Melatonin inhibits endoplasmic reticulum stress and epithelial-mesenchymal transition during bleomycin-induced pulmonary fibrosis in mice

PLoS ONE

Volumn 9, Issue 5, 2014, Pages

  Zhao, Hui ^a   Wu, Qing Qing ^a   Cao, Lin Feng ^a   Qing, Hou Ying ^a   Zhang, Cheng ^a   Chen, Yuan Hua ^a   Wang, Hua ^a   Liu, Rong Ru ^a   Xu, De Xiang ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ALPHA SMOOTH MUSCLE ACTIN; GLUCOSE REGULATED PROTEIN 78; INITIATION FACTOR 2ALPHA; MELATONIN; STRESS ACTIVATED PROTEIN KINASE; X BOX BINDING PROTEIN 1; ANTINEOPLASTIC AGENT; BLEOMYCIN;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLEOMYCIN-INDUCED PULMONARY FIBROSIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM STRESS; EPITHELIAL MESENCHYMAL TRANSITION; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; UNFOLDED PROTEIN RESPONSE; UPREGULATION; ANIMAL; CHEMICALLY INDUCED; DRUG EFFECTS; PATHOLOGY; PULMONARY FIBROSIS;

ANIMALS; ANTINEOPLASTIC AGENTS; BLEOMYCIN; ENDOPLASMIC RETICULUM STRESS; EPITHELIAL-MESENCHYMAL TRANSITION; MALE; MELATONIN; MICE; PULMONARY FIBROSIS;

EID: 84901286029     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0097266     Document Type: Article

References (44)

