Plasma carotenoids, Vitamin C, tocopherols, and retinol and the risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort

American Journal of Clinical Nutrition

Volumn 103, Issue 2, 2016, Pages 454-464

  Bakker, Marije F ^a   Peeters, Petra H M ^a,b   Klaasen, Veronique M ^a,c   Bueno De Mesquita, H Bas ^a,b,d,e   Jansen, Eugene H J M ^d   Ros, Martine M ^d   Travier, Noémie ^f   Olsen, Anja ^g   Tjønneland, Anne ^g   Overvad, Kim ^h   Rinaldi, Sabina ⁱ   Romieu, Isabelle ⁱ   Brennan, Paul ⁱ   Boutron Ruault, Marie Christine ^j,k,l   Perquier, Florence ^j,k,l   Cadeau, Claire ^j,k,l   Boeing, Heiner ^m   Aleksandrova, Krasimira ^m   Kaaks, Rudolf ⁿ   Kühn, Tilman ⁿ   Trichopoulou, Antonia ^o,p   Lagiou, Pagona ^o,q,r   Trichopoulos, Dimitrios ^p,q,r   Vineis, Paolo ^b,s   Krogh, Vittorio ^t   Panico, Salvatore ^u   Masala, Giovanna ^v   Tumino, Rosario ^w   Weiderpass, Elisabete ^x,y,z,aa   Skeie, Guri ^x   Lund, Eiliv ^x   Quirós, J Ramón ^ab   Ardanaz, Eva ^ac,ad   Navarro, Carmen ^ad,ae,af   Amiano, Pilar ^ad,ag   Sánchez, María José ^ad,ah   Buckland, Genevieve ^f   Ericson, Ulrika ^ai   Sonestedt, Emily ^ai   Johansson, Matthias ^i,aj   Sund, Malin ^ak   Travis, Ruth C ^al   Key, Timothy J ^al   Khaw, Kay Tee ^am   Wareham, Nick ^am   Riboli, Elio ^b   Van Gils, Carla H ^a   more..

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b IMPERIAL COLLEGE LONDON   (United Kingdom)

^c WAGENINGEN UNIVERSITY   (Netherlands)

^d NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^e UNIVERSITY OF MALAYA   (Malaysia)

^f CATALAN INSTITUTE OF ONCOLOGY   (Spain)

^g DANISH CANCER SOCIETY RESEARCH CENTER   (Denmark)

^h AARHUS UNIVERSITY   (Denmark)

ⁱ INTERNATIONAL AGENCY FOR RESEARCH ON CANCER   (France)

^j INSERM   (France)

^k UNIVERSITÉ PARIS SACLAY   (France)

^l IGR   (France)

^m GERMAN INSTITUTE OF HUMAN NUTRITION   (Germany)

ⁿ GERMAN CANCER RESEARCH CENTER DKFZ   (Germany)

^o UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^p HELLENIC HEALTH FOUNDATION   (Greece)

^q HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^r BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^s Human Genetics Foundation   (Italy)

^t NATIONAL CANCER INSTITUTE   (Italy)

^u UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^v CANCER RESEARCH AND PREVENTION INSTITUTE ISPO   (Italy)

^w CIVILE M P AREZZO HOSPITAL   (Italy)

^x UNIVERSITY OF TROMSØ   (Norway)

^y CANCER REGISTRY OF NORWAY   (Norway)

^z KAROLINSKA INSTITUTE   (Sweden)

^aa FOLKHÄLSAN RESEARCH CENTER   (Finland)

^ab Public Health Dir   (Spain)

^ac INSTITUTO DE SALUD PÚBLICA DE NAVARRA   (Spain)

^ad CIBER EPIDEMIOLOGÍA Y SALUD PÚBLICA CIBERESP   (Spain)

^ae DEPARTMENT OF EPIDEMIOLOGY   (Spain)

^af UNIVERSITY OF MURCIA   (Spain)

^ag BIODONOSTIA HEALTH RESEARCH INSTITUTE   (Spain)

^ah ANDALUSIAN SCHOOL OF PUBLIC HEALTH   (Spain)

^ai LUND UNIVERSITY   (Sweden)

^aj Lund University ^*  (Sweden)

^ak UMEÅ UNIVERSITY   (Sweden)

^al UNIVERSITY OF OXFORD   (United Kingdom)

^am UNIVERSITY OF CAMBRIDGE   (United Kingdom)

more..

