Melatonin set out to ER stress signaling thwarts epithelial mesenchymal transition and peritoneal dissemination via calpain-mediated C/EBPβ and NFκB cleavage

Journal of Pineal Research

Volumn 60, Issue 2, 2016, Pages 142-154

  Wu, Sheng Mao ^a   Lin, Wan Yu ^b   Shen, Chin Chang ^c   Pan, Hung Chuan ^b,d   Wang, Keh Bin ^e   Chen, Yi Ching ^e   Jan, Yee Jee ^b   Lai, De Wei ^a   Tang, Shu Ching ^a   Tien, Hsing Ru ^a   Chiu, Chien Shan ^a   Tsai, Tsung Chih ^a   Lai, Yi Liang ^f   Sheu, Meei Ling ^a,b  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b TAICHUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^c INSTITUTE OF NUCLEAR ENERGY RESEARCH   (Taiwan)

^d NATIONAL YANG MING UNIVERSITY   (Taiwan)

^e KUANG TIEN GENERAL HOSPITAL   (Taiwan)

^f TAICHUNG ARMED FORCES GENERAL HOSPITAL   (Taiwan)

Author keywords

C EBP ; calpain; endoplasmic reticulum stress; epithelial to mesenchymal transition; melatonin; peritoneal dissemination

Indexed keywords

ALPHA TUBULIN; ANTIMETASTATIC AGENT; BETA CATENIN; BIOLOGICAL MARKER; CALPAIN 1; CALPAIN 2; CASPASE 3; CASPASE 7; CCAAT ENHANCER BINDING PROTEIN BETA; CXCL1 CHEMOKINE; CYCLOOXYGENASE 2; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; INTERLEUKIN 8; MELATONIN; PROSTAGLANDIN E2; TRANSCRIPTION FACTOR ELF 1; TRANSCRIPTION FACTOR ELF 2ALPHA; TRANSCRIPTION FACTOR RELA; TRANSCRIPTION FACTOR SLUG; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; UNCLASSIFIED DRUG; UVOMORULIN; VASCULOTROPIN A; VASCULOTROPIN C; VIMENTIN; WNT PROTEIN; CALPAIN; CEBPB PROTEIN, HUMAN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; TUMOR PROTEIN;

ADULT; ANGIOGENESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BINDING AFFINITY; BINDING SITE; CARCINOMATOUS PERITONITIS; CELL INVASION; CHROMATIN IMMUNOPRECIPITATION; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; ENDOPLASMIC RETICULUM STRESS; ENZYME ACTIVITY; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOPRECIPITATION; IN VITRO STUDY; IN VIVO STUDY; MALE; MIDDLE AGED; MOUSE; NONHUMAN; NUCLEAR LOCALIZATION SIGNAL; PERITONEUM METASTASIS; PROMOTER REGION; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; STOMACH ADENOCARCINOMA; TRANSMISSION ELECTRON MICROSCOPY; TUMOR GROWTH; WNT SIGNALING PATHWAY; ANIMAL; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY; PERITONEAL NEOPLASMS; PROTEIN DEGRADATION; SECONDARY; STOMACH NEOPLASMS; TUMOR CELL LINE;

ANIMALS; CALPAIN; CCAAT-ENHANCER-BINDING PROTEIN-BETA; CELL LINE, TUMOR; ENDOPLASMIC RETICULUM STRESS; EPITHELIAL-MESENCHYMAL TRANSITION; GENE SILENCING; HUMANS; MELATONIN; MICE; NEOPLASM PROTEINS; NF-KAPPA B; PERITONEAL NEOPLASMS; PROTEOLYSIS; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS;

EID: 84956909903     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/jpi.12295     Document Type: Article

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