1. King TE Jr, Pardo A, Selman M (2011) Idiopathic pulmonary fibrosis. Lancet 378: 1949-1961.
2. Borchers AT, Chang C, Keen CL, Gershwin ME (2011) Idiopathic pulmonary fibrosis-an epidemiological and pathological review. Clin Rev Allergy Immunol 40: 117-134.
3. Adamson IY, Bowden DH (1974) The pathogenesis of bloemycin-induced pulmonary fibrosis in mice. Am J pathol 77: 185-197.
4. Moore BB, Hogaboam CM (2008) Murine models of pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol 294: L152-160. (Pubitemid 351253350)
5. Moeller A, Ask K, Warburton D, Gauldie J, Kolb M (2008) The bleomycin animal model: a useful tool to investigate treatment options for idiopathic pulmonary fibrosis? Int J Biochem Cell Biol 40: 362-382. (Pubitemid 351249887)
6. Wu J, Kaufman RJ (2006) From acute ER stress to physiological roles of the Unfolded Protein Response. Cell Death Differ 13: 374-384.
7. Ron D, Walter P (2007) Signal integration in the endoplasmic reticulum unfolded protein response. Nat Rev Mol Cell Biol 8: 519-529. (Pubitemid 46985379)
8. Kohno K (2007) How transmembrane proteins sense endoplasmic reticulum stress. Antioxid Redox Signal 9: 2295-2303.
9. Yoshida H, Matsui T, Yamamoto A, Okada T, Mori K (2001) XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell 107: 881-891. (Pubitemid 34084979)
10. Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D (2000) Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell 5: 897-904.
11. Yoshida H, Haze K, Yanagi H, Yura T, Mori K (1998) Identification of the cisacting endoplasmic reticulum stress response element responsible for transcriptional induction of mammalian glucose-regulated proteins. Involvement of basic leucine zipper transcription factors. J Biol Chem 273: 33741-33749.
12. Lawson WE, Crossno PF, Polosukhin VV, Roldan J, Cheng DS, et al. (2008) Endoplasmic reticulum stress in alveolar epithelial cells is prominent in IPF: association with altered surfactant protein processing and herpesvirus infection. Am J Physiol Lung Cell Mol Physiol 294: L1119-1126.
13. Zhong Q, Zhou B, Ann DK, Minoo P, Liu Y, et al. (2011) Role of endoplasmic reticulum stress in epithelial-mesenchymal transition of alveolar epithelial cells: effects of misfolded surfactant protein. Am J Respir Cell Mol Biol 45: 498-509.
14. Lawson WE, Cheng DS, Degryse AL, Tanjore H, Polosukhin VV, et al. (2011) Endoplasmic reticulum stress enhances fibrotic remodeling in the lungs. Proc Natl Acad Sci U S A 108: 10562-10567.
15. Galano A, Tan DX, Reiter RJ (2011) Melatonin as a natural ally against oxidative stress: a physicochemical examination. J Pineal Res 51: 1-16.
16. Galano A, Tan DX, Reiter RJ (2013) On the free radical scavenging activities of melatonin's metabolites, AFMK and AMK. J Pineal Res 54: 245-257.
17. Rodriguez C, Mayo JC, Sainz RM, Antolin I, Herrera F, et al. (2004) Regulation of antioxidant enzymes: a significant role for melatonin. J Pineal Res 36: 1-9. (Pubitemid 38130283)
18. Richter HG, Hansell JA, Raut S, Giussani DA (2009) Melatonin improves placental efficiency and birth weight and increases the placental expression of antioxidant enzymes in undernourished pregnancy. J Pineal Res 46: 357-364.
19. Crespo I, Miguel BS, Laliena A, Alvarez M, Culebras JM, et al. (2010) Melatonin prevents the decreased activity of antioxidant enzymes and activates nuclear erythroid 2-related factor 2 signaling in an animal model of fulminant hepatic failure of viral origin. J Pineal Res 49: 193-200.
20. Wu CC, Lu KC, Lin GJ, Hsieh HY, Chu P, et al. (2012) Melatonin enhances endogenous heme oxygenase-1 and represses immune responses to ameliorate experimental murine membranous nephropathy. J Pineal Res 52: 460-469.
21. Xu DX, Wang H, Ning H, Zhao L, Chen YH (2007) Maternally administered melatonin differentially regulates lipopolysaccharide-induced proinflammatory and anti-inflammatory cytokines in maternal serum, amniotic fluid, fetal liver, and fetal brain. J Pineal Res 43: 74-79. (Pubitemid 47035224)
22. Park HJ, Kim HJ, Ra J, Hong SJ, Baik HH, et al. (2007) Melatonin inhibits lipopolysaccharide-induced CC chemokine subfamily gene expression in human peripheral blood mononuclear cells in a microarray analysis. J Pineal Res 43: 121-129. (Pubitemid 47077217)
