Hypoglycemic and Hypolipidemic Effects of Aloe vera Extract Preparations: A Review

Phytotherapy Research

Volumn 30, Issue 2, 2016, Pages 200-207

  Pothuraju, Ramesh ^a   Sharma, Raj Kumar ^a   Onteru, Suneel Kumar ^a   Singh, Satvinder ^a   Hussain, Shaik Abdul ^a  

^a NATIONAL DAIRY RESEARCH INSTITUTE   (India)

Author keywords

Aloe vera; diabetes; hypoglycemic; hypolipidemic; obesity

Indexed keywords

ALOE VERA EXTRACT; PHYTOSTEROL; ANTIDIABETIC AGENT; ANTILIPEMIC AGENT; PLANT EXTRACT; SOLVENT;

ALOE VERA; ANTIDIABETIC ACTIVITY; ANTIOXIDANT ACTIVITY; BIOLOGICAL ACTIVITY; CARBOHYDRATE METABOLISM; CHEMICAL COMPOSITION; DIABETES MELLITUS; DIARRHEA; DRUG ACTIVITY; DRUG MECHANISM; GENE EXPRESSION; GLUCOSE METABOLISM; HUMAN; HYPOLIPIDEMIC EFFECT; INTESTINE FLORA; LACTOBACILLUS CASEI; LIPID METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; OBESITY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; VOMITING; ALOE; ANIMAL; CHEMISTRY; CLINICAL TRIAL (TOPIC); DRUG EFFECTS; PHYTOTHERAPY;

ALOE; ANIMALS; CARBOHYDRATE METABOLISM; CLINICAL TRIALS AS TOPIC; DIABETES MELLITUS; HUMANS; HYPOGLYCEMIC AGENTS; HYPOLIPIDEMIC AGENTS; LIPID METABOLISM; OBESITY; PHYTOTHERAPY; PLANT EXTRACTS; SOLVENTS;

EID: 84956832455     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5532     Document Type: Review

References (76)

