Long-term lithium treatment reduces glucose metabolism in the cerebellum and hippocampus of nondemented older adults: An [18F]FDG-PET study

ACS Chemical Neuroscience

Volumn 5, Issue 6, 2014, Pages 484-489

  Forlenza, Orestes V ^a   Coutinho, Artur Martins Novaes ^a   Aprahamian, Ivan ^a   Prando, Silvana ^a   Mendes, Luciana Lucas ^a   Diniz, Breno S ^b   Gattaz, Wagner F ^a   Buchpiguel, Carlos A ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

Author keywords

brain metabolism; Lithium; mild cognitive impairment

Indexed keywords

FLUORODEOXYGLUCOSE F 18; GLUCOSE; LITHIUM CARBONATE; PLACEBO; PSYCHOTROPIC AGENT; RADIOPHARMACEUTICAL AGENT;

ADULT; BIPOLAR DISORDER; CASE CONTROL STUDY; CEREBELLUM; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE TITRATION; FEMALE; GLUCOSE BRAIN LEVEL; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HIPPOCAMPUS; HUMAN; LITHIUM BLOOD LEVEL; LONG TERM CARE; MALE; MILD COGNITIVE IMPAIRMENT; MINI MENTAL STATE EXAMINATION; NEUROBIOLOGY; NEUROIMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; REVIEW; TREATMENT DURATION; AGED; BRAIN MAPPING; DRUG EFFECTS; METABOLISM; RANDOMIZED CONTROLLED TRIAL; SCINTISCANNING;

AGED; BRAIN MAPPING; CEREBELLUM; FEMALE; FLUORODEOXYGLUCOSE F18; GLUCOSE; HIPPOCAMPUS; HUMANS; LITHIUM CARBONATE; MALE; MILD COGNITIVE IMPAIRMENT; POSITRON-EMISSION TOMOGRAPHY; PSYCHOTROPIC DRUGS; RADIOPHARMACEUTICALS;

EID: 84902662709     PISSN: None     EISSN: 19487193     Source Type: Journal    
DOI: 10.1021/cn5000315     Document Type: Review

References (44)