Author keywords

Antioxidants; Breast cancer; Carotenoids; EPIC; Plasma

Indexed keywords

ALPHA CAROTENE; ASCORBIC ACID; BETA CAROTENE; ESTROGEN RECEPTOR; RETINOL; TOCOPHEROL; ZEAXANTHIN; ALPHA-CAROTENE; ANTIOXIDANT; CAROTENOID; TUMOR PROTEIN;

ADULT; ALCOHOL CONSUMPTION; ARTICLE; BODY MASS; BREAST CANCER; CANCER RISK; CASE CONTROL STUDY; COHORT ANALYSIS; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; FEMALE; FOLLOW UP; HUMAN; LEAFY VEGETABLE; MAJOR CLINICAL STUDY; MULTICENTER STUDY; PREMENOPAUSE; PROSPECTIVE STUDY; ROOT VEGETABLE; SMOKING; VITAMIN BLOOD LEVEL; BLOOD; BREAST NEOPLASMS; CLINICAL TRIAL; DIET; EUROPE; METABOLISM; MIDDLE AGED; PATHOLOGY; POSTMENOPAUSE; RISK;

ADULT; ANTIOXIDANTS; ASCORBIC ACID; BETA CAROTENE; BREAST NEOPLASMS; CAROTENOIDS; CASE-CONTROL STUDIES; COHORT STUDIES; DIET; EUROPE; FEMALE; FOLLOW-UP STUDIES; HUMANS; MIDDLE AGED; NEOPLASM PROTEINS; POSTMENOPAUSE; PREMENOPAUSE; PROSPECTIVE STUDIES; RECEPTORS, ESTROGEN; RISK; TOCOPHEROLS; VITAMIN A;

EID: 84956892327     PISSN: 00029165     EISSN: 19383207     Source Type: Journal    
DOI: 10.3945/ajcn.114.101659     Document Type: Article

References (45)