1. Ajabnoor MA,. 1990. Effect of aloes on blood glucose levels in normal and alloxan diabetic mice. J Ethanopharmacol 28: 215-220.
2. Alinejad-Mofrad S, Foadoddini M, Saadatjoo SA, Shayesteh M,. 2015. Improvement of glucose and lipid profile status with Aloe vera in pre-diabetic subjects: a randomized controlled-trial. J Diabetes Metab Disord 14: 22.
3. Arumugam M, Raes J, Pelletier E, et al,. 2011. Entero types of the human gut microbiome. Nature 473: 174-180.
4. Basannavar S, Pothuraju R, Sharma RK,. 2014. Effect of Aloe vera (Aloe barbadensis Miller) on survivability, extent of proteolysis and ACE inhibition of potential probiotic cultures in fermented milk. J Sci Food Agric 94: 2712-2717.
5. Baynes JW,. 1991. Role of oxidative stress in development of complications in diabetes. Diabetes 40: 405-412.
6. Beppu H, Koike T, Shimpo K, et al,. 2003. Radical scavenging effects of Aloe arborescens Miller on prevention of pancreatic islet B-cell destruction in rats. J Ethanopharmacol 89: 37-45.
7. Beppu H, Shimpo K, Chihara T, et al,. 2006. Antidiabetic effects of dietary administration of Aloe arborescens Miller components on multiple low-dose streptozotocin-induced diabetes inmice: investigation on hypoglycemic action and systemic absorption dynamics of aloe components. J Ethnopharmacol 103: 468-477.
8. Boban PT, Nambisan B, Sudhakaran PR,. 2006. Hypolipidemic effect of chemically different mucilages in rats: a comparative study. Br J Nutr 96: 1021-1029.
9. Brixova E,. 1981. Experimental and clinical liver steatosis. Folia Fac Med Univ Comenian Bratisl 19: 9-90.
10. Bunner AE, Chandrasekera PC, Barnard ND,. 2014. Knockout mouse models of insulin signaling: relevance past and future. World J Diabetes 5: 146-159.
11. Bunyapraphatsara N, Yongchaiyudha S, Rungpitarangsi V, Chokechaijaroenporn O,. 1996. Antidiabetic activity of Aloe vera L. juice. II. Clinical trial in diabetes mellitus patients in combination with glibenclamide. Phytomedicine 3: 245-248.
12. Can A, Akev N, Ozsoy N, et al,. 2004. Effects of Aloe vera leaf gel and pulp extracts on the liver in type-II diabetic rat models. Biol Pharm Bull 27: 694-698.
13. Cani PD, Bibiloni R, Knauf C, et al,. 2008. Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice. Diabetes 57: 1470-1481.
14. Cardenas C, Quesada AR, Medina MA,. 2006. Evaluation of the anti-angiogenic effect of aloe-emodin. Cell Mol Life Sci 63: 3083-3089.
15. Chinnusamy K, Nandagopal T, Nagaraj K, Sridharan S,. 2009. Aloe vera induced oral mucositis: a case report. Internet J Pediatr Neonatol 9.
16. Choi HC, Kim SJ, Son KY, et al,. 2013. Metabolic effects of Aloe vera gel complex in obese prediabetes and early non-treated diabetic patients: randomized controlled trial. Nutrition 29: 1110-1114.
17. Choudhary M, Kochhar A, Sangha J,. 2014. Hypoglycemic and hypolipidemic effect of Aloe vera L. in non-insulin dependent diabetics. J Food Sci Technol 51: 90-96.
18. Cirillo C, Capasso R,. 2015. Constipation and botanical medicines: an overview. Phytother Res 14.
19. Dagne E, Bisrat D, Viljoen A, Van Wyk BE,. 2000. Chemistry of Aloe species. Curr Org Chem 4: 1055-1078.
20. Devaraj S, Yimam M, Brownell LA, Jialal I, Singh S, Jia Q,. 2013. Effects of Aloe vera supplementation in subjects with prediabetes/metabolic syndrome. Metab Syndr Relat Disord 11: 35-40.
21. Diehl AM,. 2004. Obesity and alcoholic liver disease. Alcohol 34: 81-87.
22. Grindlay D, Reynolds T,. 1986. The Aloe vera phenomenon: a review of the properties and modern uses of the leaf parenchyma gel. J Ethanopharmacol 16: 117-151.
23. Hamman JH,. 2008. Composition and applications of Aloe vera leaf gel. Molecules 13: 1599-1616.
24. Hashemi SA, Madani SA, Abediankenari S,. 2015. The review on properties of Aloe vera in healing of cutaneous wounds. Biomed Res Int 1-6.
25. Hernández RJ,. 1992. Na+/K(+)-ATPase regulation by neurotransmitters. Neurochem Int 20: 1-10.
26. Hus SC, Huang CJ,. 2006. Reduced fat mass in rats fed a high oleic acid rich safflower oil diet is associated with changes in expression of hepatic PPARα and adipose SREBP-1c regulated genes. J Nutr 136: 1779-1785.
27. Huseini HF, Kianbakht S, Hajiaghaee R, Dabaghian FH,. 2012. Anti-hyperglycemic and anti-hypercholesterolemic effects of Aloe vera leaf gel in hyperlipidemic type 2 diabetic patients: a randomized double-blind placebo-controlled clinical trial. Planta Med 78: 311-316.