1. Geddes, J. R., Burgess, S., Hawton, K., Jamison, K., and Goodwin, G. M. (2004) Long-term lithium therapy for bipolar disorder: systematic review and meta-analysis of randomized controlled trials Am. J. Psychiatry 161, 217-222
2. Cipriani, A., Pretty, H., Hawton, K., and Geddes, J. R. (2005) Lithium in the prevention of suicidal behavior and all-cause mortality in patients with mood disorders: a systematic review of randomized trials Am. J. Psychiatry 162, 1805-1819
3. Ohgami, H., Terao, T., Shiotsuki, I., Ishii, N., and Iwata, N. (2009) Lithium levels in drinking water and risk of suicide Br J. Psychiatry 194, 464-465
4. Forlenza, O. V., de Paula, V. J., Machado-Vieira, R., Diniz, B. S., and Gattaz, W. F. (2012) Does lithium prevent Alzheimer's disease? Drugs Aging 29, 335-342
5. Chiò, A. and Mora, G. (2012) The final chapter of the ALS lithium saga Lancet Neurol. 12, 324-325
6. Macdonald, A., Briggs, K., Poppe, M., Higgins, A., Velayudhan, L., and Lovestone, S. (2008) A feasibility and tolerability study of lithium in Alzheimer's disease Int. J. Geriatr. Psychiatry 23 (7) 704-711
7. Hampel, H., Ewers, M., Bürger, K., Annas, P., Mörtberg, A., Bogstedt, A., Frölich, L., Schröder, J., Schönknecht, P., Riepe, M. W., Kraft, I., Gasser, T., Leyhe, T., Möller, H. J., Kurz, A., and Basun, H. (2009) Lithium trial in Alzheimer's disease: a randomized, single-blind, placebo-controlled, multicenter 10-week study J. Clin. Psychiatry 70 (6) 922-931
8. Forlenza, O. V., Diniz, B. S., Radanovic, M., Santos, F. S., Talib, L. L., and Gattaz, W. F. (2011) Disease-modifying properties of long-term lithium treatment for amnestic mild cognitive impairment: randomised controlled trial Br J. Psychiatry 198, 351-356
9. Terao, T., Nakano, H., Inoue, Y., Okamoto, T., Nakamura, J., and Iwata, N. (2006) Lithium and dementia: a preliminary study Prog. Neuro-Psychopharmacol. Biol. Psychiatry 30, 1125-1128
10. Nunes, P. V., Forlenza, O. V., and Gattaz, W. F. (2007) Lithium and risk for Alzheimer's disease in elderly patients with bipolar disorder Br J. Psychiatry 190, 359-360
11. Kessing, L. V., Forman, J. L., and Andersen, P. K. (2010) Does lithium protect against dementia? Bipolar Disord. 12, 87-94
12. Machado-Vieira, R., Manji, H. K., and Zarate, C. A., Jr (2009) The role of lithium in the treatment of bipolar disorder: convergent evidence for neurotrophic effects as a unifying hypothesis Bipolar Disord. 11 (Suppl 2) 92-109
13. Suwalska, A., Sobieska, M., and Rybakowski, J. K. (2010) Serum brain-derived neurotrophic factor in euthymic bipolar patients on prophylactic lithium therapy Neuropsychobiology 62, 229-234
14. Rybakowski, J. K. and Suwalska, A. (2010) Excellent lithium responders have normal cognitive functions and plasma BDNF levels Int. J. Neuropsychopharmacol. 13, 617-622
15. Knijff, E. M., Breunis, M. N., Kupka, R. W., de Wit, H. J., Ruwhof, C., Akkerhuis, G. W., Nolen, W. A., and Drexhage, H. A. (2007) An imbalance in the production of IL-1beta and IL-6 by monocytes of bipolar patients: restoration by lithium treatment Bipolar Disord. 9, 743-753
16. Guloksuz, S., Altinbas, K., Aktas Cetin, E., Kenis, G., Bilgic Gazioglu, S., Deniz, G., Oral, E. T., and van Os, J. (2012) Evidence for an association between tumor necrosis factor-alpha levels and lithium response J. Affective Disord. 143, 148-152
17. Khairova, R., Pawar, R., Salvadore, G., Juruena, M. F., de Sousa, R. T., Soeiro-de-Souza, M. G., Salvador, M., Zarate, C. A., Gattaz, W. F., and Machado-Vieira, R. (2012) Effects of lithium on oxidative stress parameters in healthy subjects Mol. Med. Rep. 5, 680-682
18. de Sousa, R. T., Zarate, C. A., Jr, Zanetti, M. V., Costa, A. C., Talib, L. L., Gattaz, W. F., and Machado-Vieira, R. (2014) Oxidative stress in early stage Bipolar Disorder and the association with response to lithium J. Psychiatr. Res. 50, 36-41
19. Bearden, C. E., Thompson, P. M., Dalwani, M., Hayashi, K. M., Lee, A. D., Nicoletti, M., Trakhtenbroit, M., Glahn, D. C., Brambilla, P., Sassi, R. B., Mallinger, A. G., Frank, E., Kupfer, D. J., and Soares, J. C. (2007) Greater cortical gray matter density in lithium-treated patients with bipolar disorder Biol. Psychiatry 62, 7-16
20. Moore, G. J., Cortese, B. M., Glitz, D. A., Zajac-Benitez, C., Quiroz, J. A., Uhde, T. W., Drevets, W. C., and Manji, H. K. (2009) A longitudinal study of the effects of lithium treatment on prefrontal and subgenual prefrontal gray matter volume in treatment-responsive bipolar disorder patients J. Clin. Psychiatry 70, 699-705
21. Lyoo, I. K., Dager, S. R., Kim, J. E., Yoon, S. J., Friedman, S. D., Dunner, D. L., and Renshaw, P. F. (2010) Lithium-induced gray matter volume increase as a neural correlate of treatment response in bipolar disorder: a longitudinal brain imaging study Neuropsychopharmacology 35, 1743-1750
22. van Erp, T. G., Thompson, P. M., Kieseppä, T., Bearden, C. E., Marino, A. C., Hoftman, G. D., Haukka, J., Partonen, T., Huttunen, M., Kaprio, J., Lönnqvist, J., Poutanen, V. P., Toga, A. W., and Cannon, T. D. (2012) Hippocampal morphology in lithium and non-lithium-treated bipolar I disorder patients, non-bipolar co-twins, and control twins Hum. Brain Mapp. 33, 501-510
