmüller A. Seeded growth synthesis of uniform gold nanoparticles with diameters of 15-300nm. JPhys Chem C 2011, 115(11):4502-4506.
    • (2011) JPhys Chem C , vol.115 , Issue.11 , pp. 4502-4506
    • Ziegler, C.1    Eychmüller, A.2
  • 34
    • 84874638172 scopus 로고    scopus 로고
    • Selective tumor cell targeting by the disaccharide moiety of bleomycin
    • Yu Z., Schmaltz R.M., Bozeman T.C., Paul R., Rishel M.J., Tsosie K.S., et al. Selective tumor cell targeting by the disaccharide moiety of bleomycin. JAm Chem Soc 2013, 135(8):2883-2886.
    • (2013) JAm Chem Soc , vol.135 , Issue.8 , pp. 2883-2886
    • Yu, Z.1    Schmaltz, R.M.2    Bozeman, T.C.3    Paul, R.4    Rishel, M.J.5    Tsosie, K.S.6
  • 35
    • 80052961350 scopus 로고    scopus 로고
    • Acascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein
    • Gao H., Pan S., Yang Z., Cao S., Chen C., Jiang X., et al. Acascade targeting strategy for brain neuroglial cells employing nanoparticles modified with angiopep-2 peptide and EGFP-EGF1 protein. Biomaterials 2011, 32(33):8669-8675.
    • (2011) Biomaterials , vol.32 , Issue.33 , pp. 8669-8675
    • Gao, H.1    Pan, S.2    Yang, Z.3    Cao, S.4    Chen, C.5    Jiang, X.6
  • 36
    • 59649083642 scopus 로고    scopus 로고
    • Influence of anchoring ligands and particle size on the colloidal stability and invivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice
    • Zhang G., Yang Z., Lu W., Zhang R., Huang Q., Tian M., et al. Influence of anchoring ligands and particle size on the colloidal stability and invivo biodistribution of polyethylene glycol-coated gold nanoparticles in tumor-xenografted mice. Biomaterials 2009, 30(10):1928-1936.
    • (2009) Biomaterials , vol.30 , Issue.10 , pp. 1928-1936
    • Zhang, G.1    Yang, Z.2    Lu, W.3    Zhang, R.4    Huang, Q.5    Tian, M.6
  • 37
    • 65749117793 scopus 로고    scopus 로고
    • Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy
    • Aggarwal P., Hall J.B., McLeland C.B., Dobrovolskaia M.A., McNeil S.E. Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy. Adv Drug Deliv Rev 2009, 61(6):428-437.
    • (2009) Adv Drug Deliv Rev , vol.61 , Issue.6 , pp. 428-437
    • Aggarwal, P.1    Hall, J.B.2    McLeland, C.B.3    Dobrovolskaia, M.A.4    McNeil, S.E.5
  • 38
    • 84856436072 scopus 로고    scopus 로고
    • Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake
    • Walkey C.D., Olsen J.B., Guo H., Emili A., Chan W.C. Nanoparticle size and surface chemistry determine serum protein adsorption and macrophage uptake. JAm Chem Soc 2012, 134(4):2139-2147.
    • (2012) JAm Chem Soc , vol.134 , Issue.4 , pp. 2139-2147
    • Walkey, C.D.1    Olsen, J.B.2    Guo, H.3    Emili, A.4    Chan, W.C.5
  • 39
    • 79959228150 scopus 로고    scopus 로고
    • Enhanced intracellular delivery and chemotherapy for glioma rats by transferrin-conjugated biodegradable polymersomes loaded with doxorubicin
    • Pang Z., Gao H., Yu Y., Guo L., Chen J., Pan S., et al. Enhanced intracellular delivery and chemotherapy for glioma rats by transferrin-conjugated biodegradable polymersomes loaded with doxorubicin. Bioconjug Chem 2011, 22(6):1171-1180.
    • (2011) Bioconjug Chem , vol.22 , Issue.6 , pp. 1171-1180
    • Pang, Z.1    Gao, H.2    Yu, Y.3    Guo, L.4    Chen, J.5    Pan, S.6
  • 40
    • 84858862891 scopus 로고    scopus 로고
    • Antitumor efficacy following the intracellular and interstitial release of liposomal doxorubicin
    • Bandekar A., Karve S., Chang M.Y., Mu Q., Rotolo J., Sofou S. Antitumor efficacy following the intracellular and interstitial release of liposomal doxorubicin. Biomaterials 2012, 33(17):4345-4352.
    • (2012) Biomaterials , vol.33 , Issue.17 , pp. 4345-4352
    • Bandekar, A.1    Karve, S.2    Chang, M.Y.3    Mu, Q.4    Rotolo, J.5    Sofou, S.6
  • 41
    • 42549131472 scopus 로고    scopus 로고
    • Gold nanoparticle-based miniaturized nanomaterial surface energy transfer probe for rapid and ultrasensitive detection of mercury in soil, water, and fish
    • Darbha G.K., Ray A., Ray P.C. Gold nanoparticle-based miniaturized nanomaterial surface energy transfer probe for rapid and ultrasensitive detection of mercury in soil, water, and fish. ACS Nano 2007, 1(3):208-214.