28. Ishii Y, Tanizawa H, Takino Y,. 1990. Studies of aloe. III. Mechanism of cathartic effect. Chem Pharm Bull (Tokya) 38: 197-200.
29. Jain A, Gupta Y, Jain SK,. 2007. Perspectives of biodegradable natural polysaccharides for site-specific drug delivery to the colon. J Pharm Pharm Sci 10: 86-128.
30. Kershaw EE, Flier JS,. 2004. Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89: 2548-2556.
31. Kim K, Kim H, Kwon J, et al,. 2009. Hypoglycemic and hypolipidemic effects of processed Aloe vera gel in a mouse model of non-insulin-dependent diabetes mellitus. Phytomedicine 16: 856-863.
32. Koo MWL,. 1994. Aloe vera: antiulcer and antidiabetic effects. Phytother Res 8: 461-464.
33. Kumar S, Sharma B, Tomar NR, Roy P, Gupta AK, Kumar A,. 2011. In vivo evaluation of hypoglycemic activity of Aloe spp. and identification of its mode of action on GLUT-4 gene expression in vitro. Appl Biochem Biotechnol 164: 1246-1256.
34. Langmead L, Makins RJ, Rampton DS,. 2004. Anti-inflammatory effects of Aloe vera gel in human colorectal mucosa in vitro. Aliment Pharmacol Ther 19: 521-527.
35. Lazar MA,. 2006. The humoral side of insulin resistance. Nat Med 12: 43-44.
36. Mancini MC, Halpern A,. 2006. Pharmacological treatment of obesity. Arq Bras Endocrinol Metabol 50: 377-389.
37. Mangaiyarkarasi SP, Manigandan T, Elumalai M, Cholan PK, Kaur RP,. 2015. Benefits of Aloe vera in dentistry. J Pharm Bioallied Sci 7: S2559.
38. Miroddi M, Navarra M, Calapai F, et al,. 2015. Review of clinical pharmacology of Aloe vera L. in the treatment of psoriasis. Phytother Res 29: 64855.
39. Misawa E, Tanaka M, Nomaguchi K, et al,. 2008. Administration of phytosterols isolated from Aloe vera gel reduce visceral fat mass and improve hyperglycemia in Zucker diabetic fatty (ZDF) rats. Obes Res Clin Pract 2: 239-245.
40. Misawa E, Tanaka M, Nomaguchi K, et al,. 2012. Oral ingestion of Aloe vera phytosterols alters hepatic gene expression profiles and ameliorates obesity-associated metabolic disorders in Zucker diabetic fatty rats. J Agric Food Chem 60: 2799-2806.
41. Mogale MA, Lebelo SL, Shai LJ, Eloff JN,. 2011. Aloe arborescens aqueous gel extract alters the activities of key hepatic enzymes and blood concentration of triglycerides, glucose and insulin in alloxan induced diabetic rats. Afr J Biotechnol 10: 4242-4248.
42. Mohamed EAK,. 2011. Antidiabetic, antihypercholestermic and antioxidative effect of Aloe vera gel extract in alloxan induced diabetic rats. Aust J Basic Appl Sci 5: 1321-1327.
43. Moniruzzaman M, Rokeya B, Ahmed S, Bhowmik A, Khalil MI, Gan SH,. 2012. In vitro antioxidant effects of Aloe barbadensis Miller extracts and the potential role of these extracts as antidiabetic and antilipidemic agents on streptozotocin-induced type 2 diabetic model rats. Molecules 17: 12851-12867.
44. Morrow DM, Rapaport MJ, Strick RA,. 1980. Hypersensitivity to aloe. Arch Dermatol 116: 1064-1065.
45. Nelson DL, Cox MM,. 2008. Principles of Biochemistry, 5th edn. W.H. Freeman and Company Pub: NewYork; 930.
46. Nguyen DM, El-Serag HB,. 2010. The epidemiology of obesity. Gastroenterol Clin North Am 39: 1-7.
47. Nomaguchi K, Tanaka M, Misawa E, et al,. 2011. Aloe vera phytosterols act as ligands for PPAR and improve the expression levels of PPAR target genes in the livers of mice with diet-induced obesity. Obes Res Clin Pract 5: e190-e201.
48. Noor A, Gunasekaran S, Manickam AS, Vijayalakshmi MA,. 2008. Anti-diabetic activity of Aloe vera and histology of organs. Curr Sci 94: 1070-1076.
49. Park DY, Ahn YT, Park SH, et al,. 2013. Supplementation of Lactobacillus curvatus HY7601 and Lactobacillus plantarum KY1032 in diet-induced obese mice is associated with gut microbial changes and reduction in obesity. PLoS One 8: e59470.
50. Perez YY, Jiménez-Ferrer E, Zamilpa A, et al,. 2007. Effect of polyphenol rich extract from Aloe vera gel on experimentally induced insulin resistance in mice. Am J Chin Med 35: 1037-1046.
51. Pogribna M, Freeman JP, Paine D, Boudreau MD,. 2008. Effect of Aloe vera whole leaf extract on short chain fatty acids production by Bacteroides fragilis, Bifidobacterium infantis and Eubacterium limosum. Lett Appl Microbiol 46: 575-580.
52. Pothuraju R, Sharma RK, Chagalamarri J, Jangra S, Kumar Kavadi P,. 2014. A systematic review of Gymnema sylvestre in obesity and diabetes management. J Sci Food Agric 94: 834-840.