23. Hajek, T., Calkin, C., Blagdon, R., Slaney, C., and Alda, M. (2013) Type 2 Diabetes Mellitus: A Potentially Modifiable Risk Factor for Neurochemical Brain Changes in Bipolar Disorders Biol. Psychiatry 10.1016/j.biopsych.2013.11. 007
24. Silverstone, P. H., Wu, R. H., O'Donnell, T., Ulrich, M., Asghar, S. J., and Hanstock, C. C. (2003) Chronic treatment with lithium, but not sodium valproate, increases cortical N-acetyl-aspartate concentrations in euthymic bipolar patients Int. Clin Psychopharmacol 18, 73-79
25. Forester, B. P., Finn, C. T., Berlow, Y. A., Wardrop, M., Renshaw, P. F., and Moore, C. M. (2008) Brain lithium, N-acetyl aspartate and myo-inositol levels in older adults with bipolar disorder treated with lithium: a lithium-7 and proton magnetic resonance spectroscopy study Bipolar Disord. 10, 691-700
26. Tonn, P., Bartensten, P., and Dahmen, N. (2005) Lithiumintoxikation imitiert Alzheimer-Demenz in PET und klinischen Befund Nervenarzt 76, 613-616
27. Hollander, E., Buchsbaum, M. S., Haznedar, M. M., Berenguer, J., Berlin, H. A., Chaplin, W., Goodman, C. R., LiCalzi, E. M., Newmark, R., and Pallanti, S. (2008) FDG-PET study in pathological gamblers: lithium increases orbitofrontal, dorsolateral and cingulate metabolism Neuropsychobiology 58, 37-47
28. Von Hartitzsch, B., Hoenisch, N. A., Leigh, R. J., Wilkinson, R., Frost, T. H., Weddel, A., and Posen, G. A. (1972) Permanent neurological sequelae despite haemodialysis for lithium intoxication BMJ [Br. Med. J.] 4, 757-759
29. Aditianjee, Munshi, K. R., and Thampy, A. (2005) The syndrome of irreversible lithium-effectuated neurotoxicity Clin. Neuropharmacol. 28, 38-49
30. Niethammer, M. and Ford, B. (2007) Permanent lithium-induced cerebellar toxicity: three cases and review of the literature Mov. Disord. 22, 570-573
31. Tesio, L., Porta, G. L., and Messa, E. (1987) Cerebellar syndrome in lithium poisoning: a case of partial recovery J. Neurol., Neurosurg. Psychiatry 50, 235
32. Naramoto, A., Koizumi, N., Itoh, N., and Shigematsy, H. (1993) An autopsy case of cerebellar degeneration following lithium intoxication with neuroleptic malignant syndrome Acta Pathol. Jpn. 43, 55-58
33. Dethy, S., Manto, M., Bastianelli, E., Gangji, V., Laute, M. A., Goldman, S., and Hildebrand, J. (1997) Cerebellar spongiform degeneration induced by acute lithium intoxication in the rat Neurosci. Lett. 224, 25-28
34. Dimitrova, M., Petrova, E., Gluhcheva, Y., Kadiysky, D., Dimitrova, S., Kolyovska, V., and Deleva, D. (2013) Neurodegenerative Changes in rat produced by lithium treatment J. Toxicol Environ. Health, Part A 76, 304-310
35. Bachmann, R. F., Wang, Y., Yuan, P., Zhou, R., Li, X., Alesci, S., Du, J., and Manji, H. K. (2009) Common effects of lithium and valproate on mitochondrial functions: protection against methamphetamine-induced mitochondrial damage Int. J. Neuropsychopharmacol. 12, 805-822
36. Hashimoto, R., Senatorov, V., Kanai, H., Leeds, P., and Chuang, D. M. (2003) Lithium stimulates progenitor proliferation in cultured brain neurons Neuroscience 117, 55-61
37. Kim, J. S., Chang, M. Y., Yu, I. T., Kim, J. H., Lee, S. H., Lee, Y. S., and Son, H. (2004) Lithium selectively increases neuronal differentiation of hippocampal neural progenitor cells both in vitro and in vivo J. Neurochem. 89, 324-336
38. Young, A. H. and Hammond, J. M. (2007) Lithium in mood disorders: increasing evidence base, declineing use? Br J. Psychiatry 191, 474-476
39. Grandjean, E. M. and Aubry, J. M. (2009) Lithium: updated human knowledge using an evidence-based approach: part III: clinical safety CNS Drugs 23, 397-418
40. Aprahamian, I., Santos, F. S., Santos, B., Talib, L., Diniz, B. S., Radanovic, M., Gattaz, W. F., and Forlenza, O. V. Long-term, low-dose lithium treatment does not impair renal function in the elderly: a two-year placebo-controlled trial followed by single-blind extension. J. Clin. Psychiatry 2014, in press
41. Diniz, B. S., Nunes, P. V., Yassuda, M. S., Pereira, F. S., Flaks, M. K., Viola, L. F., Radanovic, M., Abreu, I. D., Borelli, D. T., Gattaz, W. F., and Forlenza, O. V. (2008) Mild cognitive impairment: cognitive screening or neuropsychological assessment? Rev. Bras. Psiquiatr. 30, 316-321
42. Petersen, R. C., Smith, G. E., Waring, S. C., Ivnik, R. J., Tangalos, E. G., and Kokmen, E. (1999) Mild cognitive impairment: clinical characterization and outcome Arch. Neurol. 56, 303-308
43. Lancaster, J. L., Rainey, L. H., Summerlin, J. L., Freitas, C. S., Fox, P. T., Evans, A. C., Toga, A. W., and Mazziotta, J. C. (1997) Automated labeling of the human brain: A preliminary report on the development and evaluation of a forward-transform method Hum. Brain Mapp. 5, 238-242
44. Lancaster, J. L., Woldorff, M. G., Parsons, L. M., Liotti, M., Freitas, C. S., Rainey, L., Kochunov, P. V., Nickerson, D., Mikiten, S. A., and Fox, P. T. (2000) Automated Talairach Atlas labels for functional brain mapping Hum. Brain Mapp. 10, 120-131