23. Choi EY, Jin JY, Lee JY, Choi JI, Choi IS, et al. (2011) Melatonin inhibits Prevotella intermedia lipopolysaccharide-induced production of nitric oxide and interleukin-6 in murine macrophages by suppressing NF-kappaB and STAT1 activity. J Pineal Res 50: 197-206.
24. Min KJ, Jang JH, Kwon TK (2012) Inhibitory effects of melatonin on the lipopolysaccharide-induced CC chemokine expression in BV2 murine microglial cells are mediated by suppression of Akt-induced NF-kappaB and STAT/GAS activity. J Pineal Res 52: 296-304.
25. Shi D, Xiao X, Wang J, Liu L, Chen W, et al. (2012) Melatonin suppresses proinflammatory mediators in lipopolysaccharide-stimulated CRL1999 cells via targeting MAPK, NF-kappaB, c/EBPbeta, and p300 signaling. J Pineal Res 53: 154-165.
26. Xia MZ, Liang YL, Wang H, Chen X, Huang YY, et al. (2012) Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells. J Pineal Res 53: 325-334.
27. Lee YD, Kim JY, Lee KH, Kwak YJ, Lee SK, et al. (2009) Melatonin attenuates lipopolysaccharide-induced acute lung inflammation in sleep-deprived mice. J Pineal Res 46: 53-57.
28. Arslan SO, Zerin M, Vural H, Coskun A (2002) The effect of melatonin on bleomycin-induced pulmonary fibrosis in rats. J Pineal Res 32: 21-25. (Pubitemid 34123752)
29. Genovese T, Di Paola R, Mazzon E, Muia C, Caputi AP, et al. (2005) Melatonin limits lung injury in bleomycin treated mice. J Pineal Res 39: 105-112. (Pubitemid 41140747)
30. Yildirim Z, Kotuk M, Erdogan H, Iraz M, Yagmurca M, et al. (2006) Preventive effect of melatonin on bleomycin-induced lung fibrosis in rats. J Pineal Res 40: 27-33.
31. Hetz C, Martinon F, Rodriguez D, Glimcher LH (2011) The unfolded protein response: integrating stress signals through the stress sensor IRE1alpha. Physiol Rev 91: 1219-1243.
32. Walter P, Ron D (2011) The unfolded protein response: from stress pathway to homeostatic regulation. Science 334: 1081-1086.
33. Hetz C (2012) The unfolded protein response: controlling cell fate decisions under ER stress and beyond. Nat Rev Mol Cell Biol 13: 89-102.
34. Tanjore H, Cheng DS, Degryse AL, Zoz DF, Abdolrasulnia R, et al. (2011) Alveolar epithelial cells undergo epithelial-to-mesenchymal transition in response to endoplasmic reticulum stress. J Biol Chem 286: 30972-30980.
35. Korfei M, Ruppert C, Mahavadi P, Henneke I, Markart P, et al. (2008) Epithelial endoplasmic reticulum stress and apoptosis in sporadic idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 178: 838-846.
36. Wang H, Li L, Zhao M, Chen YH, Zhang ZH, et al. (2011) Melatonin alleviates lipopolysaccharide-induced placental cellular stress response in mice. J Pineal Res 50: 418-426.
37. Lin AM, Fang SF, Chao PL, Yang CH (2007) Melatonin attenuates arseniteinduced apoptosis in rat brain: involvement of mitochondrial and endoplasmic reticulum pathways and aggregation of alpha-synuclein. J Pineal Res 43: 163-171. (Pubitemid 47078924)
38. Ji YL, Wang H, Meng C, Zhao XF, Zhang C, et al. (2012) Melatonin alleviates cadmium-induced cellular stress and germ cell apoptosis in testes. J Pineal Res 52: 71-79.
39. Tunon MJ, San-Miguel B, Crespo I, Laliena A, Vallejo D, et al. (2013) Melatonin treatment reduces endoplasmic reticulum stress and modulates the unfolded protein response in rabbits with lethal fulminant hepatitis of viral origin. J Pineal Res 55: 221-228.
40. Willis BC, Liebler JM, Luby-Phelps K, Nicholson AG, Crandall ED, et al. (2005) Induction of epithelial-mesenchymal transition in alveolar epithelial cells by transforming growth factor-beta1: potential role in idiopathic pulmonary fibrosis. Am J Pathol 166: 1321-1332. (Pubitemid 40586504)
41. Vyas-Read S, Shaul PW, Yuhanna IS, Willis BC (2007) Nitric oxide attenuates epithelial-mesenchymal transition in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol 293: L212-221. (Pubitemid 47080729)
42. Muro AF, Moretti FA, Moore BB, Yan M, Atrasz RG, et al. (2008) An essential role for fibronectin extra type III domain A in pulmonary fibrosis. Am J Respir Crit Care Med 177: 638-645. (Pubitemid 351442171)
43. Hu B, Gharaee-Kermani M, Wu Z, Phan SH (2011) Essential role of MeCP2 in the regulation of myofibroblast differentiation during pulmonary fibrosis. Am J Pathol 178: 1500-1508.
44. Huang LS, Fu P, Patel P, Harijith A, Sun T, et al. (2013) Lysophosphatidic acid receptor-2 deficiency confers protection against bleomycin-induced lung injury and fibrosis in mice. Am J Respir Cell Mol Biol 49: 912-922.