1. Aune D, Chan DS, Vieira AR, Rosenblatt DA, Vieira R, Greenwood DC, Norat T. Fruits, vegetables and breast cancer risk: a systematic review and meta-analysis of prospective studies. Breast Cancer Res Treat 2012;134:479-93.
2. Natarajan L, Flatt SW, Sun X, Gamst AC, Major JM, Rock CL, Al-Delaimy W, Thomson CA, Newman VA, Pierce JP, et al. Validity and systematic error in measuring carotenoid consumption with dietary self-report instruments. Am J Epidemiol 2006;163:770-8.
3. Al-Delaimy WK, Ferrari P, Slimani N, Pala V, Johansson I, Nilsson S, Mattisson I, Wirfalt E, Galasso R, Palli D, et al. Plasma carotenoids as biomarkers of intake of fruits and vegetables: individual-level correlations in the European Prospective Investigation into Cancer and Nutrition (EPIC). Eur J Clin Nutr 2005;59:1387-96.
4. Block G, Norkus E, Hudes M, Mandel S, Helzlsouer K. Which plasma antioxidants are most related to fruit and vegetable consumption? Am J Epidemiol 2001;154:1113-8.
5. Fowke JH, Chung FL, Jin F, Qi D, Cai Q, Conaway C, Cheng JR, Shu XO, Gao YT, Zheng W. Urinary isothiocyanate levels, brassica, and human breast cancer. Cancer Res 2003;63:3980-6.
6. Tamimi RM, Hankinson SE, Campos H, Spiegelman D, Zhang S, Colditz GA,WillettWC, Hunter DJ. Plasma carotenoids, retinol, and tocopherols and risk of breast cancer. Am J Epidemiol 2005;161:153-60.
7. IARC Working Group on the Evaluation of Cancer Preventive Agents. IARC handbooks of cancer prevention. Vol. 2. Lyon (France): Carotenoids; 1998.
8. Kelley DS, Bendich A. Essential nutrients and immunologic functions. Am J Clin Nutr 1996;63:994S-6S.
9. Niki E. Action of ascorbic acid as a scavenger of active and stable oxygen radicals. Am J Clin Nutr 1991;54:1119S-24S.
10. Steinmetz KA, Potter JD. Vegetables, fruit, and cancer: II. Mechanisms. Cancer Causes Control 1991;2:427-42.
11. Aune D, Chan DS, Vieira AR, Navarro Rosenblatt DA, Vieira R, Greenwood DC, Norat T. Dietary compared with blood concentrations of carotenoids and breast cancer risk: a systematic review and meta-analysis of prospective studies. Am J Clin Nutr 2012;96: 356-73.
12. Eliassen AH, Hendrickson SJ, Brinton LA, Buring JE, Campos H, Dai Q, Dorgan JF, Franke AA, Gao YT, Goodman MT, et al. Circulating carotenoids and risk of breast cancer: pooled analysis of eight prospective studies. J Natl Cancer Inst 2012;104:1905-16.
13. Wu K, Helzlsouer KJ, Alberg AJ, Comstock GW, Norkus EP, Hoffman SC. A prospective study of plasma ascorbic acid concentrations and breast cancer (United States). Cancer Causes Control 2000;11:279-83.
14. Baglietto L, Krishnan K, Severi G, Hodge A, Brinkman M, English DR, McLean C, Hopper JL, Giles GG. Dietary patterns and risk of breast cancer. Br J Cancer 2011;104:524-31.
15. Boggs DA, Palmer JR, Wise LA, Spiegelman D, Stampfer MJ, Adams-Campbell LL, Rosenberg L. Fruit and vegetable intake in relation to risk of breast cancer in the Black Women's Health Study. Am J Epidemiol 2010;172:1268-79.
16. Fung TT, Hu FB, McCullough ML, Newby PK, Willett WC, Holmes MD. Diet quality is associated with the risk of estrogen receptor-negative breast cancer in postmenopausal women. J Nutr 2006;136: 466-72.
17. Olsen A, Tjonneland A, Thomsen BL, Loft S, Stripp C, Overvad K, Moller S, Olsen JH. Fruits and vegetables intake differentially affects estrogen receptor negative and positive breast cancer incidence rates. J Nutr 2003;133:2342-7.
18. Zhang X, Spiegelman D, Baglietto L, Bernstein L, Boggs DA, van den Brandt PA, Buring JE, Gapstur SM, Giles GG, Giovannucci E, et al. Carotenoid intakes and risk of breast cancer defined by estrogen receptor and progesterone receptor status: a pooled analysis of 18 prospective cohort studies. Am J Clin Nutr 2012;95:713-25.
19. Zhang S, Hunter DJ, Forman MR, Rosner BA, Speizer FE, Colditz GA, Manson JE, Hankinson SE, Willett WC. Dietary carotenoids and vitamins A, C, and E and risk of breast cancer. J Natl Cancer Inst 1999; 91:547-56.
20. Hultén K, Van Kappel AL, Winkvist A, Kaaks R, Hallmans G, Lenner P, Riboli E. Carotenoids, alpha-tocopherols, and retinol in plasma and breast cancer risk in northern Sweden. Cancer Causes Control 2001;12: 529-37.
21. Dorjgochoo T, Gao YT, Chow WH, Shu XO, Li H, Yang G, Cai Q, Rothman N, Cai H, Franke AA, et al. Plasma carotenoids, tocopherols, retinol and breast cancer risk: results from the ShanghaiWomen Health Study (SWHS). Breast Cancer Res Treat 2009;117:381-9.
22. Epplein M, Shvetsov YB, Wilkens LR, Franke AA, Cooney RV, Le Marchand L, Henderson BE, Kolonel LN, Goodman MT. Plasma carotenoids, retinol, and tocopherols and postmenopausal breast cancer risk in the Multiethnic Cohort Study: a nested case-control study. Breast Cancer Res 2009;11:R49.
23. Kabat GC, Kim M, Adams-Campbell LL, Caan BJ, Chlebowski RT, Neuhouser ML, Shikany JM, Rohan TE, Investigators WHI. Longitudinal study of serum carotenoid, retinol, and tocopherol concentrations in relation to breast cancer risk among postmenopausal women. Am J Clin Nutr 2009;90:162-9.