    • (2007) ACS Nano , vol.1 , Issue.3 , pp. 208-214
    • Darbha, G.K.1    Ray, A.2    Ray, P.C.3
  • 42
    • 53149106578 scopus 로고    scopus 로고
    • Synthesis, characterization, and invivo diagnostic applications of hyaluronic acid immobilized gold nanoprobes
    • Lee H., Lee K., Kim I.K., Park T.G. Synthesis, characterization, and invivo diagnostic applications of hyaluronic acid immobilized gold nanoprobes. Biomaterials 2008, 29(35):4709-4718.
    • (2008) Biomaterials , vol.29 , Issue.35 , pp. 4709-4718
    • Lee, H.1    Lee, K.2    Kim, I.K.3    Park, T.G.4
  • 43
    • 28844488494 scopus 로고    scopus 로고
    • Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles
    • Owens D.R., Peppas N.A. Opsonization, biodistribution, and pharmacokinetics of polymeric nanoparticles. Int J Pharm 2006, 307(1):93-102.
    • (2006) Int J Pharm , vol.307 , Issue.1 , pp. 93-102
    • Owens, D.R.1    Peppas, N.A.2
  • 44
    • 84861233382 scopus 로고    scopus 로고
    • Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: concepts and applications
    • Fleige E., Quadir M.A., Haag R. Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: concepts and applications. Adv Drug Deliv Rev 2012, 64(9):866-884.
    • (2012) Adv Drug Deliv Rev , vol.64 , Issue.9 , pp. 866-884
    • Fleige, E.1    Quadir, M.A.2    Haag, R.3
  • 46
    • 84883346621 scopus 로고    scopus 로고
    • Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization
    • Gao H., Yang Z., Zhang S., Cao S., Shen S., Pang Z., et al. Ligand modified nanoparticles increases cell uptake, alters endocytosis and elevates glioma distribution and internalization. Sci Rep 2013, 3:2534.
    • (2013) Sci Rep , vol.3 , pp. 2534
    • Gao, H.1    Yang, Z.2    Zhang, S.3    Cao, S.4    Shen, S.5    Pang, Z.6
  • 48
    • 84895429592 scopus 로고    scopus 로고
    • Study and evaluation of mechanisms of dual targeting drug delivery system with tumor microenvironment assays compared with normal assays
    • Gao H., Yang Z., Zhang S., Pang Z., Liu Q., Jiang X. Study and evaluation of mechanisms of dual targeting drug delivery system with tumor microenvironment assays compared with normal assays. Acta Biomater 2014, 10(2):858-867.
    • (2014) Acta Biomater , vol.10 , Issue.2 , pp. 858-867
    • Gao, H.1    Yang, Z.2    Zhang, S.3    Pang, Z.4    Liu, Q.5    Jiang, X.6
  • 49
    • 84867717316 scopus 로고    scopus 로고
    • The blood-brain/tumor barriers: challenges and chances for malignant gliomas targeted drug delivery
    • Zhan C., Lu W. The blood-brain/tumor barriers: challenges and chances for malignant gliomas targeted drug delivery. Curr Pharm Biotechnol 2012, 13(12):2380-2387.
    • (2012) Curr Pharm Biotechnol , vol.13 , Issue.12 , pp. 2380-2387
    • Zhan, C.1    Lu, W.2
  • 50
    • 84865558062 scopus 로고    scopus 로고
    • Anti-glioblastoma efficacy and safety of paclitaxel-loading angiopep-conjugated dual targeting PEG-PCL nanoparticles
    • Xin H., Sha X., Jiang X., Zhang W., Chen L., Fang X. Anti-glioblastoma efficacy and safety of paclitaxel-loading angiopep-conjugated dual targeting PEG-PCL nanoparticles. Biomaterials 2012, 33(32):8167-8176.
    • (2012) Biomaterials , vol.33 , Issue.32 , pp. 8167-8176
    • Xin, H.1    Sha, X.2    Jiang, X.3    Zhang, W.4    Chen, L.5    Fang, X.6
  • 51
    • 84894625523 scopus 로고    scopus 로고
    • Smart nanodevice combined tumor-specific vector with cellular microenvironment-triggered property for highly effective antiglioma therapy
    • Shao K., Ding N., Huang S., Ren S., Zhang Y., Kuang Y., et al. Smart nanodevice combined tumor-specific vector with cellular microenvironment-triggered property for highly effective antiglioma therapy. ACS Nano 2014, 8(2):1191-1203.
    • (2014) ACS Nano , vol.8 , Issue.2 , pp. 1191-1203
    • Shao, K.1    Ding, N.2    Huang, S.3    Ren, S.4    Zhang, Y.5    Kuang, Y.6


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