Imaging single-cell signaling dynamics with a deterministic high-density single-cell trap array

Analytical Chemistry

Volumn 83, Issue 18, 2011, Pages 7044-7052

  Chung, Kwanghun ^a   Rivet, Catherine A ^b   Kemp, Melissa L ^b,c   Lu, Hang ^a,b  

^a Georgia Institute of Technology   (United States)

^b GEORGIA INSTITUTE OF TECHNOLOGY   (United States)

^c Emory University   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL STIMULATION; CELLULAR ENVIRONMENT; CELLULAR PROCESS; CELLULAR RESPONSE; CHEMICAL STIMULI; CURRENT TECHNOLOGY; DENSE ARRAYS; DRUG RESPONSE; HIGH-DENSITY; HIGH-THROUGHPUT; INDIVIDUAL CELLS; LOADING EFFICIENCY; METABOLITE LEVEL; MICROFLUIDIC COMPONENTS; MICROFLUIDIC PLATFORMS; OSCILLATORY BEHAVIORS; SINGLE CELLS; STOCHASTICITY; TRAP DENSITY; TRAPPING MECHANISMS;

CELLS; GENE EXPRESSION; MICROFLUIDICS;

CYTOLOGY;

BAYSILON; CALCIUM; DIMETICONE; IONOMYCIN;

ARTICLE; CHEMISTRY; CONFOCAL MICROSCOPY; DRUG EFFECT; HUMAN; LEUKEMIA CELL LINE; METABOLISM; METHODOLOGY; MICROFLUIDIC ANALYSIS; SIGNAL TRANSDUCTION;

CALCIUM; DIMETHYLPOLYSILOXANES; HUMANS; IONOMYCIN; JURKAT CELLS; MICROFLUIDIC ANALYTICAL TECHNIQUES; MICROSCOPY, CONFOCAL; SIGNAL TRANSDUCTION;

EID: 80052813897     PISSN: 00032700     EISSN: None     Source Type: Journal    
DOI: 10.1021/ac2011153     Document Type: Article

References (28)

1. Raj, A.; Peskin, C. S.; Tranchina, D.; Vargas, D. Y.; Tyagi, S. PLoS Biol. 2006, 4, 1707-1719
2. Elowitz, M. B.; Levine, A. J.; Siggia, E. D.; Swain, P. S. Science 2002, 297, 1183-1186
3. Chang, H. H.; Hemberg, M.; Barahona, M.; Ingber, D. E.; Huang, S. Nature 2008, 453, 544-547
4. Singh, D. K.; Ku, C. J.; Wichaidit, C.; Steininger, R. J.; Wu, L. F.; Altschuler, S. J. Mol. Syst. Biol. 2010, 6 369
5. Cohen, A. A.; Geva-Zatorsky, N.; Eden, E.; Frenkel-Morgenstern, M.; Issaeva, I.; Sigal, A.; Milo, R.; Cohen-Saidon, C.; Liron, Y.; Kam, Z.; Cohen, L.; Danon, T.; Perzov, N.; Alon, U. Science 2008, 322, 1511-1516
6. Spencer, S. L.; Gaudet, S.; Albeck, J. G.; Burke, J. M.; Sorger, P. K. Nature 2009, 459, 428-432
7. Eldar, A.; Elowitz, M. B. Nature 2010, 467, 167-173
8. Irimia, D.; Toner, M. Lab Chip 2006, 6, 345-352
9. Wheeler, A. R.; Throndset, W. R.; Whelan, R. J.; Leach, A. M.; Zare, R. N.; Liao, Y. H.; Farrell, K.; Manger, I. D.; Daridon, A. Anal. Chem. 2003, 75, 3581-3586
10. Taff, B. M.; Voldman, J. Anal. Chem. 2005, 77, 7976-7983
11. Voldman, J.; Gray, M. L.; Toner, M.; Schmidt, M. A. Anal. Chem. 2002, 74, 3984-3990
12. Enger, J.; Goksor, M.; Ramser, K.; Hagberg, P.; Hanstorp, D. Lab Chip 2004, 4, 196-200
13. Rettig, J. R.; Folch, A. Anal. Chem. 2005, 77, 5628-5634
14. Yamamura, S.; Kishi, H.; Tokimitsu, Y.; Kondo, S.; Honda, R.; Rao, S. R.; Omori, M.; Tamiya, E.; Muraguchi, A. Anal. Chem. 2005, 77, 8050-8056
15. Figueroa, X. A.; Cooksey, G. A.; Votaw, S. V.; Horowitz, L. F.; Folch, A. Lab Chip 2010, 10, 1120-1127
16. Park, J. Y.; Morgan, M.; Sachs, A. N.; Samorezov, J.; Teller, R.; Shen, Y.; Pienta, K. J.; Takayama, S. Microfluidics Nanofluidics 2010, 8, 263-268
17. Di Carlo, D.; Aghdam, N.; Lee, L. P. Anal. Chem. 2006, 78, 4925-4930
18. Skelley, A. M.; Kirak, O.; Suh, H.; Jaenisch, R.; Voldman, J. Nat. Methods 2009, 6, 147-152
19. Tan, W. H.; Takeuchi, S. Proc. Natl. Acad. Sci. U.S.A. 2007, 104, 1146-1151
20. Faley, S.; Seale, K.; Hughey, J.; Schaffer, D. K.; VanCornpernolle, S.; McKinney, B.; Baudenbacher, F.; Unutmaz, D.; Wikswo, J. P. Lab Chip 2008, 8, 1700-1712
21. Kobel, S.; Valero, A.; Latt, J.; Renaud, P.; Lutolf, M. Lab Chip 2010, 10, 857-863
22. Kim, M. C.; Wang, Z. H.; Lam, R. H. W.; Thorsen, T. J. Appl. Phys. 2008, 103 044701
23. Chung, K.; Kim, Y.; Kanodia, J. S.; Gong, E.; Shvartsman, S. Y.; Lu, H. Nat. Methods 2011, 8, 171-176
24. McDonald, J. C.; Duffy, D. C.; Anderson, J. R.; Chiu, D. T.; Wu, H. K.; Schueller, O. J. A.; Whitesides, G. M. Electrophoresis 2000, 21, 27-40
25. Skupin, A.; Kettenmann, H.; Falcke, M. PLoS Comput. Biol. 2010, 6 (8 e1000870
26. Jeon, N. L.; Dertinger, S. K. W.; Chiu, D. T.; Choi, I. S.; Stroock, A. D.; Whitesides, G. M. Langmuir 2000, 16, 8311-8316
27. Imboden, J. B.; Weiss, A. Biochem. J. 1987, 247, 695-700
28. Nakamura, N.; Yamazawa, T.; Okubo, Y.; Iino, M. Mol. Syst. Biol. 2009, 5 247