24. Maillard V, Kuriki K, Lefebvre B, Boutron-Ruault MC, Lenoir GM, Joulin V, Clavel-Chapelon F, Chajès V. Serum carotenoid, tocopherol and retinol concentrations and breast cancer risk in the E3N-EPIC study. Int J Cancer 2010;127:1188-96.
25. Dorgan JF, Sowell A, Swanson CA, Potischman N, Miller R, Schussler N, Stephenson HE Jr. Relationships of serum carotenoids, retinol, alpha-tocopherol, and selenium with breast cancer risk: results from a prospective study in Columbia, Missouri (United States). Cancer Causes Control 1998;9:89-97.
26. Riboli E, Hunt KJ, Slimani N, Ferrari P, Norat T, Charrondière UR, Hémon B, Casagrande C, Vignat J, Overvad K, et al. European Prospective Investigation into Cancer and Nutrition (EPIC): study populations and data collection. Public Health Nutr 2002;5:1113-24.
27. Kühn T, Kaaks R, Becker S, Eomois PP, Clavel-Chapelon F, Kvaskoff M, Dossus L, Tjonneland A, Olsen A, Overvad K, et al. Plasma 25-hydroxyvitamin D and the risk of breast cancer in the European prospective investigation into cancer and nutrition: a nested case-control study. Int J Cancer 2013;133:1689-700.
28. Ros MM, Bueno-de-Mesquita HB, Kampman E, Aben KK, Büchner FL, Jansen EH, van Gils CH, Egevad L, Overvad K, Tjonneland A, et al. Plasma carotenoids and vitamin C concentrations and risk of urothelial cell carcinoma in the European Prospective Investigation into Cancer and Nutrition. Am J Clin Nutr 2012;96:902-10.
29. Steghens JP, Van Kappel AL, Riboli E, Collombel C. Simultaneous measurement of seven carotenoids, retinol and alpha-tocopherol in serum by high-performance liquid chromatography. J Chromatogr B Biomed Sci Appl 1997;694:71-81.
30. Wareham NJ, Jakes RW, Rennie KL, Schuit J, Mitchell J, Hennings S, Day NE. Validity and repeatability of a simple index derived from the short physical activity questionnaire used in the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Public Health Nutr 2003;6:407-13.
31. James RE, Lukanova A, Dossus L, Becker S, RinalDi S, Tjonneland A, Olsen A, Overvad K, Mesrine S, Engel P, et al. Postmenopausal serum sex steroids and risk of hormone receptor-positive and-negative breast cancer: a nested case-control study. Cancer Prev Res (Phila) 2011;4: 1626-35.
32. Brooks PJ. DNA damage, DNA repair, and alcohol toxicity-a review. Alcohol Clin Exp Res 1997;21:1073-82.
33. Key TJ. Fruit and vegetables and cancer risk. Br J Cancer 2011;104: 6-11.
34. Lachance PA, Nakat Z, Jeong WS. Antioxidants: an integrative approach. Nutrition 2001;17:835-8.
35. Nagel G, Linseisen J, Van Gils CH, Peeters PHM, Boutron-Ruault MC, Clavel-Chapelon F, Romieu I, Tjonneland A, Olsen A, Roswall N, et al. Dietary beta-carotene, vitamin C and E intake and breast cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Breast Cancer Res Treat 2010;119:753-65.
36. Jung S, Spiegelman D, Baglietto L, Bernstein L, Boggs DA, van den Brandt PA, Buring JE, Cerhan JR, Gaudet MM, Giles GG, et al. Fruit and vegetable intake and risk of breast cancer by hormone receptor status. J Natl Cancer Inst 2013;105:219-36.
37. Wang Y, Gapstur SM, Gaudet MM, Furtado JD, Campos H, McCullough ML. Plasma carotenoids and breast cancer risk in the Cancer Prevention Study II Nutrition Cohort. Cancer Causes Control 2015;26:1233-44.
38. Eliassen AH, Liao X, Rosner B, Tamimi M, Tworoger SS, Hankinson SE. Plasma carotenoids and risk of breast cancer over 20 y of followup. Am J Clin Nutr 2015;101:1197-205.
39. Buckland G, Travier N, Cottet V, González CA, Luján-Barroso L, Agudo A, Trichopoulou A, Lagiou P, Trichopoulos D, Peeters PHM, et al. Adherence to the Mediterranean diet and risk of breast cancer in the European Prospective Investigation into Cancer and Nutrition cohort study. Int J Cancer 2013;132:2918-27.
40. Toniolo P, Van Kappel AL, Akhmedkhanov A, Ferrari P, Kato I, Shore RE, Riboli E. Serum carotenoids and breast cancer. Am J Epidemiol 2001;153:1142-7.
41. Comstock GW, Alberg AJ, Helzlsouer KJ. Reported effects of long-term freezer storage on concentrations of retinol, beta-carotene, and alphatocopherol in serum or plasma summarized. Clin Chem 1993;39:1075-8.
42. Jenab M, Bingham S, Ferrari P, Friesen MD, Al-Delaimy WK, Luben R, Wareham N, Khaw KT, Riboli E. Long-term cryoconservation and stability of vitamin C in serum samples of the European prospective investigation into cancer and nutrition. Cancer Epidemiol Biomarkers Prev 2005;14:1837-40.
43. Jenab M, Riboli E, Ferrari P, Friesen M, Sabate J, Norat T, Slimani N, Tjonneland A, Olsen A, Overvad K, et al. Plasma and dietary carotenoid, retinol and tocopherol levels and the risk of gastric adenocarcinomas in the European Prospective Investigation into Cancer and Nutrition. Br J Cancer 2006;95:406-15.
44. Druesne-Pecollo N, Latino-Martel P, Norat T, Barrandon E, Bertrais S, Galan P, Hercberg S. Beta-carotene supplementation and cancer risk: a systematic review and metaanalysis of randomized controlled trials. Int J Cancer 2010;127:172-84.
45. Jenab M, Slimani N, Bictash M, Ferrari P, Bingham SA. Biomarkers in nutritional epidemiology: applications, needs and new horizons. Hum Genet 2009;125:507-25.