53. Pothuraju R, Sharma RK, Chagalamarri J, Kavadi PK, Jangra S,. 2015. Influence of milk fermented with Lactobacillus rhamnosus NCDC 17 alone and in combination with herbal ingredients on diet induced adiposity and related gene expression in C57BL/6 J mice. Food Funct. DOI: 10.1039/c5fo00781j.
54. Purohit V, Gao B, Song B,. 2009. Molecular mechanisms of alcoholic fatty liver. Alcohol Clin Exp Res 33: 191-205.
55. Rajasekaran S, Sivagnanam K, Subramanian S,. 2005a. Modulatory effects of Aloe vera leaf gel extract on oxidative stress in rats treated with streptozotocin. J Pharm Pharmacol 57: 241-246.
56. Rajasekaran S, Sivagnanam K, Subramanian S,. 2005b. Antioxidant effect of Aloe vera gel extract in streptozotocin-induced diabetes in rats. Pharmacol Rep 57: 90-96.
57. Rajasekaran S, Ravi K, Sivagnanam K, Subramanian S,. 2006. Beneficial effects of Aloe vera leaf gel extract on lipid profile status in rats with streptozotocin diabetes. Clin Exp Pharmacol Physiol 33: 232-237.
58. Rajasekaran S, Sriram N, Arulselvan P, Subramanian S,. 2007. Effect of Aloe vera leaf gel extract on membrane bound phosphatases and lysosomal hydrolases in rats with streptozotocin diabetes. Pharmazie 62: 221-225.
59. Ralph A, Provan GJ,. 2000. Phytoprotectants. In:, Garrow JS, James WPT, Ralph A, (eds). In Human Nutrition and Dietetics. Churchill Livingstone: Edinburgh; 417-426.
60. Saito M, Tanaka M, Misawa E, Yamada M, Yamauchi K, Iwatsuki K,. 2012. Aloe vera gel extract attenuates ethanol-induced hepatic lipid accumulation by suppressing the expression of lipogenic genes in mice. Biosci Biotechnol Biochem 76: 2049-2054.
61. Saito-Yamanaka N, Yamanaka H, Nagasawa S,. 1993. Glutathione-related detoxication functions in streptozotocin-induced diabetic rats. J Vet Med Sci 55: 991-994.
62. Sears IB, MacGinnitie MA, Kovacs LG, Graves RA,. 1996. Differentiation-dependent expression of the brown adipocyte uncoupling protein gene: regulation by peroxisome proliferator-activated receptor gamma. Mol Cell Biol 16: 3410-3419.
63. Seifter S, England S,. 1982. The liver biology and pathobiology. In Energy Metabolism, Arias I, Popper H, Schacter D, (eds). Raven Press: New York; 219-249.
64. Sweeney G, Klip A,. 1998. Regulation of the Na+/K+-ATPase by insulin: why and how? Mol Cell Biochem 182: 121-133.
65. Tanaka M, Misawa E, Ito Y, et al,. 2006. Identification of five phytosterols from Aloe vera gel as anti-diabetic compounds. Biol Pharm Bull 29: 1418-1422.
66. Thomas CE, Reed DJ,. 1990. Radical-induced inactivation of kidney Na+, K(+)-ATPase: sensitivity to membrane lipid peroxidation and the protective effect of vitamin E. Arch Biochem Biophys 281: 96-105.
67. Ulbricht C, Armstrong J, Basch E, et al,. 2008. An evidence based systematic review of Aloe vera by the natural standard research collaboration. J Herb Pharmacother 7: 279-323.
68. Walsh K, Alexander G,. 2000. Alcoholic liver disease. Postgrad Med J 76: 280-286.
69. Wang W, Cuyckens F, Van den Heuvel H, et al,. 2003. Structural characterization of chromone C-glucosides in a toxic herbal remedy. Rapid Commun Mass Spectrom 17: 49-55.
70. Wohaieb SA, Godin DV,. 1987. Alterations in free radical tissue-defense mechanisms in streptozocin-induced diabetes in rat. Effects of insulin treatment. Diabetes 36: 1014-1018.
71. Wolever TM, Campbell JE, Geleva D, Anderson GH,. 2004. High fiber cereal reduces postprandial insulin responses in hyperinsulinemic but not normoinsulinemic subjects. Diabetes Care 27: 1281-1285.
72. Yagi A, Nakamori J, Yamada T, et al,. 1999. In vivo metabolism of aloemannan. Planta Med 65: 417-420.
73. Yagi A, Hamano S, Tanaka T, Kaneo Y, Fujioka T, Mihashi K,. 2001. Biodisposition of FITC-labeled aloe mannan in mice. Planta Med 67: 297-300.
74. Yagi A, Hegazy S, Kabbash A, Wahab EA,. 2009. Possible hypoglycemic effect of Aloe vera L. high molecular weight fractions on type 2 diabetic patients. Saudi Pharm J 17: 209-215.
75. Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, Chokechaijaroenporn O,. 1996. Antidiabetic activity of Aloe vera L. juice. I. Clinical trial in new cases of diabetes mellitus. Phytomedicine 3: 241-243.
76. Zheng GH, Yang L, Chen HY, Chu JF, Mei L,. 2014. Aloe vera for prevention and treatment of infusion phlebitis. Cochrane Database Syst Rev 6.